CA2632618C - Demethylpenclomedine analogs and their use as anticancer agents - Google Patents
Demethylpenclomedine analogs and their use as anticancer agents Download PDFInfo
- Publication number
- CA2632618C CA2632618C CA2632618A CA2632618A CA2632618C CA 2632618 C CA2632618 C CA 2632618C CA 2632618 A CA2632618 A CA 2632618A CA 2632618 A CA2632618 A CA 2632618A CA 2632618 C CA2632618 C CA 2632618C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- prodrug
- salt
- cancer
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75021105P | 2005-12-13 | 2005-12-13 | |
| US60/750,211 | 2005-12-13 | ||
| PCT/US2006/047526 WO2007070568A2 (en) | 2005-12-13 | 2006-12-12 | Demethylpenclomedine analogs and their use as anticancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2632618A1 CA2632618A1 (en) | 2007-06-21 |
| CA2632618C true CA2632618C (en) | 2014-04-22 |
Family
ID=38163494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2632618A Active CA2632618C (en) | 2005-12-13 | 2006-12-12 | Demethylpenclomedine analogs and their use as anticancer agents |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8124596B2 (https=) |
| EP (1) | EP1981850B1 (https=) |
| JP (1) | JP5324921B2 (https=) |
| AU (1) | AU2006326506B9 (https=) |
| CA (1) | CA2632618C (https=) |
| WO (1) | WO2007070568A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1578341A2 (en) | 2000-10-11 | 2005-09-28 | Tularik Inc. | Modulation of ccr4 function |
| US7144903B2 (en) | 2001-05-23 | 2006-12-05 | Amgen Inc. | CCR4 antagonists |
| WO2018187414A1 (en) * | 2017-04-05 | 2018-10-11 | The Regents Of The University Of California | Inhibitors of mtor-rictor interactions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4717726A (en) | 1986-09-10 | 1988-01-05 | The Dow Chemical Company | 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine having anti-tumor activity |
| US6235761B1 (en) | 1996-06-03 | 2001-05-22 | Neil Hartman | Compound, composition and method for treating cancer |
| WO2000043009A1 (en) * | 1999-01-21 | 2000-07-27 | Southern Research Institute | Pyridine compounds, use and preparation thereof |
| HK1041648B (en) | 1999-01-21 | 2011-01-14 | 南方研究所 | Acyl derivatives of 4-demethylpenclomedine, use thereof and preparation thereof |
| US7122563B2 (en) | 2005-02-01 | 2006-10-17 | Southern Research Institute | Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof |
-
2006
- 2006-12-12 AU AU2006326506A patent/AU2006326506B9/en active Active
- 2006-12-12 WO PCT/US2006/047526 patent/WO2007070568A2/en not_active Ceased
- 2006-12-12 EP EP06845337.2A patent/EP1981850B1/en active Active
- 2006-12-12 US US12/085,789 patent/US8124596B2/en active Active
- 2006-12-12 CA CA2632618A patent/CA2632618C/en active Active
- 2006-12-12 JP JP2008545766A patent/JP5324921B2/ja active Active
-
2012
- 2012-02-22 US US13/402,660 patent/US9422241B2/en active Active
-
2016
- 2016-08-16 US US15/238,144 patent/US9884051B2/en active Active
-
2017
- 2017-12-29 US US15/859,083 patent/US10772878B2/en active Active
-
2020
- 2020-08-17 US US16/995,575 patent/US20200375964A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US9422241B2 (en) | 2016-08-23 |
| EP1981850B1 (en) | 2017-03-22 |
| WO2007070568A3 (en) | 2007-11-08 |
| JP5324921B2 (ja) | 2013-10-23 |
| US9884051B2 (en) | 2018-02-06 |
| US8124596B2 (en) | 2012-02-28 |
| WO2007070568A2 (en) | 2007-06-21 |
| US20090197844A1 (en) | 2009-08-06 |
| AU2006326506A2 (en) | 2008-07-31 |
| AU2006326506B9 (en) | 2012-11-15 |
| US20200375964A1 (en) | 2020-12-03 |
| US20120177634A1 (en) | 2012-07-12 |
| AU2006326506B2 (en) | 2012-05-17 |
| JP2009519344A (ja) | 2009-05-14 |
| CA2632618A1 (en) | 2007-06-21 |
| AU2006326506A1 (en) | 2007-06-21 |
| US20160354354A1 (en) | 2016-12-08 |
| US20180117022A1 (en) | 2018-05-03 |
| EP1981850A2 (en) | 2008-10-22 |
| US10772878B2 (en) | 2020-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20200375964A1 (en) | Demethylpenclomedine analogs and their use as anti-cancer agents | |
| US8106033B2 (en) | Composition and methods for the treatment of proliferative diseases | |
| US9340563B2 (en) | Salts of isophosphoramide mustard and analogs thereof | |
| JP4814245B2 (ja) | 低酸素選択性抗腫瘍剤としてのスルホニルヒドラジンのリン酸含有プロドラッグ | |
| AU2013350311B2 (en) | Omega-3 analogues | |
| ES2348973T3 (es) | Derivados aciclicos de 4-desmetilpenclomedina, utilizacion y preparacion de los mismos. | |
| ES2348972T3 (es) | Compuestos de piridina, utilizacion y preparacion de los mismos. | |
| JP6708670B2 (ja) | ステロイド系ラクタムおよびビス（２−クロロエチル）アミノフェノキシプロパン酸誘導体のエステル | |
| AU2010218109B2 (en) | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents | |
| CZ20004310A3 (cs) | Sloučenina sestávající z proaktivní alkylační části a bioreduktivní části a chinonový derivát |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 18TH ANNIV.) - STANDARD Year of fee payment: 18 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241205 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241205 |