CA2554466C - Sucres polymeres ramifies et leurs nucleotides - Google Patents
Sucres polymeres ramifies et leurs nucleotides Download PDFInfo
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- CA2554466C CA2554466C CA2554466A CA2554466A CA2554466C CA 2554466 C CA2554466 C CA 2554466C CA 2554466 A CA2554466 A CA 2554466A CA 2554466 A CA2554466 A CA 2554466A CA 2554466 C CA2554466 C CA 2554466C
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- Prior art keywords
- moiety
- sugar
- peg
- poly
- polymeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000000346 sugar Nutrition 0.000 title claims abstract description 209
- 239000002773 nucleotide Substances 0.000 title claims abstract description 74
- 125000003729 nucleotide group Chemical group 0.000 title claims description 60
- 150000008163 sugars Chemical class 0.000 title abstract description 36
- 150000001875 compounds Chemical class 0.000 claims description 47
- 125000000217 alkyl group Chemical group 0.000 claims description 38
- 239000000758 substrate Substances 0.000 claims description 38
- 102000004190 Enzymes Human genes 0.000 claims description 34
- 108090000790 Enzymes Proteins 0.000 claims description 34
- 125000003147 glycosyl group Chemical group 0.000 claims description 25
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 24
- 238000012546 transfer Methods 0.000 claims description 16
- 239000002777 nucleoside Substances 0.000 claims description 15
- 125000003835 nucleoside group Chemical group 0.000 claims description 10
- 230000003213 activating effect Effects 0.000 claims description 9
- 125000000539 amino acid group Chemical group 0.000 claims description 6
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- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 4
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- 125000001424 substituent group Chemical group 0.000 description 27
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 26
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- 125000003118 aryl group Chemical group 0.000 description 21
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 20
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
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Abstract
La présente invention concerne des sucres, des sucres nucléotidiques, des sucres activés contenant une ou plusieurs fractions polymères de modification dans leur structure. L'invention est illustrée dans un exemple par référence à des polymères linéaires et ramifiés tels que le polyéthylèneglycol polymère hydrosoluble.
Applications Claiming Priority (37)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53938704P | 2004-01-26 | 2004-01-26 | |
| US60/539,387 | 2004-01-26 | ||
| US54441104P | 2004-02-12 | 2004-02-12 | |
| US60/544,411 | 2004-02-12 | ||
| US54663104P | 2004-02-20 | 2004-02-20 | |
| US60/546,631 | 2004-02-20 | ||
| US55550404P | 2004-03-22 | 2004-03-22 | |
| US60/555,504 | 2004-03-22 | ||
| US57089104P | 2004-05-12 | 2004-05-12 | |
| US60/570,891 | 2004-05-12 | ||
| US59057304P | 2004-07-23 | 2004-07-23 | |
| US59064904P | 2004-07-23 | 2004-07-23 | |
| US60/590,573 | 2004-07-23 | ||
| US60/590,649 | 2004-07-23 | ||
| US59274404P | 2004-07-29 | 2004-07-29 | |
| US60/592,744 | 2004-07-29 | ||
| US61179004P | 2004-09-20 | 2004-09-20 | |
| US60/611,790 | 2004-09-20 | ||
| US61451804P | 2004-09-29 | 2004-09-29 | |
| US60/614,518 | 2004-09-29 | ||
| US62338704P | 2004-10-29 | 2004-10-29 | |
| US60/623,387 | 2004-10-29 | ||
| US62667804P | 2004-11-09 | 2004-11-09 | |
| US60/626,678 | 2004-11-09 | ||
| PCT/US2004/039712 WO2005051327A2 (fr) | 2003-11-24 | 2004-11-24 | Erythropoietine glycopegylee |
| US10/997,405 US7405198B2 (en) | 2003-11-24 | 2004-11-24 | Glycopegylated erythropoietin |
| USPCT/US04/039712 | 2004-11-24 | ||
| US10/997,405 | 2004-11-24 | ||
| PCT/US2004/040709 WO2005056760A2 (fr) | 2003-12-03 | 2004-12-03 | Hormone stimulant le follicule humain glycopegyle |
| USPCT/US04/40709 | 2004-12-03 | ||
| US64195605P | 2005-01-06 | 2005-01-06 | |
| US60/641,956 | 2005-01-06 | ||
| US64343705P | 2005-01-10 | 2005-01-10 | |
| USPCT/US05/00799 | 2005-01-10 | ||
| US60/643,437 | 2005-01-10 | ||
| PCT/US2005/000799 WO2005070138A2 (fr) | 2004-01-08 | 2005-01-10 | Glycosylation de peptides liee a o |
| PCT/US2005/002522 WO2005072371A2 (fr) | 2004-01-26 | 2005-01-26 | Sucres polymeres ramifies et leurs nucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2554466A1 CA2554466A1 (fr) | 2005-08-11 |
| CA2554466C true CA2554466C (fr) | 2014-08-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2554466A Expired - Fee Related CA2554466C (fr) | 2004-01-26 | 2005-01-26 | Sucres polymeres ramifies et leurs nucleotides |
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|---|---|
| JP (1) | JP4871739B2 (fr) |
| CA (1) | CA2554466C (fr) |
| ES (1) | ES2433867T3 (fr) |
| IL (1) | IL176773A (fr) |
| NZ (1) | NZ548308A (fr) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002044196A1 (fr) * | 2000-11-28 | 2002-06-06 | University Of Massachusetts | Methodes et reactifs pour l'introduction d'un groupe sulfhydryle dans l'extremite 5' de l'arn |
| EP2292271A3 (fr) * | 2001-10-10 | 2011-09-14 | BioGeneriX AG | Remodelage et glycoconjugation des anticorps |
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2005
- 2005-01-26 JP JP2006551450A patent/JP4871739B2/ja not_active Expired - Fee Related
- 2005-01-26 CA CA2554466A patent/CA2554466C/fr not_active Expired - Fee Related
- 2005-01-26 NZ NZ548308A patent/NZ548308A/en not_active IP Right Cessation
- 2005-01-26 ES ES05722567T patent/ES2433867T3/es active Active
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2006
- 2006-07-10 IL IL176773A patent/IL176773A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL176773A (en) | 2012-04-30 |
| IL176773A0 (en) | 2006-10-31 |
| ES2433867T3 (es) | 2013-12-12 |
| NZ548308A (en) | 2010-11-26 |
| JP2007528370A (ja) | 2007-10-11 |
| CA2554466A1 (fr) | 2005-08-11 |
| JP4871739B2 (ja) | 2012-02-08 |
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