CA2529752A1 - Transduction polypeptidique et peptides fusogenes - Google Patents
Transduction polypeptidique et peptides fusogenes Download PDFInfo
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- CA2529752A1 CA2529752A1 CA002529752A CA2529752A CA2529752A1 CA 2529752 A1 CA2529752 A1 CA 2529752A1 CA 002529752 A CA002529752 A CA 002529752A CA 2529752 A CA2529752 A CA 2529752A CA 2529752 A1 CA2529752 A1 CA 2529752A1
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- polypeptide
- virus
- protein
- tat
- fusion polypeptide
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- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16311—Influenzavirus C, i.e. influenza C virus
- C12N2760/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
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- Virology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48006503P | 2003-06-20 | 2003-06-20 | |
| US60/480,065 | 2003-06-20 | ||
| PCT/US2004/020837 WO2005084158A2 (fr) | 2003-06-20 | 2004-06-18 | Transduction polypeptidique et peptides fusogenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2529752A1 true CA2529752A1 (fr) | 2005-09-15 |
Family
ID=34919290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002529752A Abandoned CA2529752A1 (fr) | 2003-06-20 | 2004-06-18 | Transduction polypeptidique et peptides fusogenes |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060222657A1 (fr) |
| EP (1) | EP1732581A4 (fr) |
| AU (1) | AU2004316996A1 (fr) |
| CA (1) | CA2529752A1 (fr) |
| WO (1) | WO2005084158A2 (fr) |
Families Citing this family (69)
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|---|---|---|---|---|
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| ES2411962T3 (es) | 2003-10-24 | 2013-07-09 | Gencia Corporation | Métodos y composiciones para suministrar polinucleótidos |
| US20090098049A1 (en) * | 2004-09-07 | 2009-04-16 | The Regents Of The University Of California | Targeting transducible molecules to specific cell types |
| US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| WO2007031098A1 (fr) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Inhibiteurs peptidiques permeables aux cellules de la voie de transduction de signal jnk |
| US8114581B2 (en) * | 2005-09-15 | 2012-02-14 | The Regents Of The University Of California | Methods and compositions for detecting neoplastic cells |
| US8883507B2 (en) | 2005-10-18 | 2014-11-11 | The Regents Of The University Of Colorado | Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells |
| AU2014202016B2 (en) * | 2005-10-18 | 2016-05-19 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| KR100874947B1 (ko) * | 2005-11-30 | 2008-12-19 | 김정문 | 비활성 Ｗｎｔ 저해 폴리펩티드 및 그 제조방법 |
| WO2007095152A2 (fr) * | 2006-02-10 | 2007-08-23 | The Regents Of The University Of California | LIVRAISON TRANSDUCTRICE D'ARNsi PAR LIAISON ARN DOUBLE BRIN DE DOMAINES DE FUSION AU PTD/CPPS |
| WO2008008476A2 (fr) * | 2006-07-12 | 2008-01-17 | The Regents Of The University Of California | Distribution transductrice d'acides nucléiques par des groupes de protection phosphotriester réversible à neutralisation de charge |
| EP2059122B1 (fr) * | 2006-08-28 | 2012-06-20 | University of Rochester | Procédés et compositions en rapport avec l'expression d'apobec-i |
| US20090047703A1 (en) * | 2007-08-17 | 2009-02-19 | University Of Maryland, Baltimore | ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease |
| EP2242520A2 (fr) * | 2008-01-14 | 2010-10-27 | SurModics, Inc. | Dispositifs et procédés pour l'élution de complexes d'administration d'acide nucléique |
| EP2955222B1 (fr) | 2008-03-17 | 2018-09-12 | The Scripps Research Institute | Approches chimiques et génétiques combinées pour la génération de cellules souches pluripotentes induites |
| WO2009139930A2 (fr) | 2008-05-16 | 2009-11-19 | Taiga Biotechnologies, Inc. | Anticorps et leurs procédés de préparation |
| WO2009143864A1 (fr) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Utilisation d'inhibiteurs peptidiques perméables aux cellules de la voie de transduction du signal jnk pour le traitement de maladies digestives inflammatoires chroniques ou non chroniques |
| WO2009143865A1 (fr) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Utilisation d'inhibiteurs peptidiques des voies de traduction du signal jnk perméables aux cellules pour le traitement de diverses maladies |
| EP2746387A1 (fr) | 2008-07-21 | 2014-06-25 | Taiga Biotechnologies, Inc. | Cellules anucléées différenciées et leur procédé de préparation |
| DK2966084T3 (en) | 2008-08-28 | 2018-08-06 | Taiga Biotechnologies Inc | MODULATORS OF MYC, PROCEDURES FOR USING SAME AND PROCEDURES FOR IDENTIFYING SUBSTANCES MODULATING MYC |
| KR100996953B1 (ko) * | 2008-11-10 | 2010-11-26 | 메디스커브 주식회사 | 세포 내로 나노입자를 전달하는 방법 및 이를 위한 펩타이드 |
| WO2010072228A1 (fr) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Nouvelles constructions transporteuses et molécules conjuguées cargo/transporteuses |
| US20100260850A1 (en) * | 2009-04-08 | 2010-10-14 | Surmodics, Inc. | Controlled Release Devices and Methods for Delivery of Nucleic Acids |
| WO2010129033A2 (fr) * | 2009-04-29 | 2010-11-11 | Calmune Corporation | Anticorps modifiés pour immunothérapie passive |
| US20120258104A1 (en) | 2009-07-22 | 2012-10-11 | Cenix Bioscience Gmbh | Delivery System and Conjugates For Compound Delivery Via Naturally Occurring Intracellular Transport Routes |
| AU2010306940A1 (en) | 2009-10-12 | 2012-06-07 | Smith, Larry | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| ES2938049T3 (es) | 2009-10-16 | 2023-04-04 | Scripps Research Inst | Inducción de células pluripotentes |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| US9006415B2 (en) | 2010-04-06 | 2015-04-14 | Massachusetts Institute Of Technology | Targeted delivery of nucleic acids |
| ES2685171T3 (es) | 2010-06-14 | 2018-10-05 | The Scripps Research Institute | Reprogramación de células a un nuevo destino |
| WO2011160653A1 (fr) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Nouvelles molécules inhibant jnk |
| US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| EP2643484A4 (fr) | 2010-11-22 | 2014-04-16 | Univ California | Procédés d'identification d'un transcrit cellulaire naissant d'arn |
| KR20140063501A (ko) | 2010-12-22 | 2014-05-27 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| CA2825023A1 (fr) | 2011-01-26 | 2012-08-02 | Cenix Bioscience Gmbh | Systeme d'administration et conjugues pour l'administration de composes par des voies de transport intracellulaire naturelles |
| KR101605520B1 (ko) | 2011-09-22 | 2016-04-04 | 대한민국 | Ｐｔｄ를 포함하는 약독화 재조합 바이러스 및 이의 제조방법 |
| WO2013091670A1 (fr) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Nouvelles molécules inhibitrices de jnk pour le traitement de diverses maladies |
| WO2013116903A1 (fr) | 2012-02-10 | 2013-08-15 | Phylogica Limited | Procédé de caractérisation de sites d'interaction sur des protéines cibles |
| EP3358013B1 (fr) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Compositions d'acide nucléique interférent court (sina) |
| CA3133302A1 (fr) | 2012-07-20 | 2014-01-23 | Taiga Biotechnologies, Inc. | Reconstitution et auto-reconstitution ameliorees du compartiment hematopoietique comprenant un polypeptide myc |
| EP2885313A4 (fr) | 2012-08-20 | 2016-03-09 | Univ California | Polynucléotides possédant des groupes bioréversibles |
| US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
| US9365825B2 (en) | 2013-03-11 | 2016-06-14 | Taiga Biotechnologies, Inc. | Expansion of adult stem cells in vitro |
| CA2907184C (fr) | 2013-03-15 | 2022-12-06 | Sutter West Bay Hospitals | Antigene falz destine a etre utilise comme cible pour therapies destinees a traiter le cancer |
| WO2015197097A1 (fr) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | Nouvelle utilisation pour des molécules inhibitrices de la jnk, pour le traitement de diverses maladies |
| WO2014206427A1 (fr) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | Nouvelle utilisation d'inhibiteurs de peptides à perméabilité cellulaire dans la voie de transduction du signal jnk pour le traitement de diverses maladies |
| CN105658230B (zh) | 2013-08-29 | 2020-04-21 | 希望之城 | 细胞穿透缀合物及其使用方法 |
| SG10201807292YA (en) | 2014-03-04 | 2018-09-27 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| US20150266945A1 (en) * | 2014-03-21 | 2015-09-24 | Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | Fusion protein, a method of making the same, and a method of delivering antigenic peptide into the endoplasmic reticulum by the fusion protein |
| AU2015279089B2 (en) | 2014-06-26 | 2021-01-28 | Janssen Vaccines & Prevention B.V. | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| EP3172240A4 (fr) * | 2014-07-22 | 2018-04-18 | The Regents of the University of California | Domaines d'échappement endosomal pour introduire des macromolécules dans des cellules |
| WO2017026779A1 (fr) | 2015-08-10 | 2017-02-16 | Cellivery Therapeutics, Inc. | Protéine recombinée cre à perméabilité cellulaire améliorée (icp-cre) et son utilisation |
| US11441126B2 (en) | 2015-10-16 | 2022-09-13 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
| EP3500581A4 (fr) | 2016-08-17 | 2021-10-06 | Solstice Biologics, Ltd. | Constructions polynucléotidiques |
| CA3045017A1 (fr) | 2016-12-02 | 2018-06-07 | Taiga Biotechnologies, Inc. | Formulations de nanoparticules |
| EP3641801A1 (fr) | 2017-06-22 | 2020-04-29 | Catalyst Biosciences, Inc. | Polypeptides de sérine protéase 1 de type à membrane modifiée (mtsp-1) et leurs procédés d'utilisation |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| AU2018308982A1 (en) * | 2017-08-03 | 2020-02-13 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of cancer |
| US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
| US12059407B2 (en) | 2017-12-04 | 2024-08-13 | The Regents Of The University Of California | Compositions and methods for delivery of macromolecules |
| JP2022516725A (ja) | 2018-12-28 | 2022-03-02 | カタリスト・バイオサイエンシーズ・インコーポレイテッド | 改変ウロキナーゼ型プラスミノゲンアクティベータポリペプチドおよび使用方法 |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| SG10201905939WA (en) | 2019-06-26 | 2021-01-28 | Cell Mogrify Australia Pty Ltd | Cell culture methods and compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804604A (en) * | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| US6316003B1 (en) * | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
| US5670617A (en) * | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| CA2314267A1 (fr) * | 1997-12-10 | 1999-06-17 | Washington University | Systeme anti-pathogene et procedes d'utilisation |
| JP2002518521A (ja) * | 1998-06-20 | 2002-06-25 | ワシントン・ユニバーシティ | 医用画像解析、診断および治療のための膜透過性ペプチド錯体 |
| WO2002085305A2 (fr) * | 2001-04-24 | 2002-10-31 | Washington University | Compositions et methodes pouvant induire la mort de cellules cancereuses |
| US20060040882A1 (en) * | 2004-05-04 | 2006-02-23 | Lishan Chen | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
-
2004
- 2004-06-18 CA CA002529752A patent/CA2529752A1/fr not_active Abandoned
- 2004-06-18 WO PCT/US2004/020837 patent/WO2005084158A2/fr not_active Application Discontinuation
- 2004-06-18 AU AU2004316996A patent/AU2004316996A1/en not_active Abandoned
- 2004-06-18 EP EP04821562A patent/EP1732581A4/fr not_active Withdrawn
- 2004-06-18 US US10/561,092 patent/US20060222657A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1732581A2 (fr) | 2006-12-20 |
| WO2005084158A3 (fr) | 2007-07-26 |
| US20060222657A1 (en) | 2006-10-05 |
| AU2004316996A1 (en) | 2005-09-15 |
| EP1732581A4 (fr) | 2008-06-04 |
| WO2005084158A2 (fr) | 2005-09-15 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |