CA2541373A1

CA2541373A1 - Topical skin care composition containing refined peanut oil

Topical skin care composition containing refined peanut oil Download PDF

Info

Publication number: CA2541373A1
Authority: CA; Canada
Prior art keywords: peanut oil; medicament; skin; acid; agents
Prior art date: 2003-07-18
Legal status : Abandoned

Application number

CA002541373A

Other languages

English (en)

French (fr)

Inventor

Jerry Roth

Nancy Puglia

Rosario Ramirez

Current Assignee

Hill Dermaceuticals Inc

Original Assignee

Individual

Priority date

2003-07-18

Filing date

2004-07-16

Publication date

2005-02-03

2004-07-16 Application filed by Individual filed Critical Individual

2005-02-03 Publication of CA2541373A1 publication Critical patent/CA2541373A1/en

Status Abandoned legal-status Critical Current

Links

235000019483 Peanut oil Nutrition 0.000 title claims abstract description 54
239000000312 peanut oil Substances 0.000 title claims abstract description 54
239000000203 mixture Substances 0.000 title claims abstract description 41
230000000699 topical effect Effects 0.000 title abstract description 27
239000003814 drug Substances 0.000 claims abstract description 28
239000003981 vehicle Substances 0.000 claims abstract description 20
238000000034 method Methods 0.000 claims abstract description 15
230000008569 process Effects 0.000 claims abstract description 8
QIGBRXMKCJKVMJ-UHFFFAOYSA-N 1,4-Benzenediol Natural products OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 19
239000013543 active substance Substances 0.000 claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
SHGAZHPCJJPHSC-YCNIQYBTSA-N retinoic acid group Chemical group C\C(=C/C(=O)O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 14
229960001727 tretinoin Drugs 0.000 claims description 14
FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims description 11
229960004337 hydroquinone Drugs 0.000 claims description 9
239000003153 chemical reaction reagent Substances 0.000 claims description 6
239000008346 aqueous phase Substances 0.000 claims description 5
239000003246 corticosteroid Substances 0.000 claims description 5
239000003995 emulsifying agent Substances 0.000 claims description 5
150000001875 compounds Chemical class 0.000 claims description 4
239000007854 depigmenting agent Substances 0.000 claims description 4
239000003410 keratolytic agent Substances 0.000 claims description 4
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical group FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 3
229960002949 fluorouracil Drugs 0.000 claims description 3
230000002209 hydrophobic effect Effects 0.000 claims description 3
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UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical group C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
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230000001225 therapeutic effect Effects 0.000 abstract description 5
-1 serum Substances 0.000 description 46
210000003491 skin Anatomy 0.000 description 37
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 19
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VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 12
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 12
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 12
239000003921 oil Substances 0.000 description 12
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GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 10
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 10
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235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 6
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235000020232 peanut Nutrition 0.000 description 6
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NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 5
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OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 5
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UITSPQLTFPTHJZ-UHFFFAOYSA-N 2-[[3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound COC1OC(COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-UHFFFAOYSA-N 0.000 description 4
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HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 4
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