CA2561845C - Aerosol delivery systems and methods - Google Patents

Aerosol delivery systems and methods Download PDF

Info

Publication number
CA2561845C
CA2561845C CA2561845A CA2561845A CA2561845C CA 2561845 C CA2561845 C CA 2561845C CA 2561845 A CA2561845 A CA 2561845A CA 2561845 A CA2561845 A CA 2561845A CA 2561845 C CA2561845 C CA 2561845C
Authority
CA
Canada
Prior art keywords
agent
chamber
aerosolizing
aerosolizing element
orifices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2561845A
Other languages
English (en)
French (fr)
Other versions
CA2561845A1 (en
Inventor
Mark J. Papania
James J. Barry
Mark C. Bagley
Nabil A. Elkouh
Darin Knaus
Robert Trabka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Creare LLC
Centers of Disease Control and Prevention CDC
Original Assignee
Creare LLC
Centers of Disease Control and Prevention CDC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creare LLC, Centers of Disease Control and Prevention CDC filed Critical Creare LLC
Publication of CA2561845A1 publication Critical patent/CA2561845A1/en
Application granted granted Critical
Publication of CA2561845C publication Critical patent/CA2561845C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0085Inhalators using ultrasonics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/004Arrangements for controlling delivery; Arrangements for controlling the spray area comprising sensors for monitoring the delivery, e.g. by displaying the sensed value or generating an alarm
    • B05B12/006Pressure or flow rate sensors
    • B05B12/008Pressure or flow rate sensors integrated in or attached to a discharge apparatus, e.g. a spray gun
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/08Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means
    • B05B12/082Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means responsive to a condition of the discharged jet or spray, e.g. to jet shape, spray pattern or droplet size
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653Details
    • B05B17/0676Feeding means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20Valves specially adapted to medical respiratory devices
    • A61M16/208Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
    • A61M16/209Relief valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0272Electro-active or magneto-active materials
    • A61M2205/0294Piezoelectric materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/07General characteristics of the apparatus having air pumping means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3306Optical measuring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8237Charging means
    • A61M2205/825Charging means using mechanical generation of electricity, e.g. hand cranked generators

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Fluid Mechanics (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2561845A 2004-04-02 2005-04-01 Aerosol delivery systems and methods Expired - Fee Related CA2561845C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55931804P 2004-04-02 2004-04-02
US60/559,318 2004-04-02
PCT/US2005/011086 WO2006006963A2 (en) 2004-04-02 2005-04-01 Aerosol delivery systems and methods

Publications (2)

Publication Number Publication Date
CA2561845A1 CA2561845A1 (en) 2006-01-19
CA2561845C true CA2561845C (en) 2014-03-25

Family

ID=35376961

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2561845A Expired - Fee Related CA2561845C (en) 2004-04-02 2005-04-01 Aerosol delivery systems and methods

Country Status (11)

Country Link
US (2) US7954486B2 (enExample)
EP (2) EP2258428B1 (enExample)
JP (2) JP4786642B2 (enExample)
CN (2) CN101693132B (enExample)
AT (1) ATE483488T1 (enExample)
AU (2) AU2005262940B2 (enExample)
CA (1) CA2561845C (enExample)
DE (1) DE602005023969D1 (enExample)
IN (1) IN2014DN01746A (enExample)
MX (1) MXPA06011426A (enExample)
WO (1) WO2006006963A2 (enExample)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002336246B8 (en) 2001-03-15 2006-02-02 Creare Incorporated Nebulizer having cooling chamber
US7883031B2 (en) 2003-05-20 2011-02-08 James F. Collins, Jr. Ophthalmic drug delivery system
US8012136B2 (en) 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
DE102005038619A1 (de) * 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
EP1792662A1 (en) * 2005-11-30 2007-06-06 Microflow Engineering SA Volatile liquid droplet dispenser device
CN101522244B (zh) * 2006-08-01 2013-06-26 日本烟草产业株式会社 气雾吸引器
EP1905468B1 (en) * 2006-09-29 2012-11-07 Zambon S.p.A. Aerosol apparatus, in particular for children
WO2008097645A1 (en) * 2007-02-08 2008-08-14 Aerovectrx Corporation Aerosol delivery systems and methods
US9849254B2 (en) * 2007-05-15 2017-12-26 Caddo Medical Technologies Llc Pre-filled, small-volume nebulizer
US9566397B2 (en) 2007-05-15 2017-02-14 Joseph Dee Faram Small-volume nebulizers and methods of use thereof
WO2009018397A1 (en) * 2007-07-30 2009-02-05 Green Eric M One-piece foldable mask and holding chamber for use with aerosolized medications
FR2923365B1 (fr) * 2007-11-12 2010-09-10 Oreal Cartouche contenant un produit a pulveriser
DE102007056462B4 (de) 2007-11-23 2011-10-27 Pari Pharma Gmbh Einwegampulle für eine Vorrichtung zur Erzeugung von Aerosolen
NZ622583A (en) 2007-11-30 2015-08-28 Abbvie Biotechnology Ltd Protein formulations and methods of making same
DE102008022987A1 (de) * 2008-05-09 2009-11-12 Pari Pharma Gmbh Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler
US8398583B2 (en) 2008-07-09 2013-03-19 Massachusetts Institute Of Technology Method and apparatus for extraction of a sample from a sample source
WO2010063286A2 (en) * 2008-12-04 2010-06-10 Nordicaryan Aps A hand-held inhaler
KR101317736B1 (ko) * 2009-06-22 2013-10-15 파나소닉 전공 주식회사 탄성 표면파를 사용하는 미스트 또는 미세 기포의 발생 방법 및 미스트 또는 미세 기포 발생 장치
KR101740624B1 (ko) * 2009-07-17 2017-05-26 넥타르 테라퓨틱스 네거티브하게 바이어싱된 밀봉된 분무기 시스템들 및 방법들
US10525214B2 (en) 2010-01-12 2020-01-07 Dance Biopharm Inc. Preservative-free single dose inhaler system
US8950394B2 (en) 2010-01-12 2015-02-10 Dance Biopharm Inc. Preservative-free single dose inhaler systems
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US20110205075A1 (en) * 2010-02-25 2011-08-25 Sundhar Shaam P Hand cranked energy efficient light
US9492068B2 (en) 2010-06-04 2016-11-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nasal aerosol delivery system
US20110303218A1 (en) * 2010-06-09 2011-12-15 Yadidi Kambiz Nasal nebulizer
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック,インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
KR101545413B1 (ko) 2010-07-15 2015-08-18 아이노비아 인코포레이티드 점적 발생 디바이스
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US9087145B2 (en) 2010-07-15 2015-07-21 Eyenovia, Inc. Ophthalmic drug delivery
US11247003B2 (en) 2010-08-23 2022-02-15 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
US9180264B2 (en) * 2010-11-29 2015-11-10 Sanofi-Aventis Deutschland Gmbh Medicated module for an inhaler
EP4088769A1 (en) * 2011-03-03 2022-11-16 Impel Pharmaceuticals Inc. Nasal drug delivery device
JP2014516682A (ja) * 2011-05-16 2014-07-17 ザ テクノロジー パートナーシップ パブリック リミテッド カンパニー 用量容器
GB201108102D0 (en) 2011-05-16 2011-06-29 The Technology Partnership Plc Separable membrane improvements
MX343900B (es) * 2011-09-19 2016-11-28 Koninklijke Philips Nv Analisis y control de salidad de aerosol.
US20130172830A1 (en) 2011-12-12 2013-07-04 Corinthian Ophthalmic, Inc. Ejector mechanism, ejector device, and methods of use
EP2724741B1 (en) * 2012-10-26 2017-06-14 Vectura GmbH Inhalation device for use in aerosol therapy
US9603906B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Inhalable liquid formulations of DNase I
WO2013132498A2 (en) 2012-03-07 2013-09-12 Advanced Inhilation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
TWI487915B (zh) * 2012-03-08 2015-06-11 Microjet Technology Co Ltd 自動化微噴液檢測裝置
CN103308700A (zh) * 2012-03-08 2013-09-18 研能科技股份有限公司 自动化微喷液检测装置
JP6329130B2 (ja) 2012-04-10 2018-05-30 アイノビア,インコーポレイティド 噴霧エジェクタ機構、電荷分離及び制御可能な液滴電荷を提供する装置、並びに低投与量の点眼
WO2013158967A2 (en) 2012-04-20 2013-10-24 Corinthian Ophthalmic, Inc. Spray ejector device and methods of use
WO2013160883A1 (en) * 2012-04-26 2013-10-31 Koninklijke Philips N.V. A nebulizer and a method of manufacturing a nebulizer
AU2013262986A1 (en) 2012-05-14 2015-01-22 Eyenovia, Inc. Laminar flow droplet generator device and methods of use
SG10201602609XA (en) 2012-05-15 2016-05-30 Eyenovia Inc Ejector devices, methods, drivers, and circuits therefor
JP2014004211A (ja) * 2012-06-26 2014-01-16 Omron Healthcare Co Ltd 液体噴霧装置
US9248247B2 (en) 2012-07-26 2016-02-02 Nathaniel Gerald Portney Capsular medication delivery and inhalation device
EP2708219A1 (en) * 2012-09-12 2014-03-19 PARI Pharma GmbH Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element
KR101982777B1 (ko) * 2012-09-24 2019-05-27 엘지전자 주식회사 일회용 캡슐을 이용하는 정전 무화 장치
CN103143089B (zh) * 2013-03-19 2015-05-27 卓效医疗有限公司 吸气同步雾化的手持微型雾化器
CN103143088B (zh) * 2013-03-19 2015-05-27 卓效医疗有限公司 可方便换药和加药的手持微型雾化器
EP2981317A2 (en) 2013-04-04 2016-02-10 The USA As Represented by the Secretary Department of Health and Human Services Centers for Disease Control And Prevention Nasal aerosol delivery system
US9303330B2 (en) 2013-06-07 2016-04-05 General Electric Company Method for manufacturing fluid handling discs with porous mesh plates for use in ultrasonic mesh nebulizers
GB201312263D0 (en) 2013-07-09 2013-08-21 The Technology Partnership Plc Separable membrane improvements
HUE063833T2 (hu) * 2014-05-07 2024-02-28 Boehringer Ingelheim Int Tartály és jelzõszerkezet, valamint porlasztó
EP3146989A4 (en) * 2014-05-28 2017-08-30 Metran Co., Ltd. Humidifying device
DE102014215064A1 (de) 2014-07-31 2016-02-04 Pari GmbH Spezialisten für effektive Inhalation Vernebler
EP3002026A1 (en) * 2014-09-30 2016-04-06 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. System and method for stabilizing a voice coil motor
DK3204095T3 (da) * 2014-10-10 2019-07-15 Ablynx Nv Inhalationsindretning til anvendelse i aerosolbehandling af luftsvejssygdomme
WO2016055656A1 (en) 2014-10-10 2016-04-14 Ablynx N.V. Methods of treating rsv infections
IL253208B2 (en) 2015-01-04 2023-03-01 Protalix Ltd Converted DNase and its uses
KR20170102261A (ko) * 2015-01-08 2017-09-08 컨벡시티 사이언티픽 엘엘씨 분무기 장치 및 저장고
CN113230021A (zh) * 2015-01-12 2021-08-10 科达莱昂治疗公司 微滴递送设备和方法
AU2016246060B2 (en) * 2015-04-10 2020-10-22 Bausch + Lomb Ireland Limited Piezoelectric dispenser with replaceable ampoule
CN108704200A (zh) * 2015-05-16 2018-10-26 苏州汉方医药有限公司 由手动悬浮微颗粒发生器和白花蛇舌草或白花蛇舌草素组成的药盒
TWM506609U (zh) * 2015-05-27 2015-08-11 Ind Tech Res Inst 呼吸器之藥量監控裝置
DK3607984T3 (da) * 2015-06-03 2022-03-07 Novopyxis Inc Fremgangsmåde til generering af en aerosoltåge
EP3103496B1 (en) * 2015-06-11 2018-08-15 Delta Electronics, Inc. Nebulization system
CN106238244B (zh) * 2015-06-11 2019-08-06 台达电子工业股份有限公司 雾化系统、雾化器及其驱动方法
GB201511676D0 (en) 2015-07-03 2015-08-19 The Technology Partnership Plc Seperable membrane inmprovements
WO2017040391A1 (en) * 2015-08-28 2017-03-09 The Research Institute At Nationwide Children's Hospital Interactive spacer for respiratory device
IL258641B (en) 2015-10-30 2022-09-01 Johnson & Johnson Consumer Inc Aseptic aerosol misting device
IL258628B (en) * 2015-10-30 2022-09-01 Johnson & Johnson Consumer Inc Install an uncontaminated spray misting device
MA43112A (fr) * 2015-10-30 2018-09-05 Johnson & Johnson Consumer Inc Pulvérisateur d'aérosol aseptique de dose unitaire
MX2018005335A (es) 2015-10-30 2018-05-17 Johnson & Johnson Consumer Inc Nebulizador de aerosol aseptico.
US11376378B2 (en) * 2015-12-21 2022-07-05 Kindeva Drug Delivery, L.P. Flow governors for use in medicinal inhalers
US10905163B2 (en) 2016-03-31 2021-02-02 Altria Client Services Llc Aerosol-generating system with pump
RU2734463C2 (ru) * 2016-03-31 2020-10-16 Филип Моррис Продактс С.А. Генерирующая аэрозоль система с насосом
AU2017260444B2 (en) 2016-05-03 2019-05-09 Pneuma Respiratory, Inc. Droplet delivery device for delivery of fluids to the pulmonary system and methods of use
WO2017192773A1 (en) 2016-05-03 2017-11-09 Pneuma Respiratory, Inc. Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency
US11285285B2 (en) 2016-05-03 2022-03-29 Pneuma Respiratory, Inc. Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment
WO2017192774A1 (en) 2016-05-03 2017-11-09 Pneuma Respiratory, Inc. Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device
EP4591994A3 (en) 2016-05-03 2025-10-01 Pneuma Respiratory, Inc. A droplet delivery device for generating and delivering droplets to the pulmonary system
CN109496159A (zh) * 2016-07-28 2019-03-19 奇斯药制品公司 用于递送雾化药剂的方法和系统
CN107970505B (zh) * 2016-10-24 2020-11-03 田中枢 一种便携式胰岛素雾化给药装置
CN106620970A (zh) * 2016-10-30 2017-05-10 田中枢 一种便携式雾化给药装置
US10888454B2 (en) 2017-01-20 2021-01-12 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
US10668493B2 (en) 2017-03-16 2020-06-02 Boulind, Inc. Spray system with dynamically configurable droplet sizes
WO2018213834A1 (en) 2017-05-19 2018-11-22 Pneuma Respiratory, Inc. Dry powder delivery device and methods of use
KR102643190B1 (ko) 2017-06-10 2024-03-04 아이노비아 인코포레이티드 유체를 취급하기 위한, 그리고 눈에 유체를 전달하기 위한 디바이스들
US11281816B2 (en) 2020-07-21 2022-03-22 Fresh Health Inc. Systems and methods for manufacturing personalized oral care devices
US12279921B2 (en) 2017-06-30 2025-04-22 Fresh Health Inc. Cleaning device for teeth
AU2018291396B2 (en) 2017-06-30 2023-09-21 Fresh Health Inc. Systems and methods for personalized oral irrigation
TWI671125B (zh) * 2017-09-13 2019-09-11 心誠鎂行動醫電股份有限公司 霧化器
CN118203735A (zh) 2017-10-04 2024-06-18 精呼吸股份有限公司 电子呼吸致动式直线型液滴输送装置及其使用方法
EP4696353A2 (en) 2017-10-17 2026-02-18 Pneuma Respiratory, Inc. Nasal drug delivery apparatus
CN109674576B (zh) * 2017-10-19 2024-02-27 深圳市启明医药科技有限公司 流体供应单元及微液滴喷射驱动装置、发生装置
EP3706843B1 (en) 2017-11-08 2024-06-26 Pneuma Respiratory, Inc. Electronic breath actuated in-line droplet delivery device with small volume ampoule
US10342935B2 (en) 2017-11-21 2019-07-09 Caddo Medical Technologies Llc Internal nebulizer seal and method of use
AU2018380433B2 (en) 2017-12-08 2024-10-10 Bausch + Lomb Ireland Limited Fluid delivery alignment system
CN108080203B (zh) * 2018-02-01 2023-10-27 佛山市顺德区雅洛特电器有限公司 一种超声雾化精油器
US10881844B2 (en) * 2018-03-30 2021-01-05 L'oreal Systems for producing an aerosol and related methods of use
US20190314198A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical Ocular Delivery Methods and Devices for Use in the Same
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
US10258758B1 (en) 2018-04-20 2019-04-16 Caddo Medical Technologies Llc Flow controlled valve for a small-volume nebulizer
EP3806938B1 (de) * 2018-06-15 2023-12-20 Boehringer Ingelheim International GmbH System, kartusche und verfahren
JP7191559B2 (ja) 2018-06-29 2022-12-19 ロレアル 液体のミストを供給するためのデバイスおよびそれを含むアセンブリ
AU2019297326B2 (en) 2018-07-03 2025-01-09 Bausch + Lomb Ireland Limited Topical ocular delivery devices and methods for using the same
CN112534238B (zh) * 2018-07-04 2024-10-15 弗劳恩霍夫应用研究促进协会 测定气溶胶递送的装置和方法
US20200164163A1 (en) * 2018-11-26 2020-05-28 Hcmed Innovations Co., Ltd. Nebulizer and flow-guiding element thereof
CN109498951A (zh) * 2019-01-18 2019-03-22 山东大学齐鲁医院(青岛) 一种便于雾化给药的呼吸内科氧气面罩
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
WO2020191061A1 (en) * 2019-03-18 2020-09-24 Swimc Llc Paint dispensing method and apparatus involving a vibrating membrane
KR20260034073A (ko) 2019-04-15 2026-03-10 프레쉬 헬스 인코포레이티드 사용자의 구강을 세정하기 위한 시스템
JP7797201B2 (ja) * 2019-05-24 2026-01-13 スタムフォード・ディバイセズ・リミテッド 新生児cpap装置において臨床的および経済的に実現可能な吸入用量を送達するためのエアロゾルシステムおよびインターフェースの設計
JP7641272B2 (ja) * 2019-09-26 2025-03-06 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ねじれた遠位端要素を備えた吸入器物品
US12496218B1 (en) 2019-11-12 2025-12-16 Bausch + Lomb Ireland Limited Fractionated topical ocular drug delivery methods and devices for use in the same
CN115038414A (zh) 2019-12-11 2022-09-09 艾诺维亚股份有限公司 用于向眼睛输送流体的系统和装置及使用方法
WO2021212038A1 (en) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
BR112022020948A2 (pt) 2020-04-17 2023-04-11 Kedallion Therapeutics Inc Sistema de distribuição livre de conservantes hidrodinamicamente atuado
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) * 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
PL3915408T3 (pl) * 2020-05-27 2023-04-17 Joozef Urządzenie do wdychania substancji
AU2021300877A1 (en) * 2020-07-01 2023-03-02 Avid Business Pty Ltd (ACN: 083025003) Wearable personal protection device
EP4181989B1 (en) * 2020-07-14 2025-03-26 Stamford Devices Limited Aerosol administration apparatus
CN112138889B (zh) * 2020-08-05 2021-10-26 养生堂(安吉)化妆品有限公司 一种喷雾器及其维护方法
CN112058522B (zh) * 2020-08-05 2025-10-10 养生堂(安吉)化妆品有限公司 一种安全卫生的喷雾器
EP3993648B1 (en) * 2020-09-24 2025-11-05 KT & G Corporation Aerosol generating device
DE102021111630A1 (de) 2021-05-05 2022-11-10 Henke-Sass, Wolf Gmbh Vorrichtung zur tropfenweisen Abgabe eines Fluids
CN113304361B (zh) * 2021-06-07 2022-10-14 田中枢 一种精准胰岛素雾化给药及呼吸系统雾化给药装置
ES3040366T3 (en) 2021-06-22 2025-10-30 Pneuma Respiratory Inc Droplet delivery device with push ejection
EP4112094B1 (en) * 2021-07-01 2025-05-21 Fenwal, Inc. Optical device and method for measuring flow rate
US12420296B2 (en) * 2021-10-06 2025-09-23 Ford Motor Company Ultrasonic atomizer for applying a coating to a substrate with electrostatic charge to prevent droplet coalescence during atomization
CN117561093A (zh) 2022-02-21 2024-02-13 Ucs健康私人有限公司 用于提供非电雾化器的方法和系统
US12161795B2 (en) 2022-07-18 2024-12-10 Pneuma Respiratory, Inc. Small step size and high resolution aerosol generation system and method
CN115167268A (zh) * 2022-07-21 2022-10-11 河北煤炭科学研究院有限公司 基于物联网平台的自动注浆系统及方法
US20260007576A1 (en) * 2023-03-31 2026-01-08 Cf Pharmtech, Inc. Atomizer and method for conveying and atomizing fluid
IT202400003451A1 (it) * 2024-02-19 2025-08-19 Nutrintech Med Italia S R L Dispositivo per la vaporizzazione di una miscela liquida e metodo di funzionamento relativo.

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US318930A (en) 1885-05-26 Island
US2908479A (en) 1957-11-04 1959-10-13 Cornell Valve Corp Aerosol valve
DE1575050A1 (de) * 1966-01-12 1972-04-13 Misto Gen Equipment Co Ultraschall-Nebelerzeugungsgeraet
US3561444A (en) * 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3612049A (en) * 1969-05-05 1971-10-12 Veldon A Monson Personal humidifier
FR2299011A1 (fr) * 1975-01-29 1976-08-27 Obert Jean Claude Generateur d'aerosols de part
GB1561835A (en) 1976-02-11 1980-03-05 Allen & Hanburys Ltd Devices for dispensing medicamtens
US4106503A (en) * 1977-03-11 1978-08-15 Richard R. Rosenthal Metering system for stimulating bronchial spasm
US4167245A (en) 1977-08-01 1979-09-11 The Procter & Gamble Company Spray dispensing
JPS5848225B2 (ja) * 1979-01-09 1983-10-27 オムロン株式会社 超音波液体霧化装置の霧化量制御方式
US4286636A (en) 1979-07-19 1981-09-01 The Coca-Cola Company Dip tube and valve with quick-disconnect coupling for a collapsible container
JPS6168159A (ja) 1984-09-10 1986-04-08 Omron Tateisi Electronics Co 超音波霧化器
US4647013A (en) * 1985-02-21 1987-03-03 Ford Motor Company Silicon valve
US4756347A (en) 1985-11-19 1988-07-12 Jopado Baderi Filling and dispensing valve, adapter and package
GB8614805D0 (en) * 1986-06-18 1986-07-23 British American Tobacco Co Aerosol device
DE3627222A1 (de) * 1986-08-11 1988-02-18 Siemens Ag Ultraschall-taschenzerstaeubergeraet
FI82808C (fi) * 1987-12-31 1991-04-25 Etelae Haemeen Keuhkovammayhdi Ultraljudfinfoerdelningsanordning.
FR2648701B1 (fr) 1989-06-22 1995-10-20 Rhone Merieux Installation portative de vaccination aviaire
US5152456A (en) * 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
FR2667509B1 (fr) * 1990-10-04 1995-08-25 Valois Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes.
EP0516565B1 (en) * 1991-05-27 1996-04-24 TDK Corporation An ultrasonic wave nebulizer
JP2536006Y2 (ja) * 1991-11-16 1997-05-21 ティーディーケイ株式会社 超音波霧化器
JPH0544257A (ja) 1991-08-13 1993-02-23 Fujita Corp プレキヤストコンクリート柱のセツト方法
US5186057A (en) * 1991-10-21 1993-02-16 Everhart Howard R Multi-beam liquid-drop size/rate detector apparatus
GB2265845B (en) * 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
JP2546439B2 (ja) * 1992-04-09 1996-10-23 オムロン株式会社 超音波霧化装置,超音波式吸入器およびその制御方法
US5215079A (en) * 1992-05-19 1993-06-01 Armstrong Pharmaceuticals, Inc. Single dose metered dose inhaler for delivery of vaccines and other drugs
US5569189A (en) * 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
WO1994007554A1 (en) * 1992-09-28 1994-04-14 Equidyne Systems, Incorporated Hypodermic jet injector
GB2272389B (en) 1992-11-04 1996-07-24 Bespak Plc Dispensing apparatus
DE4300880C2 (de) * 1993-01-15 1996-03-21 Draegerwerk Ag Ultraschallvernebler mit Dosiereinheit
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5891086A (en) * 1993-07-31 1999-04-06 Weston Medical Limited Needle-less injector
CH686872A5 (de) 1993-08-09 1996-07-31 Disetronic Ag Medizinisches Inhalationsgeraet.
JP2790014B2 (ja) 1993-09-16 1998-08-27 オムロン株式会社 超音波式吸入器用メッシュ部材及びその製造方法
JP2809976B2 (ja) 1993-10-04 1998-10-15 株式会社カイゲン 散粉器及び散粉器に接続する散粉用ノズル
GB9324250D0 (en) * 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
FR2718357B1 (fr) * 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
JPH08196965A (ja) 1995-01-31 1996-08-06 Omron Corp 超音波霧化器
IT1277832B1 (it) * 1995-03-02 1997-11-12 Giuseppina Magni Confezione per sostanze nebulizzabili
ZA962077B (en) * 1995-03-14 1997-03-26 Siemens Ag Ultrasonic atomizer device with removable precision dosating unit
IL117474A (en) 1995-03-14 2001-04-30 Siemens Ag Removable precise dosing unit containing inhaled drugs for a hearing aid device
US5758637A (en) * 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US5826571A (en) * 1995-06-08 1998-10-27 Innovative Devices, Llc Device for use with metered dose inhalers (MDIS)
US5921232A (en) * 1995-07-12 1999-07-13 A & D Company Limited Handy type inhaler
IT1277427B1 (it) * 1995-08-03 1997-11-10 Miat Spa Apparecchio aerosol ad ultrasuoni
US5996903A (en) * 1995-08-07 1999-12-07 Omron Corporation Atomizer and atomizing method utilizing surface acoustic wave
US5848587A (en) * 1995-09-21 1998-12-15 Medi-Nuclear Corporation, Inc. Aerosol medication delivery system
ATE247948T1 (de) * 1996-04-29 2003-09-15 Dura Pharma Inc Verfahren zum inhalieren trockener pulver
ES2294819T3 (es) * 1997-10-06 2008-04-01 Omron Healthcare Co., Ltd. Atomizador.
DE69834210T2 (de) * 1997-11-19 2007-01-04 Microflow Engineering S.A. Sprühvorrichtung für einen Inhalator
US6158431A (en) * 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US6026807A (en) 1998-02-27 2000-02-22 Diemolding Corporation Metered dose inhaler cloud chamber
US6125844A (en) 1998-04-30 2000-10-03 Westwood Biomedical Portable oxygen based drug delivery system
US6745763B2 (en) 1998-10-27 2004-06-08 Garth T. Webb Vaporizing device for administering sterile medication
ES2149748T3 (es) * 1998-12-01 2007-06-16 Microflow Engineering Sa Inhalador con nebulizador de ondas ultrasonicas que presenta unas aberturas de boquilla superpuestas sobre las crestas de un patron de onda estacionaria.
JP2000233158A (ja) 1999-02-12 2000-08-29 Omron Corp 噴霧装置
US6196218B1 (en) * 1999-02-24 2001-03-06 Ponwell Enterprises Ltd Piezo inhaler
IL129208A0 (en) * 1999-03-28 2000-02-17 Liposol Ltd A method and apparatus for nebulizing a liquid particulary useful for the aerosol delivery of biopharmaceuticals
JP4198850B2 (ja) 1999-11-29 2008-12-17 オムロンヘルスケア株式会社 液体噴霧装置
JP2001149833A (ja) 1999-11-25 2001-06-05 Omron Corp 噴霧装置
JP2001149473A (ja) 1999-11-29 2001-06-05 Omron Corp 噴霧装置
US6539937B1 (en) 2000-04-12 2003-04-01 Instrumentarium Corp. Method of maximizing the mechanical displacement of a piezoelectric nebulizer apparatus
US6780220B2 (en) * 2000-05-04 2004-08-24 3M Innovative Properties Company Method for generating pollution credits while processing reactive metals
US6948491B2 (en) * 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US20020020408A1 (en) * 2000-05-25 2002-02-21 Invivotech, Inc. Inhalation medicament delivery device
US6363932B1 (en) 2000-07-06 2002-04-02 Clinical Technologies, Inc. Aerosol enhancement device
DE10040528A1 (de) * 2000-08-18 2002-02-28 Pari Gmbh Inhalationsvorrichtung und Verfahren zur Erzeugung eines Partikelnebels für Inhalationszwecke
US6769626B1 (en) * 2000-10-30 2004-08-03 Instrumentarium Corp. Device and method for detecting and controlling liquid supply to an apparatus discharging liquids
DE10053913A1 (de) 2000-10-31 2002-05-08 Inst Aerosol Medizin Inamed Gm Verfahren und Apparatur zur Optimierung einer Dosisabscheidung bei einer inhalatorischen Medikamentenapplikation
GB0029612D0 (en) 2000-12-05 2001-01-17 Bacon Raymond J Drug dispenser
AU2002336246B8 (en) 2001-03-15 2006-02-02 Creare Incorporated Nebulizer having cooling chamber
US6550472B2 (en) * 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US7677467B2 (en) * 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US6851626B2 (en) * 2002-01-07 2005-02-08 Aerogen, Inc. Methods and devices for nebulizing fluids
US20050205089A1 (en) * 2002-01-07 2005-09-22 Aerogen, Inc. Methods and devices for aerosolizing medicament
JP4761709B2 (ja) * 2002-01-15 2011-08-31 エアロジェン,インコーポレイテッド エアロゾル発生器を作動するための方法およびシステム
US20030205226A1 (en) * 2002-05-02 2003-11-06 Pre Holding, Inc. Aerosol medication inhalation system
CN2564174Y (zh) * 2002-08-06 2003-08-06 王雷 超声波雾化吸入治疗仪
US7849853B2 (en) * 2003-02-11 2010-12-14 Trudell Medical International Ventilator circuit and the method for the use thereof
US8616195B2 (en) * 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication

Also Published As

Publication number Publication date
US20110203580A1 (en) 2011-08-25
JP2011087959A (ja) 2011-05-06
EP2258428B1 (en) 2019-11-27
US8656908B2 (en) 2014-02-25
ATE483488T1 (de) 2010-10-15
JP4786642B2 (ja) 2011-10-05
US7954486B2 (en) 2011-06-07
CN101693132B (zh) 2013-05-22
MXPA06011426A (es) 2007-04-20
WO2006006963A2 (en) 2006-01-19
CA2561845A1 (en) 2006-01-19
US20090223513A1 (en) 2009-09-10
EP1737517B1 (en) 2010-10-06
DE602005023969D1 (de) 2010-11-18
EP2258428A1 (en) 2010-12-08
AU2010226896B2 (en) 2011-10-06
HK1099719A1 (zh) 2007-08-24
CN101693132A (zh) 2010-04-14
AU2010226896A1 (en) 2010-10-21
WO2006006963A3 (en) 2006-06-01
JP5351880B2 (ja) 2013-11-27
IN2014DN01746A (enExample) 2015-07-10
AU2005262940B2 (en) 2010-07-01
CN100566770C (zh) 2009-12-09
EP1737517A2 (en) 2007-01-03
JP2007531577A (ja) 2007-11-08
AU2005262940A1 (en) 2006-01-19
CN1960777A (zh) 2007-05-09

Similar Documents

Publication Publication Date Title
CA2561845C (en) Aerosol delivery systems and methods
US20090301472A1 (en) Aerosol delivery systems and methods
AU2002336246B2 (en) Nebulizer having cooling chamber
US20200206441A1 (en) Nasal aerosol delivery system
EP1278569B1 (en) Apparatus for the delivery of medicaments to the respiratory system
JP2011087959A5 (enExample)
AU2002336246A1 (en) Nebulizer having cooling chamber
JP4469972B2 (ja) 呼吸器系への薬剤の送給のための装置及び方法
HK1143096A (zh) 氣霧化輸送系統和方法
HK1099719B (en) Aerosol delivery systems and methods
US20250339628A1 (en) Methods and systems for delivering formulations to users using modular device having removable cartridge

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210401