CA2657269A1 - New indications for direct thrombin inhibitors - Google Patents
New indications for direct thrombin inhibitors Download PDFInfo
- Publication number
- CA2657269A1 CA2657269A1 CA002657269A CA2657269A CA2657269A1 CA 2657269 A1 CA2657269 A1 CA 2657269A1 CA 002657269 A CA002657269 A CA 002657269A CA 2657269 A CA2657269 A CA 2657269A CA 2657269 A1 CA2657269 A1 CA 2657269A1
- Authority
- CA
- Canada
- Prior art keywords
- disease
- compound
- methyl
- dabigatran
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| EP06117345 | 2006-07-17 | ||
| EP06117345.6 | 2006-07-17 | ||
| EP07102513.4 | 2007-02-15 | ||
| EP07102513 | 2007-02-15 | ||
| PCT/EP2007/057256 WO2008009639A2 (en) | 2006-07-17 | 2007-07-13 | New indications for direct thrombin inhibitors |
Publications (1)
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| CA2657269A1 true CA2657269A1 (en) | 2008-01-24 |
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| Application Number | Title | Priority Date | Filing Date |
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|---|---|
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| EP (1) | EP2043632A2 (https=) |
| JP (1) | JP2009543843A (https=) |
| AR (1) | AR062057A1 (https=) |
| CA (1) | CA2657269A1 (https=) |
| TW (1) | TW200813012A (https=) |
| WO (1) | WO2008009639A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2271317B1 (de) | 2008-03-28 | 2017-04-19 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung von säurepellets |
| US20110129538A1 (en) * | 2008-03-28 | 2011-06-02 | Boehringer Ingelheim International Gmbh | Process for preparing orally administered dabigatran formulations |
| JP2011527318A (ja) | 2008-07-14 | 2011-10-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ダビガトランを含有する医薬組成物の製造方法 |
| US20110306640A1 (en) * | 2008-08-19 | 2011-12-15 | Boehringer Ingelheim International Gmbh | Dabigatran in tumour therapy |
| AU2009315729A1 (en) | 2008-11-11 | 2010-05-20 | Boehringer Ingelheim International Gmbh | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy |
| EP2391893B1 (en) * | 2009-02-02 | 2014-09-03 | Boehringer Ingelheim International GmbH | Lyophilised dabigatran |
| JP2012526767A (ja) * | 2009-05-14 | 2012-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌及び線維性疾患の処置における新規な併用療法 |
| US20120142703A1 (en) * | 2009-05-14 | 2012-06-07 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of oncological and fibrotic diseases |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| SI2542224T1 (sl) * | 2010-03-01 | 2014-10-30 | Ratiopharm Gmbh | Oralni farmacevtski sestavek, ki vsebuje dabigatran eteksilat |
| PL2550966T3 (pl) * | 2011-07-25 | 2017-03-31 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg | Estry kwasu amidooksymokarboksylowego dabigatranu jako proleki i ich zastosowanie jako lek |
| WO2014001220A1 (en) | 2012-06-25 | 2014-01-03 | Boehringer Ingelheim International Gmbh | Method for prevention of stroke |
| CN105440017B (zh) * | 2014-08-19 | 2018-03-02 | 天津药物研究院 | 达比加群酯香草酸盐及其制备方法和应用 |
| CN104628733A (zh) * | 2015-03-02 | 2015-05-20 | 中国药科大学 | 四氢苯并[4,5]咪唑并[1,2-a]吡嗪类凝血酶抑制剂 |
| WO2025136810A1 (en) * | 2023-12-19 | 2025-06-26 | The Research Institute At Nationwide Children's Hospital | Anticoagulants for treating nephrotic syndrome |
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| US5863292A (en) * | 1996-09-26 | 1999-01-26 | Tosic; Aleksandar | Articulated external orthopedic fixation system and method of use |
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| GB0014136D0 (en) * | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| DE10235639A1 (de) * | 2002-08-02 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel |
| WO2004026252A2 (en) * | 2002-09-23 | 2004-04-01 | The Regents Of The University Of Michigan | Glioma treatments |
| KR20040076203A (ko) * | 2003-02-24 | 2004-08-31 | 주식회사 엘지생명과학 | 음식물-약물 상호작용을 방지하기 위한 경구 투여용약제학적 조성물 및 방법 |
| JP2006524203A (ja) * | 2003-04-24 | 2006-10-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | トロンビンの過剰形成及び／又はトロンビンレセプターの発現上昇により生じる血栓塞栓性疾病及び疾患の治療及び予防のためのジピリダモール又はモピダモールの使用 |
| EP1648232A4 (en) * | 2003-07-17 | 2009-12-30 | Smithkline Beecham Corp | ARGATROBAN TREATMENT METHOD FOR PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA |
| US20060222640A1 (en) * | 2005-03-29 | 2006-10-05 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for treatment of thrombosis |
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2007
- 2007-07-13 AR ARP070103124A patent/AR062057A1/es not_active Application Discontinuation
- 2007-07-13 WO PCT/EP2007/057256 patent/WO2008009639A2/en not_active Ceased
- 2007-07-13 JP JP2009519955A patent/JP2009543843A/ja active Pending
- 2007-07-13 CA CA002657269A patent/CA2657269A1/en not_active Abandoned
- 2007-07-13 EP EP07787524A patent/EP2043632A2/en not_active Withdrawn
- 2007-07-16 TW TW096125876A patent/TW200813012A/zh unknown
- 2007-07-17 US US11/778,748 patent/US20080200514A1/en not_active Abandoned
-
2010
- 2010-03-22 US US12/728,732 patent/US20100173947A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008009639A3 (en) | 2008-06-26 |
| TW200813012A (en) | 2008-03-16 |
| US20080200514A1 (en) | 2008-08-21 |
| JP2009543843A (ja) | 2009-12-10 |
| WO2008009639A2 (en) | 2008-01-24 |
| EP2043632A2 (en) | 2009-04-08 |
| US20100173947A1 (en) | 2010-07-08 |
| AR062057A1 (es) | 2008-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |