CA2642216A1 - New crystal forms and pharmaceutical compositions of (+)-r-zileuton - Google Patents
New crystal forms and pharmaceutical compositions of (+)-r-zileuton Download PDFInfo
- Publication number
- CA2642216A1 CA2642216A1 CA002642216A CA2642216A CA2642216A1 CA 2642216 A1 CA2642216 A1 CA 2642216A1 CA 002642216 A CA002642216 A CA 002642216A CA 2642216 A CA2642216 A CA 2642216A CA 2642216 A1 CA2642216 A1 CA 2642216A1
- Authority
- CA
- Canada
- Prior art keywords
- crystalline form
- single crystalline
- zileuton
- pharmaceutical composition
- condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 46
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- 238000000034 method Methods 0.000 claims abstract description 39
- 230000000694 effects Effects 0.000 claims abstract description 10
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- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims description 12
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 12
- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 claims description 12
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US77557906P | 2006-02-21 | 2006-02-21 | |
| US60/775,579 | 2006-02-21 | ||
| PCT/US2007/004488 WO2007098189A2 (en) | 2006-02-21 | 2007-02-21 | New crystal forms and pharmaceutical compositions of (+) -r-zileuton |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2642216A1 true CA2642216A1 (en) | 2007-08-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002642216A Abandoned CA2642216A1 (en) | 2006-02-21 | 2007-02-21 | New crystal forms and pharmaceutical compositions of (+)-r-zileuton |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8003684B2 (https=) |
| EP (2) | EP2001861A2 (https=) |
| JP (1) | JP2009527484A (https=) |
| AU (1) | AU2007217770B2 (https=) |
| CA (1) | CA2642216A1 (https=) |
| WO (1) | WO2007098189A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8445437B2 (en) * | 2006-07-27 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Treatment and prevention of cardiovascular disease using mast cell stabilizers |
| US20100273868A1 (en) * | 2007-01-05 | 2010-10-28 | Cornerstone Therapeutics Inc. | R-Zileuton for Use in Conditions Associated with Increased 5-Lipoxygenase and/or Leukotriene Activity (EG Asthma) |
| US8445435B2 (en) * | 2007-09-28 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Mast cell stabilizers in the treatment of obesity |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| EP2959899B1 (en) * | 2011-08-23 | 2017-02-22 | Cornerstone Therapeutics Inc. | Use of zileuton for the treatment of nasal polyps in cystic fibrosis patients |
| US9855243B2 (en) | 2013-10-30 | 2018-01-02 | Qurient Co., Ltd. | Topical anti-inflammatory pharmaceutical composition with zileuton cream formulation |
| KR101462474B1 (ko) | 2013-10-30 | 2014-11-19 | 주식회사 큐리언트 | 질레우톤 크림 제형의 국소용 항염증 약학적 조성물 |
| EA201692549A1 (ru) * | 2014-06-20 | 2017-08-31 | Эвайраджен Терепьютикс, Инк. | Безводная кристаллическая форма свободного основания 6-{2-[1-(6-метил-3-пиридазинил)-4-пиперидинил]этокси}-3-этокси-1,2-бензизоксазола |
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| US279263A (en) * | 1883-06-12 | Eobeet t | ||
| DE3882732T2 (de) | 1987-02-10 | 1993-12-02 | Abbott Lab | Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen. |
| EP0697868A4 (en) * | 1993-05-10 | 1998-04-08 | Sepracor Inc | THERAPIES AND COMPOSITIONS USING OPTICALLY PURE (+) - ZILEUTON |
| US5663368A (en) * | 1993-07-14 | 1997-09-02 | Smithkline Beecham Corporation | Synthesis of acid addition salts of hydroxylamines |
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2007
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- 2007-02-21 EP EP07751259A patent/EP2001861A2/en not_active Ceased
- 2007-02-21 CA CA002642216A patent/CA2642216A1/en not_active Abandoned
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- 2007-02-21 US US11/709,299 patent/US8003684B2/en not_active Expired - Fee Related
- 2007-02-21 WO PCT/US2007/004488 patent/WO2007098189A2/en not_active Ceased
- 2007-02-21 EP EP11176982A patent/EP2409973A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007217770A1 (en) | 2007-08-30 |
| JP2009527484A (ja) | 2009-07-30 |
| US20070244185A1 (en) | 2007-10-18 |
| EP2409973A1 (en) | 2012-01-25 |
| US8003684B2 (en) | 2011-08-23 |
| AU2007217770B2 (en) | 2011-09-08 |
| WO2007098189A3 (en) | 2008-04-03 |
| EP2001861A2 (en) | 2008-12-17 |
| WO2007098189A2 (en) | 2007-08-30 |
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