CA2518667C - Systems and methods of blood-based therapies having a microfluidic membraneless exchange device - Google Patents
Systems and methods of blood-based therapies having a microfluidic membraneless exchange device Download PDFInfo
- Publication number
- CA2518667C CA2518667C CA2518667A CA2518667A CA2518667C CA 2518667 C CA2518667 C CA 2518667C CA 2518667 A CA2518667 A CA 2518667A CA 2518667 A CA2518667 A CA 2518667A CA 2518667 C CA2518667 C CA 2518667C
- Authority
- CA
- Canada
- Prior art keywords
- blood
- extraction fluid
- fluid
- channel
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 238
- 239000008280 blood Substances 0.000 title claims abstract description 238
- 238000000034 method Methods 0.000 title claims abstract description 70
- 238000002560 therapeutic procedure Methods 0.000 title description 7
- 239000012530 fluid Substances 0.000 claims abstract description 360
- 239000012528 membrane Substances 0.000 claims abstract description 27
- 238000009792 diffusion process Methods 0.000 claims abstract description 16
- 238000000605 extraction Methods 0.000 claims description 134
- 108010088751 Albumins Proteins 0.000 claims description 26
- 102000009027 Albumins Human genes 0.000 claims description 26
- 210000004027 cell Anatomy 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 102000004506 Blood Proteins Human genes 0.000 claims description 15
- 108010017384 Blood Proteins Proteins 0.000 claims description 15
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 14
- 239000004202 carbamide Substances 0.000 claims description 14
- 210000000601 blood cell Anatomy 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 230000001413 cellular effect Effects 0.000 claims description 7
- 230000000717 retained effect Effects 0.000 claims description 4
- 239000002441 uremic toxin Substances 0.000 claims 10
- 239000012141 concentrate Substances 0.000 claims 6
- 238000005086 pumping Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 8
- 229920002521 macromolecule Polymers 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 6
- 230000007246 mechanism Effects 0.000 abstract description 2
- 239000000306 component Substances 0.000 description 38
- 238000000502 dialysis Methods 0.000 description 23
- 238000012545 processing Methods 0.000 description 21
- 239000000203 mixture Substances 0.000 description 14
- 230000032258 transport Effects 0.000 description 13
- 239000012503 blood component Substances 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 10
- 238000001631 haemodialysis Methods 0.000 description 10
- 230000000322 hemodialysis Effects 0.000 description 10
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 10
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 10
- 230000008901 benefit Effects 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000012546 transfer Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000010100 anticoagulation Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 230000036770 blood supply Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000011026 diafiltration Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000002594 sorbent Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 208000007788 Acute Liver Failure Diseases 0.000 description 3
- 206010000804 Acute hepatic failure Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000000823 artificial membrane Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000002616 plasmapheresis Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical group N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 231100000836 acute liver failure Toxicity 0.000 description 2
- 238000002617 apheresis Methods 0.000 description 2
- 239000012237 artificial material Substances 0.000 description 2
- 238000005842 biochemical reaction Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 208000020832 chronic kidney disease Diseases 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000011889 copper foil Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000385 dialysis solution Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 208000028208 end stage renal disease Diseases 0.000 description 2
- 201000000523 end stage renal failure Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001667 episodic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 206010028417 myasthenia gravis Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000009046 primary transport Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000003870 Drug Overdose Diseases 0.000 description 1
- 208000010334 End Stage Liver Disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020919 Hypervolaemia Diseases 0.000 description 1
- 206010033296 Overdoses Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 229920001486 SU-8 photoresist Polymers 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000009388 chemical precipitation Methods 0.000 description 1
- 208000011444 chronic liver failure Diseases 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009526 daily hemodialysis Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 231100000725 drug overdose Toxicity 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 230000002727 hyperosmolar Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 238000009536 nocturnal hemodialysis Methods 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- LLHKCFNBLRBOGN-UHFFFAOYSA-N propylene glycol methyl ether acetate Chemical compound COCC(C)OC(C)=O LLHKCFNBLRBOGN-UHFFFAOYSA-N 0.000 description 1
- 238000000820 replica moulding Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/11—Laminar flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45457903P | 2003-03-14 | 2003-03-14 | |
| US60/454,579 | 2003-03-14 | ||
| PCT/US2004/007966 WO2004082796A2 (en) | 2003-03-14 | 2004-03-15 | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2518667A1 CA2518667A1 (en) | 2004-09-30 |
| CA2518667C true CA2518667C (en) | 2011-07-19 |
Family
ID=33029896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2518667A Expired - Fee Related CA2518667C (en) | 2003-03-14 | 2004-03-15 | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20040225249A1 (enExample) |
| EP (1) | EP1622691B1 (enExample) |
| JP (1) | JP4489761B2 (enExample) |
| AT (1) | ATE510605T1 (enExample) |
| CA (1) | CA2518667C (enExample) |
| WO (1) | WO2004082796A2 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009096A1 (en) * | 2002-06-08 | 2004-01-15 | Wellman Parris S. | Substantially inertia free hemodialysis |
| US20060076295A1 (en) * | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| ATE510605T1 (de) | 2003-03-14 | 2011-06-15 | Univ Columbia | Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung |
| JP2008515551A (ja) * | 2004-10-06 | 2008-05-15 | ステイト オブ オレゴン アクティング バイ アンド スルー ザ ステイト ボード オブ ハイヤー エデュケーション オン ビハーフ オブ オレゴン ステイト ユニバーシティー | Ｍｅｃｓ透析器 |
| US7955504B1 (en) | 2004-10-06 | 2011-06-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use |
| EP1838442B1 (en) | 2005-01-18 | 2013-09-11 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
| US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
| US8354069B2 (en) * | 2005-03-08 | 2013-01-15 | Authentix, Inc. | Plug flow system for identification and authentication of markers |
| JP5114702B2 (ja) * | 2005-07-29 | 2013-01-09 | 国立大学法人 東京大学 | 両親媒性単分子膜の接触による二分子膜の形成方法およびその装置 |
| US7695956B2 (en) | 2006-01-12 | 2010-04-13 | Biocept, Inc. | Device for cell separation and analysis and method of using |
| EP2019658B1 (en) | 2006-05-22 | 2012-01-25 | The Trustees of Columbia University in the City of New York | Method of microfluidic membraneless exchange in an h-filter and filtration of the extraction fluid outlet streams |
| US9780394B2 (en) | 2006-12-21 | 2017-10-03 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Fuel cell with transport flow across gap |
| US8556844B2 (en) * | 2007-12-14 | 2013-10-15 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for blood treatment |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US8496606B2 (en) | 2008-02-04 | 2013-07-30 | The Trustees Of Columbia University In The City Of New York | Fluid separation devices, systems and methods |
| US20090211977A1 (en) * | 2008-02-27 | 2009-08-27 | Oregon State University | Through-plate microchannel transfer devices |
| US8309259B2 (en) | 2008-05-19 | 2012-11-13 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Electrochemical cell, and particularly a cell with electrodeposited fuel |
| US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
| US20100112391A1 (en) * | 2008-10-31 | 2010-05-06 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Counter-flow membraneless fuel cell |
| US20120103903A1 (en) * | 2009-04-20 | 2012-05-03 | The Trustees Of Columbia University In The City Of New York | Methods, apparatus, and systems for separating fluids |
| US8801922B2 (en) | 2009-06-24 | 2014-08-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Dialysis system |
| JP2012531256A (ja) * | 2009-06-24 | 2012-12-10 | ステイト オブ オレゴン アクティング バイ アンド スルー ザ ステイト ボード オブ ハイヤー エデュケーション オン ビハーフ オブ オレゴン ステイト ユニバーシティー | 透析用マイクロ流体デバイス |
| US20110017608A1 (en) * | 2009-07-27 | 2011-01-27 | Faraday Technology, Inc. | Electrochemical etching and polishing of conductive substrates |
| US9211377B2 (en) | 2009-07-30 | 2015-12-15 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| JP2013504425A (ja) * | 2009-09-14 | 2013-02-07 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | フィルタ血液流路方法、装置及びシステム |
| BR112012005186A2 (pt) * | 2009-09-18 | 2016-03-08 | Fluidic Inc | sistema de células eletroquímicas recarregáveis com uma comutação de modo de carga/descarga de eletrodo de carregamento nas células |
| AU2010303211B2 (en) | 2009-10-08 | 2014-06-12 | Fluidic, Inc. | Rechargeable metal-air cell with flow management system |
| US8753515B2 (en) | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
| US8580161B2 (en) | 2010-05-04 | 2013-11-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluidic devices comprising photocontrollable units |
| US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
| EP2586092B1 (en) | 2010-06-24 | 2017-01-04 | Fluidic, Inc. | Electrochemical cell with stepped scaffold fuel anode |
| KR101227453B1 (ko) | 2010-07-29 | 2013-01-29 | 서강대학교산학협력단 | 인공 신단위 장치 |
| CA2809877C (en) | 2010-09-14 | 2021-11-23 | The Regents Of The University Of California | Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices |
| CN202550031U (zh) | 2010-09-16 | 2012-11-21 | 流体公司 | 具有渐进析氧电极/燃料电极的电化学电池系统 |
| EP2966722B1 (en) | 2010-10-20 | 2018-08-29 | Fluidic, Inc. | Battery resetting process for scaffold fuel electrode |
| JP5908251B2 (ja) | 2010-11-17 | 2016-04-26 | フルイディック，インク．Ｆｌｕｉｄｉｃ，Ｉｎｃ． | 階層型アノードのマルチモード充電 |
| US20120214224A1 (en) * | 2011-02-01 | 2012-08-23 | Chan Eugene Y | Flow based clinical analysis |
| CN102179064B (zh) * | 2011-03-24 | 2013-04-10 | 西南交通大学 | 微流控双水相环隙流萃取技术及装置 |
| WO2013003624A2 (en) | 2011-06-29 | 2013-01-03 | Academia Sinica | The capture, purification and release of biological substance using a surface coating |
| WO2013052680A2 (en) * | 2011-10-07 | 2013-04-11 | Home Dialysis Plus, Ltd. | Heat exchange fluid purification for dialysis system |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| US9414752B2 (en) | 2012-11-09 | 2016-08-16 | Elwha Llc | Embolism deflector |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| EP3126814B1 (en) | 2014-04-01 | 2019-06-12 | Academia Sinica | Methods and systems for cancer diagnosis and prognosis |
| US20150314055A1 (en) | 2014-04-29 | 2015-11-05 | Michael Edward HOGARD | Dialysis system and methods |
| US10052431B2 (en) | 2014-06-09 | 2018-08-21 | Ascent Bio-Nano Technologies, Inc. | System for manipulation and sorting of particles |
| WO2015200857A1 (en) | 2014-06-27 | 2015-12-30 | The Regents Of The University Of California | Apparatus and method for label-free analysis of rare cells from bodily fluids |
| ES2936343T3 (es) * | 2014-08-20 | 2023-03-16 | Stem Sel S R L | Dispositivo para el fraccionamiento de objetos y procedimiento de fraccionamiento |
| US10112198B2 (en) | 2014-08-26 | 2018-10-30 | Academia Sinica | Collector architecture layout design |
| US20160238506A1 (en) * | 2015-02-02 | 2016-08-18 | Derek Oberreit | Ice nucleii counter technology |
| US10107726B2 (en) | 2016-03-16 | 2018-10-23 | Cellmax, Ltd. | Collection of suspended cells using a transferable membrane |
| BR112019000713B1 (pt) | 2016-07-22 | 2023-04-25 | Nantenergy, Inc | Célula eletroquímica e método de conservar umidade dentro de uma célula eletroquímica |
| JP2019517097A (ja) | 2016-07-22 | 2019-06-20 | ナントエナジー，インク． | 電気化学セル用のミスト除去システム |
| JP7025408B2 (ja) | 2016-08-19 | 2022-02-24 | アウトセット・メディカル・インコーポレイテッド | 腹膜透析システム及び方法 |
| US10717086B2 (en) | 2016-08-29 | 2020-07-21 | The Regents Of The University Of California | Integrated system for isolation and emulsification of particles and cells |
| AU2017329058A1 (en) | 2016-09-15 | 2019-04-11 | Nantenergy, Inc. | Hybrid battery system |
| WO2018075870A1 (en) | 2016-10-21 | 2018-04-26 | Fluidic Inc. | Corrugated fuel electrode |
| CN112368079A (zh) * | 2018-04-30 | 2021-02-12 | 联合治疗学有限公司 | 用于控制流体流动的设备和方法 |
| EP3815172A4 (en) | 2018-06-29 | 2022-03-09 | Form Energy, Inc. | ROLLER DIAPHRAGM SEAL |
| CN120184457A (zh) | 2018-06-29 | 2025-06-20 | 福恩能源公司 | 金属空气电化学电池构架 |
| BR112021003168A2 (pt) | 2018-08-23 | 2021-05-11 | Outset Medical, Inc. | métodos para preparar um conjunto de tubos e um dialisador, para testar vazamentos, para preparar um conjunto de tubos, para melhorar a durabilidade e operação de uma ou mais bombas de deslocamento e para prover terapia de diálise, sistema de diálise, e, acessório de queima de bomba |
| US10987671B2 (en) * | 2019-04-05 | 2021-04-27 | Zaiput Flow Technologies LLC | Reservoir-based management of volumetric flow rate in fluidic systems |
| BR112021021836A2 (pt) | 2019-04-30 | 2022-01-04 | Outset Medical Inc | Métodos para calcular a pressão arterial, para criar dialisato em um sistema de diálise, para medir a porcentagem de rejeição em um sistema de diálise, para coletar e analisar plasma sanguíneo, para remover gás de um circuito extracorpóreo de um sistema de diálise, para inferir uma pressão de linha em um circuito extracorpóreo de um sistema de diálise, para prover terapia de diálise extracorpórea e intracorpórea, para montar um conjunto de tubos de paciente no estilo cartucho em uma máquina de diálise e para preparar uma máquina de diálise para terapia de diálise, câmaras de fluxo e de remoção de ar, sistema de diálise, subsistema de dispensação de dialisato, filtro de micróbio/endotoxina de uso único, dialisador, dispositivo para medir pressão de um sistema de diálise, e, conjunto de tubos de sangue |
| US11251476B2 (en) | 2019-05-10 | 2022-02-15 | Form Energy, Inc. | Nested annular metal-air cell and systems containing same |
| WO2020264344A1 (en) | 2019-06-28 | 2020-12-30 | Form Energy Inc. | Device architectures for metal-air batteries |
| EP4147296A4 (en) | 2020-05-06 | 2025-08-13 | Form Energy Inc | ELECTROCHEMICAL ENERGY STORAGE SYSTEM WITH DECOUPLED ELECTRODE |
| CN113855886B (zh) * | 2021-10-20 | 2024-11-08 | 中国科学技术大学 | 一种无膜透析微流控制芯片 |
| CN114699581B (zh) * | 2022-03-31 | 2025-03-07 | 中国科学技术大学 | 具有并行结构的无膜透析微流控芯片 |
Family Cites Families (212)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2885782A (en) * | 1956-06-11 | 1959-05-12 | James R Groves | Vacuum ejector for dental debris |
| US3388803A (en) * | 1965-04-16 | 1968-06-18 | Applied Biolog Sciences Lab In | Wearable dialysis apparatus |
| US3799873A (en) * | 1968-04-19 | 1974-03-26 | Hydronautics | Artificial kidney |
| US3506126A (en) * | 1968-05-03 | 1970-04-14 | Milton Roy Co | Closed recirculating hemodialysis system |
| US3619423A (en) * | 1970-04-20 | 1971-11-09 | Us Health Education & Welfare | Cascade dialysis apparatus and method |
| DE2239254C2 (de) | 1970-12-30 | 1983-08-04 | Organon Teknika Corp., Oklahoma City, Okla. | "Säule zur Regenerierung einer zirkulierenden Dialysatlösung und Verwendung dieser Säule". |
| BE788759A (fr) | 1971-09-14 | 1973-01-02 | Atomic Energy Commission | Dialyseur compact pour la dialyse du sang et autres applications |
| BE792314A (fr) * | 1971-12-06 | 1973-06-05 | Rhone Poulenc Sa | Perfectionnement aux reins artificiels |
| US3994799A (en) | 1973-04-17 | 1976-11-30 | Yao Shang J | Blood and tissue detoxification apparatus |
| US3884808A (en) * | 1973-06-20 | 1975-05-20 | Res Dev Systems Inc | Wearable, self-regenerating dialysis appliance |
| DE2444524A1 (de) * | 1974-09-18 | 1976-04-08 | Oeser Henning Dr | Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilen |
| US4083786A (en) * | 1975-03-20 | 1978-04-11 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus for treating ascites |
| US4153554A (en) | 1977-02-22 | 1979-05-08 | American Micro-Bionics Corp. | Apparatus for use in artificial kidney system |
| US4094775A (en) * | 1977-02-28 | 1978-06-13 | California Institute Of Technology | Dialysis system |
| FR2385406A1 (fr) | 1977-03-28 | 1978-10-27 | Akzo Nv | Rein artificiel |
| US4243775A (en) * | 1978-11-13 | 1981-01-06 | American Cyanamid Company | Synthetic polyester surgical articles |
| US4300565A (en) | 1977-05-23 | 1981-11-17 | American Cyanamid Company | Synthetic polyester surgical articles |
| US4137921A (en) * | 1977-06-24 | 1979-02-06 | Ethicon, Inc. | Addition copolymers of lactide and glycolide and method of preparation |
| US4166800A (en) | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
| US4181983A (en) * | 1977-08-29 | 1980-01-08 | Kulkarni R K | Assimilable hydrophilic prosthesis |
| DE2843963A1 (de) | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| IT1174707B (it) * | 1978-05-03 | 1987-07-01 | Bonomini Vittorio | Rene artificiale portatile per dialisi |
| US4390519A (en) * | 1978-05-19 | 1983-06-28 | Sawyer Philip Nicholas | Bandage with hemostatic agent and methods for preparing and employing the same |
| US4212742A (en) | 1978-05-25 | 1980-07-15 | United States Of America | Filtration apparatus for separating blood cell-containing liquid suspensions |
| DE2838414C2 (de) * | 1978-09-02 | 1984-10-31 | Fresenius AG, 6380 Bad Homburg | Vorrichtung zur Hämodialyse und zum Entziehen von Ultrafiltrat |
| FR2439003A1 (fr) | 1978-10-20 | 1980-05-16 | Anvar | Nouvelles pieces d'osteosynthese, leur preparation et leur application |
| US4247393A (en) * | 1979-01-11 | 1981-01-27 | Wallace Richard A | Hemodialysis assist device |
| JPS6032505B2 (ja) | 1979-03-19 | 1985-07-29 | 株式会社吉野工業所 | 液体噴霧器 |
| US4321192A (en) * | 1980-01-10 | 1982-03-23 | Ionics Incorporated | Fractionation of protein mixtures by salt addition followed by dialysis treatment |
| US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| US5366734A (en) | 1981-02-16 | 1994-11-22 | Zeneca Limited | Continuous release pharmaceutical compositions |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4585797A (en) * | 1981-04-13 | 1986-04-29 | Seton Company | Cosmetic and pharmaceutical sheet material containing polypeptides |
| US4431019A (en) * | 1981-06-25 | 1984-02-14 | Baxter Travenol Laboratories, Inc. | Fluid flow control device |
| US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4443333A (en) * | 1981-09-24 | 1984-04-17 | Mahurkar Sakharam D | Portable dialysis system and pump therefor |
| US4409332A (en) | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| US4450449A (en) * | 1982-02-25 | 1984-05-22 | Honeywell Inc. | Patch array antenna |
| US4538603A (en) | 1982-04-22 | 1985-09-03 | E. R. Squibb & Sons, Inc. | Dressings, granules, and their use in treating wounds |
| US4539981A (en) | 1982-11-08 | 1985-09-10 | Johnson & Johnson Products, Inc. | Absorbable bone fixation device |
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| US4765899A (en) | 1983-10-11 | 1988-08-23 | E. I. Du Pont De Nemours And Company | Apparatus for continuous separation of leukocyte/platelet-enriched fraction from whole blood |
| US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
| US5197977A (en) * | 1984-01-30 | 1993-03-30 | Meadox Medicals, Inc. | Drug delivery collagen-impregnated synthetic vascular graft |
| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4568559A (en) * | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| US4578384A (en) * | 1984-02-15 | 1986-03-25 | The United States Of America As Represented By The Secretary Of The Army | Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue |
| MX163953B (es) | 1984-03-27 | 1992-07-03 | Univ New Jersey Med | Procedimiento para preparar una matriz biodegradable a base de colageno |
| US4837285A (en) | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
| US4765907A (en) * | 1984-03-28 | 1988-08-23 | Research Development Systems, Inc. | Wearable, continuously internally operable and externally regenerable dialysis device |
| US4596574A (en) * | 1984-05-14 | 1986-06-24 | The Regents Of The University Of California | Biodegradable porous ceramic delivery system for bone morphogenetic protein |
| US4663049A (en) * | 1984-07-05 | 1987-05-05 | University Of Utah | Process for therapeutic dissociation of immune complexes and removal of antigens |
| US4678566A (en) * | 1984-07-20 | 1987-07-07 | Terumo Kabushiki Kaisha | Apparatus for separating proteins from blood plasma |
| US4661246A (en) * | 1984-10-01 | 1987-04-28 | Ash Medical Systems, Inc. | Dialysis instrument with dialysate side pump for moving body fluids |
| JPH0662679B2 (ja) | 1985-06-21 | 1994-08-17 | 新田ゼラチン株式会社 | 組織親和性コラ−ゲンとその製法 |
| US4889119A (en) | 1985-07-17 | 1989-12-26 | Ethicon, Inc. | Surgical fastener made from glycolide-rich polymer blends |
| US4741337A (en) * | 1985-07-17 | 1988-05-03 | Ethicon, Inc. | Surgical fastener made from glycolide-rich polymer blends |
| US5011692A (en) * | 1985-12-28 | 1991-04-30 | Sumitomo Pharmaceuticals Company, Limited | Sustained pulsewise release pharmaceutical preparation |
| US5133755A (en) | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
| US4968422A (en) | 1986-06-23 | 1990-11-06 | Runge Thomas M | Pulsatile flow hemodialysis |
| US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US4839130A (en) | 1986-07-17 | 1989-06-13 | United States Surgical Corporation | Process of making an absorbable surgical device |
| US4744365A (en) * | 1986-07-17 | 1988-05-17 | United States Surgical Corporation | Two-phase compositions for absorbable surgical devices |
| JPS6368155A (ja) * | 1986-09-11 | 1988-03-28 | グンゼ株式会社 | 骨接合ピン |
| US5227157A (en) | 1986-10-14 | 1993-07-13 | Board Of Regents, The University Of Texas System | Delivery of therapeutic agents |
| FI80605C (fi) * | 1986-11-03 | 1990-07-10 | Biocon Oy | Benkirurgisk biokompositmaterial. |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US5051272A (en) | 1988-07-19 | 1991-09-24 | United States Surgical Corporation | Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting article |
| GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| US4844854A (en) | 1987-09-22 | 1989-07-04 | United States Surgical Corporation | Process for making a surgical device using two-phase compositions |
| US4822278A (en) * | 1987-10-16 | 1989-04-18 | The Wilkinson Dental Manufacturing Company, Inc. | Dental veneer instrument |
| GB8724914D0 (en) * | 1987-10-23 | 1987-11-25 | Research Corp Ltd | Blood purification apparatus |
| FR2623402B1 (fr) * | 1987-11-19 | 1994-04-29 | Solvay | Article en polymere d'acide lactique utilisable notamment comme prothese biodegradable et procede pour sa realisation |
| US4916193A (en) * | 1987-12-17 | 1990-04-10 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
| US4961707A (en) | 1987-12-22 | 1990-10-09 | University Of Florida | Guided periodontal tissue regeneration |
| US4898734A (en) * | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
| US5011691A (en) * | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5108753A (en) * | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
| US4968590A (en) | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
| DE3825211A1 (de) | 1988-07-25 | 1990-02-01 | Henkel Kgaa | Verbesserte koerperresorbierbare knochenwachse (iii) |
| US5250584A (en) | 1988-08-31 | 1993-10-05 | G-C Dental Industrial Corp. | Periodontium-regenerative materials |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| DE3837498A1 (de) * | 1988-11-04 | 1990-05-17 | Fresenius Ag | Verfahren und vorrichtung zur ultrafiltration bei der haemodialyse |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5324520A (en) | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
| ATE105177T1 (de) | 1988-12-22 | 1994-05-15 | American Cyanamid Co | Verfahren zur behandlung von periodontitis durch protrahierte wirkstoffabgabe von arzneimitteln in der zahnhoehle, zusammensetzung davon und vorrichtung zur verabreichung. |
| US5108755A (en) * | 1989-04-27 | 1992-04-28 | Sri International | Biodegradable composites for internal medical use |
| US6056930A (en) * | 1989-05-24 | 2000-05-02 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| US5460803A (en) | 1989-05-24 | 1995-10-24 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| US6000341A (en) | 1989-05-24 | 1999-12-14 | American Dental Association Health Foundation | Methods and composition for mineralizing and fluoridating calcified tissues |
| US5037639A (en) | 1989-05-24 | 1991-08-06 | American Dental Association Health Foundation | Methods and compositions for mineralizing calcified tissues |
| US5534244A (en) | 1989-05-24 | 1996-07-09 | Tung; Ming S. | Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds |
| US5077049A (en) | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
| US5268178A (en) | 1989-09-25 | 1993-12-07 | The Board Of Regents, The University Of Texas System | Biodegradable antibiotic implants and methods of their use in treating and preventing infections |
| US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| US5193688A (en) | 1989-12-08 | 1993-03-16 | University Of Utah | Method and apparatus for hydrodynamic relaxation and sample concentration NIN field-flow fraction using permeable wall elements |
| US5185152A (en) * | 1990-01-10 | 1993-02-09 | Peyman Gholam A | Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye |
| US5350580A (en) | 1990-03-05 | 1994-09-27 | Minnesota Mining And Manufacturing Company | Device and method for extended delivery of pharmacologically active agents to the ear |
| US5288496A (en) * | 1990-05-15 | 1994-02-22 | Stolle Research & Development Corporation | Growth promoters for animals |
| WO1991017772A1 (en) | 1990-05-16 | 1991-11-28 | Southern Research Institute | Controlled release dopamine and its use to stimulate nerve fiber growth |
| US5080665A (en) * | 1990-07-06 | 1992-01-14 | American Cyanamid Company | Deformable, absorbable surgical device |
| US5324307A (en) | 1990-07-06 | 1994-06-28 | American Cyanamid Company | Polymeric surgical staple |
| US5128136A (en) | 1990-07-16 | 1992-07-07 | The Oregon Health Sciences University | Wound healing kit comprised of gelable collagen |
| US5081106A (en) * | 1990-07-16 | 1992-01-14 | The Oregon Health Sciences University | Wound dressing protocol utilizing collagen gelatin formed with iodine |
| US5231169A (en) | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
| US5114932A (en) | 1990-11-30 | 1992-05-19 | Runge Thomas M | Hyperosmolar oxyreplete hemosubstitute |
| US5206028A (en) * | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
| US5320624A (en) | 1991-02-12 | 1994-06-14 | United States Surgical Corporation | Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom |
| US5171217A (en) | 1991-02-28 | 1992-12-15 | Indiana University Foundation | Method for delivery of smooth muscle cell inhibitors |
| US5149691A (en) | 1991-03-12 | 1992-09-22 | Creative Biomolecules, Inc. | Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone |
| US5284559A (en) * | 1992-06-16 | 1994-02-08 | Rhode Island Hospital | Preparative electrophoresis device and method |
| US5397354A (en) * | 1992-08-19 | 1995-03-14 | Wilk; Peter J. | Method and device for removing a toxic substance from blood |
| US5281419A (en) * | 1992-09-28 | 1994-01-25 | Thomas Jefferson University | Biodegradable drug delivery system for the prevention and treatment of osteomyelitis |
| US5284470A (en) * | 1992-11-02 | 1994-02-08 | Beltz Alex D | Wearable, portable, light-weight artificial kidney |
| DE4309410A1 (de) * | 1993-03-19 | 1995-02-16 | Stange Jan | Material, Verfahren und Einrichtung zur selektiven Trennung frei gelöster und stoffgebundener Stoffe aus flüssigen Stoffgemischen sowie Verfahren zur Herstellung des Materials |
| US5577891A (en) | 1993-11-30 | 1996-11-26 | Instech Laboratories, Inc. | Low power portable resuscitation pump |
| US5415532A (en) * | 1993-11-30 | 1995-05-16 | The United States Of America As Represented By The Secretary Of The Army | High effieciency balanced oscillating shuttle pump |
| US5798042A (en) * | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
| JPH07328110A (ja) * | 1994-06-10 | 1995-12-19 | Nissho Corp | 透析装置の除水制御機構 |
| AU699883B2 (en) * | 1994-10-22 | 1998-12-17 | Central Research Laboratories Limited | Method and apparatus for diffusive transfer between immiscible fluids |
| US5782796A (en) | 1995-02-10 | 1998-07-21 | Baxter International Inc. | Foldable dialysis unit with integral pump and a method for performing solution exchange |
| US5591344A (en) * | 1995-02-13 | 1997-01-07 | Aksys, Ltd. | Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof |
| US5873853A (en) * | 1995-05-23 | 1999-02-23 | Baxter International Inc. | Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same |
| CA2222126A1 (en) * | 1995-06-16 | 1997-01-03 | Fred K. Forster | Microfabricated differential extraction device and method |
| US5716852A (en) * | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
| US5944684A (en) | 1995-08-31 | 1999-08-31 | The Regents Of The University Of California | Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications |
| US5948684A (en) * | 1997-03-31 | 1999-09-07 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
| US20020090644A1 (en) * | 1999-05-21 | 2002-07-11 | Weigl Bernhard H. | Microscale diffusion immunoassay |
| EP0915967A1 (en) * | 1996-05-28 | 1999-05-19 | The Board Of Regents Of The University Of Michigan | Engineering oral tissues |
| WO1997047390A1 (en) * | 1996-06-14 | 1997-12-18 | University Of Washington | Absorption-enhanced differential extraction device |
| US5833954A (en) | 1996-08-20 | 1998-11-10 | American Dental Association Health Foundation | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
| US6432630B1 (en) * | 1996-09-04 | 2002-08-13 | Scandinanian Micro Biodevices A/S | Micro-flow system for particle separation and analysis |
| US5917322A (en) | 1996-10-08 | 1999-06-29 | Massachusetts Institute Of Technology | Method and apparatus for quantum information processing |
| US5902336A (en) * | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
| US5871360A (en) * | 1996-12-31 | 1999-02-16 | Gc Corporation | Method for restoration of a cavity of a tooth using a resin reinforced type glass ionomer cement |
| ES2129344B1 (es) | 1997-01-07 | 2000-03-01 | Univ Barcelona Autonoma | Material remineralizante de tejidos organominerales. |
| US5855562A (en) * | 1997-01-07 | 1999-01-05 | Hudson Respiratory Care Inc. | Suction control valve |
| US6001897A (en) | 1997-01-13 | 1999-12-14 | American Dental Association Health Foundation | Polymerizable conditioners for adhesive bonding to dentin and enamel |
| US6128764A (en) | 1997-02-06 | 2000-10-03 | California Institute Of Technology | Quantum error-correcting codes and devices |
| US6159739A (en) * | 1997-03-26 | 2000-12-12 | University Of Washington | Device and method for 3-dimensional alignment of particles in microfabricated flow channels |
| EP0991705B1 (en) | 1997-03-31 | 2003-09-10 | The Regents Of The University Of Michigan | Open pore biodegradable matrices |
| US5980481A (en) * | 1997-05-08 | 1999-11-09 | Transvivo, Inc. | Method and apparatus for continuous peritoneal cascade dialysis and hemofiltration (CPCD/H) |
| US6117100A (en) | 1997-06-06 | 2000-09-12 | Powers; Kathleen M. | Hemodialysis-double dialyzers in parallel |
| US6472210B1 (en) | 1997-11-14 | 2002-10-29 | Bonetec Corporation | Polymer scaffold having microporous polymer struts defining interconnected macropores |
| US6200814B1 (en) * | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
| US6114408A (en) | 1998-02-06 | 2000-09-05 | American Dental Association Health Foundation | Single-solution adhesive resin formulations |
| US6582385B2 (en) * | 1998-02-19 | 2003-06-24 | Nstage Medical, Inc. | Hemofiltration system including ultrafiltrate purification and re-infusion system |
| US6317766B1 (en) | 1998-11-02 | 2001-11-13 | Lucent Technologies Inc. | Fast quantum mechanical algorithms |
| SE9803987L (sv) * | 1998-11-20 | 2000-05-02 | Gambro Ab | Förfarande och apparat för att förhindra proteinförlust vid peritonealdialys |
| US6398859B1 (en) | 1998-12-24 | 2002-06-04 | American Dental Association Health Foundation | Resin-based pulp capping and basing cements |
| WO2000050049A2 (en) | 1999-02-24 | 2000-08-31 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Artificial salivary gland |
| US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
| US6551842B1 (en) * | 1999-03-26 | 2003-04-22 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
| US6511814B1 (en) * | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
| US6332985B1 (en) | 1999-03-29 | 2001-12-25 | Uop Llc | Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions |
| EP1171178B1 (en) * | 1999-04-23 | 2006-11-22 | RenaMed Biologics, Inc. | Extracorporeal circuit |
| US6406631B1 (en) | 1999-07-30 | 2002-06-18 | Nephros, Inc. | Two stage diafiltration method and apparatus |
| US7015499B1 (en) * | 1999-12-01 | 2006-03-21 | D-Wave Systems, Inc. | Permanent readout superconducting qubit |
| US6459097B1 (en) | 2000-01-07 | 2002-10-01 | D-Wave Systems Inc. | Qubit using a Josephson junction between s-wave and d-wave superconductors |
| DE60141454D1 (de) * | 2000-03-14 | 2010-04-15 | Micronics Inc | Mikrofluid-analysekassette |
| US6527735B1 (en) * | 2000-04-27 | 2003-03-04 | Renaltech International Llc | Method of peritoneal dialysis |
| US20010048637A1 (en) * | 2000-05-24 | 2001-12-06 | Weigl Bernhard H. | Microfluidic system and method |
| US20010055546A1 (en) * | 2000-06-23 | 2001-12-27 | Weigl Bernhard H. | Method and apparatus for controlling fluid flow rate in a microfluidic circuit |
| AU7707801A (en) * | 2000-07-21 | 2002-02-05 | Us Health | Adult human dental pulp stem cells in vitro and in vivo |
| US20020052571A1 (en) * | 2000-09-13 | 2002-05-02 | Fazio Frank A. | Artificial kidney and methods of using same |
| AU2002227111A1 (en) | 2000-10-30 | 2002-05-15 | Nephros, Inc. | Dual-stage filtration cartridge |
| US6899915B2 (en) * | 2000-11-29 | 2005-05-31 | President And Fellows Of Harvard College | Methods and compositions for culturing a biological tooth |
| RU2289426C2 (ru) | 2000-12-08 | 2006-12-20 | Нефрос, Инк. | Способ и устройство для обеспечения стерильности для систем вливания жидкости |
| DE20113789U1 (de) | 2001-01-10 | 2002-05-23 | B. Braun Melsungen Ag, 34212 Melsungen | Medizingerät |
| US6793725B2 (en) | 2001-01-24 | 2004-09-21 | Ada Foundation | Premixed calcium phosphate cement pastes |
| CA2437090C (en) | 2001-02-07 | 2010-10-19 | Nephros, Inc. | Method and apparatus for a hemodiafiltration delivery module |
| EP1399193B1 (en) | 2001-02-16 | 2014-01-08 | Piedmont Renal Clinics, P.A. | Automated peritoneal dialysis system and process with in-line sterilization of dialysate |
| SE0103013D0 (sv) * | 2001-03-09 | 2001-09-12 | Erysave Ab Ideon | System and method for treatment of whole blood |
| US6504172B2 (en) * | 2001-03-16 | 2003-01-07 | D-Wave Systems, Inc. | Superconducting dot/anti-dot flux qubit based on time-reversal symmetry breaking effects |
| US6674525B2 (en) * | 2001-04-03 | 2004-01-06 | Micronics, Inc. | Split focusing cytometer |
| US6742661B1 (en) * | 2001-04-03 | 2004-06-01 | Micronics, Inc. | Well-plate microfluidics |
| US6803599B2 (en) | 2001-06-01 | 2004-10-12 | D-Wave Systems, Inc. | Quantum processing system for a superconducting phase qubit |
| US7481936B2 (en) | 2001-10-17 | 2009-01-27 | Transvivo Inc. | Method and apparatus for patient fluid management |
| US6960179B2 (en) * | 2001-11-16 | 2005-11-01 | National Quality Care, Inc | Wearable continuous renal replacement therapy device |
| US7309323B2 (en) * | 2001-11-16 | 2007-12-18 | National Quality Care, Inc. | Wearable continuous renal replacement therapy device |
| EP1314442A1 (fr) * | 2001-11-26 | 2003-05-28 | Infomed S.A. | Dispositif d'épuration intra- et extracorporelle |
| US6614047B2 (en) | 2001-12-17 | 2003-09-02 | D-Wave Systems, Inc. | Finger squid qubit device |
| US7002174B2 (en) * | 2001-12-18 | 2006-02-21 | D-Wave Systems, Inc. | Characterization and measurement of superconducting structures |
| US6784451B2 (en) | 2001-12-18 | 2004-08-31 | D-Wave Systems Inc. | Multi-junction phase qubit |
| US20040029257A1 (en) * | 2002-01-28 | 2004-02-12 | Co2 Solution | Process for purifying energetic gases such as biogas and natural gas |
| US6796955B2 (en) | 2002-02-14 | 2004-09-28 | Chf Solutions, Inc. | Method to control blood and filtrate flowing through an extracorporeal device |
| US6670630B2 (en) | 2002-03-16 | 2003-12-30 | D-Wave Systems, Inc. | Quantum phase-charge coupled device |
| US6605822B1 (en) | 2002-03-16 | 2003-08-12 | D-Wave Systems, Inc. | Quantum phase-charge coupled device |
| US6911664B2 (en) | 2002-04-15 | 2005-06-28 | D-Wave Systems, Inc. | Extra-substrate control system |
| US6900454B2 (en) * | 2002-04-20 | 2005-05-31 | D-Wave Systems, Inc. | Resonant controlled qubit system |
| US20040009096A1 (en) * | 2002-06-08 | 2004-01-15 | Wellman Parris S. | Substantially inertia free hemodialysis |
| US20030226806A1 (en) | 2002-06-11 | 2003-12-11 | Young Lincoln C. | Methods and devices for liquid extraction |
| ES2339239T3 (es) * | 2002-07-19 | 2010-05-18 | Baxter International Inc. | Sistema para dialisis peritoneal. |
| US7150834B2 (en) | 2003-07-31 | 2006-12-19 | Arryx, Inc. | Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components |
| US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US7582482B2 (en) * | 2002-09-03 | 2009-09-01 | Dionex Corporation | Continuous ion species removal device and method |
| US7094345B2 (en) * | 2002-09-09 | 2006-08-22 | Cytonome, Inc. | Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system |
| US6878271B2 (en) * | 2002-09-09 | 2005-04-12 | Cytonome, Inc. | Implementation of microfluidic components in a microfluidic system |
| US7351218B2 (en) * | 2002-12-20 | 2008-04-01 | Gambro Lundia Ab | Device and process for extracorporeal treatment by citrate anticoagulant |
| ATE510605T1 (de) | 2003-03-14 | 2011-06-15 | Univ Columbia | Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung |
| US20060076295A1 (en) * | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| US7309232B2 (en) | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
| JP2005224775A (ja) * | 2004-02-16 | 2005-08-25 | Fuji Xerox Co Ltd | 微粒子の処理方法及び処理装置 |
| JP2008515551A (ja) | 2004-10-06 | 2008-05-15 | ステイト オブ オレゴン アクティング バイ アンド スルー ザ ステイト ボード オブ ハイヤー エデュケーション オン ビハーフ オブ オレゴン ステイト ユニバーシティー | Ｍｅｃｓ透析器 |
| US20070179435A1 (en) | 2005-12-21 | 2007-08-02 | Braig James R | Analyte detection system with periodic sample draw and body fluid analyzer |
| US8133194B2 (en) | 2006-02-22 | 2012-03-13 | Henry Ford Health System | System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits |
| EP2019658B1 (en) | 2006-05-22 | 2012-01-25 | The Trustees of Columbia University in the City of New York | Method of microfluidic membraneless exchange in an h-filter and filtration of the extraction fluid outlet streams |
-
2004
- 2004-03-15 AT AT04757489T patent/ATE510605T1/de not_active IP Right Cessation
- 2004-03-15 JP JP2006507233A patent/JP4489761B2/ja not_active Expired - Fee Related
- 2004-03-15 US US10/801,366 patent/US20040225249A1/en not_active Abandoned
- 2004-03-15 EP EP04757489A patent/EP1622691B1/en not_active Expired - Lifetime
- 2004-03-15 WO PCT/US2004/007966 patent/WO2004082796A2/en not_active Ceased
- 2004-03-15 CA CA2518667A patent/CA2518667C/en not_active Expired - Fee Related
-
2007
- 2007-07-11 US US11/776,360 patent/US7588550B2/en not_active Expired - Fee Related
-
2009
- 2009-07-07 US US12/499,038 patent/US8083706B2/en not_active Expired - Fee Related
-
2011
- 2011-11-17 US US13/298,344 patent/US8491516B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8083706B2 (en) | 2011-12-27 |
| US20100004578A1 (en) | 2010-01-07 |
| JP4489761B2 (ja) | 2010-06-23 |
| US8491516B2 (en) | 2013-07-23 |
| US20080009780A1 (en) | 2008-01-10 |
| ATE510605T1 (de) | 2011-06-15 |
| EP1622691A2 (en) | 2006-02-08 |
| EP1622691B1 (en) | 2011-05-25 |
| EP1622691A4 (en) | 2007-10-24 |
| US7588550B2 (en) | 2009-09-15 |
| CA2518667A1 (en) | 2004-09-30 |
| WO2004082796A3 (en) | 2006-02-16 |
| JP2006520246A (ja) | 2006-09-07 |
| US20040225249A1 (en) | 2004-11-11 |
| WO2004082796A2 (en) | 2004-09-30 |
| US20120061304A1 (en) | 2012-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2518667C (en) | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device | |
| US8021318B2 (en) | Methods of blood-based therapies having a microfluidic membraneless exchange device | |
| US8470180B2 (en) | Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams | |
| US8535536B1 (en) | Cross-flow split-thin-flow cell | |
| US20120205306A1 (en) | Multi-layered blood component exchange devices, systems, and methods | |
| JP2010507464A (ja) | 液体節約型カスケード血液濾過法 | |
| Leonard et al. | Dialysis without membranes: how and why? | |
| Shapley et al. | Dialysis without Membranes: How and Why? | |
| WO2024024459A1 (ja) | 血漿交換システム、及び血漿交換システムの制御方法 | |
| Yoshida | Rates of blood filtration. A brief review |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140317 |