CA2583413A1 - Delivery of polynucleotides - Google Patents

Info

Publication number

CA2583413A1

CA2583413A1 CA002583413A CA2583413A CA2583413A1 CA 2583413 A1 CA2583413 A1 CA 2583413A1 CA 002583413 A CA002583413 A CA 002583413A CA 2583413 A CA2583413 A CA 2583413A CA 2583413 A1 CA2583413 A1 CA 2583413A1

Authority

CA

Canada

Prior art keywords

weight

formulation

decoy

molecule

dsodn

Prior art date

2004-09-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 108091033319 polynucleotide Proteins 0.000 title claims abstract description 45
• 102000040430 polynucleotide Human genes 0.000 title claims description 42
• 239000002157 polynucleotide Substances 0.000 title claims description 41
• 238000012384 transportation and delivery Methods 0.000 title abstract description 43
• 239000000203 mixture Substances 0.000 claims abstract description 308
• 238000009472 formulation Methods 0.000 claims abstract description 265
• 108091034117 Oligonucleotide Proteins 0.000 claims abstract description 156
• 238000000034 method Methods 0.000 claims abstract description 109
• 239000012528 membrane Substances 0.000 claims abstract description 25
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 193
• 230000027455 binding Effects 0.000 claims description 155
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• 238000011282 treatment Methods 0.000 claims description 77
• 102000040945 Transcription factor Human genes 0.000 claims description 73
• 108091023040 Transcription factor Proteins 0.000 claims description 73
• -1 alkyl ether sulfate Chemical class 0.000 claims description 63
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 62
• 239000000839 emulsion Substances 0.000 claims description 58
• 229940057950 sodium laureth sulfate Drugs 0.000 claims description 38
• SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical group [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 38
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
• 201000010099 disease Diseases 0.000 claims description 37
• 239000003961 penetration enhancing agent Substances 0.000 claims description 34
• LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 27
• 229940046166 oligodeoxynucleotide Drugs 0.000 claims description 26
• 108010093502 E2F Transcription Factors Proteins 0.000 claims description 25
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• 230000000295 complement effect Effects 0.000 claims description 24
• 230000009870 specific binding Effects 0.000 claims description 24
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 23
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 20
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 18
• XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 17
• LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 17
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 17
• 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 17
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• 235000011067 sorbitan monolaureate Nutrition 0.000 claims description 17
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• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 16
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• BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 claims description 13
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• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
• HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 10
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• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
• 150000008051 alkyl sulfates Chemical class 0.000 claims description 5
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• YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 claims description 5
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
• 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims description 4
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims description 4
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