CA2612922A1 - 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels - Google Patents
2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels Download PDFInfo
- Publication number
- CA2612922A1 CA2612922A1 CA002612922A CA2612922A CA2612922A1 CA 2612922 A1 CA2612922 A1 CA 2612922A1 CA 002612922 A CA002612922 A CA 002612922A CA 2612922 A CA2612922 A CA 2612922A CA 2612922 A1 CA2612922 A1 CA 2612922A1
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- CA
- Canada
- Prior art keywords
- trifluoromethyl
- benzimidazol
- aniline
- disease
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 102000002582 Small-Conductance Calcium-Activated Potassium Channels Human genes 0.000 title abstract description 5
- 108010093479 Small-Conductance Calcium-Activated Potassium Channels Proteins 0.000 title abstract description 5
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69225205P | 2005-06-21 | 2005-06-21 | |
| DKPA200500910 | 2005-06-21 | ||
| US60/692,252 | 2005-06-21 | ||
| DKPA200500910 | 2005-06-21 | ||
| PCT/EP2006/063405 WO2006136580A2 (en) | 2005-06-21 | 2006-06-21 | 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
Publications (1)
| Publication Number | Publication Date |
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| CA2612922A1 true CA2612922A1 (en) | 2006-12-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002612922A Abandoned CA2612922A1 (en) | 2005-06-21 | 2006-06-21 | 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
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| Country | Link |
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| US (1) | US7960561B2 (enExample) |
| EP (1) | EP1896427A2 (enExample) |
| JP (1) | JP2008543915A (enExample) |
| CA (1) | CA2612922A1 (enExample) |
| MX (1) | MX2007015689A (enExample) |
| WO (1) | WO2006136580A2 (enExample) |
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| GB0715103D0 (en) * | 2007-08-03 | 2007-09-12 | Lectus Therapeutics Ltd | Calcium ion channel modulators and uses thereof |
| CA2999367C (en) | 2015-09-23 | 2023-09-26 | Xw Laboratories Inc. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| ES2791317T3 (es) * | 2016-02-24 | 2020-11-03 | Acesion Pharma Aps | Nuevos inhibidores de los canales de potasio |
| WO2017160922A1 (en) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
| KR102510784B1 (ko) | 2017-03-30 | 2023-03-15 | 엑스더블유파마 리미티드 | 이환형 헤테로아릴 유도체 및 이의 제조 및 용도 |
| CN111372928B (zh) * | 2017-08-23 | 2023-05-16 | 阿塞西翁制药公司 | 用作钾通道抑制剂的苯并咪唑衍生物 |
| WO2020062251A1 (en) | 2018-09-30 | 2020-04-02 | Xw Laboratories, Inc. | Compounds as neuronal histamine receptor-3 antagonists and uses thereof |
| WO2021127461A1 (en) | 2019-12-20 | 2021-06-24 | Xw Laboratories Limited | Methods of synthesizing 4-valyloxybutyric acid |
| WO2021257832A1 (en) | 2020-06-18 | 2021-12-23 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| WO2021257886A1 (en) | 2020-06-18 | 2021-12-23 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| CN119970650A (zh) | 2020-10-05 | 2025-05-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的修饰释放组合物 |
| EP4308086B1 (en) | 2021-03-19 | 2025-10-15 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
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| BE632578A (enExample) * | 1963-05-22 | |||
| GB1171904A (en) * | 1965-10-21 | 1969-11-26 | Unilever Ltd | Anilinobenzimidazoles having Antibacterial Properties |
| JP2869561B2 (ja) | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
| WO1998040381A1 (en) * | 1997-03-14 | 1998-09-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
| WO2001021160A2 (en) * | 1999-09-23 | 2001-03-29 | Axxima Pharmaceuticals Aktiengesellschaft | Carboxymide and aniline derivatives as selective inhibitors of pathogens |
| DE10060292A1 (de) | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
| EP1445957A4 (en) * | 2001-11-16 | 2009-05-06 | Ntt Docomo Inc | PICTURE CODING, PICTURE DECODING, PICTURE CODIER, IMAGE DEVELOPER, PROGRAM, COMPUTER DATA SIGNAL AND IMAGE TRANSMISSION SYSTEM |
| US20050054705A1 (en) * | 2003-02-04 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
| DE10304294A1 (de) * | 2003-02-04 | 2004-08-12 | Aventis Pharma Deutschland Gmbh | N-Substituierte(Benzoimidazol-2-yl)-phenyl, Verfahren zu ihrer Herstellung , ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP1620413A2 (en) * | 2003-04-30 | 2006-02-01 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| EP1677791A4 (en) | 2003-10-31 | 2007-08-15 | Takeda Pharmaceutical | NITROGENIC CONDENSED HETEROCYCLIC COMPOUNDS |
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| US20090076106A1 (en) | 2009-03-19 |
| WO2006136580A2 (en) | 2006-12-28 |
| US7960561B2 (en) | 2011-06-14 |
| EP1896427A2 (en) | 2008-03-12 |
| WO2006136580A3 (en) | 2007-04-12 |
| JP2008543915A (ja) | 2008-12-04 |
| MX2007015689A (es) | 2008-02-21 |
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