CA2513141A1 - Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use - Google Patents

Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use Download PDF

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Publication number
CA2513141A1
CA2513141A1 CA002513141A CA2513141A CA2513141A1 CA 2513141 A1 CA2513141 A1 CA 2513141A1 CA 002513141 A CA002513141 A CA 002513141A CA 2513141 A CA2513141 A CA 2513141A CA 2513141 A1 CA2513141 A1 CA 2513141A1
Authority
CA
Canada
Prior art keywords
alkyl
alkenyl
alkynyl
independently selected
carboline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002513141A
Other languages
English (en)
French (fr)
Inventor
Atsuo Kuki
Xinqiang Li
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2513141A1 publication Critical patent/CA2513141A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002513141A 2003-01-27 2004-01-23 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use Abandoned CA2513141A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44322303P 2003-01-27 2003-01-27
US60/443,223 2003-01-27
PCT/IB2004/000259 WO2004067531A1 (en) 2003-01-27 2004-01-23 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use

Publications (1)

Publication Number Publication Date
CA2513141A1 true CA2513141A1 (en) 2004-08-12

Family

ID=32825309

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002513141A Abandoned CA2513141A1 (en) 2003-01-27 2004-01-23 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use

Country Status (7)

Country Link
US (2) US7001912B2 (https=)
EP (1) EP1590349A1 (https=)
JP (1) JP2006516606A (https=)
BR (1) BRPI0407052A (https=)
CA (1) CA2513141A1 (https=)
MX (1) MXPA05007563A (https=)
WO (1) WO2004067531A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
CN100503607C (zh) * 2003-06-02 2009-06-24 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物类化合物及其应用
WO2005103003A2 (en) * 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
EP1873155A1 (en) * 2004-04-26 2008-01-02 Pfizer Inc. Inhibitors of the HIV integrase enzyme
BRPI0510306A (pt) 2004-04-26 2007-09-04 Pfizer inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso
ES2529038T3 (es) * 2004-05-07 2015-02-16 Merck Sharp & Dohme Corp. Inhibidores de la integrasa de VIH
EP1934220A1 (en) * 2005-10-07 2008-06-25 Pfizer Products Incorporated Inhibitors of the hiv integrase enzyme
JP4676536B2 (ja) 2005-12-30 2011-04-27 ギリアド サイエンシズ， インコーポレイテッド Ｈｉｖインテグラーゼ阻害剤の薬物動態の改善方法
CN101573333B (zh) * 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
JP5526339B2 (ja) * 2007-10-26 2014-06-18 国立大学法人 鹿児島大学 複素芳香族化合物を有効成分とする抗ウイルス剤
US9151055B2 (en) 2009-02-25 2015-10-06 Owens Corning Intellectual Capital, Llc Hip and ridge roofing material
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
CN109369510A (zh) * 2018-10-31 2019-02-22 云南大学 具有抗hiv活性的双甲氧基取代咔唑类化合物制备及用途
PH12022553233A1 (en) * 2020-07-23 2024-02-12 Cancer Research Tech Ltd Tricyclic heterocycles
CN119431371A (zh) * 2024-10-22 2025-02-14 沈阳药科大学 一种β-卡波林3,6,9-位修饰衍生物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) * 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
HUP0302962A2 (hu) * 1998-06-12 2003-12-29 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
JP3616628B2 (ja) 2001-03-01 2005-02-02 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物
JP4176477B2 (ja) 2001-03-01 2008-11-05 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
ATE348828T1 (de) * 2001-10-19 2007-01-15 Transtech Pharma Inc Beta-carbolin-derivate als ptp-inhibitoren
EP1441734B1 (en) 2001-10-26 2007-02-28 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
JP4497347B2 (ja) 2001-12-05 2010-07-07 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する誘導体
JP2005515206A (ja) 2001-12-12 2005-05-26 ブリストル−マイヤーズ　スクイブ　カンパニー Ｈｉｖインテグラーゼ・インヒビター
EP1467970B1 (en) 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
WO2003077857A2 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização

Also Published As

Publication number Publication date
WO2004067531A1 (en) 2004-08-12
US7138408B2 (en) 2006-11-21
JP2006516606A (ja) 2006-07-06
US20050165040A1 (en) 2005-07-28
US20060122211A1 (en) 2006-06-08
EP1590349A1 (en) 2005-11-02
MXPA05007563A (es) 2005-09-21
BRPI0407052A (pt) 2006-01-17
US7001912B2 (en) 2006-02-21

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Legal Events

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EEER Examination request
FZDE Dead