CA2626383A1 - Mass spectrometry with multipole ion guides - Google Patents
Mass spectrometry with multipole ion guides Download PDFInfo
- Publication number
- CA2626383A1 CA2626383A1 CA002626383A CA2626383A CA2626383A1 CA 2626383 A1 CA2626383 A1 CA 2626383A1 CA 002626383 A CA002626383 A CA 002626383A CA 2626383 A CA2626383 A CA 2626383A CA 2626383 A1 CA2626383 A1 CA 2626383A1
- Authority
- CA
- Canada
- Prior art keywords
- multipole ion
- mass
- ion
- ions
- multipole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005405 multipole Effects 0.000 title claims abstract 36
- 238000004949 mass spectrometry Methods 0.000 title 1
- 150000002500 ions Chemical class 0.000 claims abstract 88
- 238000013467 fragmentation Methods 0.000 claims abstract 6
- 238000006062 fragmentation reaction Methods 0.000 claims abstract 6
- 230000007935 neutral effect Effects 0.000 claims abstract 6
- 238000010494 dissociation reaction Methods 0.000 claims abstract 4
- 230000005593 dissociations Effects 0.000 claims abstract 4
- 238000005086 pumping Methods 0.000 claims 17
- 238000004458 analytical method Methods 0.000 claims 5
- 239000013626 chemical specie Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 238000009616 inductively coupled plasma Methods 0.000 claims 1
- 238000005040 ion trap Methods 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
A mass spectrometer (40) is configured with individual multipole ion guides (60, 62) configured in an assembly in alignment along a common centerline (5) wherein at least a portion of each multiple ion guide (60, 62) mounted in the assembly resides in a vacuum region (72, 73) with higher background pressure. Said multiple ion guides (60, 62) configured in a higher pressure vacuum region (72, 73) are operated in mass to charge selection and ion fragmentation modes. Individual sets of RF, +/- DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multiple ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide (60, 62). The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multiple ion guide into an adjacent ion guide, analoguous to a triple quadruple ion function.
Claims (24)
1. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of each said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides, and, (e) means for conducting mass to charge selection in at least one of said multipole ion guides.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of each said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides, and, (e) means for conducting mass to charge selection in at least one of said multipole ion guides.
2. An apparatus according to claim 1, wherein said ion source is an Electrospray ion source.
3. An apparatus according to claim 1, wherein said ion source is an Atmospheric Pressure Chemical Ionization ion source.
4. An apparatus according to claim 1, wherein said ion source is an Inductively Coupled Plasma ion source.
5. An apparatus according to claim 1, wherein said ion source is an Glow Discharge ion source.
6. An apparatus according to claim 1, wherein said multipole ion guide is a quadrupole.
7. An apparatus according to claim 1, wherein said multipole ion guide is a hexapole.
8. An apparatus according to claim 1, wherein said multipole ion guide is a octapole.
9. An apparatus according to claim 1, wherein said multipole ion guide has more than eight poles.
10. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring said at least two multipole ion guides in at least one said vacuum pumping stages wlierein at least a portion of each of said at least two multipole ion guides is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides;
(f) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (g) conducting mass to charge analysis in said mass analyzer.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring said at least two multipole ion guides in at least one said vacuum pumping stages wlierein at least a portion of each of said at least two multipole ion guides is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides;
(f) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (g) conducting mass to charge analysis in said mass analyzer.
11. An apparatus according to claim 10 wherein said at least two multipole ion guides are configured in series along a common centerline wherein said ions can be transferred from one multipole ion guide to the next.
12. An apparatus according to claim 10, wherein said mass analyzer is a quadrupole mass spectrometer.
13. An apparatus according to claim 10, wherein said mass analyzer is a quadrupole mass analyzer.
14. An apparatus according to claim 10, wherein said at least two multipole ion guides are configured with said mass analyze to form a triple quadrupole mass analyzer.
15. An apparatus according to claim 10, wherein said mass analyzer is a magnetic sector mass spectrometer.
16. An apparatus according to claim 10, wherein said mass analyzer is a Fourier Transform mass spectrometer.
17. An apparatus according to claim 10, wherein said mass analyzer is a ion trap mass spectrometer.
18. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer.
19. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer configured with orthogonal pulsing.
20. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer configure with linear pulsing.
21. An apparatus according to claim 10, wherein said mass anlyzer is a Time-Of-Flight mass spectrometer comprising an ion reflector.
22. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(e) a/detector configured in at least one of said vacuum pumping stages;
(d) configuring said at least two multipole ion guides in at least one said vacuum pumping stage wherein at least a portion of each said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides, (e) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (f) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(e) a/detector configured in at least one of said vacuum pumping stages;
(d) configuring said at least two multipole ion guides in at least one said vacuum pumping stage wherein at least a portion of each said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides, (e) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (f) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides.
23. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring said at least two multipole ion guides in at least one said vacuum pumping stages wherein at least a portion of each of said at least two multipole ion guides is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides;
(f) means for conducting mass to charge selection in at least one of said multipole ion guides;
(g) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides; and, (h) conducting mass to charge analysis in said mass analyzer.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least one vacuum pumping stage;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring said at least two multipole ion guides in at least one said vacuum pumping stages wherein at least a portion of each of said at least two multipole ion guides is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides;
(f) means for conducting mass to charge selection in at least one of said multipole ion guides;
(g) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides; and, (h) conducting mass to charge analysis in said mass analyzer.
24. A method for analyzing chemical species utilizing an ion source, a vacuum system with at least one vacuum pumping stage, a mass analyzer, at least two multipole ion guides configured in a adjacent alignment along a common centerline in at least one said vacuum stage and a detector, said method comprising;
(a) producing ions in said ion source;
(b) delivering said ions into said at least one said multipole ion guide;
(c) operating at least a portion of said at least two multipole ion guides in a background pressure in at least one said vacuum stage wherein collisions occur between said ions and the neutral background molecules for said ions traversing said at least one said multipole ion guide;
(d) conducting mass to charge selection of said ions in at least one said multipole ion guide;
(e) conducting collisional induced dissociation in at least one said multipole ion guide;
(f) transferring said ions from the first said multipole ion guide into the second said multipole ion guide; and, (g) conducting mass analysis of the ion population resulting from said mass to charge selection and said ion fragmentation steps performed in said first and second multipole ion guides.
(a) producing ions in said ion source;
(b) delivering said ions into said at least one said multipole ion guide;
(c) operating at least a portion of said at least two multipole ion guides in a background pressure in at least one said vacuum stage wherein collisions occur between said ions and the neutral background molecules for said ions traversing said at least one said multipole ion guide;
(d) conducting mass to charge selection of said ions in at least one said multipole ion guide;
(e) conducting collisional induced dissociation in at least one said multipole ion guide;
(f) transferring said ions from the first said multipole ion guide into the second said multipole ion guide; and, (g) conducting mass analysis of the ion population resulting from said mass to charge selection and said ion fragmentation steps performed in said first and second multipole ion guides.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8724698P | 1998-05-29 | 1998-05-29 | |
| US60/087,246 | 1998-05-29 | ||
| US23594699A | 1999-01-22 | 1999-01-22 | |
| US09/235,946 | 1999-01-22 | ||
| CA002332534A CA2332534C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Division CA2332534C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2626383A1 true CA2626383A1 (en) | 1999-12-02 |
| CA2626383C CA2626383C (en) | 2011-07-19 |
Family
ID=26776766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Expired - Lifetime CA2332534C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
| CA2626383A Expired - Lifetime CA2626383C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Expired - Lifetime CA2332534C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1090412B1 (en) |
| JP (1) | JP2002517070A (en) |
| AU (1) | AU4326599A (en) |
| CA (2) | CA2332534C (en) |
| WO (1) | WO1999062101A1 (en) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9820210D0 (en) | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
| CA2326514A1 (en) * | 2000-01-10 | 2001-07-10 | Mds Inc. | An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices |
| US6720554B2 (en) * | 2000-07-21 | 2004-04-13 | Mds Inc. | Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps |
| GB2370685B (en) | 2000-11-29 | 2003-01-22 | Micromass Ltd | Mass spectrometers and methods of mass spectrometry |
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
| JP3620479B2 (en) * | 2001-07-31 | 2005-02-16 | 株式会社島津製作所 | Method of ion selection in ion storage device |
| WO2003056604A1 (en) * | 2001-12-21 | 2003-07-10 | Mds Inc., Doing Business As Mds Sciex | Use of notched broadband waveforms in a linear ion trap |
| GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
| EP1367633B1 (en) * | 2002-05-30 | 2006-09-06 | Micromass UK Limited | Mass spectrometer |
| US7095013B2 (en) | 2002-05-30 | 2006-08-22 | Micromass Uk Limited | Mass spectrometer |
| CA2487136C (en) | 2002-05-31 | 2008-12-30 | Analytica Of Branford, Inc. | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
| US7034292B1 (en) | 2002-05-31 | 2006-04-25 | Analytica Of Branford, Inc. | Mass spectrometry with segmented RF multiple ion guides in various pressure regions |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| CA2514343C (en) * | 2003-01-24 | 2010-04-06 | Thermo Finnigan Llc | Controlling ion populations in a mass analyzer |
| DE10326156B4 (en) * | 2003-06-10 | 2011-12-01 | Micromass Uk Ltd. | Mass spectrometer with gas collision cell and AC or RF ion guide with differential pressure ranges and associated methods for mass spectrometry |
| US6977371B2 (en) | 2003-06-10 | 2005-12-20 | Micromass Uk Limited | Mass spectrometer |
| DE102004014582B4 (en) * | 2004-03-25 | 2009-08-20 | Bruker Daltonik Gmbh | Ion optical phase volume compression |
| JP2005276787A (en) * | 2004-03-26 | 2005-10-06 | Tsutomu Masujima | Mass spectrometer |
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| GB0416288D0 (en) | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| JP4848657B2 (en) * | 2005-03-28 | 2011-12-28 | 株式会社島津製作所 | MS / MS mass spectrometer |
| GB2427067B (en) * | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
| GB0506288D0 (en) * | 2005-03-29 | 2005-05-04 | Thermo Finnigan Llc | Improvements relating to mass spectrometry |
| EP1969615A4 (en) * | 2006-01-05 | 2011-08-03 | Mds Analytical Tech Bu Mds Inc | Mass defect triggered information dependent acquisition |
| US7378653B2 (en) * | 2006-01-10 | 2008-05-27 | Varian, Inc. | Increasing ion kinetic energy along axis of linear ion processing devices |
| GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| US8507850B2 (en) * | 2007-05-31 | 2013-08-13 | Perkinelmer Health Sciences, Inc. | Multipole ion guide interface for reduced background noise in mass spectrometry |
| JP2008108739A (en) * | 2007-11-26 | 2008-05-08 | Hitachi High-Technologies Corp | Mass spectroscope and measurement system provided with the same |
| JP5498958B2 (en) * | 2008-01-30 | 2014-05-21 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | Ion fragmentation in mass spectrometry. |
| GB2484136B (en) * | 2010-10-01 | 2015-09-16 | Thermo Fisher Scient Bremen | Method and apparatus for improving the throughput of a charged particle analysis system |
| EP2643845B1 (en) | 2010-11-26 | 2022-03-30 | Analytik Jena GmbH | Improvements in or relating to mass spectrometry |
| JP2011119279A (en) * | 2011-03-11 | 2011-06-16 | Hitachi High-Technologies Corp | Mass spectrometer, and measuring system using the same |
| WO2013114196A1 (en) * | 2012-02-01 | 2013-08-08 | Dh Technologies Development Pte. Ltd. | Method and apparatus for improved sensitivity in a mass spectrometer |
| CN206210749U (en) * | 2013-06-03 | 2017-05-31 | 珀金埃尔默健康科学股份有限公司 | Device including many level assemblies and mass spectrograph or external member including the device, and the device of ion is transmitted based on mass-to-charge ratio |
| GB201715777D0 (en) * | 2017-09-29 | 2017-11-15 | Shimadzu Corp | ION Trap |
| KR102305532B1 (en) * | 2020-03-04 | 2021-09-27 | 한국원자력안전기술원 | Qualitative and quantitative analysis apparatus and method for inert gas |
| CN111640646A (en) * | 2020-06-15 | 2020-09-08 | 成都艾立本科技有限公司 | High-sensitivity proton transfer time-of-flight mass spectrometer and method for measuring ion time-of-flight by using same |
| CN111613514B (en) * | 2020-06-24 | 2023-11-03 | 成都艾立本科技有限公司 | High-sensitivity ultraviolet ionization time-of-flight mass spectrometer and ion time-of-flight measurement method |
| WO2022239104A1 (en) * | 2021-05-11 | 2022-11-17 | 株式会社島津製作所 | Orthogonal acceleration time-of-flight mass spectrometer |
| US11501962B1 (en) * | 2021-06-17 | 2022-11-15 | Thermo Finnigan Llc | Device geometries for controlling mass spectrometer pressures |
| GB202114780D0 (en) * | 2021-10-15 | 2021-12-01 | Thermo Fisher Scient Bremen Gmbh | Ion transport between ion optical devices at different gas pressures |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4328420A (en) | 1980-07-28 | 1982-05-04 | French John B | Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system |
| EP0237259A3 (en) * | 1986-03-07 | 1989-04-05 | Finnigan Corporation | Mass spectrometer |
| US5179278A (en) * | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| AU1932095A (en) | 1994-02-28 | 1995-09-11 | Analytica Of Branford, Inc. | Multipole ion guide for mass spectrometry |
| DE19511333C1 (en) * | 1995-03-28 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer |
| US6075244A (en) * | 1995-07-03 | 2000-06-13 | Hitachi, Ltd. | Mass spectrometer |
| JPH11510946A (en) * | 1995-08-11 | 1999-09-21 | エムディーエス ヘルス グループ リミテッド | Spectrometer with axial electric field |
| CA2256028C (en) * | 1996-06-06 | 2007-01-16 | Mds Inc. | Axial ejection in a multipole mass spectrometer |
| WO1999030350A1 (en) * | 1997-12-05 | 1999-06-17 | University Of British Columbia | Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap |
| ATE535008T1 (en) * | 1998-01-23 | 2011-12-15 | Perkinelmer Health Sci Inc | MASS SPECTROMETRY WITH MULTIPOL ION GUIDE DEVICE |
-
1999
- 1999-05-29 EP EP99953401.9A patent/EP1090412B1/en not_active Expired - Lifetime
- 1999-05-29 CA CA002332534A patent/CA2332534C/en not_active Expired - Lifetime
- 1999-05-29 JP JP2000551420A patent/JP2002517070A/en active Pending
- 1999-05-29 CA CA2626383A patent/CA2626383C/en not_active Expired - Lifetime
- 1999-05-29 AU AU43265/99A patent/AU4326599A/en not_active Abandoned
- 1999-05-29 WO PCT/US1999/012169 patent/WO1999062101A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999062101A9 (en) | 2000-03-02 |
| EP1090412A4 (en) | 2006-01-25 |
| AU4326599A (en) | 1999-12-13 |
| WO1999062101A1 (en) | 1999-12-02 |
| EP1090412A1 (en) | 2001-04-11 |
| CA2332534A1 (en) | 1999-12-02 |
| EP1090412B1 (en) | 2014-03-05 |
| JP2002517070A (en) | 2002-06-11 |
| CA2626383C (en) | 2011-07-19 |
| CA2332534C (en) | 2008-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190529 |