CA2634398A1 - Methodes et systemes d'administration de corticosteroides presentant un meilleur profil pharmacocinetique - Google Patents
Methodes et systemes d'administration de corticosteroides presentant un meilleur profil pharmacocinetique Download PDFInfo
- Publication number
- CA2634398A1 CA2634398A1 CA002634398A CA2634398A CA2634398A1 CA 2634398 A1 CA2634398 A1 CA 2634398A1 CA 002634398 A CA002634398 A CA 002634398A CA 2634398 A CA2634398 A CA 2634398A CA 2634398 A1 CA2634398 A1 CA 2634398A1
- Authority
- CA
- Canada
- Prior art keywords
- cyclodextrin
- corticosteroid
- beta
- nebulizer
- inhalation mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229960003089 pramipexole Drugs 0.000 description 1
- 238000009117 preventive therapy Methods 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- 229960002288 procaterol Drugs 0.000 description 1
- FKNXQNWAXFXVNW-BLLLJJGKSA-N procaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)[C@@H](NC(C)C)CC FKNXQNWAXFXVNW-BLLLJJGKSA-N 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- FTSUPYGMFAPCFZ-ZWNOBZJWSA-N quinpirole Chemical compound C([C@H]1CCCN([C@@H]1C1)CCC)C2=C1C=NN2 FTSUPYGMFAPCFZ-ZWNOBZJWSA-N 0.000 description 1
- 229950001037 quinpirole Drugs 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 229960002720 reproterol Drugs 0.000 description 1
- 229940072265 rhinocort Drugs 0.000 description 1
- IYMMESGOJVNCKV-UHFFFAOYSA-N rimiterol Chemical compound C=1C=C(O)C(O)=CC=1C(O)C1CCCCN1 IYMMESGOJVNCKV-UHFFFAOYSA-N 0.000 description 1
- 229960001457 rimiterol Drugs 0.000 description 1
- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- 229960001879 ropinirole Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229960004017 salmeterol Drugs 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- CXYRUNPLKGGUJF-RAFJPFSSSA-M scopolamine methobromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)C)=CC=CC=C1 CXYRUNPLKGGUJF-RAFJPFSSSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000002462 tachykinin receptor antagonist Substances 0.000 description 1
- 229950008418 talipexole Drugs 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 125000006318 tert-butyl amino group Chemical group [H]N(*)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 239000002750 tryptase inhibitor Substances 0.000 description 1
- 229960000859 tulobuterol Drugs 0.000 description 1
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940099073 xolair Drugs 0.000 description 1
- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
- 229960005332 zileuton Drugs 0.000 description 1
- 229940124631 β2-adrenergic bronchodilator Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75276505P | 2005-12-20 | 2005-12-20 | |
| US75233205P | 2005-12-20 | 2005-12-20 | |
| US75273505P | 2005-12-20 | 2005-12-20 | |
| US60/752,735 | 2005-12-20 | ||
| US60/752,332 | 2005-12-20 | ||
| US60/752,765 | 2005-12-20 | ||
| US77399806P | 2006-02-15 | 2006-02-15 | |
| US77399906P | 2006-02-15 | 2006-02-15 | |
| US60/773,998 | 2006-02-15 | ||
| US60/773,999 | 2006-02-15 | ||
| US82009406P | 2006-07-21 | 2006-07-21 | |
| US82009606P | 2006-07-21 | 2006-07-21 | |
| US82009206P | 2006-07-21 | 2006-07-21 | |
| US60/820,096 | 2006-07-21 | ||
| US60/820,092 | 2006-07-21 | ||
| US60/820,094 | 2006-07-21 | ||
| PCT/US2006/048629 WO2007075799A2 (fr) | 2005-12-20 | 2006-12-19 | Méthodes et systèmes d'administration de corticostéroïdes présentant un meilleur profil pharmacocinétique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2634398A1 true CA2634398A1 (fr) | 2007-07-05 |
Family
ID=38218568
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002634398A Abandoned CA2634398A1 (fr) | 2005-12-20 | 2006-12-19 | Methodes et systemes d'administration de corticosteroides presentant un meilleur profil pharmacocinetique |
| CA002634413A Abandoned CA2634413A1 (fr) | 2005-12-20 | 2006-12-19 | Methode et systeme d'administration de corticosteroides presentant un meilleur profil pharmacocinetique |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002634413A Abandoned CA2634413A1 (fr) | 2005-12-20 | 2006-12-19 | Methode et systeme d'administration de corticosteroides presentant un meilleur profil pharmacocinetique |
Country Status (5)
| Country | Link |
|---|---|
| EP (6) | EP1973550A2 (fr) |
| JP (6) | JP2009520822A (fr) |
| BR (1) | BRPI0620225A2 (fr) |
| CA (2) | CA2634398A1 (fr) |
| WO (6) | WO2007075801A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070020299A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| CN101911139B (zh) * | 2007-11-16 | 2013-03-20 | 粒子监测系统有限公司 | 用于光学粒子计数器的校准验证的系统和方法 |
| WO2010042701A2 (fr) * | 2008-10-10 | 2010-04-15 | Schering Corporation | Compositions à base de corticoïdes et procédés de traitement associés |
| CA2934961A1 (fr) * | 2014-01-17 | 2015-07-23 | Nephron Pharmaceuticals Corporation | Formulation de cyclodextrine-budesonide |
| EP2923702A1 (fr) * | 2014-03-28 | 2015-09-30 | Universite De Liege | Composition de cyclodextrine avec des dérivés de budésonide pour le traitement et la prévention d'une maladie inflammatoire pulmonaire |
| KR102391676B1 (ko) * | 2014-03-28 | 2022-04-28 | 유니버시떼 드 리에즈 | 폐 염증의 치료 및 예방을 위한 사이클로덱스트린 및 부데소나이드 유도체를 포함하는 조성물 |
| US11672781B2 (en) | 2018-05-07 | 2023-06-13 | Prana Biosciences Inc | Metaxalone formulations |
| EP3906263A4 (fr) | 2019-01-03 | 2022-08-31 | Underdog Pharmaceuticals, Inc. | Dimères de cyclodextrine, leurs compositions et leurs utilisations |
| CN113491677B (zh) * | 2020-03-18 | 2023-09-26 | 南京知和医药科技有限公司 | 一类药用抗病毒药物吸入剂新型制剂及制备方法 |
| US20240189244A1 (en) * | 2021-04-09 | 2024-06-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for delivering pharmaceutical agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
| US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| GB0029562D0 (en) * | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| EA200300652A1 (ru) * | 2001-01-31 | 2003-12-25 | Пфайзер Продактс Инк. | Эфирные производные, полезные в качестве ингибиторов изозимов pde4 |
| JP4334229B2 (ja) * | 2001-03-20 | 2009-09-30 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | プロポフォール及びスルホアルキルエーテルシクロデキストリン含有製剤 |
| US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| US7244742B2 (en) * | 2002-08-17 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
| LT1585548T (lt) * | 2002-12-09 | 2018-09-25 | Abraxis Bioscience, Llc | Farmakologinių agentų kompozicijos ir įvedimo būdai |
| US20050065141A1 (en) * | 2003-07-31 | 2005-03-24 | Odink Debra A. | Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof |
| JP2007512337A (ja) * | 2003-11-21 | 2007-05-17 | コンビナトアールエックス インコーポレーティッド | 炎症性障害の治療のための方法および試薬 |
| DK1732512T3 (en) * | 2003-12-31 | 2017-07-10 | Cydex Pharmaceuticals Inc | INHALABLE FORMULATION CONTAINING SULPHALKYLETHERCYCLODEXTRIN AND CORTIC COSTEROID |
-
2006
- 2006-12-19 WO PCT/US2006/048631 patent/WO2007075801A2/fr active Application Filing
- 2006-12-19 EP EP06847837A patent/EP1973550A2/fr not_active Withdrawn
- 2006-12-19 CA CA002634398A patent/CA2634398A1/fr not_active Abandoned
- 2006-12-19 BR BRPI0620225-0A patent/BRPI0620225A2/pt not_active Application Discontinuation
- 2006-12-19 WO PCT/US2006/048628 patent/WO2007075798A2/fr active Application Filing
- 2006-12-19 JP JP2008547497A patent/JP2009520822A/ja not_active Withdrawn
- 2006-12-19 EP EP06845904A patent/EP1971345A2/fr not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048630 patent/WO2007075800A2/fr active Application Filing
- 2006-12-19 JP JP2008547495A patent/JP2009520821A/ja not_active Withdrawn
- 2006-12-19 JP JP2008547498A patent/JP2009520823A/ja not_active Withdrawn
- 2006-12-19 EP EP06847838A patent/EP1971347A2/fr not_active Withdrawn
- 2006-12-19 JP JP2008547496A patent/JP2009524590A/ja not_active Withdrawn
- 2006-12-19 EP EP06845981A patent/EP1971346A2/fr not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048927 patent/WO2007075963A2/fr active Application Filing
- 2006-12-19 WO PCT/US2006/048629 patent/WO2007075799A2/fr active Application Filing
- 2006-12-19 JP JP2008547580A patent/JP2009520828A/ja not_active Withdrawn
- 2006-12-19 CA CA002634413A patent/CA2634413A1/fr not_active Abandoned
- 2006-12-19 EP EP06848786A patent/EP1971349A2/fr not_active Withdrawn
- 2006-12-19 JP JP2008547534A patent/JP2009520827A/ja not_active Withdrawn
- 2006-12-19 EP EP06847888A patent/EP1971348A2/fr not_active Withdrawn
- 2006-12-19 WO PCT/US2006/048735 patent/WO2007075859A2/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007075800A3 (fr) | 2008-11-20 |
| JP2009520822A (ja) | 2009-05-28 |
| WO2007075798A3 (fr) | 2008-11-20 |
| JP2009524590A (ja) | 2009-07-02 |
| EP1971345A2 (fr) | 2008-09-24 |
| WO2007075859A2 (fr) | 2007-07-05 |
| BRPI0620225A2 (pt) | 2011-11-01 |
| WO2007075859A3 (fr) | 2008-12-11 |
| WO2007075963A2 (fr) | 2007-07-05 |
| EP1973550A2 (fr) | 2008-10-01 |
| EP1971348A2 (fr) | 2008-09-24 |
| WO2007075799A2 (fr) | 2007-07-05 |
| JP2009520828A (ja) | 2009-05-28 |
| WO2007075963A3 (fr) | 2008-11-27 |
| EP1971349A2 (fr) | 2008-09-24 |
| EP1971347A2 (fr) | 2008-09-24 |
| WO2007075800A2 (fr) | 2007-07-05 |
| JP2009520823A (ja) | 2009-05-28 |
| JP2009520821A (ja) | 2009-05-28 |
| WO2007075798A9 (fr) | 2007-08-23 |
| WO2007075799A3 (fr) | 2009-01-15 |
| EP1971346A2 (fr) | 2008-09-24 |
| WO2007075801A2 (fr) | 2007-07-05 |
| JP2009520827A (ja) | 2009-05-28 |
| WO2007075798A2 (fr) | 2007-07-05 |
| WO2007075801A3 (fr) | 2008-12-31 |
| CA2634413A1 (fr) | 2007-07-05 |
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Legal Events
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| FZDE | Dead |