CA2579000C - Novel 3-thia-10-aza-phenanthrene derivatives - Google Patents
Novel 3-thia-10-aza-phenanthrene derivatives Download PDFInfo
- Publication number
- CA2579000C CA2579000C CA2579000A CA2579000A CA2579000C CA 2579000 C CA2579000 C CA 2579000C CA 2579000 A CA2579000 A CA 2579000A CA 2579000 A CA2579000 A CA 2579000A CA 2579000 C CA2579000 C CA 2579000C
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- Prior art keywords
- solvate
- salt
- hydrate
- formula
- alkoxy
- Prior art date
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 18
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- CAUGAHCEDPFMJU-UHFFFAOYSA-N thian-4-amine;hydrochloride Chemical compound Cl.NC1CCSCC1 CAUGAHCEDPFMJU-UHFFFAOYSA-N 0.000 description 1
- VDHPFHUCOPGRLS-UHFFFAOYSA-N thiane-3,5-dione Chemical group O=C1CSCC(=O)C1 VDHPFHUCOPGRLS-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- WJUFSDZVCOTFON-UHFFFAOYSA-N veratraldehyde Chemical compound COC1=CC=C(C=O)C=C1OC WJUFSDZVCOTFON-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104319 | 2004-09-08 | ||
| EP04104319.1 | 2004-09-08 | ||
| PCT/EP2005/054365 WO2006027345A2 (en) | 2004-09-08 | 2005-09-05 | Novel 3-thia-10-aza-phenanthrene derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2579000A1 CA2579000A1 (en) | 2006-03-16 |
| CA2579000C true CA2579000C (en) | 2013-02-05 |
Family
ID=34929550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2579000A Expired - Fee Related CA2579000C (en) | 2004-09-08 | 2005-09-05 | Novel 3-thia-10-aza-phenanthrene derivatives |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7589205B2 (OSRAM) |
| EP (1) | EP1791847A2 (OSRAM) |
| JP (1) | JP4960870B2 (OSRAM) |
| AU (1) | AU2005281703B2 (OSRAM) |
| CA (1) | CA2579000C (OSRAM) |
| WO (1) | WO2006027345A2 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006027344A2 (en) | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors |
| AR079451A1 (es) * | 2009-12-18 | 2012-01-25 | Nycomed Gmbh | Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina |
| WO2012171903A1 (en) | 2011-06-15 | 2012-12-20 | Nycomed Gmbh | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds |
| WO2018069210A1 (en) * | 2016-10-10 | 2018-04-19 | Takeda Gmbh | Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4 |
| CN107998147A (zh) * | 2017-11-06 | 2018-05-08 | 广州医科大学附属第医院 | 一种抑制或治疗copd的雾化吸入制剂及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE233735T1 (de) * | 1996-01-31 | 2003-03-15 | Altana Pharma Ag | Neue phenanthridine |
| DK0937074T3 (da) | 1996-11-11 | 2003-06-23 | Altana Pharma Ag | Benzonaphthyridiner som bronkiale terapeutiske midler |
| JP2001514640A (ja) * | 1997-03-07 | 2001-09-11 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規のテトラゾール |
| US6306869B1 (en) * | 1998-05-05 | 2001-10-23 | Byk Gulden Lomberg Chemische Febrik Gmbh | N-oxides |
| WO2000012501A1 (de) | 1998-08-31 | 2000-03-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität |
| IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| PT1147087E (pt) * | 1999-01-15 | 2005-09-30 | Altana Pharma Ag | Feantridina-n-oxidos com actividade de inibicao de pde-iv |
| TR200101938T2 (tr) * | 1999-01-15 | 2001-12-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pde-ıv inhibe edici aktivitesi olan fenilfenantridinler. |
| WO2000042018A1 (en) | 1999-01-15 | 2000-07-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity |
| CO5150225A1 (es) * | 1999-03-19 | 2002-04-29 | Merck Sharp & Dohme | Derivados del tetrahidropirano y su uso como agentes terapeuticos |
| AU2001281965A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Novel 6-phenylphenanthridines |
| JPWO2002056160A1 (ja) | 2001-01-15 | 2004-05-20 | ソニー株式会社 | 記録媒体並びにデータ処理装置及び方法 |
| EP1539164B1 (en) | 2002-08-29 | 2006-12-20 | ALTANA Pharma AG | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| CN1926113B (zh) | 2004-03-10 | 2010-06-23 | 尼科梅德有限责任公司 | 新的酰氨基取代的羟基-6-苯基菲啶化合物及其作为pde4抑制剂的应用 |
| WO2006027344A2 (en) | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors |
-
2005
- 2005-09-05 WO PCT/EP2005/054365 patent/WO2006027345A2/en not_active Ceased
- 2005-09-05 EP EP05787333A patent/EP1791847A2/en not_active Withdrawn
- 2005-09-05 JP JP2007529364A patent/JP4960870B2/ja not_active Expired - Fee Related
- 2005-09-05 CA CA2579000A patent/CA2579000C/en not_active Expired - Fee Related
- 2005-09-05 AU AU2005281703A patent/AU2005281703B2/en not_active Ceased
- 2005-09-05 US US11/661,377 patent/US7589205B2/en not_active Expired - Fee Related
-
2009
- 2009-05-28 US US12/453,966 patent/US8324404B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005281703B2 (en) | 2011-11-17 |
| US20080103168A1 (en) | 2008-05-01 |
| US8324404B2 (en) | 2012-12-04 |
| WO2006027345A3 (en) | 2006-08-31 |
| US20090239895A1 (en) | 2009-09-24 |
| WO2006027345A2 (en) | 2006-03-16 |
| AU2005281703A1 (en) | 2006-03-16 |
| JP2008512367A (ja) | 2008-04-24 |
| CA2579000A1 (en) | 2006-03-16 |
| JP4960870B2 (ja) | 2012-06-27 |
| EP1791847A2 (en) | 2007-06-06 |
| US7589205B2 (en) | 2009-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160906 |