CA2616112A1 - Oral suspension of prednisolone acetate - Google Patents
Oral suspension of prednisolone acetate Download PDFInfo
- Publication number
- CA2616112A1 CA2616112A1 CA002616112A CA2616112A CA2616112A1 CA 2616112 A1 CA2616112 A1 CA 2616112A1 CA 002616112 A CA002616112 A CA 002616112A CA 2616112 A CA2616112 A CA 2616112A CA 2616112 A1 CA2616112 A1 CA 2616112A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- prednisolone
- prednisolone acetate
- diseases
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 title claims abstract description 51
- 229960002800 prednisolone acetate Drugs 0.000 title claims abstract description 51
- 229940100692 oral suspension Drugs 0.000 title abstract description 5
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims abstract description 30
- 229960005205 prednisolone Drugs 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 26
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- 239000002245 particle Substances 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 13
- 229920002125 Sokalan® Polymers 0.000 claims description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 229960001631 carbomer Drugs 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 10
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
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- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
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- JDOZJEUDSLGTLU-VWUMJDOOSA-N prednisolone phosphate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 JDOZJEUDSLGTLU-VWUMJDOOSA-N 0.000 description 4
- 229960002943 prednisolone sodium phosphate Drugs 0.000 description 4
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 2
- 229940102618 prednisolone 5 mg Drugs 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- DSEKYWAQQVUQTP-UHFFFAOYSA-N Cerin Natural products CC12CCC3(C)C4CC(C)(C)CCC4(C)CCC3(C)C2CCC2(C)C1CC(O)C(=O)C2C DSEKYWAQQVUQTP-UHFFFAOYSA-N 0.000 description 1
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
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- 229940068285 prednisolone 15 mg Drugs 0.000 description 1
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- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Rheumatology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70537005P | 2005-08-04 | 2005-08-04 | |
| US60/705,370 | 2005-08-04 | ||
| PCT/US2006/030140 WO2007019184A2 (en) | 2005-08-04 | 2006-08-03 | Oral suspension of prednisolone acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2616112A1 true CA2616112A1 (en) | 2007-02-15 |
Family
ID=37727875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002616112A Abandoned CA2616112A1 (en) | 2005-08-04 | 2006-08-03 | Oral suspension of prednisolone acetate |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7799331B2 (enExample) |
| EP (2) | EP1909798A4 (enExample) |
| JP (2) | JP2009503097A (enExample) |
| KR (1) | KR20080044245A (enExample) |
| CN (1) | CN101247786A (enExample) |
| AU (1) | AU2006278620B2 (enExample) |
| CA (1) | CA2616112A1 (enExample) |
| IL (1) | IL189257A0 (enExample) |
| NZ (1) | NZ566117A (enExample) |
| WO (1) | WO2007019184A2 (enExample) |
| ZA (1) | ZA200800926B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799331B2 (en) * | 2005-08-04 | 2010-09-21 | Taro Pharmaceutical North America, Inc. | Oral suspension of prednisolone acetate |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| JP5226661B2 (ja) * | 2006-04-06 | 2013-07-03 | ターロ ファーマシューティカルズ ノース アメリカ インコーポレイテッド | 親水コロイド重合体を含む新規な耐流出性製剤 |
| CN101888829A (zh) * | 2007-10-09 | 2010-11-17 | 诺瓦提斯公司 | 缬沙坦的药物制剂 |
| DK3354276T3 (da) * | 2007-11-13 | 2020-03-30 | Meritage Pharma Inc | Sammensætninger til behandlingen af gastrointestinal inflammation |
| US20090143343A1 (en) * | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
| US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| EP2328553B1 (en) * | 2008-08-20 | 2020-06-10 | The Regents of The University of California | Corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| EP2440210A4 (en) * | 2009-06-12 | 2014-01-29 | Meritage Pharma Inc | METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES |
| AU2017260327B2 (en) * | 2016-05-06 | 2018-12-20 | Harrow Ip, Llc | Pharmaceutical Ophthalmic compositions and methods for fabricating thereof |
| US9956158B2 (en) * | 2016-09-08 | 2018-05-01 | Synergistic Therapeutics, Llc | Topical hair growth formulation |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4265823A (en) * | 1979-01-04 | 1981-05-05 | Robert E. Kosinski | Aurothiosteroids |
| US4448774A (en) | 1982-12-22 | 1984-05-15 | Fisons Corporation | Steroid formulation |
| US5145675A (en) * | 1986-03-31 | 1992-09-08 | Advanced Polymer Systems, Inc. | Two step method for preparation of controlled release formulations |
| EP0653209A4 (en) * | 1992-07-30 | 1997-03-19 | Tokyo Tanabe Co | Remedy for inflammatory intestinal diseases. |
| IL108366A (en) | 1993-03-11 | 1999-11-30 | Taro Vit Ind Ltd | Semi-solid pharmaceutical compounds and a device for their use |
| US5881926A (en) | 1993-03-11 | 1999-03-16 | Taro Pharmaceutical Industries, Ltd. | Pharmaceutical compositions in semisolid form and a device for administration thereof |
| US20030203976A1 (en) * | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
| US5480914A (en) | 1994-05-06 | 1996-01-02 | Allergan, Inc. | Nonaqueous thixotropic drug delivery suspensions and methods of their use |
| US5811388A (en) * | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
| US5763449A (en) * | 1996-08-07 | 1998-06-09 | Ascent Pediatrics, Inc. | Pleasant-tasting aqueous liquid composition of a bitter-tasting drug |
| US6071523A (en) | 1998-06-03 | 2000-06-06 | Taro Pharmaceuticals Industries, Ltd. | Spill resistant pharmaceutical compositions in semi-solid form |
| WO2000012137A1 (en) | 1998-09-02 | 2000-03-09 | Allergan Sales, Inc. | Preserved cyclodextrin-containing compositions |
| US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
| WO2002058662A2 (en) * | 2001-01-24 | 2002-08-01 | Oraceutical Llc | Topical oral care compositions |
| BR0213100A (pt) | 2001-10-05 | 2004-11-30 | Combinatorx Inc | Combinações para o tratamento de distúrbios imuniinflamatórios |
| US7001615B1 (en) | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
| WO2003049745A1 (en) | 2001-12-12 | 2003-06-19 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| ATE541562T1 (de) | 2002-06-17 | 2012-02-15 | Taro Pharmaceuticals Usa Inc | Ibuprofen-suspension |
| WO2004112800A1 (en) * | 2003-06-19 | 2004-12-29 | Bodor Nicholas S | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids |
| US20050153946A1 (en) | 2003-12-24 | 2005-07-14 | Collegium Pharmaceuticals, Inc. | Temperature-stable formulations, and methods of development thereof |
| JP2007533697A (ja) * | 2004-04-22 | 2007-11-22 | デュオコート エービー | グルココルチコイド救急治療用の医薬組成物 |
| US6969706B1 (en) * | 2004-05-12 | 2005-11-29 | Allergan, Inc. | Preserved pharmaceutical compositions comprising cyclodextrins |
| US7799331B2 (en) | 2005-08-04 | 2010-09-21 | Taro Pharmaceutical North America, Inc. | Oral suspension of prednisolone acetate |
-
2006
- 2006-07-13 US US11/457,197 patent/US7799331B2/en active Active
- 2006-08-03 NZ NZ566117A patent/NZ566117A/en not_active IP Right Cessation
- 2006-08-03 CN CNA2006800290686A patent/CN101247786A/zh active Pending
- 2006-08-03 JP JP2008525163A patent/JP2009503097A/ja active Pending
- 2006-08-03 CA CA002616112A patent/CA2616112A1/en not_active Abandoned
- 2006-08-03 AU AU2006278620A patent/AU2006278620B2/en not_active Ceased
- 2006-08-03 KR KR1020087003972A patent/KR20080044245A/ko not_active Abandoned
- 2006-08-03 EP EP06789228A patent/EP1909798A4/en not_active Withdrawn
- 2006-08-03 EP EP13169273.3A patent/EP2630951A1/en not_active Withdrawn
- 2006-08-03 WO PCT/US2006/030140 patent/WO2007019184A2/en not_active Ceased
-
2008
- 2008-01-29 ZA ZA2008/00926A patent/ZA200800926B/en unknown
- 2008-02-04 IL IL189257A patent/IL189257A0/en unknown
-
2010
- 2010-08-27 US US12/870,144 patent/US8206727B2/en not_active Expired - Lifetime
-
2012
- 2012-05-30 US US13/483,273 patent/US8461139B2/en not_active Expired - Fee Related
- 2012-10-25 JP JP2012236009A patent/JP2013014634A/ja not_active Abandoned
-
2013
- 2013-02-01 US US13/756,731 patent/US20130143853A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US8461139B2 (en) | 2013-06-11 |
| US20070031459A1 (en) | 2007-02-08 |
| JP2009503097A (ja) | 2009-01-29 |
| US20130143853A1 (en) | 2013-06-06 |
| EP2630951A1 (en) | 2013-08-28 |
| JP2013014634A (ja) | 2013-01-24 |
| WO2007019184A2 (en) | 2007-02-15 |
| KR20080044245A (ko) | 2008-05-20 |
| EP1909798A2 (en) | 2008-04-16 |
| WO2007019184A3 (en) | 2007-09-20 |
| US20100324007A1 (en) | 2010-12-23 |
| EP1909798A4 (en) | 2010-10-27 |
| AU2006278620A1 (en) | 2007-02-15 |
| AU2006278620B2 (en) | 2012-02-02 |
| ZA200800926B (en) | 2012-04-24 |
| IL189257A0 (en) | 2008-08-07 |
| NZ566117A (en) | 2011-06-30 |
| US8206727B2 (en) | 2012-06-26 |
| CN101247786A (zh) | 2008-08-20 |
| US7799331B2 (en) | 2010-09-21 |
| US20120238534A1 (en) | 2012-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150326 |