CA2612922A1 - 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels - Google Patents
2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels Download PDFInfo
- Publication number
- CA2612922A1 CA2612922A1 CA002612922A CA2612922A CA2612922A1 CA 2612922 A1 CA2612922 A1 CA 2612922A1 CA 002612922 A CA002612922 A CA 002612922A CA 2612922 A CA2612922 A CA 2612922A CA 2612922 A1 CA2612922 A1 CA 2612922A1
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- CA
- Canada
- Prior art keywords
- trifluoromethyl
- benzimidazol
- aniline
- disease
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 102000002582 Small-Conductance Calcium-Activated Potassium Channels Human genes 0.000 title abstract description 5
- 108010093479 Small-Conductance Calcium-Activated Potassium Channels Proteins 0.000 title abstract description 5
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Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69225205P | 2005-06-21 | 2005-06-21 | |
| DKPA200500910 | 2005-06-21 | ||
| DKPA200500910 | 2005-06-21 | ||
| US60/692,252 | 2005-06-21 | ||
| PCT/EP2006/063405 WO2006136580A2 (en) | 2005-06-21 | 2006-06-21 | 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2612922A1 true CA2612922A1 (en) | 2006-12-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002612922A Abandoned CA2612922A1 (en) | 2005-06-21 | 2006-06-21 | 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7960561B2 (enExample) |
| EP (1) | EP1896427A2 (enExample) |
| JP (1) | JP2008543915A (enExample) |
| CA (1) | CA2612922A1 (enExample) |
| MX (1) | MX2007015689A (enExample) |
| WO (1) | WO2006136580A2 (enExample) |
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|---|---|---|---|---|
| GB0715103D0 (en) * | 2007-08-03 | 2007-09-12 | Lectus Therapeutics Ltd | Calcium ion channel modulators and uses thereof |
| US11427600B2 (en) | 2014-06-27 | 2022-08-30 | Nogra Pharma Limited | Aryl receptor modulators and methods of making and using the same |
| CN108283000B (zh) | 2015-09-23 | 2021-04-13 | 凯瑞康宁生物工程（武汉）有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
| CN109153667B (zh) * | 2016-02-24 | 2021-04-02 | 阿塞西翁制药公司 | 新型钾通道抑制剂 |
| US10653681B2 (en) | 2016-03-16 | 2020-05-19 | Recurium Ip Holdings, Llc | Analgesic compounds |
| KR102510784B1 (ko) | 2017-03-30 | 2023-03-15 | 엑스더블유파마 리미티드 | 이환형 헤테로아릴 유도체 및 이의 제조 및 용도 |
| EP3672953B1 (en) * | 2017-08-23 | 2021-07-28 | Acesion Pharma ApS | Benzimidazole derivatives useful as potassium channel inhibitors |
| CN114042070A (zh) | 2018-09-30 | 2022-02-15 | 凯瑞康宁生物工程（武汉）有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| WO2021127461A1 (en) | 2019-12-20 | 2021-06-24 | Xw Laboratories Limited | Methods of synthesizing 4-valyloxybutyric acid |
| AU2021292406B2 (en) | 2020-06-18 | 2024-03-14 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| KR102982616B1 (ko) | 2020-06-18 | 2026-06-26 | 엑스더블유파마 리미티드 | 수용성 원료의약품의 약학적 과립화제 |
| WO2022020621A1 (en) | 2020-07-24 | 2022-01-27 | XWPharma Ltd. | Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative |
| AU2021357705B2 (en) | 2020-10-05 | 2024-09-26 | XWPharma Ltd. | Modified release compositions of a gamma-hydroxybutyric acid derivative |
| DK4308086T3 (da) | 2021-03-19 | 2025-11-17 | Xwpharma Ltd | Farmakokinetik af formuleringer med kombineret frigivelse af et gamma-hydroxysmørsyrederivat |
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|---|---|---|---|---|
| BE632578A (enExample) * | 1963-05-22 | |||
| GB1171904A (en) * | 1965-10-21 | 1969-11-26 | Unilever Ltd | Anilinobenzimidazoles having Antibacterial Properties |
| JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
| ATE244717T1 (de) * | 1997-03-14 | 2003-07-15 | Vertex Pharma | Inhibitoren des impdh-enzyms |
| WO2001021160A2 (en) * | 1999-09-23 | 2001-03-29 | Axxima Pharmaceuticals Aktiengesellschaft | Carboxymide and aniline derivatives as selective inhibitors of pathogens |
| DE10060292A1 (de) * | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
| WO2003043345A1 (fr) | 2001-11-16 | 2003-05-22 | Ntt Docomo, Inc. | Procede de codage d'image, procede de decodage d'image, codeur et decodeur d'image, programme, signal de donnees informatiques et systeme d'emission d'image |
| DE10304294A1 (de) | 2003-02-04 | 2004-08-12 | Aventis Pharma Deutschland Gmbh | N-Substituierte(Benzoimidazol-2-yl)-phenyl, Verfahren zu ihrer Herstellung , ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US20050054705A1 (en) | 2003-02-04 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
| WO2004098494A2 (en) * | 2003-04-30 | 2004-11-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US7714009B2 (en) | 2003-10-31 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing fused heterocyclic compounds |
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- 2006-06-21 EP EP06777399A patent/EP1896427A2/en not_active Withdrawn
- 2006-06-21 MX MX2007015689A patent/MX2007015689A/es not_active Application Discontinuation
- 2006-06-21 CA CA002612922A patent/CA2612922A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7960561B2 (en) | 2011-06-14 |
| JP2008543915A (ja) | 2008-12-04 |
| MX2007015689A (es) | 2008-02-21 |
| WO2006136580A3 (en) | 2007-04-12 |
| EP1896427A2 (en) | 2008-03-12 |
| WO2006136580A2 (en) | 2006-12-28 |
| US20090076106A1 (en) | 2009-03-19 |
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