CA2184346A1 - Multipole ion guide for mass spectrometry - Google Patents
Multipole ion guide for mass spectrometryInfo
- Publication number
- CA2184346A1 CA2184346A1 CA002184346A CA2184346A CA2184346A1 CA 2184346 A1 CA2184346 A1 CA 2184346A1 CA 002184346 A CA002184346 A CA 002184346A CA 2184346 A CA2184346 A CA 2184346A CA 2184346 A1 CA2184346 A1 CA 2184346A1
- Authority
- CA
- Canada
- Prior art keywords
- ion
- ion guide
- multipole
- multipole ion
- atmospheric pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005405 multipole Effects 0.000 title abstract 8
- 238000004949 mass spectrometry Methods 0.000 title 1
- 150000002500 ions Chemical class 0.000 abstract 19
- 238000005086 pumping Methods 0.000 abstract 3
- 238000001816 cooling Methods 0.000 abstract 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 abstract 1
- 238000009616 inductively coupled plasma Methods 0.000 abstract 1
- 230000005596 ionic collisions Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/24—Vacuum systems, e.g. maintaining desired pressures
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an electrospray, atmospheric pressure chemical ionization or inductively coupled plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length.
The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide a and q values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide.
These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of atmospheric pressure ion source mass spectrometer instruments.
The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide a and q values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide.
These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of atmospheric pressure ion source mass spectrometer instruments.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002526197A CA2526197C (en) | 1994-02-28 | 1995-02-27 | Multipole ion guide for mass spectrometry |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20250594A | 1994-02-28 | 1994-02-28 | |
| US08/202,505 | 1994-02-28 | ||
| PCT/US1995/002378 WO1995023018A1 (en) | 1994-02-28 | 1995-02-27 | Multipole ion guide for mass spectrometry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002526197A Division CA2526197C (en) | 1994-02-28 | 1995-02-27 | Multipole ion guide for mass spectrometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2184346A1 true CA2184346A1 (en) | 1995-08-31 |
| CA2184346C CA2184346C (en) | 2007-04-03 |
Family
ID=37951691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002184346A Expired - Lifetime CA2184346C (en) | 1994-02-28 | 1995-02-27 | Multipole ion guide for mass spectrometry |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2184346C (en) |
-
1995
- 1995-02-27 CA CA002184346A patent/CA2184346C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2184346C (en) | 2007-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20150227 |
|
| MKEX | Expiry |
Effective date: 20150227 |