CA2545194C - Pharmaceutical compositions including low dosages of desmopressin - Google Patents
Pharmaceutical compositions including low dosages of desmopressin Download PDFInfo
- Publication number
- CA2545194C CA2545194C CA2545194A CA2545194A CA2545194C CA 2545194 C CA2545194 C CA 2545194C CA 2545194 A CA2545194 A CA 2545194A CA 2545194 A CA2545194 A CA 2545194A CA 2545194 C CA2545194 C CA 2545194C
- Authority
- CA
- Canada
- Prior art keywords
- desmopressin
- plasma
- dosage form
- urine
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 title claims abstract description 182
- 229960004281 desmopressin Drugs 0.000 title claims abstract description 182
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- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 title claims abstract 14
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- NFLWUMRGJYTJIN-PNIOQBSNSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-PNIOQBSNSA-N 0.000 description 169
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- 239000002504 physiological saline solution Substances 0.000 description 1
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- 210000003635 pituitary gland Anatomy 0.000 description 1
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- 229950005134 polycarbophil Drugs 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
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- 239000000661 sodium alginate Substances 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000008259 solid foam Substances 0.000 description 1
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
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- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
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- 238000011269 treatment regimen Methods 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
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- 229940099259 vaseline Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
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- 230000000007 visual effect Effects 0.000 description 1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2866501A CA2866501A1 (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/035662 WO2005046707A1 (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2866501A Division CA2866501A1 (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2545194A1 CA2545194A1 (en) | 2005-05-26 |
| CA2545194C true CA2545194C (en) | 2014-10-21 |
Family
ID=34589310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2545194A Expired - Lifetime CA2545194C (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
| CA2866501A Abandoned CA2866501A1 (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2866501A Abandoned CA2866501A1 (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
Country Status (6)
| Country | Link |
|---|---|
| EP (6) | EP2322198A2 (enExample) |
| JP (1) | JP5596252B2 (enExample) |
| CN (1) | CN1878563A (enExample) |
| AU (1) | AU2003287591C1 (enExample) |
| CA (2) | CA2545194C (enExample) |
| WO (1) | WO2005046707A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| JP5596252B2 (ja) | 2003-11-10 | 2014-09-24 | アラーガン、インコーポレイテッド | 低用量デスモプレシンを含有する医薬組成物 |
| ES2260563T3 (es) | 2003-11-13 | 2006-11-01 | Ferring B.V. | Paquete de blister y forma farmaceutica solida para ello. |
| SE0600482L (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
| EA014213B1 (ru) | 2007-02-27 | 2010-10-29 | Ивакс Фармасьютикалз Айэлэнд | Дозирующий ингалятор |
| ES2319054B1 (es) | 2007-08-06 | 2010-02-12 | Gp Pharm S.A. | Composicion farmaceutica oral de desmopresina. |
| CA2988753A1 (en) | 2007-08-06 | 2009-02-12 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| US20100286045A1 (en) * | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| JP5767103B2 (ja) * | 2008-05-21 | 2015-08-19 | フエリング・インターナシヨナル・センター・エス・アー | 夜間頻尿によって妨げられない睡眠の初期期間を増加させるための口腔内崩壊デスモプレシン |
| BRPI0923557A2 (pt) * | 2008-12-22 | 2016-01-26 | Allergan Inc | administração de desmopressina intranasal |
| ES2929471T3 (es) | 2009-06-18 | 2022-11-29 | Acerus Pharmaceuticals Usa Llc | Administración segura de desmopresina |
| AU2014293140A1 (en) * | 2013-07-23 | 2016-03-03 | Serenity Pharmaceuticals Llc | Methods and compositions comprising desmopressin in combination with a 5-alpha reductase inhibitor |
| MX2016001030A (es) * | 2013-07-23 | 2016-10-07 | Allergan Inc | Métodos y composiciones que comprenden desmopresina en combinación con un agonista del receptor beta 3-adrenérgico. |
| WO2015063602A1 (en) * | 2013-10-29 | 2015-05-07 | Ferring B.V. | Desmopressin and blood glucose |
| EP3220942B1 (en) | 2014-11-20 | 2022-04-27 | Serenity Pharmaceuticals LLC | Compositions comprising low dose desmopressin in combination with an alpha-adrenergic receptor antagonist |
| BR112018015391B1 (pt) * | 2016-01-29 | 2023-09-26 | Bosquet Silicon Corp | Preparação sólida oral, método para produzir uma preparação sólida oral e método para gerar hidrogênio |
| US11707063B2 (en) | 2016-08-23 | 2023-07-25 | Bosquet Silicon Corp. | Compound, production method therefor, and hydrogen supply method |
| WO2018037818A1 (ja) | 2016-08-23 | 2018-03-01 | 小林 光 | 水素供給材及びその製造方法、並びに水素供給方法 |
| US10952959B2 (en) * | 2017-01-11 | 2021-03-23 | Ferring B.V. | Fast disintegrating pharmaceutical composition |
| CN114432424B (zh) * | 2021-12-27 | 2023-06-27 | 南通联亚药业股份有限公司 | 一种稳定的铝塑包装去氨加压素片剂 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072668A (en) | 1973-11-06 | 1978-02-07 | The Salk Institute For Biological Studies | LH-RH Analogs |
| GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| US4285858A (en) * | 1979-10-30 | 1981-08-25 | Mt. Sinai School Of Medicine Of The City University Of N.Y. | Vasopressin analogs |
| IE53696B1 (en) | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
| GB2111423B (en) | 1981-12-02 | 1985-06-26 | Wyeth John & Brother Ltd | Making quick-dissolving pills |
| EP0081913B1 (en) | 1981-12-11 | 1985-06-26 | JOHN WYETH & BROTHER LIMITED | Process and apparatus for freezing a liquid medium |
| ATE24964T1 (de) | 1981-12-11 | 1987-01-15 | Wyeth John & Brother Ltd | Verfahren zur herstellung von festen formgegenstaenden. |
| US5188825A (en) | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
| RU2109509C1 (ru) | 1991-12-24 | 1998-04-27 | Яманути Фармасьютикал Ко., Лтд. | Композиция для буккального введения лекарственного средства и способ ее получения |
| IL105553A (en) | 1992-05-06 | 1998-01-04 | Janssen Pharmaceutica Inc | Solid dosage form comprising a porous network of matrix forming material which disperses rapidly in water |
| ES2149880T3 (es) * | 1993-06-29 | 2000-11-16 | Ferring Bv | Sintesis de peptidos ciclicos. |
| US5500413A (en) * | 1993-06-29 | 1996-03-19 | Ferring Ab | Process for manufacture of 1-deamino-8-D-arginine vasopressin |
| WO1995001782A2 (en) | 1993-07-09 | 1995-01-19 | R.P. Scherer Corporation | Method for making freeze dried drug dosage forms |
| US5837287A (en) | 1994-10-28 | 1998-11-17 | R P Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| GB9421836D0 (en) | 1994-10-28 | 1994-12-14 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances |
| US5738875A (en) | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| US5989835A (en) * | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
| US5968895A (en) | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| GB9702799D0 (en) | 1997-02-12 | 1997-04-02 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms |
| US5925730A (en) | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| US5976577A (en) | 1997-07-11 | 1999-11-02 | Rp Scherer Corporation | Process for preparing fast dispersing solid oral dosage form |
| GB9722682D0 (en) | 1997-10-27 | 1997-12-24 | Scherer Ltd R P | Pharmaceutical products |
| US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| GB9901819D0 (en) | 1999-01-27 | 1999-03-17 | Scherer Corp R P | Pharmaceutical compositions |
| GB9908014D0 (en) | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| DE10001390A1 (de) | 2000-01-14 | 2001-07-19 | Hepavec Ag Fuer Gentherapie | Zelllinie zur Herstellung und Produktion von Schafadenovirusvektoren |
| AU2003233118B8 (en) * | 2002-05-07 | 2009-07-30 | Ferring Bv | Desmopressin in an orodispersible dosage form |
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| JP5596252B2 (ja) | 2003-11-10 | 2014-09-24 | アラーガン、インコーポレイテッド | 低用量デスモプレシンを含有する医薬組成物 |
-
2003
- 2003-11-10 JP JP2005510644A patent/JP5596252B2/ja not_active Expired - Fee Related
- 2003-11-10 EP EP11000468A patent/EP2322198A2/en not_active Withdrawn
- 2003-11-10 CA CA2545194A patent/CA2545194C/en not_active Expired - Lifetime
- 2003-11-10 EP EP11000464A patent/EP2322194A2/en not_active Withdrawn
- 2003-11-10 EP EP11000466A patent/EP2322196A2/en not_active Withdrawn
- 2003-11-10 EP EP11000467A patent/EP2322197A2/en not_active Withdrawn
- 2003-11-10 WO PCT/US2003/035662 patent/WO2005046707A1/en not_active Ceased
- 2003-11-10 EP EP03781836A patent/EP1689419A4/en not_active Withdrawn
- 2003-11-10 AU AU2003287591A patent/AU2003287591C1/en not_active Ceased
- 2003-11-10 CN CNA2003801106751A patent/CN1878563A/zh active Pending
- 2003-11-10 EP EP11000465A patent/EP2322195A2/en not_active Withdrawn
- 2003-11-10 CA CA2866501A patent/CA2866501A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2322197A2 (en) | 2011-05-18 |
| AU2003287591C1 (en) | 2009-12-10 |
| EP2322195A2 (en) | 2011-05-18 |
| EP1689419A1 (en) | 2006-08-16 |
| JP2007521244A (ja) | 2007-08-02 |
| AU2003287591A8 (en) | 2005-06-06 |
| AU2003287591A1 (en) | 2004-06-06 |
| CN1878563A (zh) | 2006-12-13 |
| EP2322194A2 (en) | 2011-05-18 |
| JP5596252B2 (ja) | 2014-09-24 |
| EP2322196A2 (en) | 2011-05-18 |
| WO2005046707A1 (en) | 2005-05-26 |
| AU2003287591B2 (en) | 2009-06-04 |
| CA2545194A1 (en) | 2005-05-26 |
| CA2866501A1 (en) | 2005-05-26 |
| EP1689419A4 (en) | 2009-01-14 |
| EP2322198A2 (en) | 2011-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20231110 |