CA2523618A1 - Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands - Google Patents
Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands Download PDFInfo
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- CA2523618A1 CA2523618A1 CA002523618A CA2523618A CA2523618A1 CA 2523618 A1 CA2523618 A1 CA 2523618A1 CA 002523618 A CA002523618 A CA 002523618A CA 2523618 A CA2523618 A CA 2523618A CA 2523618 A1 CA2523618 A1 CA 2523618A1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US41304602P | 2002-09-24 | 2002-09-24 | |
| GB0222162.0 | 2002-09-24 | ||
| GB0222162A GB0222162D0 (en) | 2002-09-24 | 2002-09-24 | Methods and materials relating to neurogenesis |
| US60/413,046 | 2002-09-24 | ||
| US49459503P | 2003-08-12 | 2003-08-12 | |
| US60/494,595 | 2003-08-12 | ||
| PCT/IB2003/004598 WO2004029229A2 (en) | 2002-09-24 | 2003-09-24 | Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands |
Publications (1)
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| CA2523618A1 true CA2523618A1 (en) | 2004-04-08 |
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| CA002523618A Abandoned CA2523618A1 (en) | 2002-09-24 | 2003-09-24 | Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands |
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| EP (1) | EP1597355A2 (https=) |
| JP (1) | JP2006509497A (https=) |
| AU (1) | AU2003269354B2 (https=) |
| CA (1) | CA2523618A1 (https=) |
| WO (1) | WO2004029229A2 (https=) |
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| EP1779867A4 (en) * | 2004-07-01 | 2009-12-02 | Eisai R&D Man Co Ltd | MEANS FOR PROMOTING NERVE REVENERATION |
| EP1791949A2 (en) * | 2004-09-02 | 2007-06-06 | Neuro Therapeutics AB | Methods and materials relating to enhanced production of dopamine neurons |
| EP1827470A2 (en) * | 2004-12-09 | 2007-09-05 | Neuro Therapeutics AB | Materials and methods related to dickkopfs (dkk) and neurogenesis |
| WO2006091766A2 (en) | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| EP1871407A2 (en) * | 2005-03-31 | 2008-01-02 | The University Of Chicago | Compositions comprising wnt-3 peptide for modulating medial-lateral neuronal topographic maps |
| WO2007119180A2 (en) * | 2006-04-07 | 2007-10-25 | Neuro Therapeutics Ab | Survival and development of neural cells |
| WO2009011892A2 (en) * | 2007-07-18 | 2009-01-22 | Boston Biomedical Research Institute | Use of suif proteins and heparan sulfate in gdnf-dependent neural innervation and protection |
| FR2925903B1 (fr) * | 2008-01-02 | 2011-01-21 | Sanofi Aventis | DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| US20110244569A1 (en) * | 2008-05-13 | 2011-10-06 | Tara Louise Walker | Method of inducing proliferation and/or differentiation of neural precursor cells by introducing prolactin or wnt3a to activate latent neural precursor cells |
| EP2352817B1 (en) * | 2008-10-31 | 2016-01-27 | University Of Louisville Research Foundation, Inc. | Olfactory epithelial-derived stem cells and methods of use therefor |
| JP5802195B2 (ja) * | 2009-04-27 | 2015-10-28 | オタワ ホスピタル リサーチ インスティチュート | 幹細胞を調節するための組成物および方法ならびにその使用 |
| WO2012068170A2 (en) | 2010-11-15 | 2012-05-24 | Jau-Nan Lee | Generation of neural stem cells from human trophoblast stem cells |
| TWI481715B (zh) * | 2010-11-15 | 2015-04-21 | Jau Nan Lee | 從人類滋養層幹細胞中生成神經幹細胞 |
| WO2013040341A2 (en) | 2011-09-16 | 2013-03-21 | Ottawa Hospital Research Institute | Wnt7a compositions and methods of using the same |
| JP2014527818A (ja) | 2011-09-16 | 2014-10-23 | フェイト セラピューティクス，インコーポレイテッド | Ｗｎｔ組成物およびそのような組成物の治療的使用 |
| WO2014085493A1 (en) | 2012-11-30 | 2014-06-05 | Jau-Nan Lee | Methods of differentiating stem cells by modulating mir-124 |
| US9808490B2 (en) | 2014-11-26 | 2017-11-07 | Accelerated Biosciences Corp. | Induced hepatocytes and uses thereof |
| KR101695429B1 (ko) * | 2015-10-15 | 2017-01-12 | 한국과학기술연구원 | 생체외에서 운동 신경세포의 배양 촉진을 위한 코엔자임 q10을 포함하는 조성물 |
| JP2019106895A (ja) * | 2017-12-15 | 2019-07-04 | インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ | 神経幹細胞または神経前駆細胞からドーパミン神経細胞への分化方法 |
| TWI772790B (zh) | 2019-05-06 | 2022-08-01 | 美商加速生物科學有限公司 | 前驅調節滋胚內層細胞及其用途 |
| CN114836386A (zh) * | 2022-04-20 | 2022-08-02 | 电子科技大学 | 一种负载Wnt1蛋白且靶向脑组织的工程化外泌体及其制备方法和应用 |
| WO2025193168A1 (en) * | 2024-03-14 | 2025-09-18 | National University Of Singapore | Method of generating midbrain dopamine progenitors and neurons from stem cells |
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| JPH06157554A (ja) * | 1992-11-27 | 1994-06-03 | Toray Dow Corning Silicone Co Ltd | トリオルガノクロロシランの製造方法 |
| US6277820B1 (en) * | 1998-04-09 | 2001-08-21 | Genentech, Inc. | Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells |
| US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US6312949B1 (en) * | 1999-03-26 | 2001-11-06 | The Salk Institute For Biological Studies | Regulation of tyrosine hydroxylase expression |
| DE60035191T2 (de) * | 1999-05-03 | 2008-06-19 | Neuro Therapeutics Ab | Materialien und methoden zur entwicklung von dopaminergen neuronen |
| WO2001088100A1 (en) * | 2000-05-16 | 2001-11-22 | Kyowa Hakko Kogyo Co., Ltd. | Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof |
| WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| US20020114788A1 (en) * | 2000-07-27 | 2002-08-22 | Ole Isacson | Cell implantation therapy for neurological diseases or disorders |
| US20030211605A1 (en) * | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
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2008
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| AU2003269354B2 (en) | 2008-03-06 |
| US20090087417A1 (en) | 2009-04-02 |
| JP2006509497A (ja) | 2006-03-23 |
| EP1597355A2 (en) | 2005-11-23 |
| US20060233771A1 (en) | 2006-10-19 |
| AU2003269354A1 (en) | 2004-04-19 |
| WO2004029229A2 (en) | 2004-04-08 |
| WO2004029229A3 (en) | 2004-07-22 |
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