CA2527186A1 - Compositions comprising gastrin compounds and their use in diabetes - Google Patents
Compositions comprising gastrin compounds and their use in diabetes Download PDFInfo
- Publication number
- CA2527186A1 CA2527186A1 CA002527186A CA2527186A CA2527186A1 CA 2527186 A1 CA2527186 A1 CA 2527186A1 CA 002527186 A CA002527186 A CA 002527186A CA 2527186 A CA2527186 A CA 2527186A CA 2527186 A1 CA2527186 A1 CA 2527186A1
- Authority
- CA
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- Prior art keywords
- composition
- weeks
- cells
- gastrin compound
- gastrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- GXHMMDRXHUIUMN-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O GXHMMDRXHUIUMN-UHFFFAOYSA-N 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
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- 108010076432 minigastrin Proteins 0.000 description 1
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- 229940127264 non-peptide agonist Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
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- 239000004031 partial agonist Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- ANRIQLNBZQLTFV-DZUOILHNSA-N pentagastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1[C]2C=CC=CC2=NC=1)NC(=O)CCNC(=O)OC(C)(C)C)CCSC)C(N)=O)C1=CC=CC=C1 ANRIQLNBZQLTFV-DZUOILHNSA-N 0.000 description 1
- 229960000444 pentagastrin Drugs 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 201000009104 prediabetes syndrome Diseases 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- RZIMNEGTIDYAGZ-HNSJZBNRSA-N pro-gastrin Chemical compound N([C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C(=O)[C@@H]1CCC(=O)N1 RZIMNEGTIDYAGZ-HNSJZBNRSA-N 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
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- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
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- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- RGYLYUZOGHTBRF-BIHRQFPBSA-N tetragastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)CCSC)C(N)=O)C1=CC=CC=C1 RGYLYUZOGHTBRF-BIHRQFPBSA-N 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
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- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2207—Gastrins; Cholecystokinins [CCK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US03/16660 | 2003-05-27 | ||
| PCT/US2003/016660 WO2003100024A2 (en) | 2002-05-24 | 2003-05-27 | Treatment for diabetes |
| PCT/CA2004/000769 WO2004105780A2 (en) | 2003-05-27 | 2004-05-27 | Compositions comprising gastrin compounds and their use in diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2527186A1 true CA2527186A1 (en) | 2004-12-09 |
Family
ID=33488788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002527186A Abandoned CA2527186A1 (en) | 2003-05-27 | 2004-05-27 | Compositions comprising gastrin compounds and their use in diabetes |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1648495A2 (enExample) |
| JP (1) | JP2007513059A (enExample) |
| CN (1) | CN1829528A (enExample) |
| AU (1) | AU2004243541A1 (enExample) |
| BR (1) | BRPI0410710A (enExample) |
| CA (1) | CA2527186A1 (enExample) |
| MX (1) | MXPA05012605A (enExample) |
| NO (1) | NO20055582L (enExample) |
| PL (1) | PL379145A1 (enExample) |
| RU (1) | RU2005140518A (enExample) |
| WO (1) | WO2004105780A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1351742B1 (en) | 2001-01-12 | 2008-10-15 | Waratah Pharmaceuticals Inc. | Compositions for inducing islet neogenesis, containing gastrin/cck receptor ligands and egf receptor ligands |
| EP1837031B1 (en) | 2002-06-07 | 2009-10-14 | Waratah Pharmaceuticals, Inc. | Compositions and methods for treating diabetes |
| ES2334268T3 (es) | 2002-06-07 | 2010-03-08 | Waratah Pharmaceuticals, Inc. | Procedimientos y composiciones para el tratamiento de la diabetes. |
| AU2005207870B2 (en) * | 2004-01-30 | 2010-08-19 | Waratah Pharmaceuticals, Inc. | The combined use of GLP-1 agonists and gastrin for regulating blood glucose levels |
| US20100256061A1 (en) * | 2007-03-02 | 2010-10-07 | Antonio Cruz | Gastrin compound for diabetes treatment |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6558952B1 (en) * | 1992-12-14 | 2003-05-06 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
| CA2182034C (en) * | 1994-01-24 | 2009-04-21 | Ronald V. Nardi | Treatment for juvenile diabetes |
| EP1351742B1 (en) * | 2001-01-12 | 2008-10-15 | Waratah Pharmaceuticals Inc. | Compositions for inducing islet neogenesis, containing gastrin/cck receptor ligands and egf receptor ligands |
| PL376473A1 (en) * | 2002-10-22 | 2005-12-27 | Waratah Pharmaceuticals, Inc. | Treatment of diabetes |
-
2004
- 2004-05-27 JP JP2006529497A patent/JP2007513059A/ja active Pending
- 2004-05-27 MX MXPA05012605A patent/MXPA05012605A/es not_active Application Discontinuation
- 2004-05-27 CA CA002527186A patent/CA2527186A1/en not_active Abandoned
- 2004-05-27 RU RU2005140518/15A patent/RU2005140518A/ru not_active Application Discontinuation
- 2004-05-27 BR BRPI0410710-1A patent/BRPI0410710A/pt not_active IP Right Cessation
- 2004-05-27 PL PL379145A patent/PL379145A1/pl not_active Application Discontinuation
- 2004-05-27 EP EP04737749A patent/EP1648495A2/en not_active Withdrawn
- 2004-05-27 WO PCT/CA2004/000769 patent/WO2004105780A2/en not_active Ceased
- 2004-05-27 CN CNA200480022042XA patent/CN1829528A/zh active Pending
- 2004-05-27 AU AU2004243541A patent/AU2004243541A1/en not_active Withdrawn
-
2005
- 2005-11-25 NO NO20055582A patent/NO20055582L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20055582L (no) | 2006-02-27 |
| PL379145A1 (pl) | 2006-07-24 |
| WO2004105780A2 (en) | 2004-12-09 |
| MXPA05012605A (es) | 2006-02-22 |
| NO20055582D0 (no) | 2005-11-25 |
| BRPI0410710A (pt) | 2006-06-13 |
| CN1829528A (zh) | 2006-09-06 |
| JP2007513059A (ja) | 2007-05-24 |
| WO2004105780A3 (en) | 2005-01-20 |
| AU2004243541A1 (en) | 2004-12-09 |
| RU2005140518A (ru) | 2007-07-10 |
| EP1648495A2 (en) | 2006-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20100527 |