CA2540543A1 - Tetrahydropyridine derivatives - Google Patents
Tetrahydropyridine derivatives Download PDFInfo
- Publication number
- CA2540543A1 CA2540543A1 CA002540543A CA2540543A CA2540543A1 CA 2540543 A1 CA2540543 A1 CA 2540543A1 CA 002540543 A CA002540543 A CA 002540543A CA 2540543 A CA2540543 A CA 2540543A CA 2540543 A1 CA2540543 A1 CA 2540543A1
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- heteroaryl
- mmol
- chloro
- renal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0311146 | 2003-10-09 | ||
| EPPCT/EP03/11146 | 2003-10-09 | ||
| PCT/EP2004/011088 WO2005040120A1 (en) | 2003-10-09 | 2004-10-05 | Tetrahydropyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2540543A1 true CA2540543A1 (en) | 2005-05-06 |
Family
ID=34486009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002540543A Abandoned CA2540543A1 (en) | 2003-10-09 | 2004-10-05 | Tetrahydropyridine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080234305A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007508260A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1863773A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004283814A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2540543A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005040120A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE462703T1 (de) * | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
| GB0500784D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| AU2006272348B2 (en) * | 2005-07-22 | 2011-06-16 | Merck Frosst Canada Ltd | Renin inhibitors |
| AR058885A1 (es) | 2005-12-30 | 2008-02-27 | Novartis Ag | Compuestos de piperidina 3,5-sustituidos |
| ZA200808419B (en) * | 2006-03-03 | 2009-12-30 | Actelion Pharmaceuticals Ltd | Primary amines as renin inhibitors |
| CL2007000595A1 (es) * | 2006-03-08 | 2008-01-04 | Actelion Pharmaceuticals Ltd | Compuestos derivados de piperidina; composicion farmaceutica y uso para el tratamiento y/o profilaxis de enfermedades seleccionadas entre hipertension, insuficiencia cardiaca congestiva e insuficiencia renal entre otras. |
| EP1908471A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
| EP2162436A4 (en) | 2007-05-24 | 2010-08-04 | Merck Frosst Canada Ltd | NEW CASE OF RENININHIBITORS |
| ES2541107T3 (es) | 2007-06-25 | 2015-07-16 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina |
| AU2008288648A1 (en) | 2007-08-20 | 2009-02-26 | Merck Frosst Canada Ltd. | Renin inhibitors |
| MX2010005283A (es) | 2007-12-05 | 2010-05-27 | Basf Se | Compuestos de piridilmetil-sulfonamida. |
| KR101247840B1 (ko) | 2008-02-22 | 2013-03-26 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타 조절제 |
| PL2274295T3 (pl) | 2008-05-05 | 2016-01-29 | Idorsia Pharmaceuticals Ltd | 3,4–podstawione pochodne piperydyny jako inhibitory reniny |
| MX2011003246A (es) | 2008-10-09 | 2011-04-21 | Hoffmann La Roche | Moduladores de beta amiloide. |
| KR101293421B1 (ko) | 2008-11-10 | 2013-08-05 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 감마 분비효소 조절제 |
| EP2389373B1 (en) | 2009-01-21 | 2017-05-17 | Rigel Pharmaceuticals, Inc. | Derivatives of n2-(3-pyridyl or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases |
| CN101696187B (zh) * | 2009-09-30 | 2011-09-07 | 徐州工业职业技术学院 | N-取代基-1,2,3,6-四氢吡啶的合成方法 |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| EP2640699B1 (en) | 2010-11-17 | 2015-10-07 | Actelion Pharmaceuticals Ltd. | Bridged spiro[2,4]heptane ester derivatives |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| IL151164A0 (en) * | 2000-03-06 | 2003-04-10 | Acadia Pharm Inc | Azacyclic compounds for use in the treatment of serotonin related diseases |
| US20030013883A1 (en) * | 2000-06-16 | 2003-01-16 | Tamagnan Gilles D. | Tropane analogs binding to monoamine transporters |
| MXPA04010608A (es) * | 2002-04-29 | 2004-12-13 | Actelion Pharmaceuticals Ltd | Derivados de 7-aril-3,9-diazabiciclo(3.3.1)non-6-eno y sus usos como inhibidores de renina en el tratamiento de enfermedades de hipertension, cardiovasculares o renales. |
| EP1519920A1 (en) * | 2002-06-27 | 2005-04-06 | Actelion Pharmaceuticals Ltd. | Novel tetrahydropyridine derivatives as renin inhibitors |
-
2004
- 2004-10-05 WO PCT/EP2004/011088 patent/WO2005040120A1/en not_active Ceased
- 2004-10-05 JP JP2006530088A patent/JP2007508260A/ja active Pending
- 2004-10-05 CN CNA2004800293878A patent/CN1863773A/zh active Pending
- 2004-10-05 US US10/575,348 patent/US20080234305A1/en not_active Abandoned
- 2004-10-05 CA CA002540543A patent/CA2540543A1/en not_active Abandoned
- 2004-10-05 AU AU2004283814A patent/AU2004283814A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005040120A1 (en) | 2005-05-06 |
| US20080234305A1 (en) | 2008-09-25 |
| AU2004283814A1 (en) | 2005-05-06 |
| CN1863773A (zh) | 2006-11-15 |
| JP2007508260A (ja) | 2007-04-05 |
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