CA2547863A1 - Composes actifs du sous-type 1 de recepteur de somatostatine (sstr1) et leur utilisation en therapie - Google Patents
Composes actifs du sous-type 1 de recepteur de somatostatine (sstr1) et leur utilisation en therapie Download PDFInfo
- Publication number
- CA2547863A1 CA2547863A1 CA002547863A CA2547863A CA2547863A1 CA 2547863 A1 CA2547863 A1 CA 2547863A1 CA 002547863 A CA002547863 A CA 002547863A CA 2547863 A CA2547863 A CA 2547863A CA 2547863 A1 CA2547863 A1 CA 2547863A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- pyridin
- ylethyl
- naphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 139
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- 238000002560 therapeutic procedure Methods 0.000 title description 3
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- 230000008685 targeting Effects 0.000 claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
- 238000003384 imaging method Methods 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 63
- -1 (2R)-N-(4-Aminobutyl)-3-(1H-indol-3-yl)-2-[3-(3-phenylpropyl)-3-(2-pyridin-2-ylethyl)ureido]propionamide Chemical compound 0.000 claims description 60
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 52
- 125000003118 aryl group Chemical group 0.000 claims description 31
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 17
- 125000000304 alkynyl group Chemical group 0.000 claims description 16
- 150000002148 esters Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
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- 239000000047 product Substances 0.000 description 30
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 25
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- 239000003643 water by type Substances 0.000 description 12
- PRDSRVPZBXXDSS-UHFFFAOYSA-N 2-phenyl-n-(2-pyridin-2-ylethyl)ethanamine Chemical compound C=1C=CC=NC=1CCNCCC1=CC=CC=C1 PRDSRVPZBXXDSS-UHFFFAOYSA-N 0.000 description 10
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50907303P | 2003-12-12 | 2003-12-12 | |
FI20031824A FI20031824A0 (fi) | 2003-12-12 | 2003-12-12 | Uusia yhdisteitä ja niiden käyttö terapiassa |
FI20031824 | 2003-12-12 | ||
US60/509,073 | 2003-12-12 | ||
PCT/FI2004/000750 WO2005056520A1 (fr) | 2003-12-12 | 2004-12-09 | Composes actifs du sous-type 1 de recepteur de somatostatine (sstr1) et leur utilisation en therapie |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2547863A1 true CA2547863A1 (fr) | 2005-06-23 |
Family
ID=34680375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002547863A Abandoned CA2547863A1 (fr) | 2003-12-12 | 2004-12-09 | Composes actifs du sous-type 1 de recepteur de somatostatine (sstr1) et leur utilisation en therapie |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1692099A1 (fr) |
JP (1) | JP2007513928A (fr) |
CA (1) | CA2547863A1 (fr) |
WO (1) | WO2005056520A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011509304A (ja) | 2008-01-09 | 2011-03-24 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 炭酸脱水酵素ixの阻害剤 |
JP2011522813A (ja) * | 2008-06-04 | 2011-08-04 | アストラゼネカ アクチボラグ | 低分子レプチン受容体修飾因子 |
US8211402B2 (en) | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
WO2010065899A2 (fr) * | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Complexes de technétium- et rhénium-bis (hétéroaryles) et leurs procédés d'utilisation |
AU2009322167B2 (en) | 2008-12-05 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA |
US8465725B2 (en) | 2009-06-15 | 2013-06-18 | Molecular Insight Pharmaceuticlas, Inc. | Process for production of heterodimers of glutamic acid |
US9120837B2 (en) | 2012-01-06 | 2015-09-01 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX |
CN105025933B (zh) | 2013-01-14 | 2019-03-26 | 分子制药洞察公司 | 三嗪类放射性药物和放射性显影剂 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6492370B1 (en) * | 1998-03-26 | 2002-12-10 | Santen Pharmaceutical Co., Ltd. | Urea derivatives and pharmaceutical compositions thereof |
RU2288739C2 (ru) * | 2001-01-12 | 2006-12-10 | Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик, С.А.С. | Фармацевтические композиции, которые подавляют сосудистую пролиферацию, и способ их применения |
US7019109B2 (en) * | 2001-03-16 | 2006-03-28 | The Salk Institute For Bilogical Studies | SSTR1-selective analogs |
-
2004
- 2004-12-09 JP JP2006543564A patent/JP2007513928A/ja active Pending
- 2004-12-09 EP EP04805145A patent/EP1692099A1/fr not_active Withdrawn
- 2004-12-09 WO PCT/FI2004/000750 patent/WO2005056520A1/fr active Application Filing
- 2004-12-09 CA CA002547863A patent/CA2547863A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1692099A1 (fr) | 2006-08-23 |
WO2005056520A8 (fr) | 2005-09-15 |
WO2005056520A1 (fr) | 2005-06-23 |
JP2007513928A (ja) | 2007-05-31 |
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