CA2662083C - Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health - Google Patents

Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health Download PDF

Info

Publication number
CA2662083C
CA2662083C CA2662083A CA2662083A CA2662083C CA 2662083 C CA2662083 C CA 2662083C CA 2662083 A CA2662083 A CA 2662083A CA 2662083 A CA2662083 A CA 2662083A CA 2662083 C CA2662083 C CA 2662083C
Authority
CA
Canada
Prior art keywords
plasminogen
periodontal
tissue
periodontal disease
mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2662083A
Other languages
English (en)
French (fr)
Other versions
CA2662083A1 (en
Inventor
Tor Ny
Jinan Li
Yongzhi Guo
Tomas Lindh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnio Healer AB
Original Assignee
Omnio Healer AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnio Healer AB filed Critical Omnio Healer AB
Publication of CA2662083A1 publication Critical patent/CA2662083A1/en
Application granted granted Critical
Publication of CA2662083C publication Critical patent/CA2662083C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Birds (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2662083A 2006-08-28 2007-08-28 Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health Expired - Fee Related CA2662083C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82366506P 2006-08-28 2006-08-28
US60/823,665 2006-08-28
US94411107P 2007-06-15 2007-06-15
US60/944,111 2007-06-15
PCT/SE2007/050586 WO2008027000A2 (en) 2006-08-28 2007-08-28 Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health

Publications (2)

Publication Number Publication Date
CA2662083A1 CA2662083A1 (en) 2008-03-06
CA2662083C true CA2662083C (en) 2016-09-20

Family

ID=39136398

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2662083A Expired - Fee Related CA2662083C (en) 2006-08-28 2007-08-28 Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health

Country Status (8)

Country Link
US (3) US20100028321A1 (https=)
EP (1) EP2056865B1 (https=)
JP (1) JP5566106B2 (https=)
AU (1) AU2007290882B2 (https=)
CA (1) CA2662083C (https=)
DK (1) DK2056865T3 (https=)
ES (1) ES2453496T3 (https=)
WO (1) WO2008027000A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2849268C1 (ru) * 2025-04-21 2025-10-23 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Способ лечения периимплантита

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007290881B2 (en) 2006-08-28 2013-03-07 Omnio Healer Ab Candidates against infection
US20130164228A1 (en) * 2011-12-21 2013-06-27 Colgate-Palmolive Company Compositions comprising gallates and gallamides
US9723558B2 (en) 2012-04-27 2017-08-01 Qualcomm Incorporated Method and apparatus for signaling in dense network operations
CN104721621A (zh) * 2015-03-24 2015-06-24 孟勇 一种治疗种植体周围炎的药物组合物及其应用
ES2671844B1 (es) 2015-06-11 2019-03-22 Attwill Medical Solutions Inc Dispositivos médicos, sistemas y métodos que utilizan composiciones de anti-trombina heparina.
TWI801331B (zh) * 2015-11-03 2023-05-11 美商波麥堤克生物治療股份有限公司 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法
HK1259294A1 (zh) * 2015-11-10 2019-11-29 耶鲁大学 用於治疗自身免疫疾病和癌症的组合物及方法
JP6876066B2 (ja) * 2015-12-18 2021-05-26 タレンゲン インターナショナル リミテッドTalengen International Limited 子宮膣部びらんを予防及び治療するための方法
TWI624268B (zh) 2015-12-18 2018-05-21 Talengen Institute Of Life Sciences Co Ltd 纖溶酶原在製備藥劑上的用途及包括纖溶酶原之藥劑
WO2018107688A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗脂肪肝的方法
TWI746581B (zh) * 2016-12-15 2021-11-21 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備預防和治療脂質腎損傷之藥劑上的用途
WO2018107707A1 (zh) * 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种改善心脏病变的方法
US11207387B2 (en) 2016-12-15 2021-12-28 Talengen International Limited Method and drug for preventing and treating obesity
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
TWI787732B (zh) * 2020-02-06 2022-12-21 大陸商深圳瑞健生命科學研究院有限公司 一種預防和治療多發性硬化症的方法和藥物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3023143A (en) 1959-10-14 1962-02-27 American Cyanamid Co Process for preparing a veterinary composition
AT402367B (de) * 1990-10-11 1997-04-25 Immuno Ag Pharmazeutische zubereitung auf basis von lys-plasminogen
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
US5397578A (en) 1994-03-29 1995-03-14 Tovarischestvo S Ogranichennoi Otvetstvennostiju "Taurus" Method of treatment of chronic purulent inflammations of ear in children
US6420622B1 (en) 1997-08-01 2002-07-16 3M Innovative Properties Company Medical article having fluid control film
AU5390699A (en) * 1998-07-24 2000-02-14 Pharmacal Biotechnologies, Inc. Osseous tissue reconstruction system and method
AU3862900A (en) * 1999-03-01 2000-09-21 Uab Research Foundation Porous tissue scaffolding materials and uses thereof
US20030026794A1 (en) * 2001-07-31 2003-02-06 Howard Fein Selective enzyme treatment of skin conditions
US7067492B2 (en) * 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
JP4458240B2 (ja) * 2001-11-26 2010-04-28 ジェネンテック インコーポレイテッド カテーテル組成物とその用途
AU2003210137A1 (en) 2002-02-06 2003-09-02 N-Zyme Biotec Gmbh Method for producing recombinant proteins in micro-organisms
CN1420126A (zh) 2002-07-10 2003-05-28 牛勃 一种重组人纤溶酶原Kringle5突变体蛋白rhPK-5的制备方法
AU2007290881B2 (en) 2006-08-28 2013-03-07 Omnio Healer Ab Candidates against infection

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2849268C1 (ru) * 2025-04-21 2025-10-23 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Способ лечения периимплантита

Also Published As

Publication number Publication date
JP5566106B2 (ja) 2014-08-06
WO2008027000A3 (en) 2008-05-22
US20100028321A1 (en) 2010-02-04
JP2010502601A (ja) 2010-01-28
AU2007290882B2 (en) 2013-02-21
EP2056865B1 (en) 2013-12-25
US20180360931A1 (en) 2018-12-20
EP2056865A2 (en) 2009-05-13
EP2056865A4 (en) 2012-01-25
AU2007290882A1 (en) 2008-03-06
ES2453496T3 (es) 2014-04-08
US10086052B2 (en) 2018-10-02
US20160184411A1 (en) 2016-06-30
DK2056865T3 (en) 2014-03-24
CA2662083A1 (en) 2008-03-06
WO2008027000A2 (en) 2008-03-06
HK1134788A1 (en) 2010-05-14

Similar Documents

Publication Publication Date Title
CA2662083C (en) Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health
CN101563100B (zh) 用于预防和治疗牙周病、改善牙周创伤愈合以及促进口腔健康的新药物靶标
RU2241489C2 (ru) Композиции матриксных протеинов для залечивания ран
JP5024866B2 (ja) 創傷治癒のためのマトリックスタンパク質組成物
Aboyoussef et al. Detection of Prostaglandin E 2 and Matrix Metalloproteinases in Implant Crevicular Fluid.
JP2007291115A6 (ja) 創傷治癒のためのマトリックスタンパク質組成物
EP3413881B1 (en) Compositions and methods for treating chronic wounds
Ingman et al. Collagenase, gelatinase and elastase activities in sulcular fluid of osseointegrated implants and natural teeth
HK1134788B (en) Novel drug target of preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health
Pietruska et al. Assessment of aprotinin influence on periodontal clinical status and matrix metalloproteinases 1, 2 and their tissue inhibitors saliva concentrations in patients with chronic periodontitis
Zarandi et al. Efect of Anaheal (Bromelain) drug on the Periodontal Clinical Indices in Nonsurgical Periodontal treatment of patients with chronic Periodontitis
Deppe et al. Content of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in oral mucosa and inflamed periodontal tissue.
Kondo et al. Increased expression of angiopoietin‐like protein 4 regulates matrix metalloproteinase‐13 expression in Porphyromonas gingivalis lipopolysaccharides‐stimulated gingival fibroblasts and ligature‐induced experimental periodontitis
Kałużna-Różańska et al. Urokinase-Plasminogen Activator in Periodontitis: Role, Mechanisms and Therapeutic Potential
Wahlgren Matrix metalloproteinases in pulpitis, chronic apical periodontitis and odontogenic jaw cysts
Boushell Distribution of matrixmetalloproteinase-2 in human coronal dentin
Aslam Double blind study on the efficacy of local application of haemocoagulase solution in wound healing
Korpi Collagenase-2 (matrix metalloproteinase-8) in tongue squamous cell carcinoma, bone osteosarcoma, and wound repair
Pham Epsilon aminocaproic acid: its effect on the healing of dental extraction sites.
D OSA–TOM Nina-Li Avellán Academic Dissertation
Prajapati The regulation of proteases and mechanical loading during fibroblast populated collagen lattice contraction
Delima Pre-Wounding and Free Gingival Grafts: A Pilot Investigation

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210830