CA2632642A1 - Novel diazabicyclic aryl derivatives and their medical use - Google Patents
Novel diazabicyclic aryl derivatives and their medical use Download PDFInfo
- Publication number
- CA2632642A1 CA2632642A1 CA002632642A CA2632642A CA2632642A1 CA 2632642 A1 CA2632642 A1 CA 2632642A1 CA 002632642 A CA002632642 A CA 002632642A CA 2632642 A CA2632642 A CA 2632642A CA 2632642 A1 CA2632642 A1 CA 2632642A1
- Authority
- CA
- Canada
- Prior art keywords
- diaza
- bicyclo
- nonane
- methyl
- pyridazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000011282 treatment Methods 0.000 claims abstract description 27
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- 239000000126 substance Substances 0.000 claims abstract description 14
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- -1 selenophenyl Chemical group 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 68
- 239000000203 mixture Substances 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 37
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 125000002541 furyl group Chemical group 0.000 claims description 17
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 17
- 125000001544 thienyl group Chemical group 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000002837 carbocyclic group Chemical group 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 125000001624 naphthyl group Chemical group 0.000 claims description 14
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 13
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
- 125000004385 trihaloalkyl group Chemical group 0.000 claims description 13
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims description 12
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- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 12
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- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 12
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- 125000004076 pyridyl group Chemical group 0.000 claims description 10
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 9
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- XSQQPNAJQNHRDG-UHFFFAOYSA-N 3-(6-phenylpyridazin-3-yl)-3,9-diazabicyclo[3.3.1]nonane Chemical compound C1C(N2)CCCC2CN1C(N=N1)=CC=C1C1=CC=CC=C1 XSQQPNAJQNHRDG-UHFFFAOYSA-N 0.000 claims description 3
- YBVCONMKJCCKQC-UHFFFAOYSA-N 9-methyl-3-(6-phenylpyridazin-3-yl)-3,9-diazabicyclo[3.3.1]nonane Chemical compound CN1C(C2)CCCC1CN2C(N=N1)=CC=C1C1=CC=CC=C1 YBVCONMKJCCKQC-UHFFFAOYSA-N 0.000 claims description 3
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- FGOQONPFPVZWHX-UHFFFAOYSA-N 2-(4-chlorophenyl)-5-(9-methyl-3,9-diazabicyclo[3.3.1]nonan-3-yl)-1,3,4-thiadiazole Chemical compound CN1C(C2)CCCC1CN2C(S1)=NN=C1C1=CC=C(Cl)C=C1 FGOQONPFPVZWHX-UHFFFAOYSA-N 0.000 claims description 2
- QOQBDQPZGTZNMI-UHFFFAOYSA-N 2-(9-methyl-3,9-diazabicyclo[3.3.1]nonan-3-yl)-5-phenyl-1,3,4-oxadiazole Chemical compound CN1C(C2)CCCC1CN2C(O1)=NN=C1C1=CC=CC=C1 QOQBDQPZGTZNMI-UHFFFAOYSA-N 0.000 claims description 2
- IDISALVIHFLVGH-UHFFFAOYSA-N 2-(9-methyl-3,9-diazabicyclo[3.3.1]nonan-3-yl)-5-phenyl-1,3,4-thiadiazole Chemical compound CN1C(C2)CCCC1CN2C(S1)=NN=C1C1=CC=CC=C1 IDISALVIHFLVGH-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501724 | 2005-12-06 | ||
| DKPA200501724 | 2005-12-06 | ||
| US74822205P | 2005-12-08 | 2005-12-08 | |
| US60/748,222 | 2005-12-08 | ||
| PCT/EP2006/069316 WO2007065892A1 (en) | 2005-12-06 | 2006-12-05 | Novel diazabicyclic aryl derivatives and their medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2632642A1 true CA2632642A1 (en) | 2007-06-14 |
Family
ID=40114330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002632642A Abandoned CA2632642A1 (en) | 2005-12-06 | 2006-12-05 | Novel diazabicyclic aryl derivatives and their medical use |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8173658B2 (enExample) |
| EP (2) | EP1963323B1 (enExample) |
| JP (1) | JP2009518357A (enExample) |
| KR (1) | KR20080079250A (enExample) |
| CN (1) | CN101305004B (enExample) |
| AT (1) | ATE473978T1 (enExample) |
| AU (1) | AU2006323986A1 (enExample) |
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| NZ (1) | NZ567048A (enExample) |
| RU (1) | RU2008110911A (enExample) |
| WO (1) | WO2007065892A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700596B2 (en) | 2006-02-10 | 2010-04-20 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1987031A1 (en) | 2006-02-10 | 2008-11-05 | NeuroSearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| JP2009526777A (ja) | 2006-02-14 | 2009-07-23 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体作用薬としての３，９−ジアザビシクロ（３．３．１）ノナ−３−イル−アリールメタノン誘導体 |
| JP2009537599A (ja) | 2006-05-23 | 2009-10-29 | ノイロサーチ アクティーゼルスカブ | 新規８，１０−ジアザ−ビシクロ［４．３．１］デカン誘導体及びそれらの医学的使用 |
| US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| US20110142758A1 (en) * | 2008-06-10 | 2011-06-16 | Neurosearch A/S | Indolyl-pyridazinyl-diazabicyclononane derivatives in labelled and unlabelled form and their use in diagnostic methods |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| CN106074548A (zh) | 2010-09-23 | 2016-11-09 | 艾伯维巴哈马有限公司 | 氮杂金刚烷衍生物的一水合物 |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| BR112020019373A2 (pt) * | 2018-03-27 | 2020-12-29 | Ptc Therapeutics, Inc. | Compostos para o tratamento da doença de hutington |
| CN108658762B (zh) * | 2018-06-12 | 2021-03-02 | 浙江凯普化工有限公司 | 一种脂环邻二酯的合成方法 |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3293251A (en) | 1966-12-20 | Rearrangement process for j,b-diaza- bicyclo-(j,z,i)-octane derivatives | ||
| US5478939A (en) | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
| CN1205210C (zh) * | 1997-05-30 | 2005-06-08 | 神经研究公司 | 作为尼古丁ACh受体上胆碱能配体的9－氮杂双环(3.3.1)壬－2－烯衍生物 |
| HUP0002713A3 (en) | 1997-05-30 | 2001-02-28 | Neurosearch As | 8-azabicyclo[3,2,1]oct-2-ene and octane derivatives, process for preparation thereof, pharmaceutical compositions comprising thereof and their use |
| FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| DE60006213T2 (de) * | 1999-01-29 | 2004-07-29 | Abbott Laboratories, Abbott Park | Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden |
| CA2365258A1 (en) | 1999-05-04 | 2000-11-09 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| US6852721B2 (en) | 2000-05-25 | 2005-02-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| FR2809731B1 (fr) | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
| FR2809732B1 (fr) | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
| CN1185233C (zh) * | 2000-07-04 | 2005-01-19 | 神经研究公司 | 芳基和杂芳基－二氮杂双环烷烃,其制备和用途 |
| US20040147505A1 (en) * | 2001-06-01 | 2004-07-29 | Dan Peters | Novel heteroaryl-diazabicyclo alkanes as cns-modulators |
| FR2832712B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
| FR2832713B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| WO2003094831A2 (en) * | 2002-05-07 | 2003-11-20 | Neurosearch A/S | Novel diazabicyclic biaryl derivatives |
| EP1562945B1 (en) | 2002-11-11 | 2006-11-15 | Neurosearch A/S | 1,4-diazabicyclo(3,2,2)nonane derivatives, preparation and therapeutical use thereof |
| US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| MXPA06005019A (es) * | 2003-11-03 | 2006-07-06 | Warner Lambert Co | Nuevos inhibidores de la recaptacion de norpinefrina para el tratamiento de transtornos del sistema nervioso central. |
| MX2007004269A (es) | 2004-10-20 | 2007-06-15 | Neurosearch As | Derivados de arilo diazabiciclico nuevos y su uso medico. |
| JP2008521776A (ja) | 2004-11-30 | 2008-06-26 | ノイロサーチ アクティーゼルスカブ | コリン作動性リガンドとしての新規なジアザ二環式アリール誘導体 |
| JP2008530172A (ja) | 2005-02-16 | 2008-08-07 | ノイロサーチ アクティーゼルスカブ | ジアザ二環系アリール誘導体及びそれらのニコチン様アセチルコリン受容体におけるコリン作動性リガンドとしての使用 |
| JP5052952B2 (ja) * | 2007-05-07 | 2012-10-17 | 東芝機械株式会社 | マイクロレンズ転写成形用ロールの製造方法および製造装置 |
| AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
-
2006
- 2006-12-05 EP EP06830366A patent/EP1963323B1/en not_active Not-in-force
- 2006-12-05 DK DK06830366.8T patent/DK1963323T3/da active
- 2006-12-05 DE DE602006015523T patent/DE602006015523D1/de active Active
- 2006-12-05 KR KR1020087013706A patent/KR20080079250A/ko not_active Withdrawn
- 2006-12-05 CA CA002632642A patent/CA2632642A1/en not_active Abandoned
- 2006-12-05 NZ NZ567048A patent/NZ567048A/en not_active IP Right Cessation
- 2006-12-05 CN CN2006800416608A patent/CN101305004B/zh not_active Expired - Fee Related
- 2006-12-05 JP JP2008543818A patent/JP2009518357A/ja not_active Abandoned
- 2006-12-05 AT AT06830366T patent/ATE473978T1/de active
- 2006-12-05 US US12/093,655 patent/US8173658B2/en not_active Expired - Fee Related
- 2006-12-05 RU RU2008110911/04A patent/RU2008110911A/ru unknown
- 2006-12-05 EP EP10164285A patent/EP2246352A1/en not_active Withdrawn
- 2006-12-05 AU AU2006323986A patent/AU2006323986A1/en not_active Abandoned
- 2006-12-05 BR BRPI0617772-7A patent/BRPI0617772A2/pt not_active IP Right Cessation
- 2006-12-05 WO PCT/EP2006/069316 patent/WO2007065892A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ATE473978T1 (de) | 2010-07-15 |
| KR20080079250A (ko) | 2008-08-29 |
| EP1963323B1 (en) | 2010-07-14 |
| DE602006015523D1 (de) | 2010-08-26 |
| BRPI0617772A2 (pt) | 2011-08-09 |
| JP2009518357A (ja) | 2009-05-07 |
| US20080280912A1 (en) | 2008-11-13 |
| DK1963323T3 (da) | 2010-10-25 |
| US8173658B2 (en) | 2012-05-08 |
| CN101305004B (zh) | 2011-11-16 |
| CN101305004A (zh) | 2008-11-12 |
| NZ567048A (en) | 2010-12-24 |
| AU2006323986A1 (en) | 2007-06-14 |
| EP2246352A1 (en) | 2010-11-03 |
| WO2007065892A1 (en) | 2007-06-14 |
| RU2008110911A (ru) | 2010-01-20 |
| EP1963323A1 (en) | 2008-09-03 |
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| EEER | Examination request | ||
| FZDE | Discontinued |
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| FZDE | Discontinued |
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