CA2649811A1 - Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases - Google Patents

Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases Download PDF

Info

Publication number
CA2649811A1
CA2649811A1 CA002649811A CA2649811A CA2649811A1 CA 2649811 A1 CA2649811 A1 CA 2649811A1 CA 002649811 A CA002649811 A CA 002649811A CA 2649811 A CA2649811 A CA 2649811A CA 2649811 A1 CA2649811 A1 CA 2649811A1
Authority
CA
Canada
Prior art keywords
triazolo
isoquinolin
alkyl
benzo
aminopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002649811A
Other languages
English (en)
French (fr)
Inventor
Kenneth L. Arrington
Edward J. Brnardic
Vadim Y. Dudkin
Mark E. Fraley
Shaei Y. Huang
Cheng Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2649811A1 publication Critical patent/CA2649811A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002649811A 2006-04-25 2007-04-20 Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases Abandoned CA2649811A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79469406P 2006-04-25 2006-04-25
US60/794,694 2006-04-25
PCT/US2007/009643 WO2007127138A1 (en) 2006-04-25 2007-04-20 Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases

Publications (1)

Publication Number Publication Date
CA2649811A1 true CA2649811A1 (en) 2007-11-08

Family

ID=38441857

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002649811A Abandoned CA2649811A1 (en) 2006-04-25 2007-04-20 Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases

Country Status (9)

Country Link
US (1) US7501435B2 (OSRAM)
EP (1) EP2013212A1 (OSRAM)
JP (1) JP5229221B2 (OSRAM)
AR (1) AR060619A1 (OSRAM)
AU (1) AU2007243520B2 (OSRAM)
CA (1) CA2649811A1 (OSRAM)
DO (1) DOP2007000082A (OSRAM)
TW (1) TW200806670A (OSRAM)
WO (1) WO2007127138A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014902A (zh) * 2005-01-06 2011-04-13 默克公司 检查点激酶抑制剂
US7485649B2 (en) * 2005-01-06 2009-02-03 Merck & Co., Inc. Inhibitors of checkpoint kinases
CA2635361A1 (en) 2006-01-04 2007-07-19 Merck & Co., Inc. Inhibitors of checkpoint kinases
US9000027B2 (en) * 2008-02-04 2015-04-07 Dana-Farber Cancer Institute, Inc. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, bcl-2 and caspase-3
WO2009102537A1 (en) * 2008-02-14 2009-08-20 Merck & Co., Inc. Inhibitors of checkpoint kinases
WO2010104933A1 (en) 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibitors of akt activity
EP2800819B1 (en) * 2012-01-06 2018-04-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Phosphorylation of histones and uses thereof
KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
KR102875195B1 (ko) * 2019-04-03 2025-10-22 케미테라스, 인크. 티민 핵산 염기를 베이스로 하는 트리아졸로피리미딘류 및 그 제조 방법
TWI879771B (zh) 2019-06-06 2025-04-11 大陸商和記黃埔醫藥（上海）有限公司 三環類化合物及其用途
CN115197225B (zh) * 2021-09-03 2023-04-11 贵州大学 一种五元杂环并喹唑啉酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
PT760819E (pt) * 1994-05-24 2000-11-30 Hoffmann La Roche Derivado dicarbonilicos triciclicos
US5677309A (en) * 1996-03-22 1997-10-14 Neurogen Corporation 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
CA2519107A1 (en) * 2003-03-14 2004-09-23 Astrazeneca Ab Novel fused triazolones and the uses thereof
HRP20130429T1 (en) * 2005-06-10 2013-06-30 Merck Sharp & Dohme Corp. Inhibitors of akt activity
CA2635361A1 (en) 2006-01-04 2007-07-19 Merck & Co., Inc. Inhibitors of checkpoint kinases

Also Published As

Publication number Publication date
DOP2007000082A (es) 2007-12-31
US20070254879A1 (en) 2007-11-01
AU2007243520B2 (en) 2012-07-19
US7501435B2 (en) 2009-03-10
EP2013212A1 (en) 2009-01-14
WO2007127138A1 (en) 2007-11-08
JP2009535334A (ja) 2009-10-01
TW200806670A (en) 2008-02-01
AU2007243520A1 (en) 2007-11-08
JP5229221B2 (ja) 2013-07-03
AR060619A1 (es) 2008-07-02

Similar Documents

Publication Publication Date Title
AU2007243520B2 (en) Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases
EP1896421B1 (en) Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met
EP2049494B1 (en) Tyrosine kinase inhibitors
US8614221B2 (en) Inhibitors of Akt activity
EP2299825B1 (en) Inhibitors of akt activity
US20090233896A1 (en) Inhibitors of checkpoint kinases
US20090258852A1 (en) Inhibitors of Checkpoint Kinases
CA2714087A1 (en) Inhibitors of checkpoint kinases
US7550477B2 (en) Inhibitors of checkpoint kinases
AU2006324144A8 (en) Inhibitors of checkpoint kinases
AU2006204072C1 (en) Inhibitors of checkpoint kinases
CA2590332A1 (en) Inhibitors of checkpoint kinases
US20090182001A1 (en) Inhibitors of checkpoint kinases

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20151026