CA2553649A1 - Compounds for the sustained reduction of body weight - Google Patents
Compounds for the sustained reduction of body weight Download PDFInfo
- Publication number
- CA2553649A1 CA2553649A1 CA002553649A CA2553649A CA2553649A1 CA 2553649 A1 CA2553649 A1 CA 2553649A1 CA 002553649 A CA002553649 A CA 002553649A CA 2553649 A CA2553649 A CA 2553649A CA 2553649 A1 CA2553649 A1 CA 2553649A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000037396 body weight Effects 0.000 title claims abstract description 19
- 230000009467 reduction Effects 0.000 title claims abstract description 16
- 230000002459 sustained effect Effects 0.000 title claims abstract description 13
- 150000001875 compounds Chemical class 0.000 title claims description 27
- 230000001561 neurotransmitter reuptake Effects 0.000 claims abstract description 30
- 239000003112 inhibitor Substances 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical group C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 claims abstract description 25
- 239000012453 solvate Substances 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 53
- 125000003342 alkenyl group Chemical group 0.000 claims description 38
- 125000000304 alkynyl group Chemical group 0.000 claims description 38
- 125000001072 heteroaryl group Chemical group 0.000 claims description 31
- 125000003545 alkoxy group Chemical group 0.000 claims description 30
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 30
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
- 125000001424 substituent group Chemical group 0.000 claims description 30
- 229910052736 halogen Inorganic materials 0.000 claims description 29
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 6
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 6
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 6
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 6
- XBBDACCLCFWBSI-ZETCQYMHSA-N melevodopa Chemical compound COC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 XBBDACCLCFWBSI-ZETCQYMHSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 125000001544 thienyl group Chemical group 0.000 claims description 5
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 4
- JKPISQIIWUONPB-HNNXBMFYSA-N (-)-stepholidine Chemical compound C1CN2CC(C(=C(O)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(O)=C2 JKPISQIIWUONPB-HNNXBMFYSA-N 0.000 claims description 4
- XBGWTWPYCTZIIE-HXUWFJFHSA-N 4-phenyl-1-[[(1r)-3-phenylcyclohex-3-en-1-yl]methyl]-3,6-dihydro-2h-pyridine Chemical compound C([C@H](C1)CN2CC=C(CC2)C=2C=CC=CC=2)CC=C1C1=CC=CC=C1 XBGWTWPYCTZIIE-HXUWFJFHSA-N 0.000 claims description 4
- 229960001794 melevodopa Drugs 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 230000003442 weekly effect Effects 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 3
- 229940127470 Lipase Inhibitors Drugs 0.000 claims description 3
- 150000001204 N-oxides Chemical class 0.000 claims description 3
- 239000000150 Sympathomimetic Substances 0.000 claims description 3
- 239000000556 agonist Substances 0.000 claims description 3
- 230000001539 anorectic effect Effects 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 206010061428 decreased appetite Diseases 0.000 claims description 3
- 229960003638 dopamine Drugs 0.000 claims description 3
- 230000001975 sympathomimetic effect Effects 0.000 claims description 3
- 229940064707 sympathomimetics Drugs 0.000 claims description 3
- GELJVTSEGKGLDF-QDSMGTAFSA-N (2s)-2-[(benzylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[2,3-e]indol-8-one;(e)-but-2-enedioic acid Chemical compound OC(=O)\C=C\C(O)=O.C([C@H]1COC=2C=CC3=C(C=2O1)CC(N3)=O)NCC1=CC=CC=C1 GELJVTSEGKGLDF-QDSMGTAFSA-N 0.000 claims description 2
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 claims description 2
- NHCWZEQEFHNLBQ-PPHPATTJSA-N (4s)-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol;hydrochloride Chemical compound Cl.C1=C(O)C(O)=CC=C1[C@H]1C2=CC=C(O)C(O)=C2CNC1 NHCWZEQEFHNLBQ-PPHPATTJSA-N 0.000 claims description 2
- MNIXOHSBCFNRSH-UQGUCNKVSA-N (6ar,9r,10ar)-7-methyl-9-(1,2,4-triazol-1-ylmethyl)-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline;(z)-but-2-enedioic acid Chemical compound OC(=O)\C=C/C(O)=O.C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C)N1C=NC=N1 MNIXOHSBCFNRSH-UQGUCNKVSA-N 0.000 claims description 2
- BGOQGUHWXBGXJW-YOEHRIQHSA-N (6as,12br)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol Chemical compound N1CC2=CC=CC=C2[C@@H]2[C@@H]1CCC1=C2C=C(O)C(O)=C1 BGOQGUHWXBGXJW-YOEHRIQHSA-N 0.000 claims description 2
- LTRSPDHUDXWHRY-LURJTMIESA-N (8s)-8-methyl-6,9-diazaspiro[4.5]decane-7,10-dione Chemical compound N1C(=O)[C@H](C)NC(=O)C11CCCC1 LTRSPDHUDXWHRY-LURJTMIESA-N 0.000 claims description 2
- SNPPWIUOZRMYNY-SECBINFHSA-N (R)-bupropion Chemical compound CC(C)(C)N[C@H](C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-SECBINFHSA-N 0.000 claims description 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 2
- HTSNFXAICLXZMA-CYBMUJFWSA-N 3-[(3s)-1-propylpiperidin-3-yl]phenol Chemical compound C1N(CCC)CCC[C@H]1C1=CC=CC(O)=C1 HTSNFXAICLXZMA-CYBMUJFWSA-N 0.000 claims description 2
- JTYVLKBMXTUORS-UHFFFAOYSA-N 6-(dipropylamino)-3,4,5,6,7,8-hexahydro-2h-naphthalen-1-one Chemical compound C1C(N(CCC)CCC)CCC2=C1CCCC2=O JTYVLKBMXTUORS-UHFFFAOYSA-N 0.000 claims description 2
- ZNHLCGFCYLKGOA-UHFFFAOYSA-N 6-n,6-n-dipropyl-6,7-dihydro-5h-cyclopenta[f][1,3]benzothiazole-2,6-diamine;dihydrochloride Chemical compound Cl.Cl.C1=C2CC(N(CCC)CCC)CC2=CC2=C1SC(N)=N2 ZNHLCGFCYLKGOA-UHFFFAOYSA-N 0.000 claims description 2
- DHSSDEDRBUKTQY-UHFFFAOYSA-N 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine Chemical compound C1CN(CC=C)CCC2=C1N=C(N)S2 DHSSDEDRBUKTQY-UHFFFAOYSA-N 0.000 claims description 2
- NQRIKTDKFHAOKC-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3h-1,3-benzoxazol-2-one;hydrochloride Chemical compound Cl.C1CN(C)CCN1C1=CC=CC2=C1OC(=O)N2 NQRIKTDKFHAOKC-UHFFFAOYSA-N 0.000 claims description 2
- RRLWEQBPSAFVAS-UHFFFAOYSA-N 7-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy]-1h-quinolin-2-one Chemical compound CC1=CC=CC(N2CCN(CCCOC=3C=C4NC(=O)C=CC4=CC=3)CC2)=C1C RRLWEQBPSAFVAS-UHFFFAOYSA-N 0.000 claims description 2
- XKTGLDSNABUNGD-UHFFFAOYSA-N 9-bromo-5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol Chemical compound C1NCCC=2C(Br)=C(O)C(O)=CC=2C1C1=CC=CC=C1 XKTGLDSNABUNGD-UHFFFAOYSA-N 0.000 claims description 2
- GHWJEDJMOVUXEC-UHFFFAOYSA-N 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Chemical compound C1NCCC=2C(Cl)=C(O)C(O)=CC=2C1C1=CC=CC=C1 GHWJEDJMOVUXEC-UHFFFAOYSA-N 0.000 claims description 2
- HJWHHQIVUHOBQN-UHFFFAOYSA-N 9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol Chemical compound C1N(CC=C)CCC=2C(Cl)=C(O)C(O)=CC=2C1C1=CC=CC=C1 HJWHHQIVUHOBQN-UHFFFAOYSA-N 0.000 claims description 2
- TWUJBHBRYYTEDL-UHFFFAOYSA-N Alentemol Chemical compound OC1=CC(CC(N(CCC)CCC)C2)=C3C2=CC=CC3=C1 TWUJBHBRYYTEDL-UHFFFAOYSA-N 0.000 claims description 2
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims description 2
- CYGODHVAJQTCBG-UHFFFAOYSA-N Bifeprunox Chemical compound C=12OC(=O)NC2=CC=CC=1N(CC1)CCN1CC(C=1)=CC=CC=1C1=CC=CC=C1 CYGODHVAJQTCBG-UHFFFAOYSA-N 0.000 claims description 2
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 claims description 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 2
- 201000007114 MHC class I deficiency Diseases 0.000 claims description 2
- MNHDKMDLOJSCGN-UHFFFAOYSA-N N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide Chemical compound COC1=CC=CC=C1N1CCN(CCCCNC(=O)C=2C=C3C=CC=CC3=CC=2)CC1 MNHDKMDLOJSCGN-UHFFFAOYSA-N 0.000 claims description 2
- QBUVZVXIRYFENV-UHFFFAOYSA-N N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol Chemical compound C1=2C=C(O)C(O)=CC=2CCN(CC=C)CC1C1=CC=CC=C1 QBUVZVXIRYFENV-UHFFFAOYSA-N 0.000 claims description 2
- FHYWNBUFNGHNCP-UHFFFAOYSA-N N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide Chemical compound Br.C1N(C)CCC(C(=C(O)C(O)=C2)Cl)=C2C1C1=CC=CC(C)=C1 FHYWNBUFNGHNCP-UHFFFAOYSA-N 0.000 claims description 2
- JOAHPSVPXZTVEP-YXJHDRRASA-N Terguride Chemical compound C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)NC(=O)N(CC)CC)=C3C2=CNC3=C1 JOAHPSVPXZTVEP-YXJHDRRASA-N 0.000 claims description 2
- HGMLOQOHAYKVJN-UHFFFAOYSA-N [4-[4-(1h-benzimidazol-2-ylmethyl)piperazin-1-yl]-2-chlorophenyl]methanol Chemical compound C1=C(Cl)C(CO)=CC=C1N1CCN(CC=2NC3=CC=CC=C3N=2)CC1 HGMLOQOHAYKVJN-UHFFFAOYSA-N 0.000 claims description 2
- OMMYLOLVPCCZQZ-UHFFFAOYSA-N [6-(methylamino)-1-(2-methylpropanoyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl] 2-methylpropanoate Chemical compound C1=CC(OC(=O)C(C)C)=C(OC(=O)C(C)C)C2=C1CC(NC)CC2 OMMYLOLVPCCZQZ-UHFFFAOYSA-N 0.000 claims description 2
- KTEBZVJGMARTOQ-GCJKJVERSA-N adrogolide Chemical compound CC(=O)OC1=C(OC(C)=O)C=C2[C@H]3C(C=C(S4)CCC)=C4CN[C@@H]3CCC2=C1 KTEBZVJGMARTOQ-GCJKJVERSA-N 0.000 claims description 2
- 229950007871 adrogolide Drugs 0.000 claims description 2
- 229950007263 alentemol Drugs 0.000 claims description 2
- 229960004046 apomorphine Drugs 0.000 claims description 2
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims description 2
- 229960004372 aripiprazole Drugs 0.000 claims description 2
- 229960002802 bromocriptine Drugs 0.000 claims description 2
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 2
- 229960001058 bupropion Drugs 0.000 claims description 2
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 2
- 229960004596 cabergoline Drugs 0.000 claims description 2
- REHAKLRYABHSQJ-KDOFPFPSSA-N chembl28338 Chemical compound OC1=C(O)C=C2[C@H]3C(C=C(S4)CCC)=C4CN[C@@H]3CCC2=C1 REHAKLRYABHSQJ-KDOFPFPSSA-N 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 108010040486 cyclo(alanine-(1-amino-1-cyclopentane)carbonyl) Proteins 0.000 claims description 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 2
- 229960002179 ephedrine Drugs 0.000 claims description 2
- NULMGOSOSZBEQL-QMMMGPOBSA-N etilevodopa Chemical compound CCOC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 NULMGOSOSZBEQL-QMMMGPOBSA-N 0.000 claims description 2
- 229960001820 etilevodopa Drugs 0.000 claims description 2
- 229960002724 fenoldopam Drugs 0.000 claims description 2
- TVURRHSHRRELCG-UHFFFAOYSA-N fenoldopam Chemical compound C1=CC(O)=CC=C1C1C2=CC(O)=C(O)C(Cl)=C2CCNC1 TVURRHSHRRELCG-UHFFFAOYSA-N 0.000 claims description 2
- XFBDGHFDKJITGC-JLHYYAGUSA-N gbr-12783 Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)OCCN(CC1)CCN1C\C=C\C1=CC=CC=C1 XFBDGHFDKJITGC-JLHYYAGUSA-N 0.000 claims description 2
- 229960004502 levodopa Drugs 0.000 claims description 2
- WFGNJLMSYIJWII-FJXQXJEOSA-N methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WFGNJLMSYIJWII-FJXQXJEOSA-N 0.000 claims description 2
- WEIMMECSAQVSGO-UHFFFAOYSA-N n-(3-hydroxy-4-propylphenyl)acetamide Chemical compound CCCC1=CC=C(NC(C)=O)C=C1O WEIMMECSAQVSGO-UHFFFAOYSA-N 0.000 claims description 2
- YYMXEVCLZQHDGV-UHFFFAOYSA-N n-[2-(3,4-dihydroxyphenyl)ethyl]-3-(6-oxo-3h-purin-9-yl)propanamide Chemical compound C1=C(O)C(O)=CC=C1CCNC(=O)CCN1C(NC=NC2=O)=C2N=C1 YYMXEVCLZQHDGV-UHFFFAOYSA-N 0.000 claims description 2
- OUUMPVSFLSOGJZ-UHFFFAOYSA-N n-[4-[2-(4-phenylpiperazin-1-yl)ethyl]cyclohexyl]pyrimidin-2-amine Chemical compound C1CC(NC=2N=CC=CN=2)CCC1CCN(CC1)CCN1C1=CC=CC=C1 OUUMPVSFLSOGJZ-UHFFFAOYSA-N 0.000 claims description 2
- YBCGYAGNYOYLDH-IFXJQAMLSA-N n-[[(6ar,9s)-7-methyl-6,6a,8,9-tetrahydro-4h-indolo[4,3-fg]quinoline-9-yl]methyl]-n-methylprop-2-yn-1-amine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)CN(CC#C)C)C2)=C3C2=CNC3=C1 YBCGYAGNYOYLDH-IFXJQAMLSA-N 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 229950004349 nolomirole Drugs 0.000 claims description 2
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims description 2
- 229960001243 orlistat Drugs 0.000 claims description 2
- 229960003089 pramipexole Drugs 0.000 claims description 2
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims description 2
- 229950001815 preclamol Drugs 0.000 claims description 2
- 229960001879 ropinirole Drugs 0.000 claims description 2
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 claims description 2
- 229960003179 rotigotine Drugs 0.000 claims description 2
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 claims description 2
- 229950011111 sumanirole Drugs 0.000 claims description 2
- RKZSNTNMEFVBDT-MRVPVSSYSA-N sumanirole Chemical compound C([C@H](C1)NC)C2=CC=CC3=C2N1C(=O)N3 RKZSNTNMEFVBDT-MRVPVSSYSA-N 0.000 claims description 2
- 229960004558 terguride Drugs 0.000 claims description 2
- UCZYAFAFGFTZEW-CYBMUJFWSA-N u 86170f Chemical compound C([C@H](C1)N(CCC)CCC)C2=CC=CC3=C2N1C(=O)N3 UCZYAFAFGFTZEW-CYBMUJFWSA-N 0.000 claims description 2
- XTWUNLMHXDDOMD-SNVBAGLBSA-N u91356a Chemical compound C([C@H](C1)NCCC)C2=CC=CC3=C2N1C(=O)N3 XTWUNLMHXDDOMD-SNVBAGLBSA-N 0.000 claims description 2
- DVLKVIJLALMCBQ-VENMBWNLSA-N (3R,4aR,10aS)-3-(diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline hydrochloride Chemical compound Cl.C1=CC=C2C[C@@H]3N(CCC)C[C@H](NS(=O)(=O)N(CC)CC)C[C@H]3CC2=C1O DVLKVIJLALMCBQ-VENMBWNLSA-N 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- JUDKOGFHZYMDMF-UHFFFAOYSA-N 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Chemical compound C1=2C=C(O)C(O)=CC=2CCNCC1C1=CC=CC=C1 JUDKOGFHZYMDMF-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 description 18
- 229940125890 compound Ia Drugs 0.000 description 17
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- 239000003826 tablet Substances 0.000 description 8
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04001282.5 | 2004-01-22 | ||
| EP04001282 | 2004-01-22 | ||
| EP04005816.6 | 2004-03-11 | ||
| EP04005816 | 2004-03-11 | ||
| PCT/EP2005/000165 WO2005070427A1 (en) | 2004-01-22 | 2005-01-11 | Compounds for the sustained reduction of body weight |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2553649A1 true CA2553649A1 (en) | 2005-08-04 |
Family
ID=34809747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002553649A Abandoned CA2553649A1 (en) | 2004-01-22 | 2005-01-11 | Compounds for the sustained reduction of body weight |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050203124A1 (enExample) |
| EP (1) | EP1727547A1 (enExample) |
| JP (1) | JP2007519646A (enExample) |
| AU (1) | AU2005205880B2 (enExample) |
| CA (1) | CA2553649A1 (enExample) |
| NZ (1) | NZ547919A (enExample) |
| WO (1) | WO2005070427A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06003762A (es) * | 2003-10-16 | 2006-06-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa. |
| AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
| EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| EP2222303A1 (en) * | 2007-11-20 | 2010-09-01 | NeuroSearch A/S | A method for treating addiction |
| WO2009065845A1 (en) * | 2007-11-20 | 2009-05-28 | Neurosearch A/S | A method for treating over-eating disorders |
| WO2009080693A2 (en) * | 2007-12-20 | 2009-07-02 | Neurosearch A/S | Pharmaceutical composition comprising tesofensine or its analogue and a beta blocker |
| EP2237781A2 (en) * | 2007-12-20 | 2010-10-13 | NeuroSearch A/S | Pharmaceutical composition comprising tesofensine or its analogue and an anti-obesity |
| JP6203760B2 (ja) | 2012-02-16 | 2017-09-27 | サニオナ・エー／エス | 併用療法のための医薬組成物 |
| LT3265126T (lt) | 2015-03-03 | 2021-09-10 | Saniona A/S | Tesofensino ir metoprololio derinio kompozicija |
| WO2020084065A1 (en) * | 2018-10-24 | 2020-04-30 | Saniona A/S | Transdermal tropane compositions and methods for using the same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE299879T1 (de) | 1991-11-15 | 2005-08-15 | Res Triangle Inst | Kokainrezeptor bindende liganden |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| ATE222587T1 (de) * | 1994-04-19 | 2002-09-15 | Neurosearch As | TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN |
| JP3238414B2 (ja) * | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| US6262081B1 (en) * | 1998-07-10 | 2001-07-17 | Dupont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
| WO2002102801A1 (en) * | 2001-05-23 | 2002-12-27 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| DE10148233A1 (de) * | 2001-09-28 | 2003-04-10 | Boehringer Ingelheim Pharma | Verbindungen zur Reduzierung übermäßiger Nahrungsaufnahme |
| EP1594874A1 (en) * | 2003-02-12 | 2005-11-16 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| MXPA06003762A (es) * | 2003-10-16 | 2006-06-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa. |
| AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
| WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
-
2005
- 2005-01-11 EP EP05700803A patent/EP1727547A1/en not_active Withdrawn
- 2005-01-11 CA CA002553649A patent/CA2553649A1/en not_active Abandoned
- 2005-01-11 JP JP2006549961A patent/JP2007519646A/ja active Pending
- 2005-01-11 NZ NZ547919A patent/NZ547919A/en not_active IP Right Cessation
- 2005-01-11 AU AU2005205880A patent/AU2005205880B2/en not_active Ceased
- 2005-01-11 WO PCT/EP2005/000165 patent/WO2005070427A1/en not_active Ceased
- 2005-01-21 US US11/039,991 patent/US20050203124A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ547919A (en) | 2009-12-24 |
| EP1727547A1 (en) | 2006-12-06 |
| WO2005070427A8 (en) | 2005-11-17 |
| US20050203124A1 (en) | 2005-09-15 |
| JP2007519646A (ja) | 2007-07-19 |
| WO2005070427A1 (en) | 2005-08-04 |
| AU2005205880A1 (en) | 2005-08-04 |
| AU2005205880B2 (en) | 2010-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140613 |
|
| FZDE | Discontinued |
Effective date: 20140613 |