CA2626089C - Method and apparatus for mass selective axial transport using pulsed axial field - Google Patents

Method and apparatus for mass selective axial transport using pulsed axial field Download PDF

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Publication number
CA2626089C
CA2626089C CA2626089A CA2626089A CA2626089C CA 2626089 C CA2626089 C CA 2626089C CA 2626089 A CA2626089 A CA 2626089A CA 2626089 A CA2626089 A CA 2626089A CA 2626089 C CA2626089 C CA 2626089C
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CA
Canada
Prior art keywords
ions
group
field
mass
axial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2626089A
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English (en)
French (fr)
Other versions
CA2626089A1 (en
Inventor
Alexandre V. Loboda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
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DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of CA2626089A1 publication Critical patent/CA2626089A1/en
Application granted granted Critical
Publication of CA2626089C publication Critical patent/CA2626089C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CA2626089A 2005-11-30 2006-10-12 Method and apparatus for mass selective axial transport using pulsed axial field Expired - Fee Related CA2626089C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74064005P 2005-11-30 2005-11-30
US60/740,640 2005-11-30
PCT/CA2006/001692 WO2007062498A1 (en) 2005-11-30 2006-10-12 Method and apparatus for mass selective axial transport using pulsed axial field

Publications (2)

Publication Number Publication Date
CA2626089A1 CA2626089A1 (en) 2007-06-07
CA2626089C true CA2626089C (en) 2016-10-04

Family

ID=38091825

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2626089A Expired - Fee Related CA2626089C (en) 2005-11-30 2006-10-12 Method and apparatus for mass selective axial transport using pulsed axial field

Country Status (5)

Country Link
US (1) US7459679B2 (enExample)
EP (1) EP1955359B1 (enExample)
JP (1) JP5424085B2 (enExample)
CA (1) CA2626089C (enExample)
WO (1) WO2007062498A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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US7456389B2 (en) * 2006-07-11 2008-11-25 Thermo Finnigan Llc High throughput quadrupolar ion trap
US7633060B2 (en) * 2007-04-24 2009-12-15 Thermo Finnigan Llc Separation and axial ejection of ions based on m/z ratio
US7847240B2 (en) 2007-06-11 2010-12-07 Dana-Farber Cancer Institute, Inc. Mass spectroscopy system and method including an excitation gate
GB2467466B (en) * 2007-07-12 2010-12-29 Micromass Ltd Linear ion trap with radially dependent extraction
GB2461204B (en) * 2007-07-12 2010-11-10 Micromass Ltd Linear ion trap with radially dependent extraction
GB0713590D0 (en) 2007-07-12 2007-08-22 Micromass Ltd Mass spectrometer
GB0718468D0 (en) 2007-09-21 2007-10-31 Micromass Ltd Mass spectrometer
GB0800526D0 (en) * 2008-01-11 2008-02-20 Micromass Ltd Mass spectrometer
EP2294603A4 (en) * 2008-06-09 2017-01-18 DH Technologies Development Pte. Ltd. A multipole ion guide for providing an axial electric field whose strength increases with radial position, and a method of operating a multipole ion guide having such an axial electric field
US8766170B2 (en) * 2008-06-09 2014-07-01 Dh Technologies Development Pte. Ltd. Method of operating tandem ion traps
EP2329514A4 (en) * 2008-10-01 2015-12-23 Dh Technologies Dev Pte Ltd METHOD, SYSTEM AND DEVICE FOR MULTIPLEXING IONES IN MSN MASS SPECTROMETRY ANALYZES
JPWO2010044370A1 (ja) * 2008-10-14 2012-03-15 株式会社日立製作所 質量分析装置および質量分析方法
DE102008055899B4 (de) * 2008-11-05 2011-07-21 Bruker Daltonik GmbH, 28359 Lineare Ionenfalle als Ionenreaktor
CA2762364A1 (en) * 2009-05-27 2010-12-02 Dh Technologies Development Pte. Ltd. Linear ion trap for msms
US8633478B2 (en) * 2009-06-19 2014-01-21 Dow Corning Corporation Use of ionomeric silicone thermoplastic elastomers in electronic devices
EP2502258B1 (en) * 2009-11-16 2021-09-01 DH Technologies Development Pte. Ltd. Apparatus and method for coupling rf and ac signals to provide power to a multipole in a mass spectrometer
US20110260048A1 (en) * 2010-04-22 2011-10-27 Wouters Eloy R Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member
US8680463B2 (en) * 2010-08-04 2014-03-25 Dh Technologies Development Pte. Ltd. Linear ion trap for radial amplitude assisted transfer
JP5543912B2 (ja) * 2010-12-27 2014-07-09 日本電子株式会社 質量分析装置
US9431230B2 (en) 2011-12-27 2016-08-30 Dh Technologies Development Pte. Ltd. Method of extracting ions with a low M/Z ratio from an ion trap
CN104160473B (zh) * 2012-04-02 2017-03-15 Dh科技发展私人贸易有限公司 使用离子阱跨越质量范围进行连续窗口化获取的系统及方法
EP3058580A4 (en) * 2013-10-16 2017-04-19 DH Technologies Development PTE. Ltd. Multiplexed precursor isolation for mass spectrometry
US10163617B2 (en) * 2013-11-07 2018-12-25 Dh Technologies Development Pte. Ltd. Multiplexing of ions for improved sensitivity
GB201322515D0 (en) * 2013-12-19 2014-02-05 Micromass Ltd High pressure mass resolving ion guide with axial field
WO2015092399A1 (en) 2013-12-19 2015-06-25 Micromass Uk Limited High pressure mass resolving ion guide with axial field
WO2015198721A1 (ja) * 2014-06-25 2015-12-30 株式会社 日立ハイテクノロジーズ 質量分析装置
WO2016157030A1 (en) * 2015-04-01 2016-10-06 Dh Technologies Development Pte. Ltd. Multipole ion guide
WO2017055978A1 (en) * 2015-10-01 2017-04-06 Dh Technologies Development Pte. Ltd. Mass-selective axial ejection linear ion trap
US9899199B2 (en) * 2016-06-30 2018-02-20 Bruker Daltonics, Inc. Mass spectrometer comprising a radio frequency ion guide having continuous electrodes
CN109065437B (zh) * 2018-08-03 2020-04-24 北京理工大学 一种四极电场联合偶极电场的离子共振激发操作方法和装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007530A1 (en) * 1995-08-11 1997-02-27 Mds Health Group Limited Spectrometer with axial field
US6177668B1 (en) * 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
JP3818671B2 (ja) * 1996-06-06 2006-09-06 エムディーエス インコーポレーテッド 多重極子質量分光計の軸方向射出方法
US6504148B1 (en) * 1999-05-27 2003-01-07 Mds Inc. Quadrupole mass spectrometer with ION traps to enhance sensitivity
US6630662B1 (en) * 2002-04-24 2003-10-07 Mds Inc. Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas
EP1609167A4 (en) * 2003-03-21 2007-07-25 Dana Farber Cancer Inst Inc MASS SPECTROSCOPY SYSTEM
JP4690641B2 (ja) * 2003-07-28 2011-06-01 株式会社日立ハイテクノロジーズ 質量分析計
WO2005106922A1 (en) * 2004-05-05 2005-11-10 Mds Inc. , Doing Business As Mds Sciex Method and apparatus for mass selective axial ejection

Also Published As

Publication number Publication date
US20070120053A1 (en) 2007-05-31
WO2007062498A1 (en) 2007-06-07
JP2009517815A (ja) 2009-04-30
JP5424085B2 (ja) 2014-02-26
US7459679B2 (en) 2008-12-02
EP1955359A4 (en) 2011-01-12
CA2626089A1 (en) 2007-06-07
EP1955359A1 (en) 2008-08-13
EP1955359B1 (en) 2015-04-01

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Effective date: 20201013