CA2528160C - Use of 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine for neuronal regeneration and functional recovery - Google Patents
Use of 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine for neuronal regeneration and functional recovery Download PDFInfo
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- CA2528160C CA2528160C CA2528160A CA2528160A CA2528160C CA 2528160 C CA2528160 C CA 2528160C CA 2528160 A CA2528160 A CA 2528160A CA 2528160 A CA2528160 A CA 2528160A CA 2528160 C CA2528160 C CA 2528160C
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Classifications
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47832903P | 2003-06-12 | 2003-06-12 | |
| US47873503P | 2003-06-12 | 2003-06-12 | |
| US60/478,735 | 2003-06-12 | ||
| US60/478,329 | 2003-06-12 | ||
| US49813203P | 2003-08-26 | 2003-08-26 | |
| US60/498,132 | 2003-08-26 | ||
| US55261304P | 2004-03-12 | 2004-03-12 | |
| US60/552,613 | 2004-03-12 | ||
| PCT/US2004/019139 WO2004110387A2 (en) | 2003-06-12 | 2004-06-14 | Sigma ligands for neuronal regeneration and functional recovery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2528160A1 CA2528160A1 (en) | 2004-12-23 |
| CA2528160C true CA2528160C (en) | 2012-01-03 |
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Family Applications (1)
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| US7863272B2 (en) * | 2003-06-12 | 2011-01-04 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
| US20060052386A1 (en) * | 2003-06-12 | 2006-03-09 | Tadeusz Wieloch | Sigma ligands for neuronal regeneration and functional recovery |
| US8299062B2 (en) * | 2003-09-17 | 2012-10-30 | Franklin Volvovitz | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction |
| US20060106064A1 (en) * | 2004-11-03 | 2006-05-18 | University Of North Texas Health Science Center At Fort Worth | Butyrophenones and sigma-1 receptor antagonists protect against oxidative-stress |
| WO2006133199A2 (en) * | 2005-06-06 | 2006-12-14 | University Of South Florida | Treatment with sigma receptor agonists post-stroke |
| EP1787679A1 (en) * | 2005-07-29 | 2007-05-23 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
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| WO2007081946A2 (en) * | 2006-01-09 | 2007-07-19 | University Of South Florida | Method for the identification of drugs to treat stroke at delayed timepoints |
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| BRPI0908217A2 (pt) * | 2008-02-18 | 2015-08-25 | Esteve Labor Dr | Uso de compostos de ligação aos ligantes do receptor sigma para o tratamento de dor neuropática desenvolvida como uma consequência de quimioterapia |
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| WO2010048164A2 (en) * | 2008-10-20 | 2010-04-29 | University Of South Florida | N,n'-di-p-bromophenyl guanidine treatment for stroke at delayed timepoints |
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| WO2013166307A2 (en) * | 2012-05-02 | 2013-11-07 | University Of South Florida | N,n'-di-1 naphthylguanidine hcl (nagh) and n,n'-di-p-nitrophenylguanidine hcl (nad) treatment for stroke at delayed timepoints |
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| EP3364976A4 (en) * | 2015-10-19 | 2019-06-05 | Board of Regents, The University of Texas System | PIPERAZINYL-NORBENZOMORPHAN COMPOUNDS AND METHOD FOR USE THEREOF |
| JP7059192B2 (ja) * | 2016-02-11 | 2022-04-25 | シグマテラ・ソシエテ・パ・アクシオンス・シンプリフィエ | 神経変性疾患の治療に使用するためのイグメシン |
| CA3022512A1 (en) | 2016-04-29 | 2017-11-02 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
| AU2018269964B2 (en) | 2017-05-15 | 2022-07-07 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
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| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
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| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| EP3844171A4 (en) * | 2018-08-31 | 2022-08-10 | Texas Tech University System | ENHANCER OF NEUROLYSIN ACTIVITY |
| WO2020056418A1 (en) | 2018-09-14 | 2020-03-19 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| CN111848549B (zh) * | 2019-04-29 | 2022-04-22 | 苏州大学 | 芳基肟类化合物及其制备和应用 |
| CN116867488A (zh) * | 2020-12-11 | 2023-10-10 | 考格尼申治疗股份有限公司 | 用于治疗干性老年性黄斑变性（amd）的组合物 |
| JP2024531809A (ja) * | 2021-09-20 | 2024-08-29 | エステベ ファーマシューティカルズ，ソシエダッド アノニマ | 運動ニューロン変性の処置又は神経保護において使用するためのオキサジアザスピロ化合物 |
| WO2023154794A1 (en) * | 2022-02-09 | 2023-08-17 | University Of North Texas Health Science Center | Drug repurposing for delayed treatment of ischemic stroke |
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| US5055470A (en) * | 1989-06-01 | 1991-10-08 | Bristol-Myers Squibb Co. | Method of treatment of ischemia in brain |
| US5109002A (en) | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
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| US5229394A (en) * | 1990-07-30 | 1993-07-20 | Arch Development Corporation | Method for treatment of amyotrophic lateral sclerosis comprising administration of dmp |
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| WO1993009094A1 (en) | 1991-10-30 | 1993-05-13 | The Du Pont Merck Pharmaceutical Company | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents |
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| US6087346A (en) * | 1993-06-23 | 2000-07-11 | Cambridge Neuroscience, Inc. | Sigma receptor ligands and the use thereof |
| KR100299734B1 (ko) * | 1993-07-28 | 2002-01-09 | 모리타 다카카즈 | 1,4-(디페닐알킬)피페라진유도체 |
| GB9416571D0 (en) * | 1994-08-16 | 1994-10-12 | Battelle Memorial Institute | Novel alkylamino derivatives as sigma 2 selective ligands |
| UA64769C2 (uk) * | 1997-11-07 | 2004-03-15 | Х. Луннбек А/С | Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування |
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| GB0007842D0 (en) * | 2000-03-31 | 2000-05-17 | Spruce Barbara | Sigma receptor ligands and their medical uses |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US7863272B2 (en) * | 2003-06-12 | 2011-01-04 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
| US20060052386A1 (en) | 2003-06-12 | 2006-03-09 | Tadeusz Wieloch | Sigma ligands for neuronal regeneration and functional recovery |
| US7829562B2 (en) * | 2003-06-12 | 2010-11-09 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
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- 2004-06-14 US US10/868,048 patent/US20050020483A1/en not_active Abandoned
- 2004-06-14 EP EP04755359A patent/EP1635805A4/en not_active Withdrawn
- 2004-06-14 EP EP04776629A patent/EP1644026A4/en not_active Withdrawn
- 2004-06-14 JP JP2006533806A patent/JP4963607B2/ja not_active Expired - Fee Related
- 2004-06-14 CA CA2528160A patent/CA2528160C/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| US20050020483A1 (en) | 2005-01-27 |
| JP4963607B2 (ja) | 2012-06-27 |
| US7863272B2 (en) | 2011-01-04 |
| US20050059689A1 (en) | 2005-03-17 |
| JP2007500757A (ja) | 2007-01-18 |
| EP1644026A2 (en) | 2006-04-12 |
| WO2004110387A2 (en) | 2004-12-23 |
| WO2004110387A3 (en) | 2005-08-18 |
| EP1644026A4 (en) | 2007-10-24 |
| EP1635805A4 (en) | 2007-08-08 |
| WO2004110389A2 (en) | 2004-12-23 |
| CA2528160A1 (en) | 2004-12-23 |
| WO2004110388A3 (en) | 2005-07-28 |
| US20050032827A1 (en) | 2005-02-10 |
| WO2004110389A3 (en) | 2005-12-22 |
| EP1635805A2 (en) | 2006-03-22 |
| WO2004110388A2 (en) | 2004-12-23 |
| US20110082154A1 (en) | 2011-04-07 |
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