CA2590750A1 - Myd88 homodimerization inhibitors - Google Patents
Myd88 homodimerization inhibitors Download PDFInfo
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- CA2590750A1 CA2590750A1 CA002590750A CA2590750A CA2590750A1 CA 2590750 A1 CA2590750 A1 CA 2590750A1 CA 002590750 A CA002590750 A CA 002590750A CA 2590750 A CA2590750 A CA 2590750A CA 2590750 A1 CA2590750 A1 CA 2590750A1
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Classifications
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- C07K—PEPTIDES
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- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04425929 | 2004-12-20 | ||
| EP04425929.9 | 2004-12-20 | ||
| PCT/EP2005/056847 WO2006067091A1 (en) | 2004-12-20 | 2005-12-16 | Myd88 homodimerization inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| CA2590750A1 true CA2590750A1 (en) | 2006-06-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002590750A Abandoned CA2590750A1 (en) | 2004-12-20 | 2005-12-16 | Myd88 homodimerization inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080064643A1 (enExample) |
| EP (1) | EP1828246A1 (enExample) |
| JP (1) | JP2008524167A (enExample) |
| KR (1) | KR20070094802A (enExample) |
| CN (1) | CN101084240A (enExample) |
| AU (1) | AU2005318226A1 (enExample) |
| BR (1) | BRPI0519148A2 (enExample) |
| CA (1) | CA2590750A1 (enExample) |
| MX (1) | MX2007007259A (enExample) |
| WO (1) | WO2006067091A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0323204D0 (en) * | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
| CN101745094A (zh) * | 2010-01-28 | 2010-06-23 | 华中科技大学同济医学院附属同济医院 | MyD88拓扑类肽化合物作为免疫抑制剂在医学上的用途 |
| WO2012047175A1 (en) | 2010-10-05 | 2012-04-12 | Kemijski inštitut | Fusion polypeptides comprising tir and dimerization domain for modulation of tlr/innate immunity signaling |
| CN102336720B (zh) | 2011-03-02 | 2016-01-13 | 华中科技大学 | 2-氨基噻唑衍生物及制备方法和应用 |
| US10465247B2 (en) | 2011-07-01 | 2019-11-05 | Dana-Farber Cancer Institute, Inc. | Discovery of a somatic mutation in MYD88 gene in lymphoplasmacytic lymphoma |
| PT3366302T (pt) * | 2011-07-18 | 2022-03-07 | Univ Kentucky Res Found | Proteção de células da degeneração induzida por rna alu e inibidores para proteger as células |
| EP2561873A1 (de) * | 2011-08-26 | 2013-02-27 | Forschungsverbund Berlin e.V. | Strukturmimetika prolinreicher Peptide und ihre Verwendung |
| US9707235B1 (en) | 2012-01-13 | 2017-07-18 | University Of Kentucky Research Foundation | Protection of cells from degeneration and treatment of geographic atrophy |
| WO2013112834A1 (en) * | 2012-01-25 | 2013-08-01 | Vanderbilt University | Compositions and methods for treating infections |
| WO2013169382A1 (en) | 2012-05-07 | 2013-11-14 | DePuy Synthes Products, LLC | Methods and devices for treating intervertebral disc disease |
| EP2920197B1 (en) * | 2012-09-26 | 2021-03-17 | President and Fellows of Harvard College | Proline-locked stapled peptides and uses thereof |
| WO2015038887A1 (en) | 2013-09-12 | 2015-03-19 | Dana-Farber Cancer Institute Inc. | Methods for evaluating and treating waldenstrom's macroglobulinemia |
| WO2015085075A1 (en) | 2013-12-06 | 2015-06-11 | Dana-Farber Cancer Institute, Inc. | Methods to distinguish waldenström's macroglobulinemia from igm monoclonal gammopathy of undetermined significance |
| AU2014361798B2 (en) | 2013-12-13 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| EP3230300B1 (de) | 2014-12-11 | 2021-11-24 | Forschungsverbund Berlin E.V. | Inhibitoren zur hemmung der tumormetastasierung |
| JP2019069905A (ja) * | 2016-02-29 | 2019-05-09 | 国立大学法人大阪大学 | 組織損傷治療剤 |
| JP2019518006A (ja) | 2016-04-29 | 2019-06-27 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｙｄ８８変異型疾患における治療標的としてのｈｃｋ |
| EP3464325A1 (en) | 2016-06-07 | 2019-04-10 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88) |
| KR20200064075A (ko) | 2017-09-07 | 2020-06-05 | 포그 파마슈티컬스 인코포레이티드 | 베타-카테닌 기능을 조절하는 제제 및 이의 방법 |
| CN112153897B (zh) * | 2018-01-02 | 2023-02-03 | 拉什大学医学中心 | 用于治疗神经病学和其他病症的组合物和方法 |
| WO2024096677A1 (ko) * | 2022-11-03 | 2024-05-10 | 한국과학기술연구원 | Tlr 신호 억제 펩타이드 및 이를 포함하는 염증성 질환의 예방 또는 치료용 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2446458A1 (en) | 2001-05-09 | 2002-11-14 | Yale University | Toll/interleukin-1 receptor adaptor protein (tirap) |
| AU2002366331A1 (en) * | 2001-12-17 | 2003-06-30 | Cedars-Sinai Medical Center | Treating vascular disease by inhibiting myeloid differentiation factor 88 |
-
2005
- 2005-12-16 CA CA002590750A patent/CA2590750A1/en not_active Abandoned
- 2005-12-16 CN CNA2005800437629A patent/CN101084240A/zh active Pending
- 2005-12-16 US US11/793,516 patent/US20080064643A1/en not_active Abandoned
- 2005-12-16 BR BRPI0519148-3A patent/BRPI0519148A2/pt not_active IP Right Cessation
- 2005-12-16 EP EP05823931A patent/EP1828246A1/en not_active Withdrawn
- 2005-12-16 JP JP2007546073A patent/JP2008524167A/ja not_active Withdrawn
- 2005-12-16 AU AU2005318226A patent/AU2005318226A1/en not_active Abandoned
- 2005-12-16 MX MX2007007259A patent/MX2007007259A/es not_active Application Discontinuation
- 2005-12-16 KR KR1020077016815A patent/KR20070094802A/ko not_active Withdrawn
- 2005-12-16 WO PCT/EP2005/056847 patent/WO2006067091A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0519148A2 (pt) | 2008-12-30 |
| CN101084240A (zh) | 2007-12-05 |
| WO2006067091A1 (en) | 2006-06-29 |
| US20080064643A1 (en) | 2008-03-13 |
| KR20070094802A (ko) | 2007-09-21 |
| MX2007007259A (es) | 2007-08-14 |
| AU2005318226A1 (en) | 2006-06-29 |
| EP1828246A1 (en) | 2007-09-05 |
| JP2008524167A (ja) | 2008-07-10 |
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