CA2623123C - Graft with bioabsorbable support frame - Google Patents
Graft with bioabsorbable support frame Download PDFInfo
- Publication number
- CA2623123C CA2623123C CA2623123A CA2623123A CA2623123C CA 2623123 C CA2623123 C CA 2623123C CA 2623123 A CA2623123 A CA 2623123A CA 2623123 A CA2623123 A CA 2623123A CA 2623123 C CA2623123 C CA 2623123C
- Authority
- CA
- Canada
- Prior art keywords
- medical device
- bioabsorbable
- support frame
- magnesium
- graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000012360 testing method Methods 0.000 description 1
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71856705P | 2005-09-19 | 2005-09-19 | |
| US60/718,567 | 2005-09-19 | ||
| PCT/US2006/036578 WO2007035791A2 (en) | 2005-09-19 | 2006-09-19 | Graft with bioabsorbable support frame |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2623123A1 CA2623123A1 (en) | 2007-03-29 |
| CA2623123C true CA2623123C (en) | 2014-03-25 |
Family
ID=37807858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2623123A Active CA2623123C (en) | 2005-09-19 | 2006-09-19 | Graft with bioabsorbable support frame |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8663308B2 (enExample) |
| EP (1) | EP1942833B1 (enExample) |
| JP (1) | JP5114801B2 (enExample) |
| AU (1) | AU2006292237B2 (enExample) |
| CA (1) | CA2623123C (enExample) |
| WO (1) | WO2007035791A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220233748A1 (en) * | 2019-04-26 | 2022-07-28 | Waldemar Link Gmbh & Co. Kg | Ductile coating for an implant component |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002345328A1 (en) | 2001-06-27 | 2003-03-03 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
| US20050131520A1 (en) | 2003-04-28 | 2005-06-16 | Zilla Peter P. | Compliant blood vessel graft |
| US7998188B2 (en) | 2003-04-28 | 2011-08-16 | Kips Bay Medical, Inc. | Compliant blood vessel graft |
| ES2375566T3 (es) | 2003-04-28 | 2012-03-02 | Kips Bay Medical, Inc. | Injerto venoso distensible. |
| US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
| US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
| DE102006042313A1 (de) * | 2006-09-06 | 2008-03-27 | Biotronik Vi Patent Ag | Biokorrodierbares metallisches Implantat mit einer Beschichtung oder Kavitätenfüllung aus Gelatine |
| JP2010503490A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 調整可能な表面特徴を備えた内部人工器官 |
| EP2959925B1 (en) | 2006-09-15 | 2018-08-29 | Boston Scientific Limited | Medical devices and methods of making the same |
| EP2399616A1 (en) | 2006-09-15 | 2011-12-28 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
| WO2008034066A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
| WO2008036548A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
| EP2125065B1 (en) | 2006-12-28 | 2010-11-17 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making same |
| US9636438B2 (en) * | 2007-03-07 | 2017-05-02 | Coloplast A/S | Fistula plug comprising ECM |
| US9283302B2 (en) * | 2011-12-16 | 2016-03-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix encasement structures and methods |
| US9066993B2 (en) * | 2007-05-10 | 2015-06-30 | Cormatrix Cardiovascular, Inc. | Extracellular matrix encasement structures and methods |
| US20220023503A9 (en) | 2007-05-10 | 2022-01-27 | Aziyo Med, Llc | Extracellular Matrix Tissue Prostheses |
| WO2009047598A2 (en) * | 2007-05-18 | 2009-04-16 | Fernando Briceno Rincon | Tissue regenerator device based on collagen and process for the production of this device |
| DE602007009369D1 (de) * | 2007-05-28 | 2010-11-04 | Acrostak Corp Bvi | Magnesiumbasierte Legierungen |
| US9034007B2 (en) | 2007-09-21 | 2015-05-19 | Insera Therapeutics, Inc. | Distal embolic protection devices with a variable thickness microguidewire and methods for their use |
| US8118857B2 (en) | 2007-11-29 | 2012-02-21 | Boston Scientific Corporation | Medical articles that stimulate endothelial cell migration |
| US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
| WO2010003442A2 (de) * | 2008-07-07 | 2010-01-14 | Syntellix Ag | Endoprothese zur implantation in den menschlichen oder tierischen körper |
| US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
| US9119906B2 (en) * | 2008-09-24 | 2015-09-01 | Integran Technologies, Inc. | In-vivo biodegradable medical implant |
| US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
| DE102008054920A1 (de) * | 2008-12-18 | 2010-07-01 | Biotronik Vi Patent Ag | Implantat sowie Verfahren zur Herstellung einer Schichtstruktur |
| WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
| WO2011082206A1 (en) * | 2009-12-31 | 2011-07-07 | Ams Research Corporation | Pelvic implants having perimeter imaging features |
| WO2011119573A1 (en) | 2010-03-23 | 2011-09-29 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
| CA2793568C (en) * | 2010-03-25 | 2015-12-29 | Biotronik Ag | Implant made of a biodegradable magnesium alloy |
| ES2522265T3 (es) | 2010-06-21 | 2014-11-14 | Zorion Medical, Inc. | Implantes bioabsorbibles |
| WO2012018680A1 (en) * | 2010-07-31 | 2012-02-09 | Global Therapeutics Llc | Methods and systems for generating a tissue pocket in a patient |
| US8986369B2 (en) | 2010-12-01 | 2015-03-24 | Zorion Medical, Inc. | Magnesium-based absorbable implants |
| PL2744532T3 (pl) * | 2011-08-15 | 2016-02-29 | Meko Laserstrahl Mat E K | Resorbowalne stenty zawierające stop magnezu |
| DE102011082210A1 (de) * | 2011-09-06 | 2013-03-07 | Syntellix Ag | Medizinisches Implantat für den menschlichen und tierischen Körper |
| ES2418848B1 (es) * | 2012-02-10 | 2014-04-30 | Universidad De Valladolid | Soportes para la regeneración, crecimiento y trasplante de células y tejidos |
| JP5959260B2 (ja) * | 2012-03-26 | 2016-08-02 | オリンパス株式会社 | マグネシウム合金製インプラントの加工方法 |
| DE102012007640A1 (de) * | 2012-04-18 | 2013-10-24 | Rheinisch-Westfälische Technische Hochschule Aachen | Stent und Stent-Implantationskatheter |
| CA2888669A1 (en) * | 2012-10-23 | 2014-05-01 | Zorion Medical, Inc. | Fully absorbable intraluminal devices and methods of manufacturing the same |
| US9883956B2 (en) | 2012-10-31 | 2018-02-06 | W. L. Gore & Associates, Inc. | Post-implantation contractible or expandable devices and method of using and making the same |
| CN103110465B (zh) * | 2012-11-08 | 2015-02-25 | 江阴宝易德医疗科技有限公司 | 一种镁合金冠脉支架 |
| US20140172118A1 (en) | 2012-12-19 | 2014-06-19 | Cook Medical Technologies Llc | Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof |
| AU2014237360B2 (en) | 2013-03-15 | 2018-07-26 | Insera Therapeutics, Inc. | Vascular treatment devices and methods |
| US8690907B1 (en) | 2013-03-15 | 2014-04-08 | Insera Therapeutics, Inc. | Vascular treatment methods |
| US8715314B1 (en) | 2013-03-15 | 2014-05-06 | Insera Therapeutics, Inc. | Vascular treatment measurement methods |
| US8679150B1 (en) | 2013-03-15 | 2014-03-25 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy methods |
| JP2014240455A (ja) * | 2013-06-11 | 2014-12-25 | オリンパス株式会社 | 離型材スラリとインプラントの製造方法 |
| EP3089750A2 (en) | 2014-01-02 | 2016-11-09 | Cook Medical Technologies LLC | Compositions, devices and methods for treating infections |
| US20150283308A1 (en) * | 2014-04-03 | 2015-10-08 | Cook Biotech, Incorporated | Endoluminal device and method of implanting same |
| CN103948453A (zh) * | 2014-04-21 | 2014-07-30 | 上海市第六人民医院 | 一种可降解镁合金覆膜支架及覆膜支架系统 |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| JP2019508201A (ja) | 2016-02-16 | 2019-03-28 | インセラ セラピューティクス，インク． | 吸引装置および固定された血流迂回装置 |
| WO2018039444A1 (en) * | 2016-08-25 | 2018-03-01 | Mico Innovations, Llc | Neurovascular stent |
| US11724009B2 (en) | 2017-02-03 | 2023-08-15 | Zorion Medical, Inc. | Wire-formed bio-absorbable implants and methods for assembly |
| US10939990B2 (en) * | 2017-11-28 | 2021-03-09 | Medtronic Vascular, Inc. | Graft material having selectively advanced permeability structure and method |
| US20190159913A1 (en) * | 2017-11-28 | 2019-05-30 | Covidien Lp | Colorectal stents |
| US20210353822A1 (en) * | 2018-09-17 | 2021-11-18 | Labnpeople Co.,Ltd. | Thread embedding therapy rope and thread embedding therapy needle apparatus comprising same |
| US11911272B2 (en) | 2019-01-18 | 2024-02-27 | W. L. Gore & Associates, Inc. | Bioabsorbable medical devices |
| US20220151619A1 (en) * | 2019-03-11 | 2022-05-19 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Anastomosing stent and methods of use |
| US20240252718A1 (en) * | 2021-06-03 | 2024-08-01 | Biotronik Ag | Implant with a biodegradable support structure |
| CN114159197B (zh) * | 2022-02-14 | 2022-05-17 | 北京美中双和医疗器械股份有限公司 | 一种可降解生物医用镁合金药物洗脱血管支架及制备方法 |
| WO2024243381A2 (en) * | 2023-05-23 | 2024-11-28 | Steele Physician Services Plcc | System for treating a patient |
| CN118903662B (zh) * | 2024-08-20 | 2025-12-09 | 复旦大学附属眼耳鼻喉科医院 | 咽鼓管缓释给药支架及咽鼓管缓释给药系统 |
| CN118873305B (zh) * | 2024-08-20 | 2025-12-02 | 复旦大学附属眼耳鼻喉科医院 | 可降解咽鼓管支架及可降解咽鼓管支架系统 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4116731A (en) | 1976-08-30 | 1978-09-26 | Nina Mikhailovna Tikhova | Heat treated and aged magnesium-base alloy |
| IL94138A (en) * | 1990-04-19 | 1997-03-18 | Instent Inc | Device for the treatment of constricted fluid conducting ducts |
| CA2484826C (en) | 1994-04-29 | 2007-12-18 | Scimed Life Systems, Inc. | Stent with collagen |
| WO1996004409A1 (en) | 1994-08-01 | 1996-02-15 | Franz Hehmann | Selected processing for non-equilibrium light alloys and products |
| AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| US5865723A (en) | 1995-12-29 | 1999-02-02 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
| ES2208974T3 (es) | 1996-08-23 | 2004-06-16 | Cook Biotech, Inc. | Protesis de injertos, materiales y metodos. |
| DE19731021A1 (de) * | 1997-07-18 | 1999-01-21 | Meyer Joerg | In vivo abbaubares metallisches Implantat |
| US6626939B1 (en) | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
| EP0966979B1 (de) | 1998-06-25 | 2006-03-08 | Biotronik AG | Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent |
| US6395208B1 (en) | 1999-01-25 | 2002-05-28 | Atrium Medical Corporation | Method of making an expandable fluoropolymer device |
| US7637886B2 (en) | 1999-01-25 | 2009-12-29 | Atrium Medical Corporation | Expandable fluoropolymer device and method of making |
| US6312457B1 (en) * | 1999-04-01 | 2001-11-06 | Boston Scientific Corporation | Intraluminal lining |
| WO2002053202A1 (de) | 2001-01-05 | 2002-07-11 | Gerd Hausdorf | Durch korrosion abbaubare metallische medizinische implante |
| US20020165601A1 (en) | 2001-05-04 | 2002-11-07 | Clerc Claude O. | Bioabsorbable stent-graft and covered stent |
| DE10163106A1 (de) | 2001-12-24 | 2003-07-10 | Univ Hannover | Medizinische Implantate, Prothesen, Protheseteile, medizinische Instrumente, Geräte und Hilfsmittel aus einem halogenid-modifizierten Magnesiumwerkstoff |
| US6939369B2 (en) | 2002-04-03 | 2005-09-06 | Cook Incorporated | Intraluminal graft assembly and vessel repair system |
| US20050202058A1 (en) | 2002-05-02 | 2005-09-15 | Hiles Michael C. | Cell-seeded extracellular matrix grafts |
| DE10237572A1 (de) | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Stent mit polymerer Beschichtung |
| DE10237571A1 (de) | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endovaskuläres Implantat mit aktiver Beschichtung |
| US7550004B2 (en) * | 2002-08-20 | 2009-06-23 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
| JP2005052419A (ja) * | 2003-08-05 | 2005-03-03 | National Cardiovascular Center | ステント |
| AU2003268438A1 (en) | 2002-09-06 | 2004-03-29 | Cook Biotech Incorporated | Tissue graft prosthesis devices containing juvenile or small diameter submucosa |
| DE10253634A1 (de) * | 2002-11-13 | 2004-05-27 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endoprothese |
| DE10261822A1 (de) | 2002-12-20 | 2004-07-01 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Helix-Steg-Verbindung |
| WO2005034807A1 (en) | 2003-10-10 | 2005-04-21 | William A. Cook Australia Pty. Ltd | Composite stent graft |
| JP4887159B2 (ja) | 2004-01-20 | 2012-02-29 | クック・インコーポレイテッド | 腔内人工器官装置およびその形成方法 |
| DE102004026104A1 (de) | 2004-05-25 | 2005-12-15 | Restate Patent Ag | Implantat zur Gefäßligatur |
| DE102004044679A1 (de) | 2004-09-09 | 2006-03-16 | Biotronik Vi Patent Ag | Implantat mit geringer Radialfestigkeit |
| JP2006167078A (ja) * | 2004-12-15 | 2006-06-29 | Terumo Corp | 医療用インプラント |
| US20070050009A1 (en) * | 2005-08-30 | 2007-03-01 | Aiden Flanagan | Bioabsorbable stent |
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2006
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- 2006-09-19 CA CA2623123A patent/CA2623123C/en active Active
- 2006-09-19 EP EP06814993.9A patent/EP1942833B1/en not_active Not-in-force
- 2006-09-19 JP JP2008532332A patent/JP5114801B2/ja not_active Expired - Fee Related
- 2006-09-19 WO PCT/US2006/036578 patent/WO2007035791A2/en not_active Ceased
- 2006-09-19 AU AU2006292237A patent/AU2006292237B2/en not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220233748A1 (en) * | 2019-04-26 | 2022-07-28 | Waldemar Link Gmbh & Co. Kg | Ductile coating for an implant component |
| US12109325B2 (en) * | 2019-04-26 | 2024-10-08 | Waldemar Link Gmbh &Co. Kg | Ductile coating for an implant component |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100262221A1 (en) | 2010-10-14 |
| AU2006292237A1 (en) | 2007-03-29 |
| US8663308B2 (en) | 2014-03-04 |
| EP1942833B1 (en) | 2019-03-06 |
| AU2006292237B2 (en) | 2012-01-12 |
| WO2007035791A2 (en) | 2007-03-29 |
| JP2009508644A (ja) | 2009-03-05 |
| WO2007035791A3 (en) | 2007-05-10 |
| JP5114801B2 (ja) | 2013-01-09 |
| CA2623123A1 (en) | 2007-03-29 |
| EP1942833A2 (en) | 2008-07-16 |
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