CA2538619C - Re-targeted toxin conjugates - Google Patents
Re-targeted toxin conjugates Download PDFInfo
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- CA2538619C CA2538619C CA2538619A CA2538619A CA2538619C CA 2538619 C CA2538619 C CA 2538619C CA 2538619 A CA2538619 A CA 2538619A CA 2538619 A CA2538619 A CA 2538619A CA 2538619 C CA2538619 C CA 2538619C
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- protease
- agonist
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Zoology (AREA)
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- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
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- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0321344.4A GB0321344D0 (en) | 2003-09-11 | 2003-09-11 | Re-targeted toxin conjugates |
| GB0321344.4 | 2003-09-11 | ||
| PCT/GB2004/003904 WO2005023309A2 (en) | 2003-09-11 | 2004-09-13 | Design of re-targeted toxin conjugates |
Publications (2)
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| CA2538619A1 CA2538619A1 (en) | 2005-03-17 |
| CA2538619C true CA2538619C (en) | 2012-10-16 |
Family
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| CA2538619A Expired - Fee Related CA2538619C (en) | 2003-09-11 | 2004-09-13 | Re-targeted toxin conjugates |
Country Status (7)
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| US (4) | US20070184048A1 (enExample) |
| EP (1) | EP1667725A2 (enExample) |
| JP (2) | JP2007505094A (enExample) |
| AU (1) | AU2004269979B2 (enExample) |
| CA (1) | CA2538619C (enExample) |
| GB (1) | GB0321344D0 (enExample) |
| WO (1) | WO2005023309A2 (enExample) |
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| US7192596B2 (en) * | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| EP1700918B1 (en) | 1999-08-25 | 2014-01-15 | Allergan, Inc. | Activatable recombinant neurotoxins |
| US7138127B1 (en) | 2000-01-19 | 2006-11-21 | Allergan, Inc. | Clostridial toxin derivatives and methods for treating pain |
| WO2006026780A1 (en) | 2004-09-01 | 2006-03-09 | Allergan, Inc. | Degradable clostridial toxins |
| US8778634B2 (en) | 2004-12-01 | 2014-07-15 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| AU2005311086B2 (en) * | 2004-12-01 | 2012-03-29 | Allergan, Inc. | Fusion proteins |
| US8512984B2 (en) | 2004-12-01 | 2013-08-20 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| CA2588292C (en) * | 2004-12-01 | 2019-01-15 | Health Protection Agency | Non-cytotoxic protein conjugates |
| US8603779B2 (en) | 2004-12-01 | 2013-12-10 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| US8399400B2 (en) | 2004-12-01 | 2013-03-19 | Syntaxin, Ltd. | Fusion proteins |
| GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| GB0426397D0 (en) | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| US7659092B2 (en) | 2004-12-01 | 2010-02-09 | Syntaxin, Ltd. | Fusion proteins |
| US8052979B2 (en) | 2005-03-15 | 2011-11-08 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| US8021859B2 (en) | 2005-03-15 | 2011-09-20 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| DE602006013481D1 (de) * | 2005-09-19 | 2010-05-20 | Allergan Inc | Mit clostriedientoxin aktivierbare clostridientoxine |
| GB0610868D0 (en) * | 2006-06-01 | 2006-07-12 | Syntaxin Ltd | Treatment of pain |
| EP2041162A2 (en) | 2006-07-11 | 2009-04-01 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity |
| CA2658260A1 (en) | 2006-07-11 | 2008-01-17 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells |
| WO2009020748A2 (en) * | 2007-07-16 | 2009-02-12 | Avaxia Biologics, Inc. | Antibody therapy for modulating function of intestinal receptors |
| EP2244735A4 (en) | 2007-10-02 | 2011-02-23 | Avaxia Biologics Inc | ANTIBODY THERAPY FOR USE IN THE DIGESTIVE TUBE |
| WO2009055351A1 (en) * | 2007-10-23 | 2009-04-30 | Allergan, Inc. | Methods of treating urogenital-neurological disorders using modified clostridial toxins |
| GB0803068D0 (en) | 2008-02-20 | 2008-03-26 | Health Prot Agency | Cross-linked biological indicator |
| US10466245B2 (en) | 2008-02-20 | 2019-11-05 | The Secretary Of State For Health | Covalently linked thermostable kinase for decontamination process validation |
| CN102083451A (zh) | 2008-06-12 | 2011-06-01 | 赛恩泰新公司 | 癌症的抑制 |
| US8796216B2 (en) | 2008-06-12 | 2014-08-05 | Syntaxin Limited | Suppression of neuroendocrine diseases |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| GB0903006D0 (en) | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
| EP2568285B1 (en) | 2009-03-13 | 2019-12-25 | Allergan, Inc. | Immuno-based retargeted endopeptidase activity assays |
| JP2013503198A (ja) | 2009-08-27 | 2013-01-31 | シナプティック リサーチ，リミテッド ライアビリティ カンパニー | 人工多能性幹（ｉＰＳ）細胞または組織特異的細胞を誘導するための新規タンパク質送達系 |
| CN102753681A (zh) | 2009-12-16 | 2012-10-24 | 阿勒根公司 | 包含整合型蛋白酶裂解位点-结合结构域的经过修饰的梭菌毒素 |
| SG182691A1 (en) | 2010-01-25 | 2012-08-30 | Allergan Inc | Methods of intracellular conversion of single-chain proteins into their di-chain form |
| CN103228286B (zh) | 2010-05-20 | 2018-01-02 | 阿勒根公司 | 可降解梭菌毒素 |
| US20130330369A1 (en) | 2010-10-08 | 2013-12-12 | Allergan, Inc. | Reduction Of Antibody Response Against Botulinum Neurotoxin And Variants Thereof |
| GB201108108D0 (en) * | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
| US20140056870A1 (en) * | 2012-08-27 | 2014-02-27 | Allergan, Inc. | Fusion proteins |
| GB201219024D0 (en) * | 2012-10-23 | 2012-12-05 | Syntaxin Ltd | Assay |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| TW201814045A (zh) | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
| US20210277071A1 (en) | 2016-09-29 | 2021-09-09 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN112511569B (zh) * | 2021-02-07 | 2021-05-11 | 杭州筋斗腾云科技有限公司 | 网络资源访问请求的处理方法、系统及计算机设备 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
| GB9305735D0 (en) * | 1993-03-19 | 1993-05-05 | North John R | Novel agent for controlling cell activity |
| GB9508204D0 (en) * | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| GB9617671D0 (en) * | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| AU755513B2 (en) * | 1998-05-13 | 2002-12-12 | Merz Pharma Gmbh & Co. Kgaa | Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof |
| US6822076B2 (en) * | 1998-05-13 | 2004-11-23 | Biotecon Therapeutics Gmbh | Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof |
| GB9818548D0 (en) * | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| GB9922554D0 (en) * | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
| KR100870123B1 (ko) * | 2000-10-20 | 2008-11-25 | 츄가이 세이야꾸 가부시키가이샤 | 저분자화 아고니스트 항체 |
| CA2424371A1 (en) * | 2000-10-20 | 2003-04-01 | Chugai Seiyaku Kabushiki Kaisha | Agonistic monoclonal antibody fragments |
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2003
- 2003-09-11 GB GBGB0321344.4A patent/GB0321344D0/en not_active Ceased
-
2004
- 2004-09-13 EP EP04768450A patent/EP1667725A2/en not_active Ceased
- 2004-09-13 CA CA2538619A patent/CA2538619C/en not_active Expired - Fee Related
- 2004-09-13 WO PCT/GB2004/003904 patent/WO2005023309A2/en not_active Ceased
- 2004-09-13 JP JP2006525899A patent/JP2007505094A/ja active Pending
- 2004-09-13 US US10/571,515 patent/US20070184048A1/en not_active Abandoned
- 2004-09-13 AU AU2004269979A patent/AU2004269979B2/en not_active Ceased
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2009
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2012
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- 2012-06-20 US US13/528,762 patent/US20130122526A1/en not_active Abandoned
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2018
- 2018-06-28 US US16/021,540 patent/US20180362951A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005023309A3 (en) | 2005-09-15 |
| CA2538619A1 (en) | 2005-03-17 |
| GB0321344D0 (en) | 2003-10-15 |
| US20090291457A1 (en) | 2009-11-26 |
| US20180362951A1 (en) | 2018-12-20 |
| EP1667725A2 (en) | 2006-06-14 |
| US20070184048A1 (en) | 2007-08-09 |
| JP2007505094A (ja) | 2007-03-08 |
| JP2012139222A (ja) | 2012-07-26 |
| WO2005023309A2 (en) | 2005-03-17 |
| JP6122243B2 (ja) | 2017-04-26 |
| US20130122526A1 (en) | 2013-05-16 |
| AU2004269979B2 (en) | 2009-12-10 |
| AU2004269979A1 (en) | 2005-03-17 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200914 |
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| MKLA | Lapsed |
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