CA2571424A1 - Derives de bisaryluree utiles pour inhiber chk1 - Google Patents
Derives de bisaryluree utiles pour inhiber chk1 Download PDFInfo
- Publication number
- CA2571424A1 CA2571424A1 CA002571424A CA2571424A CA2571424A1 CA 2571424 A1 CA2571424 A1 CA 2571424A1 CA 002571424 A CA002571424 A CA 002571424A CA 2571424 A CA2571424 A CA 2571424A CA 2571424 A1 CA2571424 A1 CA 2571424A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- group
- methyl
- compound
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58308004P | 2004-06-25 | 2004-06-25 | |
US60/583,080 | 2004-06-25 | ||
PCT/US2005/022515 WO2006012308A1 (fr) | 2004-06-25 | 2005-06-24 | Dérivés de bisarylurée utiles pour inhiber chk1 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2571424A1 true CA2571424A1 (fr) | 2006-02-02 |
Family
ID=35307890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002571424A Abandoned CA2571424A1 (fr) | 2004-06-25 | 2005-06-24 | Derives de bisaryluree utiles pour inhiber chk1 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1765808A1 (fr) |
JP (1) | JP2008504283A (fr) |
KR (1) | KR20070028591A (fr) |
CN (1) | CN101006075A (fr) |
AU (1) | AU2005267185A1 (fr) |
BR (1) | BRPI0512593A (fr) |
CA (1) | CA2571424A1 (fr) |
MX (1) | MX2007000259A (fr) |
WO (1) | WO2006012308A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101115727A (zh) * | 2004-08-19 | 2008-01-30 | 艾科斯有限公司 | 用于抑制chk1的化合物 |
SI1869020T1 (sl) | 2005-03-29 | 2011-02-28 | Icos Corp | Derivati heteroaril uree, ki so uporabni za inhibicijo chk1 |
GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
TWI725041B (zh) | 2015-07-23 | 2021-04-21 | 美商美國禮來大藥廠 | 用於治療神經母細胞瘤及/或軟組織肉瘤之chk1/2抑制劑 |
WO2023287839A2 (fr) * | 2021-07-13 | 2023-01-19 | Brown University | Traitement du cancer du tractus urinaire guidé par le paysage mutationnel |
CA3233080A1 (fr) * | 2021-09-28 | 2023-04-06 | Pioneer Hi-Bred International, Inc. | Conditions de germination et de croissance de semis |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01163723A (ja) * | 1987-12-21 | 1989-06-28 | Nippon Telegr & Teleph Corp <Ntt> | 有機非線形光学材料 |
JPH09249628A (ja) * | 1996-03-12 | 1997-09-22 | Tanabe Seiyaku Co Ltd | フェノール誘導体 |
ATE297383T1 (de) * | 1997-12-22 | 2005-06-15 | Bayer Pharmaceuticals Corp | Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen |
UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
WO2003022273A1 (fr) * | 2001-09-13 | 2003-03-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methodes de traitement de maladies mediees par la cytokine |
US20030236287A1 (en) * | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
US7202244B2 (en) * | 2002-05-29 | 2007-04-10 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
-
2005
- 2005-06-24 WO PCT/US2005/022515 patent/WO2006012308A1/fr active Application Filing
- 2005-06-24 CA CA002571424A patent/CA2571424A1/fr not_active Abandoned
- 2005-06-24 KR KR1020077001927A patent/KR20070028591A/ko not_active Application Discontinuation
- 2005-06-24 AU AU2005267185A patent/AU2005267185A1/en not_active Abandoned
- 2005-06-24 EP EP05788966A patent/EP1765808A1/fr not_active Withdrawn
- 2005-06-24 CN CNA2005800277583A patent/CN101006075A/zh active Pending
- 2005-06-24 MX MX2007000259A patent/MX2007000259A/es not_active Application Discontinuation
- 2005-06-24 BR BRPI0512593-6A patent/BRPI0512593A/pt not_active IP Right Cessation
- 2005-06-24 JP JP2007518316A patent/JP2008504283A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BRPI0512593A (pt) | 2008-03-25 |
KR20070028591A (ko) | 2007-03-12 |
EP1765808A1 (fr) | 2007-03-28 |
CN101006075A (zh) | 2007-07-25 |
WO2006012308A1 (fr) | 2006-02-02 |
AU2005267185A1 (en) | 2006-02-02 |
MX2007000259A (es) | 2007-07-20 |
JP2008504283A (ja) | 2008-02-14 |
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CA2463822A1 (fr) | Heteroaryl amines utiles comme inhibiteurs de glycogene synthase kinase 3beta (inhibiteurs de gsk3) | |
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AU2002258451A1 (en) | Aryl and Heteroaryl Urea CHK1 Inhibitors for Use as Radiosensitizers and Chemosensitizers | |
CA2571424A1 (fr) | Derives de bisaryluree utiles pour inhiber chk1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |