CA2521996A1 - Embolic occlusion of uterine arteries - Google Patents
Embolic occlusion of uterine arteries Download PDFInfo
- Publication number
- CA2521996A1 CA2521996A1 CA002521996A CA2521996A CA2521996A1 CA 2521996 A1 CA2521996 A1 CA 2521996A1 CA 002521996 A CA002521996 A CA 002521996A CA 2521996 A CA2521996 A CA 2521996A CA 2521996 A1 CA2521996 A1 CA 2521996A1
- Authority
- CA
- Canada
- Prior art keywords
- embolic material
- bioabsorbable
- bolus
- polylactic acid
- embolic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000003073 embolic effect Effects 0.000 title claims abstract description 70
- 210000000685 uterine artery Anatomy 0.000 title claims abstract description 66
- 239000000463 material Substances 0.000 claims abstract description 73
- 239000004626 polylactic acid Substances 0.000 claims abstract description 29
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 28
- 229920001577 copolymer Polymers 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 21
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 21
- 239000002904 solvent Substances 0.000 claims abstract description 16
- 229920000954 Polyglycolide Polymers 0.000 claims abstract description 11
- 239000004633 polyglycolic acid Substances 0.000 claims abstract description 11
- 239000012530 fluid Substances 0.000 claims abstract description 10
- 210000001367 artery Anatomy 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 17
- 230000001225 therapeutic effect Effects 0.000 claims description 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
- 229920001610 polycaprolactone Polymers 0.000 claims description 10
- 239000004632 polycaprolactone Substances 0.000 claims description 10
- 239000003021 water soluble solvent Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 32
- 238000011282 treatment Methods 0.000 abstract description 11
- 208000016599 Uterine disease Diseases 0.000 abstract description 6
- 210000004204 blood vessel Anatomy 0.000 abstract description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 4
- 235000014655 lactic acid Nutrition 0.000 abstract description 2
- 239000004310 lactic acid Substances 0.000 abstract description 2
- 238000000151 deposition Methods 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 description 37
- 210000004291 uterus Anatomy 0.000 description 31
- 206010046798 Uterine leiomyoma Diseases 0.000 description 27
- 230000017531 blood circulation Effects 0.000 description 17
- 208000007536 Thrombosis Diseases 0.000 description 15
- 239000002245 particle Substances 0.000 description 12
- 206010046788 Uterine haemorrhage Diseases 0.000 description 11
- 238000009802 hysterectomy Methods 0.000 description 10
- 230000010102 embolization Effects 0.000 description 9
- 230000036770 blood supply Effects 0.000 description 8
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000002611 ovarian Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 210000001672 ovary Anatomy 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 230000002146 bilateral effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 230000002357 endometrial effect Effects 0.000 description 4
- 210000001105 femoral artery Anatomy 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 3
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003527 fibrinolytic agent Substances 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 229960000103 thrombolytic agent Drugs 0.000 description 3
- 229960000187 tissue plasminogen activator Drugs 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- 206010053567 Coagulopathies Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000004696 endometrium Anatomy 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- BGOFCVIGEYGEOF-UJPOAAIJSA-N helicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UJPOAAIJSA-N 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010069729 Collateral circulation Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000029312 Muscular tumor Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000036364 Normal newborn Diseases 0.000 description 1
- 206010033165 Ovarian failure Diseases 0.000 description 1
- 241000404883 Pisa Species 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000010108 arterial embolization Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002697 interventional radiology Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002632 myometrial effect Effects 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 201000004535 ovarian dysfunction Diseases 0.000 description 1
- 231100000539 ovarian failure Toxicity 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 206010036601 premature menopause Diseases 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 description 1
- 201000007954 uterine fibroid Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/411,690 US20040202694A1 (en) | 2003-04-11 | 2003-04-11 | Embolic occlusion of uterine arteries |
| US10/411,690 | 2003-04-11 | ||
| PCT/US2004/010525 WO2004091683A2 (en) | 2003-04-11 | 2004-04-04 | Embolic occlusion of uterine arteries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2521996A1 true CA2521996A1 (en) | 2004-10-28 |
Family
ID=33131047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002521996A Abandoned CA2521996A1 (en) | 2003-04-11 | 2004-04-04 | Embolic occlusion of uterine arteries |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040202694A1 (https=) |
| EP (1) | EP1613365A2 (https=) |
| JP (1) | JP2006522651A (https=) |
| AU (1) | AU2004229378A1 (https=) |
| CA (1) | CA2521996A1 (https=) |
| WO (1) | WO2004091683A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6176240B1 (en) | 1995-06-07 | 2001-01-23 | Conceptus, Inc. | Contraceptive transcervical fallopian tube occlusion devices and their delivery |
| US6705323B1 (en) | 1995-06-07 | 2004-03-16 | Conceptus, Inc. | Contraceptive transcervical fallopian tube occlusion devices and methods |
| US7875036B2 (en) | 2004-10-27 | 2011-01-25 | Vascular Control Systems, Inc. | Short term treatment for uterine disorder |
| US7815661B2 (en) | 2005-01-25 | 2010-10-19 | Tyco Healthcare Group, Lp | Method and apparatus for implanting an occlusive structure |
| US20060251581A1 (en) * | 2005-05-09 | 2006-11-09 | Mcintyre Jon T | Method for treatment of uterine fibroid tumors |
| EP3092954A1 (en) | 2005-06-06 | 2016-11-16 | AMS Research Corporation | Devices for ligating uterine arteries |
| US20060276808A1 (en) * | 2005-06-06 | 2006-12-07 | Arnal Kevin R | Minimally Invasive Methods and Apparatus for Accessing and Ligating Uterine Arteries with Sutures |
| US20090043295A1 (en) * | 2005-06-06 | 2009-02-12 | Ams Research Corporation | Fibroid Treatment Methods and Devices |
| US9017361B2 (en) | 2006-04-20 | 2015-04-28 | Covidien Lp | Occlusive implant and methods for hollow anatomical structure |
| US20080114382A1 (en) * | 2006-11-03 | 2008-05-15 | Ams Research Corporation | Uterine Artery Ligation Devices and Methods |
| US20090157064A1 (en) * | 2007-05-11 | 2009-06-18 | Hodel Michael R | RFID System and Method Therefor |
| US9486286B2 (en) | 2007-05-14 | 2016-11-08 | Boston Scientific Scimed, Inc. | Medical laser user interface |
| US20090054915A1 (en) * | 2007-08-23 | 2009-02-26 | Peter Meier | Obstruction of uterine arteries to treat uterine fibroids using mechanical instruments to twist the vessels |
| US20090054916A1 (en) * | 2007-08-23 | 2009-02-26 | Peter Meier | Clip-based method for treatment of uterine fibroids by obstruction of the uterine arteries |
| US20090062827A1 (en) * | 2007-08-31 | 2009-03-05 | Peter Meier | Vacuum-based method for obstruction of uterine arteries to treat uterine fibroids |
| JP2010162063A (ja) * | 2009-01-13 | 2010-07-29 | Japan Health Science Foundation | 塞栓材 |
| US8597262B2 (en) | 2009-07-09 | 2013-12-03 | Ams Research Corporation | Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue |
| US20120271230A1 (en) * | 2011-02-23 | 2012-10-25 | Ams Research Corporation | Fibroid Treatment System and Method |
| TWI641396B (zh) | 2011-09-23 | 2018-11-21 | Bvw控股公司 | 醫療共聚物 |
| US9517572B2 (en) † | 2011-12-27 | 2016-12-13 | Urschel Laboratories, Inc. | Apparatuses for cutting food products |
| TWI503132B (zh) * | 2012-04-27 | 2015-10-11 | Univ Nat Cheng Kung | 栓塞用醫藥微粒 |
| US12239322B2 (en) | 2018-08-17 | 2025-03-04 | Empress Medical, Inc. | Device and method for passing tension member around tissue mass |
| US11419610B2 (en) | 2018-08-17 | 2022-08-23 | Empress Medical, Inc. | Device and method for passing tension member around tissue mass |
| WO2020036981A1 (en) | 2018-08-17 | 2020-02-20 | Empress Medical, Inc. | Devices and methods for compressing tumors |
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-
2003
- 2003-04-11 US US10/411,690 patent/US20040202694A1/en not_active Abandoned
-
2004
- 2004-04-04 EP EP04759154A patent/EP1613365A2/en not_active Withdrawn
- 2004-04-04 WO PCT/US2004/010525 patent/WO2004091683A2/en not_active Ceased
- 2004-04-04 JP JP2006509728A patent/JP2006522651A/ja active Pending
- 2004-04-04 AU AU2004229378A patent/AU2004229378A1/en not_active Abandoned
- 2004-04-04 CA CA002521996A patent/CA2521996A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040202694A1 (en) | 2004-10-14 |
| WO2004091683A2 (en) | 2004-10-28 |
| AU2004229378A1 (en) | 2004-10-28 |
| WO2004091683A3 (en) | 2005-05-06 |
| JP2006522651A (ja) | 2006-10-05 |
| EP1613365A2 (en) | 2006-01-11 |
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