CA2507404A1 - Microspheres d'hydrogels polymeres associees a des radioisotopes et procedes de production et d'utilisation de celles-ci - Google Patents

Microspheres d'hydrogels polymeres associees a des radioisotopes et procedes de production et d'utilisation de celles-ci Download PDF

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Publication number
CA2507404A1
CA2507404A1 CA002507404A CA2507404A CA2507404A1 CA 2507404 A1 CA2507404 A1 CA 2507404A1 CA 002507404 A CA002507404 A CA 002507404A CA 2507404 A CA2507404 A CA 2507404A CA 2507404 A1 CA2507404 A1 CA 2507404A1
Authority
CA
Canada
Prior art keywords
microsphere
particles
metal
polymeric material
radioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002507404A
Other languages
English (en)
Inventor
James A. Krom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosphere Medical Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2507404A1 publication Critical patent/CA2507404A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Abstract

L'invention concerne des matériaux polymères qui sont marqués par des métaux colloïdaux, de préférence de l'or colloïdal; des procédés de production associés; et des procédés d'utilisation de ces matériaux dans des applications prophylactiques, thérapeutiques et cosmétiques. De manière spécifique, l'invention concerne des microparticules poreuses injectables et implantables, de préférence des microsphères, qui sont associées à des métaux colloïdaux radioactifs de façon que ces microparticules soient visibles ou détectables à la lumière normale, au moyen de techniques radiologiques et/ou d'imagerie par résonance magnétique. Lesdites microparticules comprenant des métaux colloïdaux radioactifs s'avèrent particulièrement utiles pour l'embolisation, la radiothérapie, l'administration de médicament, la thérapie génique, et d'autres applications médicales prophylactiques ou thérapeutiques.
CA002507404A 2002-11-04 2003-10-17 Microspheres d'hydrogels polymeres associees a des radioisotopes et procedes de production et d'utilisation de celles-ci Abandoned CA2507404A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42354702P 2002-11-04 2002-11-04
US60/423,547 2002-11-04
PCT/US2003/033140 WO2004040972A2 (fr) 2002-11-04 2003-10-17 Microspheres d'hydrogels polymeres associees a des radioisotopes et procedes de production et d'utilisation de celles-ci

Publications (1)

Publication Number Publication Date
CA2507404A1 true CA2507404A1 (fr) 2004-05-21

Family

ID=32312672

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002507404A Abandoned CA2507404A1 (fr) 2002-11-04 2003-10-17 Microspheres d'hydrogels polymeres associees a des radioisotopes et procedes de production et d'utilisation de celles-ci

Country Status (4)

Country Link
EP (1) EP1578455A4 (fr)
AU (1) AU2003285905A1 (fr)
CA (1) CA2507404A1 (fr)
WO (1) WO2004040972A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
WO2006036269A2 (fr) * 2004-09-24 2006-04-06 Biosphere Medical, Inc. Microspheres pouvant se lier a des radio-isotopes, comprenant eventuellement des microparticules metalliques, et methodes d'utilisation associees
EP1814519A1 (fr) * 2004-11-16 2007-08-08 Université de Liège Dispositif d administration d une substance active comprenant une matrice d hydrogel et des microporteurs
WO2006063418A2 (fr) * 2004-12-17 2006-06-22 Facultes Universitaires Notre-Dame De La Paix Dispositif radioactif
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US20070141727A1 (en) * 2005-12-15 2007-06-21 Kimberly-Clark Worldwide, Inc. Luminescent metallic cluster particles and uses thereof
WO2009046281A2 (fr) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Particules injectables
JP6373961B2 (ja) 2013-03-13 2018-08-15 バイオスフィア メディカル，インコーポレイテッド ラジオアイソトープ結合微粒子の組成物及び結合方法
EP2923712A1 (fr) 2014-03-28 2015-09-30 Spago Imaging AB Nanostructures et leurs applications
PL3465697T3 (pl) * 2016-05-24 2020-11-16 Qsa Global Inc. Kuliste źródło irydu o niskiej gęstości
CN111012929B (zh) * 2019-11-27 2022-05-17 原子高科股份有限公司 一种携带放射性粒子的栓剂及其制备方法
EP4241793A1 (fr) 2022-03-08 2023-09-13 Spago Nanomedical AB Nanostructures globulaires
EP4241792A1 (fr) 2022-03-08 2023-09-13 Spago Nanomedical AB Nanostructures et leurs applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676927B1 (fr) * 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
WO2000006243A2 (fr) * 1998-07-28 2000-02-10 Innerdyne, Inc. Dispositifs absorbables d'apport pour curietherapie et chimiotherapie et procedes correspondants
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
AUPR098300A0 (en) * 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres

Also Published As

Publication number Publication date
EP1578455A4 (fr) 2008-12-31
EP1578455A2 (fr) 2005-09-28
WO2004040972A2 (fr) 2004-05-21
WO2004040972A3 (fr) 2004-10-14
AU2003285905A1 (en) 2004-06-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued