CA2641940A1 - Mass spectrometry with segmented rf multiple ion guides in various pressure regions - Google Patents
Mass spectrometry with segmented rf multiple ion guides in various pressure regions Download PDFInfo
- Publication number
- CA2641940A1 CA2641940A1 CA002641940A CA2641940A CA2641940A1 CA 2641940 A1 CA2641940 A1 CA 2641940A1 CA 002641940 A CA002641940 A CA 002641940A CA 2641940 A CA2641940 A CA 2641940A CA 2641940 A1 CA2641940 A1 CA 2641940A1
- Authority
- CA
- Canada
- Prior art keywords
- multipole ion
- mass
- ions
- ion
- multipole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004949 mass spectrometry Methods 0.000 title 1
- 230000005405 multipole Effects 0.000 claims abstract 35
- 238000005086 pumping Methods 0.000 claims abstract 18
- 150000002500 ions Chemical class 0.000 claims 76
- 238000004458 analytical method Methods 0.000 claims 5
- 239000013626 chemical specie Substances 0.000 claims 5
- 230000007935 neutral effect Effects 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 4
- 238000010494 dissociation reaction Methods 0.000 claims 3
- 230000005593 dissociations Effects 0.000 claims 3
- 238000013467 fragmentation Methods 0.000 claims 3
- 238000006062 fragmentation reaction Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 238000009616 inductively coupled plasma Methods 0.000 claims 1
- 238000005040 ion trap Methods 0.000 claims 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
A mass spectrometer is configured with individual multipole ion guides, configured in an assembly in alignment along a common centerline. A linear (22) of four independent quadrupole ion guides (23, 24, 25, 26) and three smaller quadrupole ion guide segments (39, 40, 41) are positioned along common axis (27) and are configured in a six vaccum pumping stage hybrid API source-multiple quadrupole TOF mass analyzer.
Claims (24)
1. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (e) means for conducting mass to charge selection in at least one of said multipole ion guides.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (e) means for conducting mass to charge selection in at least one of said multipole ion guides.
2. An apparatus according to claim 1, wherein said ion source is an Electrospray ion source.
3. An apparatus according to claim 1, wherein said ion source is an Atmospheric Pressure Chemical Ionization ion source.
4. An apparatus according to claim 1, wherein said ion source is an Inductively Coupled Plasma ion source.
5. An apparatus according to claim 1, wherein said ion source is an Glow Discharge ion source.
6. An apparatus according to claim 1, wherein said multipole ion guide is a quadrupole.
7. An apparatus according to claim 1, wherein said multipole ion guide is a hexapole.
8. An apparatus according to claim 1, wherein said multipole ion guide is a octapole.
9. An apparatus according to claim 1, wherein said multipole ion guide has more than eight poles.
10. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (f) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (g) conducting mass to charge analysis in said mass analyzer.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (f) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (g) conducting mass to charge analysis in said mass analyzer.
11. An apparatus according to claim 10 wherein said at least two multipole ion guides are configured in series along a common centerline wherein said ions can be transferred from one multipole ion guide to the next.
12. An apparatus according to claim 10, wherein said mass analyzer is a quadrupole mass spectrometer.
13. An apparatus according to claim 10, wherein said mass analyzer is a quadrupole mass analyzer.
14. An apparatus according to claim 10, wherein said at least two multipole ion guides are configured with said mass analyze to form a triple quadrupole mass analyzer.
15. An apparatus according to claim 10, wherein said mass analyzer is a magnetic sector mass spectrometer.
16. An apparatus according to claim 10, wherein said mass analyzer is a Fourier Transform mass spectrometer.
17. An apparatus according to claim 10, wherein said mass analyzer is a ion trap mass spectrometer.
18. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer.
19. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer configured with orthogonal pulsing.
20. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer configure with linear pulsing.
21. An apparatus according to claim 10, wherein said mass analyzer is a Time-Of-Flight mass spectrometer comprising an ion reflector.
22. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (e) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (f) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (e) means for conducting mass to charge selection in at least one of said multipole ion guides; and, (f) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides.
23. An apparatus for analyzing chemical species, comprising:
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions,between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (f) means for conducting mass to charge selection in at least one of said multipole ion guides;
(g) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides; and, (h) conducting mass to charge analysis in said mass analyzer.
(a) an ion source for operation at substantially atmospheric pressure to produce ions from a sample substance;
(b) a vacuum system with at least two vacuum pumping stages;
(c) a detector configured in at least one of said vacuum pumping stages;
(d) a mass analyzer for conducting mass to charge analysis;
(e) configuring at least two multipole ion guides in at least one of said vacuum pumping stages wherein at least a portion of one said multipole ion guide is positioned in at least one of said vacuum pumping stages wherein the background pressure in said vacuum stage is maintained sufficiently high so that collisions,between said ions and neutral gas molecules occur with ions in said two multipole ion guides; while at least a portion of the other ion guide is positioned in at least one of said vacuum stage is maintained sufficiently low so that few or no collisions occur, and, (f) means for conducting mass to charge selection in at least one of said multipole ion guides;
(g) means for conducting collisional induced dissociation ion fragmentation in at least one said multipole ion guides; and, (h) conducting mass to charge analysis in said mass analyzer.
24. A method for analyzing chemical species utilizing an ion source, a vacuum system with at least one vacuum pumping stage, a mass analyzer, at least two multipole ion guides configured in a adjacent alignment along a common centerline in at least one said vacuum stage and a detector, said method comprising;
(a) producing ions in said ion source;
(b) delivering said ions into said at least one said multipole ion guide;
(c) operating at least a portion of said at least two multipole ion guides in a background pressure in at least one said vacuum stage wherein collisions occur between said ions and the neutral background molecules for said ions traversing said at least one said multipole ion guide;
(d) conducting mass to charge selection of said ions in at least one said multipole ion guide;
(e) conducting collisional Induced dissociation in at least one said multipole ion guide;
(f) transferring said ions from the first said multipole ion guide into the second said multipole ion guide; and, (g) conducting mass analysis of the ion population resulting from said mass to charge selection and said ion fragmentation steps performed in said first and second multipole ion guides.
(a) producing ions in said ion source;
(b) delivering said ions into said at least one said multipole ion guide;
(c) operating at least a portion of said at least two multipole ion guides in a background pressure in at least one said vacuum stage wherein collisions occur between said ions and the neutral background molecules for said ions traversing said at least one said multipole ion guide;
(d) conducting mass to charge selection of said ions in at least one said multipole ion guide;
(e) conducting collisional Induced dissociation in at least one said multipole ion guide;
(f) transferring said ions from the first said multipole ion guide into the second said multipole ion guide; and, (g) conducting mass analysis of the ion population resulting from said mass to charge selection and said ion fragmentation steps performed in said first and second multipole ion guides.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38510002P | 2002-05-31 | 2002-05-31 | |
| US60/385,100 | 2002-05-31 | ||
| CA002487136A CA2487136C (en) | 2002-05-31 | 2003-05-30 | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002487136A Division CA2487136C (en) | 2002-05-31 | 2003-05-30 | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2641940A1 true CA2641940A1 (en) | 2003-12-11 |
| CA2641940C CA2641940C (en) | 2011-11-15 |
Family
ID=29712134
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2641940A Expired - Lifetime CA2641940C (en) | 2002-05-31 | 2003-05-30 | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
| CA002487136A Expired - Lifetime CA2487136C (en) | 2002-05-31 | 2003-05-30 | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002487136A Expired - Lifetime CA2487136C (en) | 2002-05-31 | 2003-05-30 | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP2421023A1 (en) |
| AU (1) | AU2003249685A1 (en) |
| CA (2) | CA2641940C (en) |
| WO (1) | WO2003102508A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10325579B4 (en) | 2003-06-05 | 2007-10-11 | Bruker Daltonik Gmbh | Ion fragmentation by electron capture in linear ion traps |
| GB0514964D0 (en) * | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| DE102004051785B4 (en) | 2004-10-25 | 2008-04-24 | Bruker Daltonik Gmbh | Protein profiles with air MALDI |
| US20060208187A1 (en) * | 2005-03-18 | 2006-09-21 | Alex Mordehai | Apparatus and method for improved sensitivity and duty cycle |
| CA2641561A1 (en) * | 2006-02-08 | 2007-08-16 | Applera Corporation | Radio frequency ion guide |
| GB0900973D0 (en) * | 2009-01-21 | 2009-03-04 | Micromass Ltd | Method and apparatus for performing MS^N |
| WO2014197348A2 (en) * | 2013-06-03 | 2014-12-11 | Perkinelmer Health Sciences, Inc. | Ion guide or filters with selected gas conductance |
| GB201802917D0 (en) | 2018-02-22 | 2018-04-11 | Micromass Ltd | Charge detection mass spectrometry |
| WO2021207494A1 (en) | 2020-04-09 | 2021-10-14 | Waters Technologies Corporation | Ion detector |
| US20240087870A1 (en) * | 2021-01-25 | 2024-03-14 | Dh Technologies Development Pte. Ltd. | Pressure Control in Vacuum Chamber of Mass Spectrometer |
| GB2624012A (en) * | 2022-11-04 | 2024-05-08 | Thermo Fisher Scient Bremen Gmbh | Enhancing mass spectrometer signals |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US694542A (en) | 1901-10-31 | 1902-03-04 | John Peter Gorton | Telegraphy. |
| US2118496A (en) | 1936-03-09 | 1938-05-24 | Corley Mfg Company | Feeding mechanism for sawmills |
| US3410997A (en) | 1964-09-08 | 1968-11-12 | Bell & Howell Co | Multipole mass filter |
| US4542293A (en) | 1983-04-20 | 1985-09-17 | Yale University | Process and apparatus for changing the energy of charged particles contained in a gaseous medium |
| CA1307859C (en) | 1988-12-12 | 1992-09-22 | Donald James Douglas | Mass spectrometer and method with improved ion transmission |
| US5179278A (en) | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| US5521380A (en) | 1992-05-29 | 1996-05-28 | Wells; Gregory J. | Frequency modulated selected ion species isolation in a quadrupole ion trap |
| US5689111A (en) | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
| US6011259A (en) | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| WO1995023018A1 (en) | 1994-02-28 | 1995-08-31 | Analytica Of Branford, Inc. | Multipole ion guide for mass spectrometry |
| AU6653296A (en) | 1995-08-11 | 1997-03-12 | Mds Health Group Limited | Spectrometer with axial field |
| US6177668B1 (en) | 1996-06-06 | 2001-01-23 | Mds Inc. | Axial ejection in a multipole mass spectrometer |
| US6093929A (en) * | 1997-05-16 | 2000-07-25 | Mds Inc. | High pressure MS/MS system |
| GB9717926D0 (en) * | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| US6331702B1 (en) * | 1999-01-25 | 2001-12-18 | University Of Manitoba | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
| AU4326599A (en) * | 1998-05-29 | 1999-12-13 | Analytica Of Branford, Inc. | Mass spectrometry with multipole ion guides |
| US6177688B1 (en) | 1998-11-24 | 2001-01-23 | North Carolina State University | Pendeoepitaxial gallium nitride semiconductor layers on silcon carbide substrates |
| US6194717B1 (en) * | 1999-01-28 | 2001-02-27 | Mds Inc. | Quadrupole mass analyzer and method of operation in RF only mode to reduce background signal |
| US6504148B1 (en) * | 1999-05-27 | 2003-01-07 | Mds Inc. | Quadrupole mass spectrometer with ION traps to enhance sensitivity |
| US6340814B1 (en) | 1999-07-15 | 2002-01-22 | Sciex, A Division Of Mds Inc. | Mass spectrometer with multiple capacitively coupled mass analysis stages |
-
2003
- 2003-05-30 CA CA2641940A patent/CA2641940C/en not_active Expired - Lifetime
- 2003-05-30 EP EP11185701A patent/EP2421023A1/en not_active Withdrawn
- 2003-05-30 AU AU2003249685A patent/AU2003249685A1/en not_active Abandoned
- 2003-05-30 WO PCT/US2003/017437 patent/WO2003102508A1/en not_active Application Discontinuation
- 2003-05-30 EP EP03756377A patent/EP1549914B1/en not_active Expired - Lifetime
- 2003-05-30 CA CA002487136A patent/CA2487136C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1549914A4 (en) | 2009-03-25 |
| CA2487136C (en) | 2008-12-30 |
| AU2003249685A1 (en) | 2003-12-19 |
| CA2641940C (en) | 2011-11-15 |
| EP1549914B1 (en) | 2012-12-26 |
| EP1549914A1 (en) | 2005-07-06 |
| EP2421023A1 (en) | 2012-02-22 |
| CA2487136A1 (en) | 2003-12-11 |
| WO2003102508A1 (en) | 2003-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2626383A1 (en) | Mass spectrometry with multipole ion guides | |
| US11017990B2 (en) | Compact mass spectrometer | |
| US6872939B2 (en) | Mass spectrometer | |
| CA2670286C (en) | Differential-pressure dual ion trap mass analyzer and methods of use thereof | |
| US7932487B2 (en) | Mass spectrometer with looped ion path | |
| US10978288B2 (en) | Compact mass spectrometer | |
| EP2113128B1 (en) | Mass spectrometer | |
| US9190251B2 (en) | Pre-scan for mass to charge ratio range | |
| US9123517B2 (en) | Ion guide with different order multipolar field order distributions across like segments | |
| CA2656956A1 (en) | Multipole ion guide for mass spectrometry | |
| US6781117B1 (en) | Efficient direct current collision and reaction cell | |
| US6707036B2 (en) | Ionization apparatus and method for mass spectrometer system | |
| US10090138B2 (en) | Compact mass spectrometer | |
| US10128092B2 (en) | Compact mass spectrometer | |
| GB2399939A (en) | A method of operating a mass spectrometer in which ions are sent an even number of times though the same mass filter/analyser | |
| GB2355108A (en) | Mass spectrometer with interchangeable ion sources and ion guides | |
| GB2520788A (en) | Compact mass spectrometer | |
| CA2641940A1 (en) | Mass spectrometry with segmented rf multiple ion guides in various pressure regions | |
| EP2715774B1 (en) | Ion inlet for a mass spectrometer | |
| GB2520786A (en) | Compact mass spectrometer | |
| CN118016511A (en) | Ion transmission system with double photoionization sources connected in series | |
| CA2733436A1 (en) | Mass spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230530 |