CA2523714A1 - Substituted carboxylic acids - Google Patents

Info

Publication number

CA2523714A1

CA2523714A1 CA002523714A CA2523714A CA2523714A1 CA 2523714 A1 CA2523714 A1 CA 2523714A1 CA 002523714 A CA002523714 A CA 002523714A CA 2523714 A CA2523714 A CA 2523714A CA 2523714 A1 CA2523714 A1 CA 2523714A1

Authority

CA

Canada

Prior art keywords

alkyl

phenyl

biphenyl

benzyl

benzofuran

Prior art date

2003-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 150000001735 carboxylic acids Chemical class 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 354
• 238000000034 method Methods 0.000 claims abstract description 86
• 150000003839 salts Chemical class 0.000 claims abstract description 23
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
• 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 16
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 250
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 240
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 187
• 229910052736 halogen Inorganic materials 0.000 claims description 162
• 150000002367 halogens Chemical class 0.000 claims description 162
• -1 phenyl (C1-C4) alkyl Chemical group 0.000 claims description 128
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 78
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 69
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 68
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 64
• 125000000217 alkyl group Chemical group 0.000 claims description 60
• 125000005037 alkyl phenyl group Chemical group 0.000 claims description 60
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 52
• 125000001188 haloalkyl group Chemical group 0.000 claims description 46
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 41
• JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 39
• 125000004438 haloalkoxy group Chemical group 0.000 claims description 39
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 38
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 37
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 28
• 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims description 27
• 125000001041 indolyl group Chemical group 0.000 claims description 27
• 125000003545 alkoxy group Chemical group 0.000 claims description 25
• 125000003118 aryl group Chemical group 0.000 claims description 23
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 21
• 125000002252 acyl group Chemical group 0.000 claims description 21
• 125000004122 cyclic group Chemical group 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
• 125000003386 piperidinyl group Chemical group 0.000 claims description 17
• 125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 claims description 17
• 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims description 16
• TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 claims description 15
• 125000005545 phthalimidyl group Chemical group 0.000 claims description 15
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 15
• 125000002757 morpholinyl group Chemical group 0.000 claims description 14
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 13
• 125000004076 pyridyl group Chemical group 0.000 claims description 13
• 125000004988 dibenzothienyl group Chemical group C1(=CC=CC=2SC3=C(C21)C=CC=C3)* 0.000 claims description 12
• 125000001072 heteroaryl group Chemical group 0.000 claims description 12
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 11
• 125000001624 naphthyl group Chemical group 0.000 claims description 10
• MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims description 9
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 9
• 239000002671 adjuvant Substances 0.000 claims description 8
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 8
• 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 8
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
• 239000002904 solvent Substances 0.000 claims description 7
• FOUKSPNWVQXNSE-UHFFFAOYSA-N 4-[4-(4-dibenzofuran-4-ylphenyl)phenyl]-4-oxo-2-[[3-(trifluoromethyl)phenyl]methyl]butanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=CC=1C(=O)CC(C(=O)O)CC1=CC=CC(C(F)(F)F)=C1 FOUKSPNWVQXNSE-UHFFFAOYSA-N 0.000 claims description 5
• UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical compound C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 claims description 5
• 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims description 5
• 229960005190 phenylalanine Drugs 0.000 claims description 5
• NQDPPXMOGTWHAA-UHFFFAOYSA-N 2-benzyl-4-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]-4-oxobutanoic acid Chemical compound C=1C=CC=CC=1CC(C(=O)O)CC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1C(C1=CC=CC=C1O1)=C1CC1=CC=CC=C1 NQDPPXMOGTWHAA-UHFFFAOYSA-N 0.000 claims description 4
• 125000002541 furyl group Chemical group 0.000 claims description 4
• LSKFWNSFOPZXKV-UHFFFAOYSA-N methyl 4-[4-(4-dibenzofuran-4-ylphenyl)phenyl]-4-oxo-2-[[3-(trifluoromethyl)phenyl]methyl]butanoate Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C=3OC4=CC=CC=C4C=3C=CC=2)C=CC=1C(=O)CC(C(=O)OC)CC1=CC=CC(C(F)(F)F)=C1 LSKFWNSFOPZXKV-UHFFFAOYSA-N 0.000 claims description 4
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 4
• BCAPAVNRPJLWBU-UHFFFAOYSA-N 2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]butanoic acid Chemical compound C1=CC(S(=O)(=O)NC(CC)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 BCAPAVNRPJLWBU-UHFFFAOYSA-N 0.000 claims description 3
• WAKZELVPMHJKIX-UHFFFAOYSA-N 2-benzyl-4-[2-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]-4-oxobutanoic acid Chemical compound C=1C=CC=CC=1CC(C(=O)O)CC(=O)C1=CC=CC=C1C(C=C1)=CC=C1C(C1=CC=CC=C1O1)=C1CC1=CC=CC=C1 WAKZELVPMHJKIX-UHFFFAOYSA-N 0.000 claims description 3
• VCOJXFLHAWTRFN-UHFFFAOYSA-N 2-benzyl-4-[3-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]-4-oxobutanoic acid Chemical compound C=1C=CC=CC=1CC(C(=O)O)CC(=O)C(C=1)=CC=CC=1C(C=C1)=CC=C1C(C1=CC=CC=C1O1)=C1CC1=CC=CC=C1 VCOJXFLHAWTRFN-UHFFFAOYSA-N 0.000 claims description 3
• MPXRREHOMCUVNZ-UHFFFAOYSA-N 2-benzyl-4-[4-(4-indol-1-ylphenyl)phenyl]-4-oxobutanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)N2C3=CC=CC=C3C=C2)C=CC=1C(=O)CC(C(=O)O)CC1=CC=CC=C1 MPXRREHOMCUVNZ-UHFFFAOYSA-N 0.000 claims description 3
• WLXCNKISKIXXST-UHFFFAOYSA-N 2-benzyl-4-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2,6-dimethylphenyl]-4-oxobutanoic acid Chemical compound CC1=CC(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)=CC(C)=C1C(=O)CC(C(O)=O)CC1=CC=CC=C1 WLXCNKISKIXXST-UHFFFAOYSA-N 0.000 claims description 3
• JZUWBNLKHMQGNS-UHFFFAOYSA-N 4-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]-2-[(4-methylsulfonylphenyl)methyl]-4-oxobutanoic acid Chemical compound C1=CC(S(=O)(=O)C)=CC=C1CC(C(O)=O)CC(=O)C1=CC=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 JZUWBNLKHMQGNS-UHFFFAOYSA-N 0.000 claims description 3
• QNYLAIBEHNOPPA-UHFFFAOYSA-N 4-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]-2-[2-(1,3-dioxoisoindol-2-yl)ethyl]-4-oxobutanoic acid Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCC(C(=O)O)CC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1C(C1=CC=CC=C1O1)=C1CC1=CC=CC=C1 QNYLAIBEHNOPPA-UHFFFAOYSA-N 0.000 claims description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 3
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 3
• RVJUPLWFUPACJL-JGCGQSQUSA-N (2r)-2-[4-[4-(1-butylindolizin-2-yl)phenyl]phenoxy]-3-phenylpropanoic acid Chemical compound C([C@@H](OC1=CC=C(C=C1)C1=CC=C(C=C1)C=1C(=C2C=CC=CN2C=1)CCCC)C(O)=O)C1=CC=CC=C1 RVJUPLWFUPACJL-JGCGQSQUSA-N 0.000 claims description 2
• ALOFTPNNFBMPOW-MGBGTMOVSA-N (2r)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-n-methyl-2-nitroanilino]-3-phenylpropanoic acid Chemical compound C([C@@H](N(C)C=1C(=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)[N+]([O-])=O)C(O)=O)C1=CC=CC=C1 ALOFTPNNFBMPOW-MGBGTMOVSA-N 0.000 claims description 2
• QXMNORFCWALUQG-XIFFEERXSA-N (2s)-2-[4-[4-(1-butylindolizin-2-yl)phenyl]phenoxy]-4-phenylbutanoic acid Chemical compound C([C@H](OC1=CC=C(C=C1)C1=CC=C(C=C1)C=1C(=C2C=CC=CN2C=1)CCCC)C(O)=O)CC1=CC=CC=C1 QXMNORFCWALUQG-XIFFEERXSA-N 0.000 claims description 2
• LBHTUNQLUBVJPB-KDXMTYKHSA-N (2s)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-[(2-phenylacetyl)amino]anilino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NC=1C(=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)NC(=O)CC=1C=CC=CC=1)C1=CC=CC=C1 LBHTUNQLUBVJPB-KDXMTYKHSA-N 0.000 claims description 2
• TVGXOXUAFKXOQE-VWLOTQADSA-N (2s)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-nitroanilino]-3-hydroxypropanoic acid Chemical compound C1=C([N+]([O-])=O)C(N[C@@H](CO)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 TVGXOXUAFKXOQE-VWLOTQADSA-N 0.000 claims description 2
• VZQPGBMZSRZGNS-HKBQPEDESA-N (2s)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-nitroanilino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NC=1C(=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)[N+]([O-])=O)C1=CC=CC=C1 VZQPGBMZSRZGNS-HKBQPEDESA-N 0.000 claims description 2
• PLDAFOFKTYIKNJ-MHZLTWQESA-N (2s)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-nitroanilino]-4-methylsulfanylbutanoic acid Chemical compound C1=C([N+]([O-])=O)C(N[C@@H](CCSC)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 PLDAFOFKTYIKNJ-MHZLTWQESA-N 0.000 claims description 2
• QENAYTQFCPCMNZ-IBGZPJMESA-N (2s)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-nitroanilino]propanoic acid Chemical compound C1=C([N+]([O-])=O)C(N[C@@H](C)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 QENAYTQFCPCMNZ-IBGZPJMESA-N 0.000 claims description 2
• CTHQHLFBRGKYCW-PMERELPUSA-N (2s)-2-[4-[4-(2-benzyl-4-fluoro-1-benzofuran-3-yl)phenyl]-2-nitroanilino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NC=1C(=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=C(F)C=CC=C2OC=1CC=1C=CC=CC=1)[N+]([O-])=O)C1=CC=CC=C1 CTHQHLFBRGKYCW-PMERELPUSA-N 0.000 claims description 2
• JIZSLXVSDDGOQR-DHUJRADRSA-N (2s)-2-[4-[4-[(2-benzyl-7-ethoxy-1-benzofuran-4-yl)methyl]phenyl]-2-nitroanilino]-3-phenylpropanoic acid Chemical compound C([C@H](NC1=CC=C(C=C1[N+]([O-])=O)C1=CC=C(C=C1)CC1=CC=C(C=2OC(CC=3C=CC=CC=3)=CC=21)OCC)C(O)=O)C1=CC=CC=C1 JIZSLXVSDDGOQR-DHUJRADRSA-N 0.000 claims description 2
• SKVKSLAIKOIQDV-HKBQPEDESA-N (2s)-2-[[4-[4-(1-butylindolizin-2-yl)phenyl]benzoyl]amino]-3-phenylpropanoic acid Chemical compound C([C@H](NC(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)C=1C(=C2C=CC=CN2C=1)CCCC)C(O)=O)C1=CC=CC=C1 SKVKSLAIKOIQDV-HKBQPEDESA-N 0.000 claims description 2
• YAMKTWOCIRVYGC-HKBQPEDESA-N (2s)-2-[[4-[4-(1-butylindolizin-2-yl)phenyl]phenyl]sulfonylamino]-3-phenylpropanoic acid Chemical compound C([C@H](NS(=O)(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)C=1C(=C2C=CC=CN2C=1)CCCC)C(O)=O)C1=CC=CC=C1 YAMKTWOCIRVYGC-HKBQPEDESA-N 0.000 claims description 2
• JBPANPVYVLBQAD-YTTGMZPUSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-fluorophenyl]sulfonyl-methylamino]-3-phenylpropanoic acid Chemical compound C([C@H](N(C)S(=O)(=O)C=1C(=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)F)C(O)=O)C1=CC=CC=C1 JBPANPVYVLBQAD-YTTGMZPUSA-N 0.000 claims description 2
• LJPVNLNUYKHZES-HKBQPEDESA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-fluorophenyl]sulfonylamino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NS(=O)(=O)C=1C(=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)F)C1=CC=CC=C1 LJPVNLNUYKHZES-HKBQPEDESA-N 0.000 claims description 2
• YTZDCEHZTQGKTO-YTTGMZPUSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]benzoyl]-methylamino]-3-methylbutanoic acid Chemical compound C1=CC(C(=O)N(C)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 YTZDCEHZTQGKTO-YTTGMZPUSA-N 0.000 claims description 2
• QEYCNFONUGAJSK-XIFFEERXSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]benzoyl]-methylamino]-3-phenylpropanoic acid Chemical compound C([C@H](N(C)C(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 QEYCNFONUGAJSK-XIFFEERXSA-N 0.000 claims description 2
• DBWYMVBSMCVXFS-YTTGMZPUSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]benzoyl]amino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C1=CC=CC=C1 DBWYMVBSMCVXFS-YTTGMZPUSA-N 0.000 claims description 2
• FCMQUHSEXDYETR-BHVANESWSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-[[3-(trifluoromethyl)phenyl]methyl]amino]-4-methylpentanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=CC=1S(=O)(=O)N([C@@H](CC(C)C)C(O)=O)CC1=CC=CC(C(F)(F)F)=C1 FCMQUHSEXDYETR-BHVANESWSA-N 0.000 claims description 2
• NNFVGFXSJCCBRK-XIFFEERXSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-methylamino]-3-(3-fluorophenyl)propanoic acid Chemical compound C([C@H](N(C)S(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C(O)=O)C1=CC=CC(F)=C1 NNFVGFXSJCCBRK-XIFFEERXSA-N 0.000 claims description 2
• ZRECXQDSNGZOPR-XIFFEERXSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-methylamino]-3-(4-fluorophenyl)propanoic acid Chemical compound C([C@H](N(C)S(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C(O)=O)C1=CC=C(F)C=C1 ZRECXQDSNGZOPR-XIFFEERXSA-N 0.000 claims description 2
• DUJKEHAVYGLFTH-XIFFEERXSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-methylamino]-3-phenylpropanoic acid Chemical compound C([C@H](N(C)S(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 DUJKEHAVYGLFTH-XIFFEERXSA-N 0.000 claims description 2
• ZVKRFSNAJWLMPK-YTTGMZPUSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]-3-(3-fluorophenyl)propanoic acid Chemical compound C([C@@H](C(=O)O)NS(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C1=CC=CC(F)=C1 ZVKRFSNAJWLMPK-YTTGMZPUSA-N 0.000 claims description 2
• MXGLLBXKUZEPRM-YTTGMZPUSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]-3-(4-fluorophenyl)propanoic acid Chemical compound C([C@@H](C(=O)O)NS(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C1=CC=C(F)C=C1 MXGLLBXKUZEPRM-YTTGMZPUSA-N 0.000 claims description 2
• POXAPKDSOPLBBL-YTTGMZPUSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NS(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C1=CC=CC=C1 POXAPKDSOPLBBL-YTTGMZPUSA-N 0.000 claims description 2
• RSVSZFODKAFGLI-LJAQVGFWSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]-4-methylpentanoic acid Chemical compound C1=CC(S(=O)(=O)N[C@@H](CC(C)C)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 RSVSZFODKAFGLI-LJAQVGFWSA-N 0.000 claims description 2
• XYZCEZUHZMQLDP-FQEVSTJZSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]propanoic acid Chemical compound C1=CC(S(=O)(=O)N[C@@H](C)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 XYZCEZUHZMQLDP-FQEVSTJZSA-N 0.000 claims description 2
• NOCKIGVUZLZBOZ-NDEPHWFRSA-N (2s)-2-[[4-[4-(5-methylindol-1-yl)phenyl]benzoyl]amino]-3-phenylpropanoic acid Chemical compound C([C@H](NC(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)N1C2=CC=C(C=C2C=C1)C)C(O)=O)C1=CC=CC=C1 NOCKIGVUZLZBOZ-NDEPHWFRSA-N 0.000 claims description 2
• QVQXHODTLOOOCB-YTTGMZPUSA-N (2s)-2-[[4-[4-[(2-butyl-1-benzofuran-3-yl)methyl]phenyl]benzoyl]-methylamino]-3-phenylpropanoic acid Chemical compound C([C@H](N(C)C(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)CC=1C2=CC=CC=C2OC=1CCCC)C(O)=O)C1=CC=CC=C1 QVQXHODTLOOOCB-YTTGMZPUSA-N 0.000 claims description 2
• JYDNEWUUQHTPMP-YTTGMZPUSA-N (2s)-2-[[4-[4-[(2-butyl-1-benzofuran-3-yl)methyl]phenyl]phenyl]sulfonyl-methylamino]-3-phenylpropanoic acid Chemical compound C([C@H](N(C)S(=O)(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)CC=1C2=CC=CC=C2OC=1CCCC)C(O)=O)C1=CC=CC=C1 JYDNEWUUQHTPMP-YTTGMZPUSA-N 0.000 claims description 2
• LHKBJCSEDWDFQU-UHFFFAOYSA-N 2-[3-chloro-4-(4-dibenzofuran-4-ylphenyl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C(Cl)=CC=1OC(C(=O)O)C1=CC=CC=C1 LHKBJCSEDWDFQU-UHFFFAOYSA-N 0.000 claims description 2
• UHAOLYKGVURGHY-UHFFFAOYSA-N 2-[4-(1-benzylindol-6-yl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=CC=CC=1C(C(=O)O)OC(C=C1)=CC=C1C(C=C12)=CC=C1C=CN2CC1=CC=CC=C1 UHAOLYKGVURGHY-UHFFFAOYSA-N 0.000 claims description 2
• QQYFRIAAVHUCJW-UHFFFAOYSA-N 2-[4-(4-dibenzofuran-4-ylphenyl)-3-(trifluoromethyl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C(C(F)(F)F)=CC=1OC(C(=O)O)C1=CC=CC=C1 QQYFRIAAVHUCJW-UHFFFAOYSA-N 0.000 claims description 2
• OZTCLTRYZGGMDA-UHFFFAOYSA-N 2-[4-(4-dibenzofuran-4-ylphenyl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 OZTCLTRYZGGMDA-UHFFFAOYSA-N 0.000 claims description 2
• RKZNTKWULWPQCU-UHFFFAOYSA-N 2-[4-(4-dibenzothiophen-4-ylphenyl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4S3)C=CC=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 RKZNTKWULWPQCU-UHFFFAOYSA-N 0.000 claims description 2
• PVFRKJHMBYMZRC-UHFFFAOYSA-N 2-[4-(4-indol-1-ylphenyl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)N2C3=CC=CC=C3C=C2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 PVFRKJHMBYMZRC-UHFFFAOYSA-N 0.000 claims description 2
• SQMLYPGVSZMVOH-UHFFFAOYSA-N 2-[4-[4-(1-benzofuran-2-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2OC3=CC=CC=C3C=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 SQMLYPGVSZMVOH-UHFFFAOYSA-N 0.000 claims description 2
• KSKAMSSJHOSHJP-UHFFFAOYSA-N 2-[4-[4-(1-benzothiophen-3-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3SC=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 KSKAMSSJHOSHJP-UHFFFAOYSA-N 0.000 claims description 2
• HHLFYYQYYWYHRW-UHFFFAOYSA-N 2-[4-[4-(1-benzylindol-5-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=CC=CC=1C(C(=O)O)OC(C=C1)=CC=C1C(C=C1)=CC=C1C(C=C1C=C2)=CC=C1N2CC1=CC=CC=C1 HHLFYYQYYWYHRW-UHFFFAOYSA-N 0.000 claims description 2
• QCVMHQBNRWYXOD-UHFFFAOYSA-N 2-[4-[4-(1-butylindolizin-2-yl)phenyl]anilino]-2-phenylacetic acid Chemical compound C=1N2C=CC=CC2=C(CCCC)C=1C(C=C1)=CC=C1C(C=C1)=CC=C1NC(C(O)=O)C1=CC=CC=C1 QCVMHQBNRWYXOD-UHFFFAOYSA-N 0.000 claims description 2
• QJPDJMOOIBYJFT-UHFFFAOYSA-N 2-[4-[4-(1-butylindolizin-2-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1N2C=CC=CC2=C(CCCC)C=1C(C=C1)=CC=C1C(C=C1)=CC=C1OC(C(O)=O)C1=CC=CC=C1 QJPDJMOOIBYJFT-UHFFFAOYSA-N 0.000 claims description 2
• DTLZRYDPCAKNOU-UHFFFAOYSA-N 2-[4-[4-(1-butylindolizin-2-yl)phenyl]phenoxy]propanoic acid Chemical compound C=1N2C=CC=CC2=C(CCCC)C=1C(C=C1)=CC=C1C1=CC=C(OC(C)C(O)=O)C=C1 DTLZRYDPCAKNOU-UHFFFAOYSA-N 0.000 claims description 2
• FESFWYIPANZSEP-UHFFFAOYSA-N 2-[4-[4-(1-butylindolizin-2-yl)phenyl]phenyl]sulfonyl-2-phenylacetic acid Chemical compound C=1N2C=CC=CC2=C(CCCC)C=1C(C=C1)=CC=C1C(C=C1)=CC=C1S(=O)(=O)C(C(O)=O)C1=CC=CC=C1 FESFWYIPANZSEP-UHFFFAOYSA-N 0.000 claims description 2
• VZQPGBMZSRZGNS-UHFFFAOYSA-N 2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-nitroanilino]-3-phenylpropanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C([N+]([O-])=O)C=1NC(C(=O)O)CC1=CC=CC=C1 VZQPGBMZSRZGNS-UHFFFAOYSA-N 0.000 claims description 2
• CBAKPPAEHFOGJA-UHFFFAOYSA-N 2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenoxy]-3-phenylpropanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=CC=1OC(C(=O)O)CC1=CC=CC=C1 CBAKPPAEHFOGJA-UHFFFAOYSA-N 0.000 claims description 2
• PUBMZUOBSIJWOM-UHFFFAOYSA-N 2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenoxy]propanoic acid Chemical compound C1=CC(OC(C)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 PUBMZUOBSIJWOM-UHFFFAOYSA-N 0.000 claims description 2
• CPNWIHWVKIGEIY-UHFFFAOYSA-N 2-[4-[4-(5-chloroindol-1-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)N2C3=CC=C(Cl)C=C3C=C2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 CPNWIHWVKIGEIY-UHFFFAOYSA-N 0.000 claims description 2
• ZNNQOHFMKNTICX-UHFFFAOYSA-N 2-[4-[4-(5-methylindol-1-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C1=CC2=CC(C)=CC=C2N1C(C=C1)=CC=C1C(C=C1)=CC=C1OC(C(O)=O)C1=CC=CC=C1 ZNNQOHFMKNTICX-UHFFFAOYSA-N 0.000 claims description 2
• QQNUVDFADZMUMM-UHFFFAOYSA-N 2-[4-[4-[(9-oxofluoren-1-yl)oxymethyl]phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(COC=3C=4C(=O)C5=CC=CC=C5C=4C=CC=3)=CC=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 QQNUVDFADZMUMM-UHFFFAOYSA-N 0.000 claims description 2
• WHASZUKPNPIWMA-UHFFFAOYSA-N 2-[4-[4-[2-(1,3-benzoxazol-2-yl)phenyl]phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2OC3=CC=CC=C3N=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 WHASZUKPNPIWMA-UHFFFAOYSA-N 0.000 claims description 2
• YPIRSCGUZYBDQH-UHFFFAOYSA-N 2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-[[3-(trifluoromethyl)phenyl]methyl]amino]butanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=CC=1S(=O)(=O)N(C(CC)C(O)=O)CC1=CC=CC(C(F)(F)F)=C1 YPIRSCGUZYBDQH-UHFFFAOYSA-N 0.000 claims description 2
• XYEFJDMJYCPCII-UHFFFAOYSA-N 2-[benzyl-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=CC=1S(=O)(=O)N(CC(=O)O)CC1=CC=CC=C1 XYEFJDMJYCPCII-UHFFFAOYSA-N 0.000 claims description 2
• CNEKYBTXUMIHHG-UHFFFAOYSA-N 3-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]benzoyl]amino]butanoic acid Chemical compound C1=CC(C(=O)NC(CC(O)=O)C)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 CNEKYBTXUMIHHG-UHFFFAOYSA-N 0.000 claims description 2
• XWPMVHQMDVXBDB-UHFFFAOYSA-N 4-(4-dibenzofuran-4-ylphenyl)-4-oxo-2-[[3-(trifluoromethyl)phenyl]methyl]butanoic acid Chemical compound C=1C=C(C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=CC=1C(=O)CC(C(=O)O)CC1=CC=CC(C(F)(F)F)=C1 XWPMVHQMDVXBDB-UHFFFAOYSA-N 0.000 claims description 2
• BVVWCVAFOUVSLH-UHFFFAOYSA-N C=1C=C(C=2C=CC(=CC=2)C=2C=3OC4=CC=CC=C4C=3C=CC=2)C=CC=1CON=C(CC(=O)O)C1=CC=CC=C1 Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C=3OC4=CC=CC=C4C=3C=CC=2)C=CC=1CON=C(CC(=O)O)C1=CC=CC=C1 BVVWCVAFOUVSLH-UHFFFAOYSA-N 0.000 claims description 2
• 125000003342 alkenyl group Chemical group 0.000 claims description 2
• 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims description 2
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
• SSAQFHYJPWVVMQ-XIFFEERXSA-N ethyl (2s)-2-[[4-[4-(1-butylindolizin-2-yl)phenyl]benzoyl]amino]-3-phenylpropanoate Chemical compound C([C@H](NC(=O)C1=CC=C(C=C1)C1=CC=C(C=C1)C=1C(=C2C=CC=CN2C=1)CCCC)C(=O)OCC)C1=CC=CC=C1 SSAQFHYJPWVVMQ-XIFFEERXSA-N 0.000 claims description 2
• JVRMASRCOAIISL-DHUJRADRSA-N ethyl (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-methylamino]-3-phenylpropanoate Chemical compound C([C@@H](C(=O)OCC)N(C)S(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C1=CC=CC=C1 JVRMASRCOAIISL-DHUJRADRSA-N 0.000 claims description 2
• YYKVWSSLOPRIFV-UHFFFAOYSA-N ethyl 2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonylamino]-2-phenylacetate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)NS(=O)(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1C(C1=CC=CC=C1O1)=C1CC1=CC=CC=C1 YYKVWSSLOPRIFV-UHFFFAOYSA-N 0.000 claims description 2
• 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims description 2
• GOJVWLJXXMZQMI-UHFFFAOYSA-N methyl 2-(4-naphtho[3,2-b][1]benzofuran-11-ylphenoxy)propanoate Chemical compound C1=CC(OC(C)C(=O)OC)=CC=C1C1=C2C3=CC=CC=C3OC2=CC2=CC=CC=C12 GOJVWLJXXMZQMI-UHFFFAOYSA-N 0.000 claims description 2
• BXTZNECSSGCFGY-UHFFFAOYSA-N methyl 2-[4-[4-(1-benzofuran-2-yl)phenyl]phenoxy]-2-phenylacetate Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2OC3=CC=CC=C3C=2)C=CC=1OC(C(=O)OC)C1=CC=CC=C1 BXTZNECSSGCFGY-UHFFFAOYSA-N 0.000 claims description 2
• AZRGQGBUQRSTGD-UHFFFAOYSA-N methyl 2-[4-[4-(1-benzylindol-5-yl)phenyl]phenoxy]-2-phenylacetate Chemical compound C=1C=CC=CC=1C(C(=O)OC)OC(C=C1)=CC=C1C(C=C1)=CC=C1C(C=C1C=C2)=CC=C1N2CC1=CC=CC=C1 AZRGQGBUQRSTGD-UHFFFAOYSA-N 0.000 claims description 2
• RMWMMNSXLJCHAU-UHFFFAOYSA-N methyl 2-[4-[4-(1-benzylindol-6-yl)phenyl]phenoxy]-2-phenylacetate Chemical compound C=1C=CC=CC=1C(C(=O)OC)OC(C=C1)=CC=C1C(C=C1)=CC=C1C(C=C12)=CC=C1C=CN2CC1=CC=CC=C1 RMWMMNSXLJCHAU-UHFFFAOYSA-N 0.000 claims description 2
• KIQNHLZNRDWUMP-UHFFFAOYSA-N methyl 2-[4-[4-(1-butylindolizin-2-yl)phenyl]phenyl]sulfonyl-2-phenylacetate Chemical compound C=1N2C=CC=CC2=C(CCCC)C=1C(C=C1)=CC=C1C(C=C1)=CC=C1S(=O)(=O)C(C(=O)OC)C1=CC=CC=C1 KIQNHLZNRDWUMP-UHFFFAOYSA-N 0.000 claims description 2
• SGPSKBLLMIGOLM-UHFFFAOYSA-N methyl 2-[4-[4-[(2-benzoylphenoxy)methyl]phenyl]phenoxy]-2-phenylacetate Chemical compound C=1C=CC=CC=1C(C(=O)OC)OC(C=C1)=CC=C1C(C=C1)=CC=C1COC1=CC=CC=C1C(=O)C1=CC=CC=C1 SGPSKBLLMIGOLM-UHFFFAOYSA-N 0.000 claims description 2
• GPNPPRXNPRQBAM-UHFFFAOYSA-N methyl 2-[4-[4-[(2-benzylphenoxy)methyl]phenyl]phenoxy]-2-phenylacetate Chemical compound C=1C=CC=CC=1C(C(=O)OC)OC(C=C1)=CC=C1C(C=C1)=CC=C1COC1=CC=CC=C1CC1=CC=CC=C1 GPNPPRXNPRQBAM-UHFFFAOYSA-N 0.000 claims description 2
• 125000002071 phenylalkoxy group Chemical group 0.000 claims description 2
• 125000003884 phenylalkyl group Chemical group 0.000 claims description 2
• 125000000335 thiazolyl group Chemical group 0.000 claims description 2
• NHIMACVYYZIWJC-UMSFTDKQSA-N (2s)-2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-ethylamino]-3-(4-fluorophenyl)propanoic acid Chemical compound C([C@H](N(CC)S(=O)(=O)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1C2=CC=CC=C2OC=1CC=1C=CC=CC=1)C(O)=O)C1=CC=C(F)C=C1 NHIMACVYYZIWJC-UMSFTDKQSA-N 0.000 claims 1
• CPYOVRVBMTZDAG-SANMLTNESA-N (2s)-5-amino-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-nitroanilino]-5-oxopentanoic acid Chemical compound C1=C([N+]([O-])=O)C(N[C@@H](CCC(=O)N)C(O)=O)=CC=C1C1=CC=C(C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C1 CPYOVRVBMTZDAG-SANMLTNESA-N 0.000 claims 1
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
• LIKQUXALWNYQST-UHFFFAOYSA-N 2-[2-chloro-4-(4-dibenzofuran-4-ylphenyl)phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=C(Cl)C=1OC(C(=O)O)C1=CC=CC=C1 LIKQUXALWNYQST-UHFFFAOYSA-N 0.000 claims 1
• XNIYTDCYFRYSBN-UHFFFAOYSA-N 2-[4-(4-dibenzofuran-4-ylphenyl)-2-fluorophenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=C(F)C=1OC(C(=O)O)C1=CC=CC=C1 XNIYTDCYFRYSBN-UHFFFAOYSA-N 0.000 claims 1
• GSUCSJIGNHMJKC-UHFFFAOYSA-N 2-[4-(4-dibenzofuran-4-ylphenyl)-3-methylphenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C(C)=CC=1OC(C(O)=O)C1=CC=CC=C1 GSUCSJIGNHMJKC-UHFFFAOYSA-N 0.000 claims 1
• UTEAUCDPBZAWGI-UHFFFAOYSA-N 2-[4-[4-(1-benzothiophen-2-yl)phenyl]phenoxy]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2SC3=CC=CC=C3C=2)C=CC=1OC(C(=O)O)C1=CC=CC=C1 UTEAUCDPBZAWGI-UHFFFAOYSA-N 0.000 claims 1
• OQDDQVVATCIZAD-UHFFFAOYSA-N 2-[4-[4-(1-benzylindol-6-yl)phenyl]phenoxy]-2-phenylacetic acid 4-[4-(4-dibenzofuran-4-ylphenyl)phenyl]-4-oxo-2-[[3-(trifluoromethyl)phenyl]methyl]butanoic acid Chemical compound C(C1=CC=CC=C1)N1C=CC2=CC=C(C=C12)C1=CC=C(C=C1)C1=CC=C(C=C1)OC(C(=O)O)C1=CC=CC=C1.C1=CC=C(C=2OC3=C(C21)C=CC=C3)C3=CC=C(C=C3)C3=CC=C(C=C3)C(CC(C(=O)O)CC3=CC(=CC=C3)C(F)(F)F)=O OQDDQVVATCIZAD-UHFFFAOYSA-N 0.000 claims 1
• QECPNSUUEYVMAI-UHFFFAOYSA-N 2-[[4-(2-dibenzofuran-4-yl-1,3-thiazol-4-yl)phenyl]sulfonyl-ethylamino]-3-phenylpropanoic acid Chemical compound C=1C=C(C=2N=C(SC=2)C=2C=3OC4=CC=CC=C4C=3C=CC=2)C=CC=1S(=O)(=O)N(CC)C(C(O)=O)CC1=CC=CC=C1 QECPNSUUEYVMAI-UHFFFAOYSA-N 0.000 claims 1
• FYGNDRLHDRXPDZ-UHFFFAOYSA-N 2-[[4-(4-dibenzofuran-4-ylphenyl)phenyl]methoxyimino]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C=3OC4=CC=CC=C4C=3C=CC=2)C=CC=1CON=C(C(=O)O)C1=CC=CC=C1 FYGNDRLHDRXPDZ-UHFFFAOYSA-N 0.000 claims 1
• YGUFREKTZUPJMX-UHFFFAOYSA-N 2-[[4-(4-dibenzofuran-4-ylphenyl)phenyl]sulfonylamino]-2-phenylacetic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=CC=1S(=O)(=O)NC(C(=O)O)C1=CC=CC=C1 YGUFREKTZUPJMX-UHFFFAOYSA-N 0.000 claims 1
• IPAXGSIXWVRGDU-UHFFFAOYSA-N 2-[[4-(4-dibenzofuran-4-ylphenyl)phenyl]sulfonylamino]-3-phenylpropanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=C(C4=CC=CC=C4O3)C=CC=2)C=CC=1S(=O)(=O)NC(C(=O)O)CC1=CC=CC=C1 IPAXGSIXWVRGDU-UHFFFAOYSA-N 0.000 claims 1
• JBPANPVYVLBQAD-UHFFFAOYSA-N 2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-2-fluorophenyl]sulfonyl-methylamino]-3-phenylpropanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=C(F)C=1S(=O)(=O)N(C)C(C(O)=O)CC1=CC=CC=C1 JBPANPVYVLBQAD-UHFFFAOYSA-N 0.000 claims 1
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• NHIMACVYYZIWJC-UHFFFAOYSA-N 2-[[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]phenyl]sulfonyl-ethylamino]-3-(4-fluorophenyl)propanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C=2C3=CC=CC=C3OC=2CC=2C=CC=CC=2)C=CC=1S(=O)(=O)N(CC)C(C(O)=O)CC1=CC=C(F)C=C1 NHIMACVYYZIWJC-UHFFFAOYSA-N 0.000 claims 1
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