AR090736A1 - Conjugado de compuesto triciclo-polimero - Google Patents
Conjugado de compuesto triciclo-polimeroInfo
- Publication number
- AR090736A1 AR090736A1 ARP130101280A ARP130101280A AR090736A1 AR 090736 A1 AR090736 A1 AR 090736A1 AR P130101280 A ARP130101280 A AR P130101280A AR P130101280 A ARP130101280 A AR P130101280A AR 090736 A1 AR090736 A1 AR 090736A1
- Authority
- AR
- Argentina
- Prior art keywords
- tricycle
- conjugate
- compound
- polymer compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Abstract
Se proporciona un conjugado de compuesto triciclo-polímero que incluye un conjugado que comprende un compuesto triciclo y un compuesto de poliláctido sustituido con alquilo. También se proporciona una composición farmacéutica que comprende el conjugado. Reivindicación 3: El conjugado de acuerdo con la reivindicación 2, caracterizado porque el compuesto triciclo es de la estructura de fórmula (1). Reivindicación 4: El conjugado de acuerdo con cualquiera de las reivindicaciones 1 - 3, caracterizado porque el compuesto poliláctido sustituido con alquilo es el que tiene la estructura de fórmula (2), donde Z² se selecciona del grupo que consiste en -CH₃ y -CH₂-O-Z⁵; y donde Z¹, Z³, Z⁴, y Z⁵, cada uno de modo independiente tiene la estructura de fórmula (3), donde R¹, R², R³, y R⁴ se eligen de modo independiente del grupo que consiste en alquilo, H alquenilo y alquilarilo; donde n es 1 a 100; donde X es hidrógeno, -C(O)-CH=CH₂ o cualquier otro grupo funcional o de entrecruzamiento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261636186P | 2012-04-20 | 2012-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR090736A1 true AR090736A1 (es) | 2014-12-03 |
Family
ID=49380707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130101280A AR090736A1 (es) | 2012-04-20 | 2013-04-18 | Conjugado de compuesto triciclo-polimero |
Country Status (4)
Country | Link |
---|---|
US (1) | US20130281638A1 (es) |
AR (1) | AR090736A1 (es) |
TW (1) | TW201345524A (es) |
WO (1) | WO2013157664A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6830907B2 (ja) | 2016-01-08 | 2021-02-17 | 日本化薬株式会社 | マクロライド系免疫抑制剤の高分子誘導体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7063857B1 (en) * | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
PT1883665T (pt) * | 2005-04-22 | 2017-11-14 | Univ Geneve | Composições polilactídeo e usos das mesmas |
JP2012051823A (ja) * | 2010-08-31 | 2012-03-15 | Fujifilm Corp | 難容性薬物含有水中油型乳化組成物及びその製造方法 |
-
2013
- 2013-04-18 AR ARP130101280A patent/AR090736A1/es unknown
- 2013-04-19 US US13/866,745 patent/US20130281638A1/en not_active Abandoned
- 2013-04-19 TW TW102113919A patent/TW201345524A/zh unknown
- 2013-04-19 WO PCT/JP2013/062303 patent/WO2013157664A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20130281638A1 (en) | 2013-10-24 |
TW201345524A (zh) | 2013-11-16 |
WO2013157664A1 (en) | 2013-10-24 |
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Legal Events
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