CA2514255C - Process for preparing pyridine-substituted amino ketal derivatives - Google Patents
Process for preparing pyridine-substituted amino ketal derivatives Download PDFInfo
- Publication number
- CA2514255C CA2514255C CA2514255A CA2514255A CA2514255C CA 2514255 C CA2514255 C CA 2514255C CA 2514255 A CA2514255 A CA 2514255A CA 2514255 A CA2514255 A CA 2514255A CA 2514255 C CA2514255 C CA 2514255C
- Authority
- CA
- Canada
- Prior art keywords
- formula
- hydroxide
- process step
- acetylpyridine
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/51—Acetal radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10305391A DE10305391A1 (de) | 2003-02-11 | 2003-02-11 | Verfahren zur Herstellung von Pyridin-substituierten Aminoketal-Derivaten |
| DE10305391.3 | 2003-02-11 | ||
| PCT/EP2004/000640 WO2004072026A2 (en) | 2003-02-11 | 2004-01-27 | Process for preparing pyridine-substituted amino ketal derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2514255A1 CA2514255A1 (en) | 2004-08-26 |
| CA2514255C true CA2514255C (en) | 2012-01-24 |
Family
ID=32730947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2514255A Expired - Fee Related CA2514255C (en) | 2003-02-11 | 2004-01-27 | Process for preparing pyridine-substituted amino ketal derivatives |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1601648A2 (ru) |
| JP (1) | JP4709741B2 (ru) |
| KR (1) | KR101114893B1 (ru) |
| CN (1) | CN100393701C (ru) |
| AR (1) | AR043132A1 (ru) |
| AU (1) | AU2004212038B2 (ru) |
| BR (1) | BRPI0407349A (ru) |
| CA (1) | CA2514255C (ru) |
| CO (1) | CO5690583A2 (ru) |
| DE (1) | DE10305391A1 (ru) |
| HK (1) | HK1086007A1 (ru) |
| IL (1) | IL169900A (ru) |
| MX (1) | MXPA05007961A (ru) |
| NO (1) | NO332353B1 (ru) |
| NZ (1) | NZ541735A (ru) |
| PL (1) | PL376654A1 (ru) |
| RU (1) | RU2336271C2 (ru) |
| TW (1) | TWI316054B (ru) |
| WO (1) | WO2004072026A2 (ru) |
| ZA (1) | ZA200505298B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115477926B (zh) * | 2022-09-15 | 2024-06-25 | 江苏科技大学 | 一种相变材料及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746669A (en) * | 1985-12-23 | 1988-05-24 | Merck & Co., Inc. | Substituted thiazoles as immunoregulants |
| US4798841A (en) * | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
| US5792871A (en) * | 1996-07-22 | 1998-08-11 | Merck & Co., Inc. | Process for N-Boc-N-(R)-2(3-pyridyl)-2-hydroxy-ethyl)-N-2(4-aminophenyl)ethyl amine and 2-(4-aminophenyl)-N-2-(2(R)-hydroxy-2-phyridin-S-yl-ethyl)acetamide |
| FR2780973B1 (fr) * | 1998-07-09 | 2001-10-05 | Hoechst Marion Roussel Inc | Procede de preparation du 4-(3-pyridinyl)-1h-imidazole, et les intermediaires mis en oeuvre |
-
2003
- 2003-02-11 DE DE10305391A patent/DE10305391A1/de not_active Withdrawn
-
2004
- 2004-01-27 CA CA2514255A patent/CA2514255C/en not_active Expired - Fee Related
- 2004-01-27 WO PCT/EP2004/000640 patent/WO2004072026A2/en active Application Filing
- 2004-01-27 EP EP04705409A patent/EP1601648A2/en not_active Withdrawn
- 2004-01-27 BR BR0407349-5A patent/BRPI0407349A/pt not_active IP Right Cessation
- 2004-01-27 NZ NZ541735A patent/NZ541735A/en not_active IP Right Cessation
- 2004-01-27 PL PL376654A patent/PL376654A1/pl not_active Application Discontinuation
- 2004-01-27 MX MXPA05007961A patent/MXPA05007961A/es active IP Right Grant
- 2004-01-27 AU AU2004212038A patent/AU2004212038B2/en not_active Ceased
- 2004-01-27 KR KR1020057014743A patent/KR101114893B1/ko not_active IP Right Cessation
- 2004-01-27 CN CNB2004800034784A patent/CN100393701C/zh not_active Expired - Fee Related
- 2004-01-27 JP JP2006501606A patent/JP4709741B2/ja not_active Expired - Fee Related
- 2004-01-27 RU RU2005128281/04A patent/RU2336271C2/ru not_active IP Right Cessation
- 2004-02-09 TW TW093102879A patent/TWI316054B/zh not_active IP Right Cessation
- 2004-02-09 AR ARP040100398A patent/AR043132A1/es not_active Application Discontinuation
-
2005
- 2005-06-30 ZA ZA200505298A patent/ZA200505298B/en unknown
- 2005-07-26 IL IL169900A patent/IL169900A/en not_active IP Right Cessation
- 2005-08-09 CO CO05078811A patent/CO5690583A2/es active IP Right Grant
- 2005-09-07 NO NO20054167A patent/NO332353B1/no not_active IP Right Cessation
-
2006
- 2006-05-25 HK HK06106012A patent/HK1086007A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL169900A0 (en) | 2007-07-04 |
| BRPI0407349A (pt) | 2006-01-10 |
| CN1747932A (zh) | 2006-03-15 |
| AR043132A1 (es) | 2005-07-20 |
| MXPA05007961A (es) | 2005-09-20 |
| TW200504020A (en) | 2005-02-01 |
| DE10305391A1 (de) | 2004-08-19 |
| CN100393701C (zh) | 2008-06-11 |
| IL169900A (en) | 2010-12-30 |
| PL376654A1 (pl) | 2006-01-09 |
| RU2336271C2 (ru) | 2008-10-20 |
| CO5690583A2 (es) | 2006-10-31 |
| NO20054167D0 (no) | 2005-09-07 |
| AU2004212038A1 (en) | 2004-08-26 |
| NZ541735A (en) | 2008-06-30 |
| JP2006518716A (ja) | 2006-08-17 |
| EP1601648A2 (en) | 2005-12-07 |
| ZA200505298B (en) | 2008-01-30 |
| WO2004072026A3 (en) | 2004-09-30 |
| RU2005128281A (ru) | 2006-02-10 |
| CA2514255A1 (en) | 2004-08-26 |
| AU2004212038B2 (en) | 2010-11-25 |
| KR101114893B1 (ko) | 2012-03-06 |
| HK1086007A1 (en) | 2006-09-08 |
| WO2004072026B1 (en) | 2004-11-18 |
| NO332353B1 (no) | 2012-09-03 |
| NO20054167L (no) | 2005-10-31 |
| WO2004072026A2 (en) | 2004-08-26 |
| TWI316054B (en) | 2009-10-21 |
| JP4709741B2 (ja) | 2011-06-22 |
| KR20050101205A (ko) | 2005-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160127 |