CA2530589A1 - Arylmethyl triazolo and imidazopyrazines as c-met inhibitors - Google Patents

Arylmethyl triazolo and imidazopyrazines as c-met inhibitors Download PDF

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Publication number
CA2530589A1
CA2530589A1 CA002530589A CA2530589A CA2530589A1 CA 2530589 A1 CA2530589 A1 CA 2530589A1 CA 002530589 A CA002530589 A CA 002530589A CA 2530589 A CA2530589 A CA 2530589A CA 2530589 A1 CA2530589 A1 CA 2530589A1
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CA
Canada
Prior art keywords
group
substituted
heteroalicyclic
lower alkyl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002530589A
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English (en)
French (fr)
Inventor
Jingrong Cui
Iriny Botrous
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2530589A1 publication Critical patent/CA2530589A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002530589A 2003-07-02 2004-06-25 Arylmethyl triazolo and imidazopyrazines as c-met inhibitors Abandoned CA2530589A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48422003P 2003-07-02 2003-07-02
US60/484,220 2003-07-02
US10/875,507 US7250417B2 (en) 2003-07-02 2004-06-25 Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors
PCT/US2004/020062 WO2005004607A1 (en) 2003-07-02 2004-06-25 Arylmethyl triazolo and imidazopyrazines as c-met inhibitors
US10/875,507 2004-06-25

Publications (1)

Publication Number Publication Date
CA2530589A1 true CA2530589A1 (en) 2005-01-20

Family

ID=34068189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002530589A Abandoned CA2530589A1 (en) 2003-07-02 2004-06-25 Arylmethyl triazolo and imidazopyrazines as c-met inhibitors

Country Status (7)

Country Link
US (1) US7250417B2 (https=)
EP (1) EP1643836A4 (https=)
JP (1) JP2007516180A (https=)
BR (1) BRPI0412003A (https=)
CA (1) CA2530589A1 (https=)
MX (1) MXPA06000091A (https=)
WO (1) WO2005004607A1 (https=)

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DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
US8592448B2 (en) 2008-11-20 2013-11-26 OSI Pharmaceuticals, LLC Substituted pyrrolo[2,3-b]-pyridines and -pyrazines
WO2010068483A2 (en) * 2008-11-25 2010-06-17 University Of Rochester Mlk inhibitors and methods of use
SI2361250T1 (sl) 2008-12-22 2013-12-31 Merck Patent Gmbh Nove polimorfne oblike 6-(1-metil-1h-pirazol-4-il)-2-(3-(5-(2-morfolin-4-il-etoksi)-pirimidin- 2-il)-benzil)-2h-piridazin-3-on dihidrogenfosfata in postopki za proizvodnjo le-tega
DE102009003975A1 (de) 2009-01-07 2010-07-08 Merck Patent Gmbh Benzothiazolonderivate
AU2010232729A1 (en) 2009-03-31 2011-10-20 Arqule, Inc. Substituted indolo-pyridinone compounds
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (ru) 2009-08-12 2012-09-28 Новартис Аг Гетероциклические гидразоны и их применение для лечения рака и воспаления
CA2771432A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
EA030141B1 (ru) * 2009-12-31 2018-06-29 Хатчисон Медифарма Лимитед Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
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EP2569315A1 (en) 2010-05-14 2013-03-20 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
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MY170236A (en) 2010-10-06 2019-07-11 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
WO2012059932A1 (en) 2010-11-01 2012-05-10 Aurigene Discovery Technologies Limited 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors
CN102532141A (zh) 2010-12-08 2012-07-04 中国科学院上海药物研究所 [1,2,4]三唑并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途
JP2014513724A (ja) 2011-05-16 2014-06-05 オーエスアイ・ファーマシューティカルズ,エルエルシー 融合二環キナーゼ阻害剤
WO2012178038A1 (en) 2011-06-24 2012-12-27 The Broad Institute, Inc. Methods of treating cancer
CN104109166B (zh) * 2013-04-17 2017-06-20 上海医药集团股份有限公司 喹啉类化合物、其制备方法、中间体、药物组合物和应用
CN104250257B (zh) * 2013-06-25 2017-06-16 上海翰森生物医药科技有限公司 3,4‑二氢‑1H‑苯并[c][1,2]噁硼酸类化合物或其可药用盐及其制备方法和用途
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Also Published As

Publication number Publication date
JP2007516180A (ja) 2007-06-21
MXPA06000091A (es) 2006-04-07
US20050107391A1 (en) 2005-05-19
EP1643836A4 (en) 2006-12-06
US7250417B2 (en) 2007-07-31
BRPI0412003A (pt) 2006-08-15
WO2005004607A1 (en) 2005-01-20
EP1643836A1 (en) 2006-04-12

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued