CA2649777C - Methods and nucleic acids for the detection of colorectal cell proliferative disorders - Google Patents

Methods and nucleic acids for the detection of colorectal cell proliferative disorders Download PDF

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Publication number
CA2649777C
CA2649777C CA2649777A CA2649777A CA2649777C CA 2649777 C CA2649777 C CA 2649777C CA 2649777 A CA2649777 A CA 2649777A CA 2649777 A CA2649777 A CA 2649777A CA 2649777 C CA2649777 C CA 2649777C
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Prior art keywords
seq
methylation
nucleic acid
sequence
dna
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CA2649777A
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English (en)
French (fr)
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CA2649777A1 (en
Inventor
Catherine Lofton-Day
Matthias Ebert
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Epigenomics AG
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Epigenomics AG
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Priority claimed from PCT/US2006/014131 external-priority patent/WO2006113466A2/en
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of CA2649777A1 publication Critical patent/CA2649777A1/en
Application granted granted Critical
Publication of CA2649777C publication Critical patent/CA2649777C/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2649777A 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders Active CA2649777C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2006/014131 WO2006113466A2 (en) 2005-04-15 2006-04-17 Methods and nucleic acids for analyses of cellular proliferative disorders
USPCT/US2006/014131 2006-04-17
EP06090119.6 2006-06-27
EP06090119 2006-06-27
PCT/EP2007/003380 WO2007118704A2 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders

Publications (2)

Publication Number Publication Date
CA2649777A1 CA2649777A1 (en) 2007-10-25
CA2649777C true CA2649777C (en) 2018-08-14

Family

ID=40030469

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2649777A Active CA2649777C (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders

Country Status (7)

Country Link
US (1) US20220260570A1 (https=)
EP (3) EP2484778A3 (https=)
JP (2) JP5323680B2 (https=)
AU (1) AU2007237444B2 (https=)
CA (1) CA2649777C (https=)
ES (1) ES2587068T3 (https=)
WO (1) WO2007118704A2 (https=)

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KR20130021400A (ko) 2005-04-15 2013-03-05 에피제노믹스 아게 세포 증식 질환을 분석하기 위한 방법 및 핵산
WO2008122447A2 (en) * 2007-04-10 2008-10-16 Epigenomics Ag Dna methylation assay for the diagnosis or prognosis of medical conditions
BR112013005929B1 (pt) * 2010-09-13 2021-02-09 Clinical Genomics Pty. Ltd. métodos de triagem de início ou predisposição para início de neoplasma do intestino grosso ou monitoramento do progresso de neoplasma em indivíduo
FR2967165B1 (fr) * 2010-11-04 2014-10-10 Assist Publ Hopitaux De Paris Methode de depistage du cancer colorectal
WO2013007702A1 (en) 2011-07-08 2013-01-17 Epigenomics Ag Methods and nucleic acids for determining the prognosis of a cancer subject
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
CN104046680B (zh) * 2013-03-11 2016-04-06 苏州承美生物科技有限公司 甲基化dna检测方法
JP6722659B2 (ja) * 2014-06-04 2020-07-15 クエスト ダイアグノスティクス インベストメンツ インコーポレイテッド 結腸直腸癌のためのメチル化マーカー
KR20190054086A (ko) * 2016-09-29 2019-05-21 이에이 파마 가부시키가이샤 고발성 대장암 발증 가능성의 판정 방법
WO2018087129A1 (en) * 2016-11-08 2018-05-17 Region Nordjylland, Aalborg University Hospital Colorectal cancer methylation markers
EP3660172A1 (en) * 2018-11-28 2020-06-03 Bioscreening and Diagnostics LLC Method for detection of traumatic brain injury (tbi)
CN111826441A (zh) * 2019-04-23 2020-10-27 博尔诚（北京）科技有限公司 用于体外检测消化道五癌的体系，在该体系中使用的组合物，以及包含该组合物的试剂盒
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用

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Also Published As

Publication number Publication date
WO2007118704A3 (en) 2008-04-24
AU2007237444A1 (en) 2007-10-25
JP5323680B2 (ja) 2013-10-23
ES2587068T3 (es) 2016-10-20
EP2479283B1 (en) 2016-06-22
US20220260570A1 (en) 2022-08-18
JP5846693B2 (ja) 2016-01-20
CA2649777A1 (en) 2007-10-25
JP2013230153A (ja) 2013-11-14
AU2007237444B2 (en) 2013-05-23
WO2007118704A2 (en) 2007-10-25
JP2009533066A (ja) 2009-09-17
EP2484778A2 (en) 2012-08-08
EP2484778A3 (en) 2012-10-10
EP2013360A2 (en) 2009-01-14
EP2479283A1 (en) 2012-07-25

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