CA2572084A1 - Tetrahydroquinazolin-4(3h)-one-related and tetrahydropyrido[2,3-d]pyrimidin-4(3h)-one-related compounds, compositions and methods for their use - Google Patents
Tetrahydroquinazolin-4(3h)-one-related and tetrahydropyrido[2,3-d]pyrimidin-4(3h)-one-related compounds, compositions and methods for their use Download PDFInfo
- Publication number
- CA2572084A1 CA2572084A1 CA002572084A CA2572084A CA2572084A1 CA 2572084 A1 CA2572084 A1 CA 2572084A1 CA 002572084 A CA002572084 A CA 002572084A CA 2572084 A CA2572084 A CA 2572084A CA 2572084 A1 CA2572084 A1 CA 2572084A1
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- Prior art keywords
- compound
- alkyl
- group
- aryl
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- ULRUXGFKZSCZIE-UHFFFAOYSA-N 3,4a,5,8-tetrahydro-2H-pyrido[2,3-d]pyrimidin-4-one Chemical compound N1CNC(C2C1=NC=CC2)=O ULRUXGFKZSCZIE-UHFFFAOYSA-N 0.000 title 1
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- General Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58382304P | 2004-06-28 | 2004-06-28 | |
| US60/583,823 | 2004-06-28 | ||
| PCT/US2005/023275 WO2006004925A1 (en) | 2004-06-28 | 2005-06-28 | Tetrahydroquinazolin-4(3h)-one-related and tetrahydropyrido[2,3-d]pyrimidin-4(3h)-one-related compounds, compositions and methods for their use |
Publications (1)
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|---|---|
| CA2572084A1 true CA2572084A1 (en) | 2006-01-12 |
Family
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| CA002572084A Abandoned CA2572084A1 (en) | 2004-06-28 | 2005-06-28 | Tetrahydroquinazolin-4(3h)-one-related and tetrahydropyrido[2,3-d]pyrimidin-4(3h)-one-related compounds, compositions and methods for their use |
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| EP (1) | EP1765818A1 (OSRAM) |
| JP (1) | JP2008504304A (OSRAM) |
| AU (1) | AU2005260630A1 (OSRAM) |
| CA (1) | CA2572084A1 (OSRAM) |
| MX (1) | MX2007000044A (OSRAM) |
| WO (1) | WO2006004925A1 (OSRAM) |
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| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7939538B2 (en) * | 2004-06-28 | 2011-05-10 | Amgen Inc. | Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases |
| TW200714610A (en) * | 2005-02-16 | 2007-04-16 | Univ Maryland | CXCR3 is a gliadin receptor |
| EP1889622A4 (en) * | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
| WO2007002701A2 (en) * | 2005-06-27 | 2007-01-04 | Amgen Inc. | Anti-inflammatory aryl nitrile compounds |
| US20110034487A1 (en) * | 2008-01-22 | 2011-02-10 | Amgen Inc. | Cxcr3 antagonists |
| JP5718233B2 (ja) * | 2008-10-20 | 2015-05-13 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 甲状腺刺激ホルモン受容体（ｔｓｈｒ）の低分子量アゴニスト |
| WO2011127388A2 (en) | 2010-04-08 | 2011-10-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inverse agonists and neutral antagonists for the tsh receptor |
| BR112013032771B1 (pt) | 2011-06-27 | 2021-01-12 | Parion Sciences, Inc. | dipeptídio quimicamente e metabolicamente estável possuindo potente atividade bloqueadora de canais de sódio |
| AR086745A1 (es) * | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| AP2014007400A0 (en) | 2011-07-13 | 2014-01-31 | Novartis Ag | 4-Piperidinyl compounds for use as tankyrase inhibitors |
| US9227982B2 (en) | 2011-07-13 | 2016-01-05 | Novartis Ag | 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors |
| US9181266B2 (en) | 2011-07-13 | 2015-11-10 | Novartis Ag | 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| DK2855435T3 (en) | 2012-05-29 | 2018-07-16 | Parion Sciences Inc | DENDRIMER-LIKE AMINOAMIDES WITH SODIUM CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF DRY EYES AND OTHER MILK DISEASES |
| BR112015014349A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente |
| US9029382B2 (en) | 2012-12-17 | 2015-05-12 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX389256B (es) | 2013-10-04 | 2025-03-20 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| EA201691872A1 (ru) | 2014-03-19 | 2017-04-28 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN108349985A (zh) | 2015-09-14 | 2018-07-31 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| TWI816696B (zh) * | 2017-09-14 | 2023-10-01 | 日商住友金屬礦山股份有限公司 | 近紅外線吸收纖維及使用其之纖維製品 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0481614A1 (en) | 1990-10-01 | 1992-04-22 | Merck & Co. Inc. | Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists |
| US5256667A (en) * | 1991-09-25 | 1993-10-26 | Merck & Co., Inc. | Quinazolinones and pyridopyrimidinones |
| US5202322A (en) * | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| WO1996028444A1 (en) * | 1995-03-15 | 1996-09-19 | Pfizer Inc. | 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS |
| US6140064A (en) * | 1996-09-10 | 2000-10-31 | Theodor-Kocher Institute | Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3 |
| FR2778662B1 (fr) | 1998-05-12 | 2000-06-16 | Adir | Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4831906B2 (ja) * | 1999-08-27 | 2011-12-07 | ケモセントリックス， インコーポレイテッド | Ｃｘｃｒ３機能を調節するための複素環式化合物および方法 |
| WO2001019800A2 (en) | 1999-09-16 | 2001-03-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| EP1686120A3 (en) | 1999-10-27 | 2007-05-30 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| BR0116096A (pt) | 2000-12-11 | 2005-10-18 | Tularik Inc | Composto, composição farmacêutica, e, métodos para tratar uma condição ou doença inflamatória ou imune em um paciente, para tratar uma condição ou doença mediada por cxcr3 em um paciente, e para a modulação da função de cxcr3 em uma célula |
| US6794379B2 (en) * | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
| EP1521746B1 (en) | 2002-03-07 | 2011-04-27 | X-Ceptor Therapeutics, Inc. | Quinazolinone modulators of nuclear receptors |
| US7166595B2 (en) * | 2002-05-09 | 2007-01-23 | Cytokinetics, Inc. | Compounds, methods and compositions |
| US20040242498A1 (en) | 2003-02-27 | 2004-12-02 | Collins Tassie L. | CXCR3 antagonists |
| EP1613322A4 (en) | 2003-04-11 | 2008-08-13 | Taigen Biotechnology Co Ltd | AMINOQUINOLINE COMPOUNDS |
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2005
- 2005-06-27 US US11/168,006 patent/US7375102B2/en not_active Expired - Fee Related
- 2005-06-28 CA CA002572084A patent/CA2572084A1/en not_active Abandoned
- 2005-06-28 WO PCT/US2005/023275 patent/WO2006004925A1/en not_active Ceased
- 2005-06-28 MX MX2007000044A patent/MX2007000044A/es active IP Right Grant
- 2005-06-28 EP EP05768335A patent/EP1765818A1/en not_active Withdrawn
- 2005-06-28 JP JP2007518382A patent/JP2008504304A/ja active Pending
- 2005-06-28 AU AU2005260630A patent/AU2005260630A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007000044A (es) | 2007-05-11 |
| AU2005260630A1 (en) | 2006-01-12 |
| US7375102B2 (en) | 2008-05-20 |
| US20060069106A1 (en) | 2006-03-30 |
| JP2008504304A (ja) | 2008-02-14 |
| WO2006004925A1 (en) | 2006-01-12 |
| EP1765818A1 (en) | 2007-03-28 |
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| FZDE | Discontinued | ||
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Effective date: 20120628 |