CA2606497A1 - Nouvelles substances thyromimetiques contenant du phosphore - Google Patents
Nouvelles substances thyromimetiques contenant du phosphore Download PDFInfo
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- CA2606497A1 CA2606497A1 CA002606497A CA2606497A CA2606497A1 CA 2606497 A1 CA2606497 A1 CA 2606497A1 CA 002606497 A CA002606497 A CA 002606497A CA 2606497 A CA2606497 A CA 2606497A CA 2606497 A1 CA2606497 A1 CA 2606497A1
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- optionally substituted
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- 229910052698 phosphorus Inorganic materials 0.000 title claims description 48
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title claims description 44
- 239000011574 phosphorus Substances 0.000 title claims description 44
- 230000000929 thyromimetic effect Effects 0.000 title claims description 21
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- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims abstract description 67
- 239000013078 crystal Substances 0.000 claims abstract description 43
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- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
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Classifications
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- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4426—Amides of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/137,773 US7514419B2 (en) | 2003-11-19 | 2005-05-26 | Phosphorus-containing thyromimetics |
US11/137,773 | 2005-05-26 | ||
US72517005P | 2005-10-06 | 2005-10-06 | |
US60/725,170 | 2005-10-06 | ||
PCT/US2006/020607 WO2006128055A2 (fr) | 2005-05-26 | 2006-05-26 | Nouvelles substances thyromimetiques contenant du phosphore |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2606497A1 true CA2606497A1 (fr) | 2006-11-30 |
Family
ID=37057345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002606497A Abandoned CA2606497A1 (fr) | 2005-05-26 | 2006-05-26 | Nouvelles substances thyromimetiques contenant du phosphore |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1891080A2 (fr) |
JP (1) | JP2008545710A (fr) |
CN (1) | CN101189248A (fr) |
AU (1) | AU2006249347A1 (fr) |
CA (1) | CA2606497A1 (fr) |
MX (1) | MX2007014493A (fr) |
WO (1) | WO2006128055A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7829552B2 (en) | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
US20120046364A1 (en) | 2009-02-10 | 2012-02-23 | Metabasis Therapeutics, Inc. | Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use |
EP3541395A4 (fr) * | 2016-11-21 | 2020-07-01 | Viking Therapeutics, Inc. | Méthodes de traitement de glycogénose |
US11707472B2 (en) * | 2017-06-05 | 2023-07-25 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
CN112135832A (zh) * | 2018-03-22 | 2020-12-25 | 维京治疗公司 | 化合物的晶型和制备化合物的晶型的方法 |
WO2020118564A1 (fr) * | 2018-12-12 | 2020-06-18 | Autobahn Therapeutics, Inc. | Nouveaux thyromimétiques |
WO2020123861A1 (fr) | 2018-12-12 | 2020-06-18 | Autobahn Therapeutics, Inc. | Nouveaux thyromimétiques |
WO2020180624A1 (fr) | 2019-03-01 | 2020-09-10 | Autobahn Therapeutics, Inc. | Nouveaux thyromimétiques |
CN112300211B (zh) * | 2019-07-26 | 2023-12-08 | 广东东阳光药业股份有限公司 | 一种作为甲状腺激素β受体激动剂的化合物及其用途 |
WO2021032218A1 (fr) * | 2019-08-19 | 2021-02-25 | 苏州闻天医药科技有限公司 | COMPOSÉ AGONISTE DU RÉCEPTEUR THR-β HÉTÉROCYCLIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION |
CN110726801A (zh) * | 2019-10-31 | 2020-01-24 | 山东泰星新材料股份有限公司 | 一种监测烷基次膦酸反应状态的方法 |
CN113336792A (zh) | 2020-02-18 | 2021-09-03 | 甘莱制药有限公司 | 一种环状膦酸酯化合物的制备方法 |
US11752161B2 (en) | 2020-03-27 | 2023-09-12 | Gannex Pharma Co., Ltd. | Pharmaceutical compositions, method of making and method of using thereof |
CN114315902A (zh) * | 2020-09-30 | 2022-04-12 | 甘莱制药有限公司 | 一种甲状腺激素β受体激动剂的晶体及其制备方法和用途 |
CN114763363A (zh) * | 2021-01-12 | 2022-07-19 | 上海喀露蓝科技有限公司 | 磷酸或磷酸酯类衍生物及其制备方法和其在医药上的用途 |
WO2023158607A1 (fr) * | 2022-02-18 | 2023-08-24 | Viking Therapeutics, Inc. | Formes polymorphes et procédés de production de formes polymorphes d'un composé |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3357887A (en) * | 1962-12-03 | 1967-12-12 | Upjohn Co | 4-phenoxy-3, 5-dihalophenylalkanols and hypocholesteremic compositions containing the same |
GB9713739D0 (en) * | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
IL137672A0 (en) * | 2000-08-03 | 2001-10-31 | Dpharm Ltd | Derivatives of branched-chain lipophilic molecules and uses thereof |
EP1469863A2 (fr) * | 2002-01-18 | 2004-10-27 | Merck & Co., Inc. | Antagonisteses lectifs du recepteur s1p1/edg1 |
US7829552B2 (en) * | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
-
2006
- 2006-05-26 CA CA002606497A patent/CA2606497A1/fr not_active Abandoned
- 2006-05-26 WO PCT/US2006/020607 patent/WO2006128055A2/fr active Application Filing
- 2006-05-26 AU AU2006249347A patent/AU2006249347A1/en not_active Abandoned
- 2006-05-26 JP JP2008513783A patent/JP2008545710A/ja not_active Withdrawn
- 2006-05-26 MX MX2007014493A patent/MX2007014493A/es not_active Application Discontinuation
- 2006-05-26 CN CNA2006800177325A patent/CN101189248A/zh active Pending
- 2006-05-26 EP EP06760469A patent/EP1891080A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2008545710A (ja) | 2008-12-18 |
MX2007014493A (es) | 2008-02-07 |
WO2006128055A2 (fr) | 2006-11-30 |
AU2006249347A1 (en) | 2006-11-30 |
EP1891080A2 (fr) | 2008-02-27 |
CN101189248A (zh) | 2008-05-28 |
WO2006128055A3 (fr) | 2007-05-24 |
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