CA2605652C - Polylactide compositions and uses thereof - Google Patents

Polylactide compositions and uses thereof Download PDF

Info

Publication number
CA2605652C
CA2605652C CA2605652A CA2605652A CA2605652C CA 2605652 C CA2605652 C CA 2605652C CA 2605652 A CA2605652 A CA 2605652A CA 2605652 A CA2605652 A CA 2605652A CA 2605652 C CA2605652 C CA 2605652C
Authority
CA
Canada
Prior art keywords
administration
pharmaceutical preparation
compound
alkyl
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2605652A
Other languages
English (en)
French (fr)
Other versions
CA2605652A1 (en
Inventor
Michael Moller
Thomas Trimaille
Robert Gurny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Geneva
Original Assignee
University of Geneva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Geneva filed Critical University of Geneva
Publication of CA2605652A1 publication Critical patent/CA2605652A1/en
Application granted granted Critical
Publication of CA2605652C publication Critical patent/CA2605652C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
CA2605652A 2005-04-22 2006-04-21 Polylactide compositions and uses thereof Expired - Fee Related CA2605652C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US67410305P 2005-04-22 2005-04-22
US60/674,103 2005-04-22
US75014105P 2005-12-14 2005-12-14
US60/750,141 2005-12-14
PCT/IB2006/002849 WO2007012979A2 (en) 2005-04-22 2006-04-21 Polylactide compositions and uses thereof

Publications (2)

Publication Number Publication Date
CA2605652A1 CA2605652A1 (en) 2007-02-01
CA2605652C true CA2605652C (en) 2016-05-24

Family

ID=37603048

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2605652A Expired - Fee Related CA2605652C (en) 2005-04-22 2006-04-21 Polylactide compositions and uses thereof

Country Status (9)

Country Link
US (5) US8466133B2 (enExample)
EP (2) EP1883665B1 (enExample)
JP (5) JP5749881B2 (enExample)
CA (1) CA2605652C (enExample)
DK (1) DK1883665T3 (enExample)
ES (1) ES2646141T3 (enExample)
PL (1) PL1883665T3 (enExample)
PT (1) PT1883665T (enExample)
WO (1) WO2007012979A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5749881B2 (ja) * 2005-04-22 2015-07-15 ユニヴェルシテ デ ジュネーブ ポリラクチド組成物およびその使用
JP2010522624A (ja) * 2007-03-28 2010-07-08 ボストン サイエンティフィック サイムド，インコーポレイテッド 治療剤の放出のための生体侵食性層を有する医療装置
WO2009025719A1 (en) * 2007-08-03 2009-02-26 University Of Massachusetts Medical School Polymer compositions for biomedical and material applications
US8697098B2 (en) * 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
CN101665566B (zh) * 2008-09-01 2012-01-04 南京工业大学 一种利用双螺杆挤出机制备聚乳酸及其制品的方法
FR2942800B1 (fr) * 2009-03-06 2012-04-20 Minasolve Procede de polymerisation par voie catalytique de 1,4-dioxanes-2,5 diones et les polymeres correspondants
CA2824250A1 (en) * 2010-01-08 2011-07-14 University Of Prince Edward Island Star polymers having controlled tacticity and methods of making same
WO2012014011A1 (en) * 2010-07-26 2012-02-02 Universite De Geneve Compositions comprising polymers prepared from 2-hydroxyalkyl acids
CA2828253C (en) 2011-02-25 2016-10-18 South Dakota State University Polymer conjugated protein micelles
WO2013083605A1 (en) 2011-12-05 2013-06-13 Ferring Bv Triptorelin pharmaceutical composition
EP2809344B1 (en) 2012-02-02 2016-08-24 ESBATech - a Novartis Company LLC Antibody-containing sustained-release formulation for ocular administration
AR092821A1 (es) * 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
AR090736A1 (es) * 2012-04-20 2014-12-03 Sucampo Ag Conjugado de compuesto triciclo-polimero
JP6422893B2 (ja) * 2013-02-08 2018-11-14 トタル リサーチ アンド テクノロジー フエリユイ 環状エステルおよび環状アミドの製造方法
US8975344B2 (en) * 2013-07-10 2015-03-10 Xerox Corporation Polyester/polycarbonate block copolymers via one-pot, neat ring opening polymerization
US9080012B2 (en) * 2013-07-10 2015-07-14 Xerox Corporation One-pot, neat ring opening polymerization to prepare resin
DE102013018193A1 (de) 2013-10-30 2015-05-13 Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts Injizierbare Depotformulierungen zur kontrollierten Wirkstofffreisetzung
US9999704B2 (en) * 2014-02-26 2018-06-19 University Of Massachusetts Amphiphilic degradable polymers for immobilization and sustained delivery of biomolecules
DE102014005782A1 (de) 2014-04-23 2015-10-29 Martin-Luther-Universität Halle-Wittenberg lnjizierbare und implantierbare Trägersysteme auf Basis von modifizierten Poly(dikarbonsäure-multiol estern) zur kontrollierten Wirkstofffreisetzung
WO2015184256A2 (en) * 2014-05-30 2015-12-03 Shire Human Genetic Therapies, Inc. Biodegradable lipids for delivery of nucleic acids
WO2016079416A1 (fr) * 2014-11-17 2016-05-26 Roquette Freres Composition à base d'amidon thermoplastique et de polyester aliphatique
JP2017535645A (ja) * 2014-12-16 2017-11-30 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 生分解性ポリマー組成物
US9260550B1 (en) 2015-01-27 2016-02-16 International Business Machines Corporation Lactide-based acrylate polymers
JP6148701B2 (ja) * 2015-07-31 2017-06-14 ユニベルシテ ドゥ ジュネーブ ２−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
US10035877B1 (en) 2017-03-08 2018-07-31 International Business Machines Corporation Matrix-bondable lactide monomors for polylactide synthesis
US10072121B1 (en) 2017-03-08 2018-09-11 International Business Machines Corporation Bottlebrush polymers derived from poly(methylidenelactide)
US10202489B2 (en) 2017-03-08 2019-02-12 International Business Machines Corporation Lactide copolymers and ring-opened lactide copolymers
US10570252B2 (en) 2017-03-08 2020-02-25 International Business Machines Corporation Flame retardant lactide monomors for polylactide synthesis
JP2021512943A (ja) 2018-01-26 2021-05-20 アピデル エス・アＡｐｉｄｅｌ ＳＡ 新規なスピロノラクトン製剤およびその使用
CA2994005A1 (fr) * 2018-02-05 2019-08-05 Hydro-Quebec Copolymeres d'unites ester et ether, leurs procedes de fabrication et leurs utilisations
EP3656378A1 (en) * 2018-11-26 2020-05-27 ValMeyer Sàrl New composition of amide and ester local anesthetics and uses thereof
US11407855B2 (en) 2019-08-23 2022-08-09 The Board Of Trustees Of The University Of Illinois Ring opening polymerization in an aqueous dispersion
CN116217900B (zh) * 2021-12-02 2025-12-30 惠生工程（中国）有限公司 一种乙交酯、丙交酯开环共聚合制备pgla的装置及工艺
WO2024064758A2 (en) * 2022-09-21 2024-03-28 Hercules Llc Coating composition comprising a bioresorbable copolymer and an anti-microbial agent

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1098443A (en) * 1977-05-20 1981-03-31 Namassivaya Doddi Absorbable p-dioxanone polymer-drug compositions
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
AU664561B2 (en) 1991-06-21 1995-11-23 University Of Cincinnati, The Orally administrable therapeutic proteins and method of making
US5756353A (en) 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5686630A (en) * 1993-09-29 1997-11-11 Chronopol, Inc. Purifying cyclic esters by aqueous solvent extraction
ATE155681T1 (de) 1992-05-18 1997-08-15 Minnesota Mining & Mfg Einrichtung zur transmucosalen wirkstoffabgabe
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
KR970002523B1 (en) * 1993-04-24 1997-03-05 Korea Inst Sci & Tech Biodegradable polylactic acid having improved properties and method for manufacturing the same
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5580579A (en) 1995-02-15 1996-12-03 Nano Systems L.L.C. Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6451346B1 (en) 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
AU2098901A (en) 1999-12-13 2001-06-18 Michigan State University Process for the preparation of polymers of dimeric cyclic esters
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
KR100484371B1 (ko) 2001-10-25 2005-04-20 가부시키가이샤 아텍스 히터선부착 시트체의 제조방법
ATE475435T1 (de) * 2002-08-13 2010-08-15 Medtronic Inc Medizinische vorrichtung mit verbesserter haftung zwischen einem polymeren berzug und einem substrat
AU2003275263A1 (en) * 2002-09-26 2004-04-19 Angiotech International Ag Perivascular wraps
US7533176B2 (en) 2004-07-14 2009-05-12 International Business Machines Corporation Method for supporting connection establishment in an offload of network protocol processing
JP5749881B2 (ja) * 2005-04-22 2015-07-15 ユニヴェルシテ デ ジュネーブ ポリラクチド組成物およびその使用

Also Published As

Publication number Publication date
WO2007012979A2 (en) 2007-02-01
US20180271984A1 (en) 2018-09-27
JP6491614B2 (ja) 2019-03-27
JP2015038121A (ja) 2015-02-26
EP1883665B1 (en) 2017-10-11
JP6559198B2 (ja) 2019-08-14
JP2017222712A (ja) 2017-12-21
ES2646141T3 (es) 2017-12-12
EP3339348B1 (en) 2019-12-04
DK1883665T3 (da) 2017-11-13
US9925267B2 (en) 2018-03-27
US20090281068A1 (en) 2009-11-12
CA2605652A1 (en) 2007-02-01
PL1883665T3 (pl) 2018-05-30
JP6346540B2 (ja) 2018-06-20
US9375482B2 (en) 2016-06-28
US20130331464A1 (en) 2013-12-12
WO2007012979A3 (en) 2007-05-03
US10314913B2 (en) 2019-06-11
JP5749881B2 (ja) 2015-07-15
US8741877B2 (en) 2014-06-03
JP2008538589A (ja) 2008-10-30
US8466133B2 (en) 2013-06-18
JP2016128506A (ja) 2016-07-14
PT1883665T (pt) 2017-11-14
EP1883665A2 (en) 2008-02-06
EP3339348A1 (en) 2018-06-27
US20160367680A1 (en) 2016-12-22
US20150073060A1 (en) 2015-03-12
JP2014065722A (ja) 2014-04-17

Similar Documents

Publication Publication Date Title
US10314913B2 (en) Polylactide compositions and uses thereof
JP3363142B1 (ja) 難水溶性薬物を可溶化するための重合組成物及びその製造方法
US7879317B2 (en) Polymeric micelle compositions with improved stability and methods of making thereof
AU2001294828B2 (en) Thermogelling biodegradable aqueous polymer solution
Trimaille et al. Poly (hexyl‐substituted lactides): Novel injectable hydrophobic drug delivery systems
US20110070320A1 (en) Biodegradable thermoresponsive 3-arm polyethylene glycol poly(lactide-co-glycolide) copolymer for ginseng administration
JP6147664B2 (ja) ２−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
Yang et al. In vitro degradation behavior of poly (lactide)–poly (ethylene glycol) block copolymer micelles in aqueous solution
Trimaille et al. Synthesis and properties of novel poly (hexyl-substituted lactides) for pharmaceutical applications
KR100492805B1 (ko) 안정성이 향상된 고분자 미셀 조성물
JP6148701B2 (ja) ２−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
US20100240859A1 (en) Semi-Crystalline Absorbable Microspheres
Vogel Synthesis of polyanhydrides for controlled drug delivery

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210421