CA2523998C - Nouveaux peptides antimicrobiens - Google Patents

Nouveaux peptides antimicrobiens Download PDF

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Publication number
CA2523998C
CA2523998C CA2523998A CA2523998A CA2523998C CA 2523998 C CA2523998 C CA 2523998C CA 2523998 A CA2523998 A CA 2523998A CA 2523998 A CA2523998 A CA 2523998A CA 2523998 C CA2523998 C CA 2523998C
Authority
CA
Canada
Prior art keywords
antimicrobial
peptides
peptide
bacterial infection
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2523998A
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English (en)
Other versions
CA2523998A1 (fr
Inventor
Artur Schmidtchen
Martin Malmsten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pergamum AB
Original Assignee
Pergamum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pergamum AB filed Critical Pergamum AB
Publication of CA2523998A1 publication Critical patent/CA2523998A1/fr
Application granted granted Critical
Publication of CA2523998C publication Critical patent/CA2523998C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2523998A 2003-05-19 2004-05-19 Nouveaux peptides antimicrobiens Expired - Fee Related CA2523998C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32020403P 2003-05-19 2003-05-19
SE0301431A SE0301431D0 (sv) 2003-05-19 2003-05-19 Novel antimicrobial peptides
US60/320,204 2003-05-19
SE0301431-3 2003-05-19
PCT/SE2004/000797 WO2005061535A1 (fr) 2003-05-19 2004-05-19 Nouveaux peptides antimicrobiens presentant une activite de liaison a l'heparine

Publications (2)

Publication Number Publication Date
CA2523998A1 CA2523998A1 (fr) 2005-07-07
CA2523998C true CA2523998C (fr) 2014-05-13

Family

ID=20291321

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2523998A Expired - Fee Related CA2523998C (fr) 2003-05-19 2004-05-19 Nouveaux peptides antimicrobiens

Country Status (12)

Country Link
US (2) US20070185019A1 (fr)
EP (1) EP1625155B1 (fr)
JP (1) JP4611979B2 (fr)
KR (1) KR101160474B1 (fr)
CN (2) CN101161284B (fr)
AU (1) AU2004303728B2 (fr)
CA (1) CA2523998C (fr)
ES (1) ES2395206T3 (fr)
HK (1) HK1119390A1 (fr)
PL (1) PL1625155T3 (fr)
SE (1) SE0301431D0 (fr)
WO (1) WO2005061535A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0402807D0 (sv) * 2004-11-17 2004-11-17 Dermagen Ab Novel antimicrobial peptides
US20090312265A1 (en) * 2006-02-10 2009-12-17 Dermagen Ab Novel antimicrobial peptides and use thereof
CA2637221A1 (fr) * 2006-02-10 2007-08-16 Dermagen Ab Nouveaux peptides antimicrobiens et leur utilisation
MX2008014415A (es) 2006-05-16 2009-01-29 Dermagen Ab Peptidos antimicrobianos mejorados.
US20080139518A1 (en) * 2006-12-04 2008-06-12 Concert, Llc Topical compositions for treatment of skin conditions
WO2008157483A2 (fr) * 2007-06-14 2008-12-24 The Research Foundation Of State University Of New York Polypeptides et procédés d'utilisation
GB0821721D0 (en) * 2008-11-27 2008-12-31 Hansa Medical Ab Antimicrobial therapy
WO2010080819A1 (fr) 2009-01-06 2010-07-15 C3 Jian, Inc. Fragments antimicrobiens ciblés
US8883153B2 (en) * 2009-03-27 2014-11-11 The Research for The State University of New York Methods for preventing and treating angioedema
FR2960877B1 (fr) * 2010-06-04 2014-08-29 Agronomique Inst Nat Rech Fraction de proteines et peptides issus du blanc d'oeuf et proteine issue du blanc d'oeuf et leur utilisation comme agent anti-listeria
CN102507936B (zh) * 2011-11-09 2013-10-23 北京正旦国际科技有限责任公司 一种肝癌标志物多抗免疫质谱试剂盒
WO2013170935A1 (fr) * 2012-05-14 2013-11-21 Merck Patent Gmbh Particules pour afficheurs électrophorétiques
WO2015138494A1 (fr) 2014-03-10 2015-09-17 Georges Belfort Peptides anti-microbiens et procédé de conception de nouveaux peptides anti-microbiens
JP6823790B2 (ja) * 2015-06-30 2021-02-03 チェイン アンチマイクロバイアルズ オイＣｈａｉｎ Ａｎｔｉｍｉｃｒｏｂｉａｌｓ Ｏｙ 新規な抗菌ペプチド、その変異体及び使用
US11174288B2 (en) * 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
WO2021034418A2 (fr) * 2019-07-02 2021-02-25 Trustees Of Tufts College Nouveau peptide, compositions et méthode d'administration d'agents dans des cellules et des tissus

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5912230A (en) * 1991-11-01 1999-06-15 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
CA2158058C (fr) * 1993-03-12 2000-08-01 Roger G. Ii Little Peptides biologiquement actifs provenant de domaines fonctionnels de proteines bactericides et augmentant la permeabilite; leurs utilisations
US5733872A (en) 1993-03-12 1998-03-31 Xoma Corporation Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
AU1086595A (en) 1993-11-08 1995-05-29 Demeter Biotechnologies, Ltd. Methylated lysine-rich lytic peptides and method of making same by reductive alkylation
JP3459314B2 (ja) 1994-08-31 2003-10-20 社団法人農林水産技術情報協会 新規ペプチド、抗菌剤、新規ペプチド遺伝子、新規な組み換え体ｄｎａ及び新規ペプチドの製造法
JPH08208692A (ja) * 1994-09-28 1996-08-13 Sumitomo Pharmaceut Co Ltd 新規な細胞接着抑制ペプチド誘導体
CA2192782C (fr) 1995-12-15 2008-10-14 Nobuyuki Takechi Production de microsphere
US6503881B2 (en) 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
IL121134A0 (en) * 1997-06-22 1997-11-20 Yeda Res & Dev Peptides and antiallergic compositions comprising them
WO2000027415A2 (fr) * 1998-11-10 2000-05-18 Temple University - Of The Commonwealth System Of Higher Education Inhibition de l'angiogenese au moyen d'analogues de peptide du domaine 5 de la kininogene de poids moleculaire eleve
AU773862B2 (en) 1998-11-10 2004-06-10 Temple University - Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof
US20030083244A1 (en) 2000-04-26 2003-05-01 Vernet Corine A.M. Novel proteins and nucleic acids encoding same
WO2002032459A2 (fr) * 2000-10-17 2002-04-25 Massachusetts Institute Of Technology Procede permettant d'ameliorer l'efficacite des antibiotiques par complexion avec des cyclodextrines
GB2382775B (en) * 2001-12-06 2005-05-25 Johnson & Johnson Medical Ltd Controlled release therapeutic wound dressings
RU2360922C2 (ru) * 2002-07-12 2009-07-10 БАЙЕР ХелсКер ЛЛСи Агонисты рецептора (vpac2) гипофизарного пептида, активирующего аденилатциклазу (расар), и фармакологические способы их применения
US20060173162A1 (en) 2002-08-15 2006-08-03 Rene Djurup Bactericidak anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp)

Also Published As

Publication number Publication date
AU2004303728A1 (en) 2005-07-07
US20090074864A1 (en) 2009-03-19
EP1625155A1 (fr) 2006-02-15
WO2005061535A1 (fr) 2005-07-07
SE0301431D0 (sv) 2003-05-19
CN101161284A (zh) 2008-04-16
JP2007531691A (ja) 2007-11-08
KR20060028676A (ko) 2006-03-31
KR101160474B1 (ko) 2012-06-28
PL1625155T3 (pl) 2013-06-28
AU2004303728B2 (en) 2011-03-31
US20070185019A1 (en) 2007-08-09
CN1791612A (zh) 2006-06-21
JP4611979B2 (ja) 2011-01-12
ES2395206T3 (es) 2013-02-11
EP1625155B1 (fr) 2012-08-29
HK1119390A1 (en) 2009-03-06
CN100362017C (zh) 2008-01-16
CN101161284B (zh) 2011-10-05
US8551954B2 (en) 2013-10-08
CA2523998A1 (fr) 2005-07-07

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Effective date: 20160519