CA2605302A1 - Combined pharmaceutical preparation for treatment of type 2 diabetes - Google Patents
Combined pharmaceutical preparation for treatment of type 2 diabetes Download PDFInfo
- Publication number
- CA2605302A1 CA2605302A1 CA002605302A CA2605302A CA2605302A1 CA 2605302 A1 CA2605302 A1 CA 2605302A1 CA 002605302 A CA002605302 A CA 002605302A CA 2605302 A CA2605302 A CA 2605302A CA 2605302 A1 CA2605302 A1 CA 2605302A1
- Authority
- CA
- Canada
- Prior art keywords
- combined pharmaceutical
- mitiglinide
- hydrate
- blood glucose
- voglibose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims abstract description 22
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 5
- 229960003365 mitiglinide Drugs 0.000 claims abstract description 56
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 49
- 239000008103 glucose Substances 0.000 claims abstract description 49
- 239000008280 blood Substances 0.000 claims abstract description 36
- 210000004369 blood Anatomy 0.000 claims abstract description 36
- FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical compound OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 claims abstract description 31
- 229960001729 voglibose Drugs 0.000 claims abstract description 30
- WPGGHFDDFPHPOB-BBWFWOEESA-N mitiglinide Chemical compound C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)O)C1=CC=CC=C1 WPGGHFDDFPHPOB-BBWFWOEESA-N 0.000 claims abstract description 18
- 230000000291 postprandial effect Effects 0.000 claims abstract description 15
- 230000003247 decreasing effect Effects 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 206010022489 Insulin Resistance Diseases 0.000 claims abstract description 10
- 239000003112 inhibitor Substances 0.000 claims description 27
- QEVLNUAVAONTEW-UZYHXJQGSA-L calcium;(2s)-4-[(3as,7ar)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoate;dihydrate Chemical compound O.O.[Ca+2].C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)[O-])C1=CC=CC=C1.C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)[O-])C1=CC=CC=C1 QEVLNUAVAONTEW-UZYHXJQGSA-L 0.000 claims description 24
- 235000012054 meals Nutrition 0.000 claims description 12
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 230000002195 synergetic effect Effects 0.000 claims description 4
- 201000005577 familial hyperlipidemia Diseases 0.000 claims description 2
- 230000000081 effect on glucose Effects 0.000 claims 1
- 230000000667 effect on insulin Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 abstract description 9
- 229960002632 acarbose Drugs 0.000 abstract description 9
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 abstract description 9
- 238000002560 therapeutic procedure Methods 0.000 abstract description 4
- 230000037356 lipid metabolism Effects 0.000 abstract description 3
- 229940122069 Glycosidase inhibitor Drugs 0.000 abstract 1
- 239000003316 glycosidase inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 26
- 239000003826 tablet Substances 0.000 description 23
- PMRVFZXOCRHXFE-FMEJWYFOSA-L Kad 1229 Chemical compound [Ca+2].C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)[O-])C1=CC=CC=C1.C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)[O-])C1=CC=CC=C1 PMRVFZXOCRHXFE-FMEJWYFOSA-L 0.000 description 20
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 229960000698 nateglinide Drugs 0.000 description 8
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 description 8
- 102000004877 Insulin Human genes 0.000 description 7
- 108090001061 Insulin Proteins 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 229940125396 insulin Drugs 0.000 description 6
- 229960004793 sucrose Drugs 0.000 description 6
- 229920002261 Corn starch Polymers 0.000 description 5
- 208000018522 Gastrointestinal disease Diseases 0.000 description 5
- FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical compound C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 238000002648 combination therapy Methods 0.000 description 5
- 239000008120 corn starch Substances 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 229960002354 repaglinide Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 239000002547 new drug Substances 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229940122199 Insulin secretagogue Drugs 0.000 description 3
- 229940123452 Rapid-acting insulin Drugs 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 108010026951 Short-Acting Insulin Proteins 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000003538 oral antidiabetic agent Substances 0.000 description 3
- 229940127209 oral hypoglycaemic agent Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 230000000580 secretagogue effect Effects 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- IBAQFPQHRJAVAV-ULAWRXDQSA-N Miglitol Chemical compound OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO IBAQFPQHRJAVAV-ULAWRXDQSA-N 0.000 description 2
- 229940100389 Sulfonylurea Drugs 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 230000003914 insulin secretion Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229960001110 miglitol Drugs 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010054805 Macroangiopathy Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229950008138 carmellose Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000013681 dietary sucrose Nutrition 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229950000269 emiglitate Drugs 0.000 description 1
- NWWORXYTJRPSMC-QKPAOTATSA-N ethyl 4-[2-[(2r,3r,4r,5s)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1OCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1 NWWORXYTJRPSMC-QKPAOTATSA-N 0.000 description 1
- 238000009207 exercise therapy Methods 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- BNYHRGTXRPWASY-UHFFFAOYSA-N nonylsulfonylurea Chemical compound CCCCCCCCCS(=O)(=O)NC(N)=O BNYHRGTXRPWASY-UHFFFAOYSA-N 0.000 description 1
- 229940125395 oral insulin Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000001521 two-tailed test Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005-121862 | 2005-04-20 | ||
| JP2005121862 | 2005-04-20 | ||
| JP2005166314 | 2005-06-07 | ||
| JP2005-166314 | 2005-06-07 | ||
| PCT/JP2006/308110 WO2006115115A1 (ja) | 2005-04-20 | 2006-04-18 | ２型糖尿病治療用の併用医薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2605302A1 true CA2605302A1 (en) | 2006-11-02 |
Family
ID=37214736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002605302A Abandoned CA2605302A1 (en) | 2005-04-20 | 2006-04-18 | Combined pharmaceutical preparation for treatment of type 2 diabetes |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7888382B2 (enExample) |
| EP (1) | EP1872781A4 (enExample) |
| JP (3) | JP4230524B2 (enExample) |
| KR (1) | KR101380813B1 (enExample) |
| CN (1) | CN101198326B (enExample) |
| CA (1) | CA2605302A1 (enExample) |
| WO (1) | WO2006115115A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1872781A4 (en) * | 2005-04-20 | 2009-04-01 | Kissei Pharmaceutical | COMBINED PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF TYPE 2 DIABETES |
| CN105296620B (zh) | 2015-10-26 | 2019-01-15 | 上海市内分泌代谢病研究所 | 肠道宏基因组特征作为2型糖尿病阿卡波糖疗效筛选标志 |
| JP7680822B2 (ja) * | 2017-08-08 | 2025-05-21 | 日本ケミファ株式会社 | 糖尿病治療剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4917712B2 (ja) * | 2000-02-24 | 2012-04-18 | 武田薬品工業株式会社 | 併用医薬 |
| CA2401356A1 (en) * | 2000-02-24 | 2001-08-30 | Takeda Chemical Industries, Ltd. | Combination drug |
| US6830759B2 (en) * | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
| AU2003244082A1 (en) * | 2002-06-28 | 2004-01-19 | Kissei Pharmaceutical Co., Ltd. | Drug composition for blood sugar control |
| WO2004082621A2 (en) * | 2003-03-15 | 2004-09-30 | Bethesda Pharmaceuticals, Inc. | Novel ppar agonists, pharmaceutical compositions and uses thereof |
| CA2549015A1 (en) * | 2003-08-01 | 2005-02-10 | Janssen Pharmaceutica N.V. | Substituted fused heterocyclic c-glycosides |
| WO2005082414A2 (en) * | 2004-03-02 | 2005-09-09 | Astellas Pharma Inc. | Concomitant drugs of a sulfonamide and another therapeutic agent |
| EP1872781A4 (en) * | 2005-04-20 | 2009-04-01 | Kissei Pharmaceutical | COMBINED PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF TYPE 2 DIABETES |
| EP1931359A4 (en) | 2005-09-14 | 2009-04-01 | Elixir Pharmaceuticals Inc | COMBINATORY THERAPY FOR CONTROLLED DIGESTION OF CARBOHYDRATES |
-
2006
- 2006-04-18 EP EP06732039A patent/EP1872781A4/en not_active Withdrawn
- 2006-04-18 KR KR1020077025214A patent/KR101380813B1/ko not_active Expired - Fee Related
- 2006-04-18 CA CA002605302A patent/CA2605302A1/en not_active Abandoned
- 2006-04-18 JP JP2007514602A patent/JP4230524B2/ja active Active
- 2006-04-18 CN CN2006800218679A patent/CN101198326B/zh not_active Expired - Fee Related
- 2006-04-18 US US11/918,654 patent/US7888382B2/en not_active Expired - Fee Related
- 2006-04-18 WO PCT/JP2006/308110 patent/WO2006115115A1/ja not_active Ceased
-
2008
- 2008-03-14 JP JP2008066772A patent/JP5117230B2/ja active Active
-
2012
- 2012-01-05 JP JP2012000738A patent/JP2012092140A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012092140A (ja) | 2012-05-17 |
| JP4230524B2 (ja) | 2009-02-25 |
| KR101380813B1 (ko) | 2014-04-04 |
| US20090030063A1 (en) | 2009-01-29 |
| JPWO2006115115A1 (ja) | 2008-12-18 |
| KR20070118163A (ko) | 2007-12-13 |
| CN101198326A (zh) | 2008-06-11 |
| JP2008189679A (ja) | 2008-08-21 |
| EP1872781A1 (en) | 2008-01-02 |
| US7888382B2 (en) | 2011-02-15 |
| JP5117230B2 (ja) | 2013-01-16 |
| CN101198326B (zh) | 2011-10-12 |
| EP1872781A4 (en) | 2009-04-01 |
| WO2006115115A1 (ja) | 2006-11-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2301142T3 (es) | Combinaciones que comprenden inhibidores de dipeptidilpeptidasa-iv y agentes antidiabeticos. | |
| JP2015205909A (ja) | 組合せ | |
| AU2024219736A1 (en) | Sublingual epinephrine tablets | |
| US20210401880A1 (en) | Pharmaceutical Composition For Preventing Or Treating Obesity, Containing CYCLO(HIS-PRO) As Active Ingredient | |
| US12090125B2 (en) | Combination therapy | |
| US7888382B2 (en) | Combined pharmaceutical preparation for treatment of type 2 diabetes | |
| EP2837380A1 (en) | Lercanidipine hydrochloride and losartan potassium compound preparation and preparation method thereof | |
| AU2010276461B2 (en) | Pharmaceutical composition of levamlodipine or pharmaceutically acceptable salt thereof and beta receptor blocking agent, and use thereof | |
| US20240374538A1 (en) | Compositions comprising natural products for improving carbohydrate and lipid metabolism | |
| CN112641776A (zh) | 一种以二甲双胍或其可药用盐和澳格列汀或其可药用盐为活性成分的药用组合物 | |
| KR100709531B1 (ko) | 당뇨병성 합병증의 예방 또는 진전저지용 의약조성물 | |
| EP1124547A1 (en) | Pharmaceutical combination of mildronate and enalapril | |
| EP2374457B1 (en) | Antihypertensive pharmaceutical composition | |
| WO2012133693A1 (ja) | 糖尿病治療用の組合せ医薬 | |
| HK1102422B (en) | Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents | |
| HK1102424B (en) | Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents | |
| HK1108359B (en) | Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents | |
| JP2007091641A (ja) | ２型糖尿病治療用の併用医薬 | |
| HK1102405B (en) | Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents | |
| MX2012014757A (es) | Composicion farmaceutica de una meglitinida y una tiazolidinediona o sus sales farmaceuticamente aceptables y su uso. | |
| HK1117735A (en) | Use of rimonabant for the preparation of medicaments that can be used in the prevention and treatment of type 2 diabetes | |
| HK1194307B (en) | Lixisenatide and metformin for treatment of diabetes type 2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140422 |