CA2538619C - Re-targeted toxin conjugates - Google Patents
Re-targeted toxin conjugates Download PDFInfo
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- CA2538619C CA2538619C CA2538619A CA2538619A CA2538619C CA 2538619 C CA2538619 C CA 2538619C CA 2538619 A CA2538619 A CA 2538619A CA 2538619 A CA2538619 A CA 2538619A CA 2538619 C CA2538619 C CA 2538619C
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- protease
- agonist
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Zoology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0321344.4 | 2003-09-11 | ||
| GBGB0321344.4A GB0321344D0 (en) | 2003-09-11 | 2003-09-11 | Re-targeted toxin conjugates |
| PCT/GB2004/003904 WO2005023309A2 (en) | 2003-09-11 | 2004-09-13 | Design of re-targeted toxin conjugates |
Publications (2)
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| CA2538619A1 CA2538619A1 (en) | 2005-03-17 |
| CA2538619C true CA2538619C (en) | 2012-10-16 |
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| CA2538619A Expired - Fee Related CA2538619C (en) | 2003-09-11 | 2004-09-13 | Re-targeted toxin conjugates |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20070184048A1 (enExample) |
| EP (1) | EP1667725A2 (enExample) |
| JP (2) | JP2007505094A (enExample) |
| AU (1) | AU2004269979B2 (enExample) |
| CA (1) | CA2538619C (enExample) |
| GB (1) | GB0321344D0 (enExample) |
| WO (1) | WO2005023309A2 (enExample) |
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| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US7192596B2 (en) * | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| KR100876060B1 (ko) | 1999-08-25 | 2008-12-26 | 알러간, 인코포레이티드 | 활성화가능한 재조합 신경독 |
| US7138127B1 (en) | 2000-01-19 | 2006-11-21 | Allergan, Inc. | Clostridial toxin derivatives and methods for treating pain |
| EP1784420B1 (en) | 2004-09-01 | 2008-12-03 | Allergan, Inc. | Degradable clostridial toxins |
| GB0426397D0 (en) | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| US8603779B2 (en) | 2004-12-01 | 2013-12-10 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| EP1877073B1 (en) * | 2004-12-01 | 2013-09-25 | The Secretary of State for Health | Non-cytotoxic protein conjugates |
| US8399400B2 (en) | 2004-12-01 | 2013-03-19 | Syntaxin, Ltd. | Fusion proteins |
| US8512984B2 (en) | 2004-12-01 | 2013-08-20 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| US7659092B2 (en) | 2004-12-01 | 2010-02-09 | Syntaxin, Ltd. | Fusion proteins |
| CA2595115C (en) | 2004-12-01 | 2014-01-21 | Health Protection Agency | Fusion proteins for treating, preventing or ameliorating pain |
| US8778634B2 (en) | 2004-12-01 | 2014-07-15 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| US8052979B2 (en) | 2005-03-15 | 2011-11-08 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| US8021859B2 (en) | 2005-03-15 | 2011-09-20 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| ATE463506T1 (de) | 2005-09-19 | 2010-04-15 | Allergan Inc | Mit clostriedientoxin aktivierbare clostridientoxine |
| GB0610868D0 (en) * | 2006-06-01 | 2006-07-12 | Syntaxin Ltd | Treatment of pain |
| CA2658260A1 (en) | 2006-07-11 | 2008-01-17 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells |
| CA2657460A1 (en) | 2006-07-11 | 2008-09-04 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity |
| WO2009020748A2 (en) * | 2007-07-16 | 2009-02-12 | Avaxia Biologics, Inc. | Antibody therapy for modulating function of intestinal receptors |
| WO2009046168A1 (en) | 2007-10-02 | 2009-04-09 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| EP2211890A1 (en) * | 2007-10-23 | 2010-08-04 | Allergan, Inc. | Methods of treating urogenital-neurological disorders using modified clostridial toxins |
| GB0803068D0 (en) | 2008-02-20 | 2008-03-26 | Health Prot Agency | Cross-linked biological indicator |
| US10466245B2 (en) | 2008-02-20 | 2019-11-05 | The Secretary Of State For Health | Covalently linked thermostable kinase for decontamination process validation |
| CA2726092A1 (en) | 2008-06-12 | 2009-12-17 | Syntaxin Limited | Suppression of cancers |
| US8796216B2 (en) | 2008-06-12 | 2014-08-05 | Syntaxin Limited | Suppression of neuroendocrine diseases |
| GB0820970D0 (en) * | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| GB0903006D0 (en) * | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
| PT3281953T (pt) | 2009-03-13 | 2020-01-15 | Allergan Inc | Ensaios de base imunológica da actividade de endopeptidase redireccionada |
| EP2470664A4 (en) * | 2009-08-27 | 2013-01-16 | Synaptic Res Llc | NEW PROTEIN RELEASE SYSTEM FOR GENERATING INDUCED PLURIPOTENTAL STEM CELLS OR TISSUE-SPECIFIC CELLS |
| AU2010353292A1 (en) | 2009-12-16 | 2012-07-12 | Allergan, Inc. | Modified Clostridial toxins comprising an integrated protease cleavage site-binding domain |
| MX2012008650A (es) | 2010-01-25 | 2012-11-23 | Allergan Inc | Metodos de conversion intracelular de proteinas monocatenarias en su formula bicatenaria. |
| RU2561465C2 (ru) | 2010-05-20 | 2015-08-27 | Аллерган, Инк. | Разрушаемые клостридиальные токсины |
| WO2012048246A1 (en) | 2010-10-08 | 2012-04-12 | Allergan, Inc. | Reduction of antibody response against botulinum neurotoxin and variants thereof |
| GB201108108D0 (en) * | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
| US20140056870A1 (en) * | 2012-08-27 | 2014-02-27 | Allergan, Inc. | Fusion proteins |
| GB201219024D0 (en) * | 2012-10-23 | 2012-12-05 | Syntaxin Ltd | Assay |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| TW201814045A (zh) | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
| WO2018060351A1 (en) | 2016-09-29 | 2018-04-05 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN112511569B (zh) * | 2021-02-07 | 2021-05-11 | 杭州筋斗腾云科技有限公司 | 网络资源访问请求的处理方法、系统及计算机设备 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
| GB9305735D0 (en) * | 1993-03-19 | 1993-05-05 | North John R | Novel agent for controlling cell activity |
| GB9508204D0 (en) * | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| GB9617671D0 (en) * | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| EP1084146B1 (de) * | 1998-05-13 | 2002-11-13 | BioteCon Gesellschaft für Biotechnologische Entwicklung und Consulting mbH | Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung |
| US6822076B2 (en) * | 1998-05-13 | 2004-11-23 | Biotecon Therapeutics Gmbh | Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof |
| GB9818548D0 (en) * | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| GB9922554D0 (en) | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
| AU2002210918B2 (en) * | 2000-10-20 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | Degraded agonist antibody |
| EP2351838A1 (en) * | 2000-10-20 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Crosslinking agonistic antibodies |
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2003
- 2003-09-11 GB GBGB0321344.4A patent/GB0321344D0/en not_active Ceased
-
2004
- 2004-09-13 US US10/571,515 patent/US20070184048A1/en not_active Abandoned
- 2004-09-13 CA CA2538619A patent/CA2538619C/en not_active Expired - Fee Related
- 2004-09-13 EP EP04768450A patent/EP1667725A2/en not_active Ceased
- 2004-09-13 AU AU2004269979A patent/AU2004269979B2/en not_active Ceased
- 2004-09-13 WO PCT/GB2004/003904 patent/WO2005023309A2/en not_active Ceased
- 2004-09-13 JP JP2006525899A patent/JP2007505094A/ja active Pending
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2009
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2012
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2018
- 2018-06-28 US US16/021,540 patent/US20180362951A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070184048A1 (en) | 2007-08-09 |
| EP1667725A2 (en) | 2006-06-14 |
| JP6122243B2 (ja) | 2017-04-26 |
| AU2004269979A1 (en) | 2005-03-17 |
| CA2538619A1 (en) | 2005-03-17 |
| GB0321344D0 (en) | 2003-10-15 |
| JP2012139222A (ja) | 2012-07-26 |
| US20130122526A1 (en) | 2013-05-16 |
| US20180362951A1 (en) | 2018-12-20 |
| WO2005023309A3 (en) | 2005-09-15 |
| WO2005023309A2 (en) | 2005-03-17 |
| AU2004269979B2 (en) | 2009-12-10 |
| US20090291457A1 (en) | 2009-11-26 |
| JP2007505094A (ja) | 2007-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200914 |
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| MKLA | Lapsed |
Effective date: 20200914 |