CA2648243A1 - Nanoparticule et formes polymeres d'analogues et d'antagonistes de l'hormone thyroidienne et leurs formulations - Google Patents
Nanoparticule et formes polymeres d'analogues et d'antagonistes de l'hormone thyroidienne et leurs formulations Download PDFInfo
- Publication number
- CA2648243A1 CA2648243A1 CA002648243A CA2648243A CA2648243A1 CA 2648243 A1 CA2648243 A1 CA 2648243A1 CA 002648243 A CA002648243 A CA 002648243A CA 2648243 A CA2648243 A CA 2648243A CA 2648243 A1 CA2648243 A1 CA 2648243A1
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- Prior art keywords
- thyroid hormone
- polymer
- nanoparticle
- acid
- angiogenesis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ceramic Engineering (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79123506P | 2006-04-11 | 2006-04-11 | |
US60/791,235 | 2006-04-11 | ||
US83174006P | 2006-07-17 | 2006-07-17 | |
US60/831,740 | 2006-07-17 | ||
US85645006P | 2006-11-02 | 2006-11-02 | |
US60/856,450 | 2006-11-02 | ||
US66304707A | 2007-03-15 | 2007-03-15 | |
US11/663,047 | 2007-03-15 | ||
PCT/US2007/009026 WO2008051291A2 (fr) | 2006-04-11 | 2007-04-11 | Nanoparticule et formes polymères d'analogues et d'antagonistes de l'hormone thyroïdienne et leurs formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2648243A1 true CA2648243A1 (fr) | 2008-05-02 |
CA2648243C CA2648243C (fr) | 2015-12-22 |
Family
ID=39272220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2648243A Expired - Fee Related CA2648243C (fr) | 2006-04-11 | 2007-04-11 | Nanoparticule et formes polymeres d'analogues et d'antagonistes de l'hormone thyroidienne et leurs formulations |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2018186A2 (fr) |
CA (1) | CA2648243C (fr) |
WO (1) | WO2008051291A2 (fr) |
Cited By (2)
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CN103113579A (zh) * | 2013-02-21 | 2013-05-22 | 华东理工大学 | 聚谷氨酸衍生物及其水凝胶和制备方法 |
CN116183311A (zh) * | 2022-09-07 | 2023-05-30 | 武汉理碳环保科技有限公司 | 一种用于碳封存的镁橄榄石封存二氧化碳的监测采集装置 |
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EP2335694B1 (fr) | 2003-09-15 | 2018-06-13 | NanoPharmaceuticals LLC | Analogues des hormones thyroidiennes et leur utilisation |
US8668926B1 (en) | 2003-09-15 | 2014-03-11 | Shaker A. Mousa | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof |
US8071134B2 (en) | 2003-09-15 | 2011-12-06 | Ordway Research Institute, Inc. | Thyroid hormone analogs and methods of use |
US9198887B2 (en) | 2003-09-15 | 2015-12-01 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use |
US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
US9220788B2 (en) * | 2009-06-17 | 2015-12-29 | Nanopharmaceuticals Llc | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
US10130686B2 (en) | 2005-09-15 | 2018-11-20 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders |
US9498536B2 (en) | 2005-09-15 | 2016-11-22 | Nanopharmaceuticals Llc | Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders |
WO2007035612A2 (fr) | 2005-09-16 | 2007-03-29 | Ordway Research Institute, Inc. | Composes de liaison rgd et leurs procedes d'utilisation |
WO2007070682A2 (fr) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | Systeme de criblage de particules |
WO2007133807A2 (fr) * | 2006-05-15 | 2007-11-22 | Massachusetts Institute Of Technology | Polymères pour particules fonctionnelles |
WO2007150030A2 (fr) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Synthèse microfluidique de nanoparticules organiques |
AU2007353426A1 (en) | 2006-12-22 | 2008-11-20 | Albany College Of Pharmacy And Health Sciences | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof |
WO2008098165A2 (fr) | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Bioréacteur oscillant pour la culture de cellules |
WO2008124639A2 (fr) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Fractions de ciblage de poly (acide aminé) |
MX2010003642A (es) | 2007-10-12 | 2010-08-09 | Massachusetts Inst Technology | Nanotecnologia de vacuna. |
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MX2011012015A (es) * | 2009-05-15 | 2012-04-30 | Univ Kentucky Res Found | Tratamiento de deterioro cognitivo leve y enfermedad de alzheimer. |
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US8404281B2 (en) | 2009-06-08 | 2013-03-26 | Avant Garde Therapeutics & Technologies Llc | Formulations |
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US20160030349A1 (en) * | 2014-08-01 | 2016-02-04 | Boehringer Ingelheim Vetmedica Gmbh | Nanoparticles, methods of preparation, and uses thereof |
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Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0831769B2 (fr) * | 1995-06-07 | 2008-07-23 | Lavin, Dr., Thomas N. | Utilisations innovantes d'hormones thyroidiennes ou de composes ressemblant a des hormones thyroidiennes |
KR19990085365A (ko) * | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
US7008633B2 (en) * | 2000-12-18 | 2006-03-07 | Board Of Regents, The University Of Texas System | Local regional chemotherapy and radiotherapy using in situ hydrogel |
WO2006031922A2 (fr) * | 2004-09-15 | 2006-03-23 | Ordway Research Institute | Analogues d'hormones thyroidiennes et procedes d'utilisation correspondants |
EP2335694B1 (fr) * | 2003-09-15 | 2018-06-13 | NanoPharmaceuticals LLC | Analogues des hormones thyroidiennes et leur utilisation |
US7968085B2 (en) * | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
-
2007
- 2007-04-11 CA CA2648243A patent/CA2648243C/fr not_active Expired - Fee Related
- 2007-04-11 EP EP07867073A patent/EP2018186A2/fr not_active Withdrawn
- 2007-04-11 WO PCT/US2007/009026 patent/WO2008051291A2/fr active Application Filing
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103113579A (zh) * | 2013-02-21 | 2013-05-22 | 华东理工大学 | 聚谷氨酸衍生物及其水凝胶和制备方法 |
CN116183311A (zh) * | 2022-09-07 | 2023-05-30 | 武汉理碳环保科技有限公司 | 一种用于碳封存的镁橄榄石封存二氧化碳的监测采集装置 |
CN116183311B (zh) * | 2022-09-07 | 2023-09-26 | 武汉理碳环保科技有限公司 | 一种用于碳封存的镁橄榄石封存二氧化碳的监测采集装置 |
Also Published As
Publication number | Publication date |
---|---|
EP2018186A2 (fr) | 2009-01-28 |
WO2008051291A2 (fr) | 2008-05-02 |
WO2008051291A3 (fr) | 2008-12-24 |
CA2648243C (fr) | 2015-12-22 |
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