CA2572964C - Purified amphiphilic peptide compositions and uses thereof - Google Patents
Purified amphiphilic peptide compositions and uses thereof Download PDFInfo
- Publication number
- CA2572964C CA2572964C CA2572964A CA2572964A CA2572964C CA 2572964 C CA2572964 C CA 2572964C CA 2572964 A CA2572964 A CA 2572964A CA 2572964 A CA2572964 A CA 2572964A CA 2572964 C CA2572964 C CA 2572964C
- Authority
- CA
- Canada
- Prior art keywords
- peptide chains
- gel
- polypeptides
- peptide
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58591404P | 2004-07-06 | 2004-07-06 | |
| US60/585,914 | 2004-07-06 | ||
| US11/176,781 | 2005-07-06 | ||
| PCT/US2005/024198 WO2006014570A2 (en) | 2004-07-06 | 2005-07-06 | Purified amphilic peptide compositions and uses thereof |
| US11/176,781 US20060084607A1 (en) | 2004-07-06 | 2005-07-06 | Purified amphiphilic peptide compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2572964A1 CA2572964A1 (en) | 2006-02-09 |
| CA2572964C true CA2572964C (en) | 2018-03-06 |
Family
ID=35787660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2572964A Expired - Lifetime CA2572964C (en) | 2004-07-06 | 2005-07-06 | Purified amphiphilic peptide compositions and uses thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20060084607A1 (enExample) |
| EP (4) | EP4049671A1 (enExample) |
| JP (2) | JP5255274B2 (enExample) |
| CA (1) | CA2572964C (enExample) |
| WO (1) | WO2006014570A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223544B2 (en) * | 2003-06-27 | 2007-05-29 | Cornell Research Foundation, Inc. | Nucleic acid-engineered materials |
| CA2572964C (en) * | 2004-07-06 | 2018-03-06 | 3D Matrix, Inc. | Purified amphiphilic peptide compositions and uses thereof |
| US7429567B2 (en) * | 2005-01-04 | 2008-09-30 | The Brigham And Women's Hospital, Inc. | Sustained delivery of PDGF using self-assembling peptide nanofibers |
| US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
| US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
| US8187621B2 (en) * | 2005-04-19 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Methods and compositions for treating post-myocardial infarction damage |
| JP5204646B2 (ja) | 2005-04-25 | 2013-06-05 | マサチューセッツ インスティテュート オブ テクノロジー | 止血および他の生理学的活性を促進するための組成物および方法 |
| US9162005B2 (en) * | 2005-04-25 | 2015-10-20 | Arch Biosurgery, Inc. | Compositions for prevention of adhesions and other barrier applications |
| US20070048759A1 (en) * | 2005-06-10 | 2007-03-01 | Dan Luo | Detection of target molecules with labeled nucleic acid detection molecules |
| US8299032B2 (en) * | 2005-06-27 | 2012-10-30 | Menicon Co., Ltd. | Self-assembling peptide and gel produced from the same |
| US20070148246A1 (en) * | 2005-08-11 | 2007-06-28 | Dan Luo | Nucleic Acid-Based Matrixes |
| US20100136614A1 (en) * | 2005-10-18 | 2010-06-03 | Dan Luo | Dendrimer-like modular delivery vector |
| US8486621B2 (en) * | 2005-08-11 | 2013-07-16 | Cornell Research Foundation, Inc. | Nucleic acid-based matrixes |
| JP2007217375A (ja) * | 2006-02-17 | 2007-08-30 | Nagoya Institute Of Technology | 自己組織化ペプチド |
| JP2007217376A (ja) * | 2006-02-17 | 2007-08-30 | Nagoya Institute Of Technology | 自己組織化ペプチド組成物 |
| ES2673947T3 (es) | 2006-04-25 | 2018-06-26 | Massachusetts Institute Of Technology | Composiciones y métodos para afectar al movimiento de contaminantes, líquidos corporales u otras entidades y/o afectar a otras condiciones fisiológicas |
| AU2014203694B2 (en) * | 2006-04-25 | 2016-08-11 | Massachusetts Institute Of Technology | Compositions and methods for affecting movement of contaminants, bodily fluids or other entities and/or affecting other physiological conditions |
| EP3219294A1 (en) | 2006-06-20 | 2017-09-20 | Ben-Gurion University of The Negev Research and Development Authority | Amphiphilic peptides and hydrogel matrices thereof for bone repair |
| US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
| US9005672B2 (en) | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
| WO2008073392A2 (en) | 2006-12-11 | 2008-06-19 | 3D Matrix, Inc. | Compositions and methods for cardiac tissue protection and regeneration |
| EP2146733B1 (en) * | 2007-03-14 | 2020-11-25 | Arch Biosurgery, Inc. | Treatment of leaky or damaged tight junctions and enhancing extracellular matrix |
| WO2009026729A1 (en) * | 2007-08-30 | 2009-03-05 | University Of Waterloo | Amino acid pairing-based self assembling peptides and methods |
| US9457056B2 (en) * | 2007-12-04 | 2016-10-04 | Ben-Gurion University Of The Negev Research And Development Authority | Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis |
| EP2229960B1 (en) * | 2007-12-05 | 2015-04-08 | 3-D Matrix, Ltd. | Wound healing/skin reconstruction material |
| JP5311456B2 (ja) * | 2008-06-19 | 2013-10-09 | 国立大学法人 名古屋工業大学 | 二次元微細薄膜の作製方法 |
| US10570172B1 (en) * | 2008-09-30 | 2020-02-25 | The United States Of America, As Represented By The Secretary Of Agriculture | Self-assembling amphiphilic peptides |
| US10576123B2 (en) * | 2008-10-06 | 2020-03-03 | 3-D Matrix, Ltd. | Tissue occluding agent comprising an IEIKIEIKIEIKI peptide |
| US8298765B2 (en) * | 2009-01-01 | 2012-10-30 | Cornell University | Multifunctional nucleic acid nano-structures |
| SG174857A1 (en) * | 2009-03-09 | 2011-11-28 | Menicon Co Ltd | Self-assembling peptide and peptide gel with high strength |
| JP2011012041A (ja) * | 2009-07-02 | 2011-01-20 | Three D Matrix:Kk | 核酸複合体徐放担体 |
| JP2011012042A (ja) * | 2009-07-03 | 2011-01-20 | Three D Matrix:Kk | 核酸徐放担体 |
| US9439941B2 (en) | 2009-12-14 | 2016-09-13 | The University Of Hong Kong | Nano cancer barrier device (NCBD) to immobilize and inhibit the division of metastic cancer stem cells |
| US8999916B2 (en) | 2010-03-31 | 2015-04-07 | Agency For Science, Technology And Research | Crosslinked peptide hydrogels |
| ES2574056T3 (es) | 2010-03-31 | 2016-06-14 | Agency For Science, Technology And Research | Péptido/peptoide anfifílico lineal e hidrogel que comprende el mismo |
| US9687591B2 (en) | 2010-03-31 | 2017-06-27 | Agency For Science, Technology And Research | Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes |
| JP5855651B2 (ja) * | 2010-07-16 | 2016-02-09 | マサチューセッツ インスティテュート オブ テクノロジー | 改変を組み込んだ自己組織化ペプチドおよびその使用方法 |
| US8741833B2 (en) * | 2010-07-16 | 2014-06-03 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| JP2012082180A (ja) * | 2010-10-14 | 2012-04-26 | Nagoya Univ | 骨再生用自己組織化ペプチドハイドロゲル |
| CA2845886A1 (en) | 2011-08-23 | 2013-02-28 | President And Fellows Of Harvard College | Peptide nanoparticles and uses thereof |
| GB2496654A (en) * | 2011-11-18 | 2013-05-22 | Reckitt & Colman Overseas | Self-assembling peptides |
| EP2607373A1 (en) * | 2011-12-23 | 2013-06-26 | Solvay Sa | Liquid phase synthesis of self-assembling peptides to be linked to polymers or to other bioactive and/or self-assembling peptides |
| GB201203085D0 (en) | 2012-02-22 | 2012-04-04 | Univ Manchester | Hydrogels |
| WO2014008400A2 (en) | 2012-07-06 | 2014-01-09 | 3-D Matrix, Inc. | Fill-finish process for peptide solutions |
| US9120841B2 (en) * | 2012-09-28 | 2015-09-01 | Agency For Science, Technology And Research | Amphiphilic linear peptidepeptoid and hydrogel comprising the same |
| EP2919826B1 (en) * | 2012-11-14 | 2025-06-11 | 3-D Matrix Ltd. | Vascular embolic system |
| HK1220116A1 (zh) * | 2013-03-06 | 2017-04-28 | 3-D Matrix Ltd. | 使用纯化的两亲性多肽组合物的外科手术方法 |
| WO2014141160A1 (en) * | 2013-03-14 | 2014-09-18 | 3-D Matrix, Ltd | Treatment for bile leakage |
| AU2014308597B2 (en) | 2013-08-22 | 2017-01-19 | Arch Biosurgery, Inc. | Implantable meshes for controlling the movement of fluids |
| US10369237B2 (en) | 2014-03-10 | 2019-08-06 | 3-D Matrix, Ltd. | Sterilization and filtration of peptide compositions |
| BR112016020584A2 (pt) | 2014-03-10 | 2017-10-03 | 3 D Matrix Ltd | Composições de peptídeo auto-organizável |
| EP3116524B1 (en) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary bulla |
| US20170128622A1 (en) * | 2014-06-20 | 2017-05-11 | 3-D Matrix, Ltd. | Materials and methods for filling bone voids |
| WO2015196020A1 (en) * | 2014-06-20 | 2015-12-23 | 3-D Matrix, Ltd. | Materials and methods for filling dental bone voids |
| WO2016004216A2 (en) * | 2014-07-01 | 2016-01-07 | Vicus Therapeutics, Llc | Hydrogels for treating and ameliorating infections and methods of making and using them |
| DE102015000363A1 (de) | 2015-01-20 | 2016-07-21 | Emc Microcollections Gmbh | Neue modular funktionalisierbare Peptid-Hydrogele |
| JP2018527978A (ja) * | 2015-07-28 | 2018-09-27 | トラスティーズ オブ タフツ カレッジ | ポリペプチドモノリス |
| CN108289926A (zh) | 2015-10-14 | 2018-07-17 | 西北大学 | 用于生长因子递送和骨再生的纳米纤维糊剂 |
| AU2015416589B2 (en) * | 2015-12-10 | 2021-04-01 | Menicon Co., Ltd. | Peptide composition |
| US11298397B2 (en) | 2015-12-18 | 2022-04-12 | 3-D Matrix, Ltd. | Hemostatic composition and hemostatic method using hemostatic composition |
| WO2017120092A1 (en) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
| US20190091376A1 (en) * | 2016-03-18 | 2019-03-28 | 3-D Matrix, Ltd. | Preventing Biological Tissue Adhesion |
| JP7012950B2 (ja) | 2016-11-17 | 2022-01-31 | 地方独立行政法人東京都立産業技術研究センター | 生体組織孔閉鎖用、潰瘍保護用及び血管塞栓療術用ゾル |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| CN106986922B (zh) * | 2017-04-14 | 2020-03-06 | 江南大学 | 一种自组装双亲短肽及其应用 |
| CN117085140A (zh) | 2017-12-15 | 2023-11-21 | 立美基股份有限公司 | 表面活性剂肽纳米结构及在药物递送中的用途 |
| CN110373404B (zh) * | 2018-03-07 | 2021-11-16 | 江南大学 | 一种酶突变体 |
| WO2019182905A1 (en) * | 2018-03-23 | 2019-09-26 | Arch Biosurgery, Inc. | Sap and peptidomimetics for treatment of eye disease |
| US20210220429A1 (en) | 2018-10-05 | 2021-07-22 | Kurume University | Pharmaceutical composition for treating or preventing ulcer or fistula in intestinal tract |
| CN109248343A (zh) * | 2018-11-20 | 2019-01-22 | 南京汉瑞生物科技有限公司 | 一种自组装多肽水凝胶支架及其制备方法 |
| JP7466876B2 (ja) * | 2019-02-20 | 2024-04-15 | 国立大学法人東京農工大学 | 自己組織化ペプチド |
| BR112021021212A2 (pt) | 2019-06-20 | 2021-12-28 | UCB Biopharma SRL | Detecção de agentes de floculação em uma amostra de proteína baseada em hplc |
| EP4125995A4 (en) | 2020-03-31 | 2024-04-10 | 3-D Matrix, Ltd. | STERILIZATION OF SELF-ASSEMBLY PEPTIDES BY IRRADIATION |
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| CN114409734B (zh) * | 2022-01-25 | 2023-05-12 | 四川大学华西医院 | 一种可诱导局部麻醉药生物矿化的自组装短肽及其制得的长效局部麻醉和镇痛药物制剂 |
| EP4286397A1 (en) | 2022-06-01 | 2023-12-06 | ETH Zurich | Hydrogel-forming proteins |
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-
2005
- 2005-07-06 CA CA2572964A patent/CA2572964C/en not_active Expired - Lifetime
- 2005-07-06 EP EP22152608.0A patent/EP4049671A1/en active Pending
- 2005-07-06 WO PCT/US2005/024198 patent/WO2006014570A2/en not_active Ceased
- 2005-07-06 US US11/176,781 patent/US20060084607A1/en not_active Abandoned
- 2005-07-06 EP EP05770153A patent/EP1843776A4/en active Pending
- 2005-07-06 JP JP2007520521A patent/JP5255274B2/ja not_active Expired - Lifetime
- 2005-07-06 EP EP15195734.7A patent/EP3031466B1/en not_active Revoked
- 2005-07-06 EP EP21215151.8A patent/EP4023240A1/en active Pending
-
2012
- 2012-08-27 JP JP2012186897A patent/JP5730828B2/ja not_active Expired - Lifetime
-
2013
- 2013-04-19 US US13/866,135 patent/US20130281547A1/en not_active Abandoned
-
2016
- 2016-03-09 US US15/065,758 patent/US20160317607A1/en not_active Abandoned
-
2023
- 2023-02-13 US US18/109,096 patent/US20230190864A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006014570A3 (en) | 2006-04-06 |
| US20060084607A1 (en) | 2006-04-20 |
| EP4049671A1 (en) | 2022-08-31 |
| US20230190864A1 (en) | 2023-06-22 |
| JP2012250988A (ja) | 2012-12-20 |
| EP1843776A4 (en) | 2011-05-11 |
| EP3031466A1 (en) | 2016-06-15 |
| EP4023240A1 (en) | 2022-07-06 |
| EP3031466B1 (en) | 2018-11-28 |
| JP5255274B2 (ja) | 2013-08-07 |
| US20160317607A1 (en) | 2016-11-03 |
| EP1843776A2 (en) | 2007-10-17 |
| JP2008505919A (ja) | 2008-02-28 |
| JP5730828B2 (ja) | 2015-06-10 |
| CA2572964A1 (en) | 2006-02-09 |
| US20130281547A1 (en) | 2013-10-24 |
| WO2006014570A2 (en) | 2006-02-09 |
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