CA2332534A1 - Mass spectrometry with multipole ion guides - Google Patents
Mass spectrometry with multipole ion guides Download PDFInfo
- Publication number
- CA2332534A1 CA2332534A1 CA002332534A CA2332534A CA2332534A1 CA 2332534 A1 CA2332534 A1 CA 2332534A1 CA 002332534 A CA002332534 A CA 002332534A CA 2332534 A CA2332534 A CA 2332534A CA 2332534 A1 CA2332534 A1 CA 2332534A1
- Authority
- CA
- Canada
- Prior art keywords
- ion
- ion guide
- fragmentation
- mass
- guide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005405 multipole Effects 0.000 title abstract 2
- 238000004949 mass spectrometry Methods 0.000 title 1
- 150000002500 ions Chemical class 0.000 abstract 16
- 238000013467 fragmentation Methods 0.000 abstract 3
- 238000006062 fragmentation reaction Methods 0.000 abstract 3
- 230000005540 biological transmission Effects 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
A mass spectrometer (40) is configured with individual multipole ion guides (60, 62) configured in an assembly in alignment along a common centerline (5) wherein at least a portion of each multiple ion guide (60, 62) mounted in the assembly resides in a vacuum region (72, 73) with higher background pressure. Said multiple ion guides (60, 62) configured in a higher pressure vacuum region (72, 73) are operated in mass to charge selection and ion fragmentation modes.
Individual sets of RF, +/- DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multiple ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide (60, 62). The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multiple ion guide into an adjacent ion guide, analoguous to a triple quadruple ion function.
Individual sets of RF, +/- DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multiple ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide (60, 62). The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multiple ion guide into an adjacent ion guide, analoguous to a triple quadruple ion function.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2626383A CA2626383C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8724698P | 1998-05-29 | 1998-05-29 | |
US60/087,246 | 1998-05-29 | ||
US23594699A | 1999-01-22 | 1999-01-22 | |
US09/235,946 | 1999-01-22 | ||
PCT/US1999/012169 WO1999062101A1 (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2626383A Division CA2626383C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2332534A1 true CA2332534A1 (en) | 1999-12-02 |
CA2332534C CA2332534C (en) | 2008-07-22 |
Family
ID=26776766
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2626383A Expired - Lifetime CA2626383C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
CA002332534A Expired - Lifetime CA2332534C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2626383A Expired - Lifetime CA2626383C (en) | 1998-05-29 | 1999-05-29 | Mass spectrometry with multipole ion guides |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1090412B1 (en) |
JP (1) | JP2002517070A (en) |
AU (1) | AU4326599A (en) |
CA (2) | CA2626383C (en) |
WO (1) | WO1999062101A1 (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9820210D0 (en) | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
CA2326514A1 (en) * | 2000-01-10 | 2001-07-10 | Mds Inc. | An apparatus for and method of discriminating against unwanted ionized species in mass spectrometry with collision and reaction devices |
US6720554B2 (en) * | 2000-07-21 | 2004-04-13 | Mds Inc. | Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps |
GB2370685B (en) | 2000-11-29 | 2003-01-22 | Micromass Ltd | Mass spectrometers and methods of mass spectrometry |
US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
JP3620479B2 (en) * | 2001-07-31 | 2005-02-16 | 株式会社島津製作所 | Method of ion selection in ion storage device |
AU2002350343A1 (en) | 2001-12-21 | 2003-07-15 | Mds Inc., Doing Business As Mds Sciex | Use of notched broadband waveforms in a linear ion trap |
GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
EP1367633B1 (en) * | 2002-05-30 | 2006-09-06 | Micromass UK Limited | Mass spectrometer |
US7095013B2 (en) | 2002-05-30 | 2006-08-22 | Micromass Uk Limited | Mass spectrometer |
CA2641940C (en) * | 2002-05-31 | 2011-11-15 | Analytica Of Branford, Inc. | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
US7034292B1 (en) | 2002-05-31 | 2006-04-25 | Analytica Of Branford, Inc. | Mass spectrometry with segmented RF multiple ion guides in various pressure regions |
GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
US6987261B2 (en) * | 2003-01-24 | 2006-01-17 | Thermo Finnigan Llc | Controlling ion populations in a mass analyzer |
US6977371B2 (en) | 2003-06-10 | 2005-12-20 | Micromass Uk Limited | Mass spectrometer |
DE10326156B4 (en) * | 2003-06-10 | 2011-12-01 | Micromass Uk Ltd. | Mass spectrometer with gas collision cell and AC or RF ion guide with differential pressure ranges and associated methods for mass spectrometry |
DE102004014582B4 (en) * | 2004-03-25 | 2009-08-20 | Bruker Daltonik Gmbh | Ion optical phase volume compression |
JP2005276787A (en) * | 2004-03-26 | 2005-10-06 | Tsutomu Masujima | Mass spectrometer |
US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
GB0416288D0 (en) | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
JP4848657B2 (en) * | 2005-03-28 | 2011-12-28 | 株式会社島津製作所 | MS / MS mass spectrometer |
GB2427067B (en) | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
GB0506288D0 (en) | 2005-03-29 | 2005-05-04 | Thermo Finnigan Llc | Improvements relating to mass spectrometry |
EP1969615A4 (en) * | 2006-01-05 | 2011-08-03 | Mds Analytical Tech Bu Mds Inc | Mass defect triggered information dependent acquisition |
US7378653B2 (en) * | 2006-01-10 | 2008-05-27 | Varian, Inc. | Increasing ion kinetic energy along axis of linear ion processing devices |
GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
US8507850B2 (en) | 2007-05-31 | 2013-08-13 | Perkinelmer Health Sciences, Inc. | Multipole ion guide interface for reduced background noise in mass spectrometry |
JP2008108739A (en) * | 2007-11-26 | 2008-05-08 | Hitachi High-Technologies Corp | Mass spectroscope and measurement system provided with the same |
WO2009094783A1 (en) * | 2008-01-30 | 2009-08-06 | Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division | Ion fragmentation in mass spectrometry |
GB2484136B (en) * | 2010-10-01 | 2015-09-16 | Thermo Fisher Scient Bremen | Method and apparatus for improving the throughput of a charged particle analysis system |
EP2643845B1 (en) | 2010-11-26 | 2022-03-30 | Analytik Jena GmbH | Improvements in or relating to mass spectrometry |
JP2011119279A (en) * | 2011-03-11 | 2011-06-16 | Hitachi High-Technologies Corp | Mass spectrometer, and measuring system using the same |
EP2810297A4 (en) * | 2012-02-01 | 2015-06-24 | Dh Technologies Dev Pte Ltd | Method and apparatus for improved sensitivity in a mass spectrometer |
US9355831B2 (en) * | 2013-06-03 | 2016-05-31 | Perkinelmer Health Sciences, Inc. | Ion guide or filters with selected gas conductance |
GB201715777D0 (en) * | 2017-09-29 | 2017-11-15 | Shimadzu Corp | ION Trap |
KR102305532B1 (en) * | 2020-03-04 | 2021-09-27 | 한국원자력안전기술원 | Qualitative and quantitative analysis apparatus and method for inert gas |
CN111640646A (en) * | 2020-06-15 | 2020-09-08 | 成都艾立本科技有限公司 | High-sensitivity proton transfer time-of-flight mass spectrometer and method for measuring ion time-of-flight by using same |
CN111613514B (en) * | 2020-06-24 | 2023-11-03 | 成都艾立本科技有限公司 | High-sensitivity ultraviolet ionization time-of-flight mass spectrometer and ion time-of-flight measurement method |
JPWO2022239104A1 (en) * | 2021-05-11 | 2022-11-17 | ||
US11501962B1 (en) * | 2021-06-17 | 2022-11-15 | Thermo Finnigan Llc | Device geometries for controlling mass spectrometer pressures |
GB202114780D0 (en) * | 2021-10-15 | 2021-12-01 | Thermo Fisher Scient Bremen Gmbh | Ion transport between ion optical devices at different gas pressures |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4328420A (en) | 1980-07-28 | 1982-05-04 | French John B | Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system |
EP0237259A3 (en) * | 1986-03-07 | 1989-04-05 | Finnigan Corporation | Mass spectrometer |
US5179278A (en) * | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
JP3671354B2 (en) | 1994-02-28 | 2005-07-13 | アナリチカ オブ ブランフォード,インコーポレーテッド | Multipole ion guide for mass spectrometry |
DE19511333C1 (en) * | 1995-03-28 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer |
WO1997002591A1 (en) * | 1995-07-03 | 1997-01-23 | Hitachi, Ltd. | Mass spectrometer |
AU6653296A (en) * | 1995-08-11 | 1997-03-12 | Mds Health Group Limited | Spectrometer with axial field |
EP0902963B1 (en) * | 1996-06-06 | 2002-09-04 | MDS Inc. | Axial ejection in a multipole mass spectrometer |
CA2312806A1 (en) * | 1997-12-05 | 1999-06-17 | University Of British Columbia | Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap |
WO1999038193A1 (en) * | 1998-01-23 | 1999-07-29 | Analytica Of Branford, Inc. | Mass spectrometry with multipole ion guide |
-
1999
- 1999-05-29 CA CA2626383A patent/CA2626383C/en not_active Expired - Lifetime
- 1999-05-29 EP EP99953401.9A patent/EP1090412B1/en not_active Expired - Lifetime
- 1999-05-29 CA CA002332534A patent/CA2332534C/en not_active Expired - Lifetime
- 1999-05-29 AU AU43265/99A patent/AU4326599A/en not_active Abandoned
- 1999-05-29 JP JP2000551420A patent/JP2002517070A/en active Pending
- 1999-05-29 WO PCT/US1999/012169 patent/WO1999062101A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1090412A4 (en) | 2006-01-25 |
CA2332534C (en) | 2008-07-22 |
CA2626383C (en) | 2011-07-19 |
CA2626383A1 (en) | 1999-12-02 |
EP1090412A1 (en) | 2001-04-11 |
EP1090412B1 (en) | 2014-03-05 |
JP2002517070A (en) | 2002-06-11 |
WO1999062101A9 (en) | 2000-03-02 |
AU4326599A (en) | 1999-12-13 |
WO1999062101A1 (en) | 1999-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20190529 |