CA2600924A1 - Barrier stent and use thereof - Google Patents
Barrier stent and use thereof Download PDFInfo
- Publication number
- CA2600924A1 CA2600924A1 CA002600924A CA2600924A CA2600924A1 CA 2600924 A1 CA2600924 A1 CA 2600924A1 CA 002600924 A CA002600924 A CA 002600924A CA 2600924 A CA2600924 A CA 2600924A CA 2600924 A1 CA2600924 A1 CA 2600924A1
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- Prior art keywords
- stent
- vascular
- layer
- agent
- vascular stent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Textile Engineering (AREA)
- Mechanical Engineering (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
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| CA2600924A1 true CA2600924A1 (en) | 2006-09-21 |
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| CA002600924A Abandoned CA2600924A1 (en) | 2005-03-09 | 2006-03-09 | Barrier stent and use thereof |
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| CA (1) | CA2600924A1 (enExample) |
| WO (1) | WO2006099020A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7416559B2 (en) * | 2000-10-27 | 2008-08-26 | Poly-Med, Inc. | Micromantled drug-eluting stent |
| US8038708B2 (en) * | 2001-02-05 | 2011-10-18 | Cook Medical Technologies Llc | Implantable device with remodelable material and covering material |
| US8043323B2 (en) | 2006-10-18 | 2011-10-25 | Inspiremd Ltd. | In vivo filter assembly |
| CA2843097C (en) | 2005-05-24 | 2015-10-27 | Inspire M.D Ltd. | Stent apparatuses for treatment via body lumens and methods of use |
| US8961586B2 (en) | 2005-05-24 | 2015-02-24 | Inspiremd Ltd. | Bifurcated stent assemblies |
| WO2007016251A2 (en) * | 2005-07-28 | 2007-02-08 | Cook Incorporated | Implantable thromboresistant valve |
| US20070293936A1 (en) * | 2006-04-28 | 2007-12-20 | Dobak John D Iii | Systems and methods for creating customized endovascular stents and stent grafts |
| CA2887189C (en) | 2006-10-18 | 2018-05-01 | Inspiremd Ltd. | Knitted stent jackets |
| JP2008125682A (ja) * | 2006-11-17 | 2008-06-05 | Kanazawa Inst Of Technology | 人体埋め込み部材 |
| CA2670724C (en) | 2006-11-22 | 2018-12-11 | Inspiremd Ltd. | Intravascular aneurysm treatment device and methods |
| JP2008253297A (ja) * | 2007-03-30 | 2008-10-23 | Univ Kansai Medical | 医療用チューブ |
| EP2155934A2 (en) | 2007-05-30 | 2010-02-24 | Dow Global Technologies Inc. | High-output solvent-based electrospinning |
| US20100070020A1 (en) | 2008-06-11 | 2010-03-18 | Nanovasc, Inc. | Implantable Medical Device |
| US7799261B2 (en) * | 2007-11-30 | 2010-09-21 | Cook Incorporated | Needle-to-needle electrospinning |
| US8795577B2 (en) | 2007-11-30 | 2014-08-05 | Cook Medical Technologies Llc | Needle-to-needle electrospinning |
| US8998974B2 (en) * | 2007-12-17 | 2015-04-07 | Cook Medical Technologies Llc | Woven fabric with carbon nanotube strands |
| US8388994B1 (en) * | 2008-06-09 | 2013-03-05 | Ingo Scheer | Fibrous non-woven polymeric material |
| US20100137976A1 (en) * | 2008-12-02 | 2010-06-03 | Medtronic Vascular, Inc. | Systems and Methods for Treating Heart Tissue Via Localized Delivery of Parp Inhibitors |
| US20130268062A1 (en) | 2012-04-05 | 2013-10-10 | Zeus Industrial Products, Inc. | Composite prosthetic devices |
| DK2384375T3 (en) | 2009-01-16 | 2017-10-16 | Zeus Ind Products Inc | ELECTROSPINING PTFE WITH HIGH-VISUAL MATERIALS |
| MY162372A (en) * | 2009-04-17 | 2017-06-15 | Tyco Healthcare | Vascular stenting for aneurysms |
| CN102470030A (zh) | 2009-08-07 | 2012-05-23 | 宙斯工业产品股份有限公司 | 包含静电纺纤维层的假体装置及其制备方法 |
| EP2471497A4 (en) * | 2009-08-26 | 2013-10-09 | Otsuka Medical Devices Co Ltd | MEDICAL DEVICE FOR PLACEMENT IN A LUMEN AND METHOD FOR THE PRODUCTION THEREOF |
| US8637109B2 (en) * | 2009-12-03 | 2014-01-28 | Cook Medical Technologies Llc | Manufacturing methods for covering endoluminal prostheses |
| EP2575678B1 (en) * | 2010-06-02 | 2018-05-16 | Occlutech Holding AG | Device for placement in a hollow organ, in particular for holding open said hollow organ and method for producing such device |
| KR101187212B1 (ko) | 2010-12-30 | 2012-10-02 | 주식회사 엠아이텍 | 전기방사를 이용한 담관의 양성협착 치료용 약물방출 스텐트의 제조 방법 |
| WO2012103501A1 (en) | 2011-01-28 | 2012-08-02 | Merit Medical Systems, Inc. | Electrospun ptfe coated stent and method of use |
| US10105246B2 (en) | 2011-06-07 | 2018-10-23 | Qing Liu | Hybrid polymer stent fabricated by a non-laser cut fabrication method |
| US9175427B2 (en) | 2011-11-14 | 2015-11-03 | Cook Medical Technologies Llc | Electrospun patterned stent graft covering |
| AU2013209965B2 (en) | 2012-01-16 | 2016-06-30 | Merit Medical Systems, Inc. | Rotational spun material covered medical appliances and methods of manufacture |
| JP2015513349A (ja) * | 2012-02-13 | 2015-05-11 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 組織修復のための基礎材システム |
| US9173753B1 (en) | 2012-05-11 | 2015-11-03 | W. L. Gore & Associates, Inc. | System and method for forming an endoluminal device |
| US11541154B2 (en) | 2012-09-19 | 2023-01-03 | Merit Medical Systems, Inc. | Electrospun material covered medical appliances and methods of manufacture |
| US9198999B2 (en) | 2012-09-21 | 2015-12-01 | Merit Medical Systems, Inc. | Drug-eluting rotational spun coatings and methods of use |
| US10154918B2 (en) | 2012-12-28 | 2018-12-18 | Cook Medical Technologies Llc | Endoluminal prosthesis with fiber matrix |
| US10561605B2 (en) * | 2013-01-22 | 2020-02-18 | Robert F. Wallace | Electrospun therapeutic carrier and implant |
| US9827703B2 (en) | 2013-03-13 | 2017-11-28 | Merit Medical Systems, Inc. | Methods, systems, and apparatuses for manufacturing rotational spun appliances |
| WO2014159710A1 (en) | 2013-03-13 | 2014-10-02 | Merit Medical Systems, Inc. | Serially deposited fiber materials and associated devices and methods |
| US9545301B2 (en) | 2013-03-15 | 2017-01-17 | Covidien Lp | Coated medical devices and methods of making and using same |
| US9320592B2 (en) | 2013-03-15 | 2016-04-26 | Covidien Lp | Coated medical devices and methods of making and using same |
| US9668890B2 (en) | 2013-11-22 | 2017-06-06 | Covidien Lp | Anti-thrombogenic medical devices and methods |
| EP3197515A1 (en) * | 2014-09-23 | 2017-08-02 | Boston Scientific Scimed Inc. | Implantable medical device with shape memory polymer filter layer |
| US9789228B2 (en) | 2014-12-11 | 2017-10-17 | Covidien Lp | Antimicrobial coatings for medical devices and processes for preparing such coatings |
| CA3285239A1 (en) | 2015-02-26 | 2025-11-29 | Merit Medical Systems Inc | Layered medical appliances and methods |
| CN106175980A (zh) * | 2015-05-04 | 2016-12-07 | 聂绍平 | 生物可降解高分子膜单层金属覆膜支架 |
| CN105525368B (zh) * | 2016-03-07 | 2018-06-29 | 吉林大学 | 用于静电纺丝机的辅助接收装置 |
| CN107137790B (zh) * | 2017-05-09 | 2020-03-17 | 上海脉全医疗器械有限公司 | 一种表面附着药物涂层的全降解聚合物支架及其制备方法 |
| US11027046B2 (en) * | 2017-10-31 | 2021-06-08 | Hothouse Medical Limited | Textile products having selectively applied sealant or coating and method of manufacture |
| GB201717885D0 (en) * | 2017-10-31 | 2017-12-13 | Hothouse Medical Ltd | Prothesis and method of manufacture |
| CN108186162A (zh) * | 2017-12-06 | 2018-06-22 | 江苏百优达生命科技有限公司 | 一种三层结构复合型人造血管 |
| CN108567451B (zh) | 2018-04-24 | 2020-04-14 | 天津大学 | 基于海绵的变刚度自然腔道手术器械支撑结构及使用方法 |
| CN109009561B (zh) * | 2018-08-13 | 2019-05-14 | 哈尔滨工业大学（威海） | 一种人造血管及其制备方法 |
| CN108744071A (zh) * | 2018-08-20 | 2018-11-06 | 南京永明医疗器械有限公司 | 一种生物可降解聚合物支架的多功能涂层及制备方法 |
| CN110859995B (zh) * | 2019-11-14 | 2021-09-28 | 浙江大学 | 一种基于双层异相结构的药物缓释涂层及其制备方法和应用 |
| WO2022183215A1 (en) | 2021-02-26 | 2022-09-01 | Merit Medical Systems, Inc. | Fibrous constructs with therapeutic material particles |
| CN113017914B (zh) * | 2021-03-17 | 2023-07-04 | 复旦大学附属中山医院 | 一种防止覆膜支架出入口内膜增生的外周血管复合支架 |
| CN113151980A (zh) * | 2021-03-19 | 2021-07-23 | 苏州大学 | Ptfe管状覆膜支架及其制备方法 |
| CN113908347B (zh) * | 2021-10-11 | 2023-01-31 | 北京博辉瑞进生物科技有限公司 | 用于容置植入型医疗设备的生物套及其制备方法、用途 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3620218A (en) * | 1963-10-31 | 1971-11-16 | American Cyanamid Co | Cylindrical prosthetic devices of polyglycolic acid |
| GB1527592A (en) * | 1974-08-05 | 1978-10-04 | Ici Ltd | Wound dressing |
| GB2121286B (en) * | 1982-06-02 | 1985-11-06 | Ethicon Inc | Improvements in synthetic vascular grafts, and methods of manufacturing such grafts |
| US4997440A (en) * | 1985-04-25 | 1991-03-05 | American Cyanamid Company | Vascular graft with absorbable and nonabsorbable components |
| US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| AU7998091A (en) * | 1990-05-17 | 1991-12-10 | Harbor Medical Devices, Inc. | Medical device polymer |
| US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
| US5599352A (en) * | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
| US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
| US5578075B1 (en) * | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
| US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
| US5628782A (en) * | 1992-12-11 | 1997-05-13 | W. L. Gore & Associates, Inc. | Method of making a prosthetic vascular graft |
| US5716395A (en) * | 1992-12-11 | 1998-02-10 | W.L. Gore & Associates, Inc. | Prosthetic vascular graft |
| US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| US5824048A (en) * | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
| US5723004A (en) * | 1993-10-21 | 1998-03-03 | Corvita Corporation | Expandable supportive endoluminal grafts |
| US5824037A (en) * | 1995-10-03 | 1998-10-20 | Medtronic, Inc. | Modular intraluminal prostheses construction and methods |
| US5628788A (en) * | 1995-11-07 | 1997-05-13 | Corvita Corporation | Self-expanding endoluminal stent-graft |
| US6162537A (en) * | 1996-11-12 | 2000-12-19 | Solutia Inc. | Implantable fibers and medical articles |
| WO1999018893A1 (en) * | 1997-10-10 | 1999-04-22 | Drexel University | Hybrid nanofibril matrices for use as tissue engineering devices |
| US6488701B1 (en) * | 1998-03-31 | 2002-12-03 | Medtronic Ave, Inc. | Stent-graft assembly with thin-walled graft component and method of manufacture |
| US6156064A (en) * | 1998-08-14 | 2000-12-05 | Schneider (Usa) Inc | Stent-graft-membrane and method of making the same |
| US7615373B2 (en) * | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| US6312457B1 (en) * | 1999-04-01 | 2001-11-06 | Boston Scientific Corporation | Intraluminal lining |
| US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
| US6379383B1 (en) * | 1999-11-19 | 2002-04-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal device exhibiting improved endothelialization and method of manufacture thereof |
| US6849085B2 (en) * | 1999-11-19 | 2005-02-01 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same |
| US7947069B2 (en) * | 1999-11-24 | 2011-05-24 | University Of Washington | Medical devices comprising small fiber biomaterials, and methods of use |
| US6730313B2 (en) * | 2000-01-25 | 2004-05-04 | Edwards Lifesciences Corporation | Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia |
| US6379382B1 (en) * | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
| KR100860860B1 (ko) * | 2000-03-15 | 2008-09-29 | 오르버스네이치 메디칼 인코포레이티드 | 내피 세포 부착을 촉진하는 코팅 |
| JP2002016150A (ja) * | 2000-06-29 | 2002-01-18 | Nec Corp | 半導体記憶装置及びその製造方法 |
| DE10040897B4 (de) * | 2000-08-18 | 2006-04-13 | TransMIT Gesellschaft für Technologietransfer mbH | Nanoskalige poröse Fasern aus polymeren Materialien |
| US6716444B1 (en) * | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| CA2425665C (en) * | 2000-10-31 | 2013-07-16 | Cook Incorporated | Coated implantable medical device |
| US20070031607A1 (en) * | 2000-12-19 | 2007-02-08 | Alexander Dubson | Method and apparatus for coating medical implants |
| US7244272B2 (en) * | 2000-12-19 | 2007-07-17 | Nicast Ltd. | Vascular prosthesis and method for production thereof |
| US20040030377A1 (en) * | 2001-10-19 | 2004-02-12 | Alexander Dubson | Medicated polymer-coated stent assembly |
| US7192604B2 (en) * | 2000-12-22 | 2007-03-20 | Ethicon, Inc. | Implantable biodegradable devices for musculoskeletal repair or regeneration |
| WO2002072167A1 (en) * | 2001-03-13 | 2002-09-19 | Implant Sciences Corporation. | Drug eluting encapsulated stent |
| US6660034B1 (en) * | 2001-04-30 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Stent for increasing blood flow to ischemic tissues and a method of using the same |
| US6685956B2 (en) * | 2001-05-16 | 2004-02-03 | The Research Foundation At State University Of New York | Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications |
| US6645618B2 (en) * | 2001-06-15 | 2003-11-11 | 3M Innovative Properties Company | Aliphatic polyester microfibers, microfibrillated articles and use thereof |
| US6790455B2 (en) * | 2001-09-14 | 2004-09-14 | The Research Foundation At State University Of New York | Cell delivery system comprising a fibrous matrix and cells |
| US7014654B2 (en) * | 2001-11-30 | 2006-03-21 | Scimed Life Systems, Inc. | Stent designed for the delivery of therapeutic substance or other agents |
| US20050187605A1 (en) * | 2002-04-11 | 2005-08-25 | Greenhalgh Skott E. | Electrospun skin capable of controlling drug release rates and method |
| US7105021B2 (en) * | 2002-04-25 | 2006-09-12 | Scimed Life Systems, Inc. | Implantable textile prostheses having PTFE cold drawn yarns |
| US7270675B2 (en) * | 2002-05-10 | 2007-09-18 | Cordis Corporation | Method of forming a tubular membrane on a structural frame |
| AU2003257604A1 (en) * | 2002-08-23 | 2004-03-29 | Bridgestone Corporation | Stent and process for producing the same |
| US6702850B1 (en) * | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| GB0223870D0 (en) * | 2002-10-14 | 2002-11-20 | Cathnet Science Holding As | Stent assembly |
| US20040098023A1 (en) * | 2002-11-15 | 2004-05-20 | Scimed Life Systems, Inc. | Embolic device made of nanofibers |
| US7371256B2 (en) * | 2002-12-16 | 2008-05-13 | Poly-Med, Inc | Composite vascular constructs with selectively controlled properties |
| EP1603485A4 (en) * | 2003-02-26 | 2011-03-30 | Medivas Llc | BIOACTIVE STENTS AND METHOD OF USE THEREOF |
| US20040213826A1 (en) * | 2003-04-28 | 2004-10-28 | Marx Steven O. | Medical devices and methods for inhibiting proliferation of smooth muscle cells |
| US20050131520A1 (en) * | 2003-04-28 | 2005-06-16 | Zilla Peter P. | Compliant blood vessel graft |
| US20050049691A1 (en) * | 2003-09-02 | 2005-03-03 | Mericle Robert A. | Polymeric reconstrainable, repositionable, detachable, percutaneous endovascular stentgraft |
| JP2007508121A (ja) * | 2003-10-14 | 2007-04-05 | キューブ メディカル エーエス | 血管形成術用バルーン |
| US8435285B2 (en) * | 2003-11-25 | 2013-05-07 | Boston Scientific Scimed, Inc. | Composite stent with inner and outer stent elements and method of using the same |
| JP2007534389A (ja) * | 2004-04-29 | 2007-11-29 | キューブ・メディカル・アクティーゼルスカブ | 血管形成に用いるバルーン |
| WO2006044904A2 (en) * | 2004-10-15 | 2006-04-27 | Vanderbilt University | Nano- and micro-scale engineering of polymeric scaffolds for vascular tissue engineering |
| EP1815820A4 (en) * | 2004-11-19 | 2010-03-03 | Teijin Ltd | CYLINDRICAL LINK AND METHOD FOR THE PRODUCTION THEREOF |
| US8048150B2 (en) * | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
| US20080208325A1 (en) * | 2007-02-27 | 2008-08-28 | Boston Scientific Scimed, Inc. | Medical articles for long term implantation |
-
2006
- 2006-03-09 CN CN200680014867.6A patent/CN101170965A/zh active Pending
- 2006-03-09 JP JP2008500902A patent/JP2008532643A/ja not_active Withdrawn
- 2006-03-09 EP EP06737539A patent/EP1868529A2/en not_active Withdrawn
- 2006-03-09 US US11/371,652 patent/US20070043428A1/en not_active Abandoned
- 2006-03-09 WO PCT/US2006/008377 patent/WO2006099020A2/en not_active Ceased
- 2006-03-09 CA CA002600924A patent/CA2600924A1/en not_active Abandoned
-
2009
- 2009-12-07 US US12/632,777 patent/US20100179644A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101170965A (zh) | 2008-04-30 |
| EP1868529A2 (en) | 2007-12-26 |
| US20070043428A1 (en) | 2007-02-22 |
| WO2006099020A2 (en) | 2006-09-21 |
| JP2008532643A (ja) | 2008-08-21 |
| WO2006099020A3 (en) | 2007-09-13 |
| US20100179644A1 (en) | 2010-07-15 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |