CA2560753C - Procede et appareil pour la fragmentation d'ions par capture d'electrons - Google Patents

Procede et appareil pour la fragmentation d'ions par capture d'electrons Download PDF

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Publication number
CA2560753C
CA2560753C CA2560753A CA2560753A CA2560753C CA 2560753 C CA2560753 C CA 2560753C CA 2560753 A CA2560753 A CA 2560753A CA 2560753 A CA2560753 A CA 2560753A CA 2560753 C CA2560753 C CA 2560753C
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CA
Canada
Prior art keywords
ions
ion
fragmentation chamber
fragmentation
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2560753A
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English (en)
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CA2560753A1 (fr
Inventor
Alexander Alekseevich Makarov
Eduard V. Denisov
Gerhard Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Finnigan LLC
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Thermo Finnigan LLC
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Publication date
Application filed by Thermo Finnigan LLC filed Critical Thermo Finnigan LLC
Publication of CA2560753A1 publication Critical patent/CA2560753A1/fr
Application granted granted Critical
Publication of CA2560753C publication Critical patent/CA2560753C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0054—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by an electron beam, e.g. electron impact dissociation, electron capture dissociation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

La présente invention a trait à un procédé et un appareil pour la fragmentation d'ions par capture d'électrons. La présente invention a trait à un procédé de génération d'ions fragmentaires par capture d'électrons, comprenant : l'acheminement des ions à fragmenter dans une enceinte d'un dispositif de spectrométrie de masse; le piégeage d'au moins certains des ions à fragmenter dans au moins une direction de l'enceinte de fragmentation au moyen d'un champ magnétique, les ions étant piégés au sein d'un volume V ; la génération d'un faisceau d'électrons au moyen d'une source d'électrons située à distance du volume V; l'irradiation des ions piégés dans le volume V avec les électrons générés par la source d'électrons en présence dudit champ magnétique, en vue de provoquer la séparation; et l'éjection des ions fragmentaires obtenus depuis l'enceinte de fragmentation pour une analyse ultérieure à un site différent éloigné de l'enceinte de fragmentation.
CA2560753A 2004-03-30 2005-03-29 Procede et appareil pour la fragmentation d'ions par capture d'electrons Expired - Fee Related CA2560753C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0407152.8 2004-03-30
GB0407152A GB2414855A (en) 2004-03-30 2004-03-30 Ion fragmentation by electron capture
PCT/GB2005/001198 WO2005096342A2 (fr) 2004-03-30 2005-03-29 Procede et appareil pour la fragmentation d'ions par capture d'electrons

Publications (2)

Publication Number Publication Date
CA2560753A1 CA2560753A1 (fr) 2005-10-13
CA2560753C true CA2560753C (fr) 2013-08-06

Family

ID=32247517

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2560753A Expired - Fee Related CA2560753C (fr) 2004-03-30 2005-03-29 Procede et appareil pour la fragmentation d'ions par capture d'electrons

Country Status (5)

Country Link
US (1) US7612335B2 (fr)
CA (1) CA2560753C (fr)
DE (1) DE112005000720B4 (fr)
GB (2) GB2414855A (fr)
WO (1) WO2005096342A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919562B1 (en) * 2002-05-31 2005-07-19 Analytica Of Branford, Inc. Fragmentation methods for mass spectrometry
JP4806214B2 (ja) * 2005-01-28 2011-11-02 株式会社日立ハイテクノロジーズ 電子捕獲解離反応装置
US7449687B2 (en) 2005-06-13 2008-11-11 Agilent Technologies, Inc. Methods and compositions for combining ions and charged particles
JP4996962B2 (ja) * 2007-04-04 2012-08-08 株式会社日立ハイテクノロジーズ 質量分析装置
JP4957805B2 (ja) * 2007-09-18 2012-06-20 株式会社島津製作所 Ｍｓ／ｍｓ型質量分析装置
US20090194679A1 (en) * 2008-01-31 2009-08-06 Agilent Technologies, Inc. Methods and apparatus for reducing noise in mass spectrometry
WO2009155082A1 (fr) * 2008-05-30 2009-12-23 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Cellule électrostatique/magnétostatique hybride sans radiofréquence pour transporter, piéger et dissocier des ions dans des spectromètres de masse
CN103367094B (zh) * 2012-03-31 2016-12-14 株式会社岛津制作所 离子阱分析器以及离子阱质谱分析方法
WO2014028695A1 (fr) 2012-08-16 2014-02-20 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Source d'électrons destinée à une cellule de dissociation à induction électronique électromagnétostatique dépourvue de rf et utilisation dans un spectromètre de masse en tandem
US9588047B2 (en) * 2015-04-14 2017-03-07 Honeywell International Inc. Multi-cell apparatus and method for single ion addressing
US9715950B2 (en) * 2015-04-14 2017-07-25 Honeywell International Inc. Single cell apparatus and method for single ion addressing
JP6835210B2 (ja) * 2017-04-10 2021-02-24 株式会社島津製作所 イオン分析装置及びイオン解離方法
US11217437B2 (en) * 2018-03-16 2022-01-04 Agilent Technologies, Inc. Electron capture dissociation (ECD) utilizing electron beam generated low energy electrons
EP3864685A1 (fr) * 2018-10-09 2021-08-18 DH Technologies Development Pte. Ltd. Guide d'ions rf à transmission améliorée d'électrons
US20210175063A1 (en) 2019-12-10 2021-06-10 Thermo Finnigan Llc Axial ci source - off-axis electron beam

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905258A (en) * 1997-06-02 1999-05-18 Advanced Research & Techology Institute Hybrid ion mobility and mass spectrometer
DE10058706C1 (de) 2000-11-25 2002-02-28 Bruker Daltonik Gmbh Ionenfragmentierung durch Elektroneneinfang in Hochfrequenz-Ionenfallen
US20020092980A1 (en) * 2001-01-18 2002-07-18 Park Melvin A. Method and apparatus for a multipole ion trap orthogonal time-of-flight mass spectrometer
ATE321356T1 (de) * 2001-03-22 2006-04-15 Univ Syddansk Massenspektrometrisches verfahren mit elektroneneinfang durch ionen und massenspektrometer zum durchführen des verfahrens
GB2404784B (en) 2001-03-23 2005-06-22 Thermo Finnigan Llc Mass spectrometry method and apparatus
US20030104483A1 (en) 2001-11-30 2003-06-05 Boehringer Ingelheim Pharmaceuticals, Inc. Liquid chromatography/fourier-transform mass spectrometry/electron capture dissociation for the analysis of proteins
DE10213652B4 (de) 2002-03-27 2008-02-21 Bruker Daltonik Gmbh Verfahren zur Bestrahlung von Ionen in einer Ionenzyklotronresonanz-Falle mit Elektronen und/oder Photonen
CA2643534C (fr) * 2002-05-31 2011-08-02 Analytica Of Branford, Inc. Procedes de fragmentation pour spectrometrie de masse
US6770871B1 (en) * 2002-05-31 2004-08-03 Michrom Bioresources, Inc. Two-dimensional tandem mass spectrometry
US6891157B2 (en) * 2002-05-31 2005-05-10 Micromass Uk Limited Mass spectrometer
WO2003103007A1 (fr) * 2002-06-03 2003-12-11 The State Of Oregon Acting By And Through The State Board Of Higher Education Onbehalf Of Oregonof Oregon State University Spectrometre de masse
US7227133B2 (en) * 2003-06-03 2007-06-05 The University Of North Carolina At Chapel Hill Methods and apparatus for electron or positron capture dissociation

Also Published As

Publication number Publication date
DE112005000720B4 (de) 2013-11-28
CA2560753A1 (fr) 2005-10-13
GB2414855A (en) 2005-12-07
GB0618953D0 (en) 2006-11-08
US20070138386A1 (en) 2007-06-21
GB2427069B (en) 2007-09-26
DE112005000720T5 (de) 2008-07-03
GB2427069A (en) 2006-12-13
US7612335B2 (en) 2009-11-03
WO2005096342A2 (fr) 2005-10-13
GB0407152D0 (en) 2004-05-05
WO2005096342A3 (fr) 2006-08-10

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MKLA Lapsed

Effective date: 20220301

MKLA Lapsed

Effective date: 20200831