CA2501565A1 - Procede de phosphitylation - Google Patents

Procede de phosphitylation Download PDF

Info

Publication number
CA2501565A1
CA2501565A1 CA002501565A CA2501565A CA2501565A1 CA 2501565 A1 CA2501565 A1 CA 2501565A1 CA 002501565 A CA002501565 A CA 002501565A CA 2501565 A CA2501565 A CA 2501565A CA 2501565 A1 CA2501565 A1 CA 2501565A1
Authority
CA
Canada
Prior art keywords
group
substituted
process according
unsubstituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002501565A
Other languages
English (en)
Other versions
CA2501565C (fr
Inventor
Nanda Dulal Sinha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Avecia Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2501565A1 publication Critical patent/CA2501565A1/fr
Application granted granted Critical
Publication of CA2501565C publication Critical patent/CA2501565C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé destiné à la phosphitylation d'un alcool ou d'un thiol avec un agent de phosphitylation en présence d'un activateur. Cet activateur est représenté par la formule générale (1) dans laquelle p vaut 0 ou désigne un entier compris entre 1 et 4 et R désigne un substituant. De préférence, X?7¿ désigne O et p vaut 0. L'activateur est généralement utilisé comme un complexe de sel avec une base organique. Les alcools et les thiols préférés comprennent des nucléosides et des oligonucléotides. Le procédé est particulièrement adapté pour la synthèse de phosphoramidites.
CA2501565A 2002-10-15 2003-10-08 Procede de phosphitylation Expired - Lifetime CA2501565C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41818502P 2002-10-15 2002-10-15
US60/418,185 2002-10-15
PCT/GB2003/004312 WO2004035599A1 (fr) 2002-10-15 2003-10-08 Procede de phosphitylation

Publications (2)

Publication Number Publication Date
CA2501565A1 true CA2501565A1 (fr) 2004-04-29
CA2501565C CA2501565C (fr) 2011-03-15

Family

ID=32107901

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2501565A Expired - Lifetime CA2501565C (fr) 2002-10-15 2003-10-08 Procede de phosphitylation

Country Status (10)

Country Link
US (1) US7247720B2 (fr)
EP (1) EP1554300B1 (fr)
JP (1) JP4756863B2 (fr)
KR (1) KR101065715B1 (fr)
CN (1) CN1329408C (fr)
AT (1) ATE362937T1 (fr)
AU (1) AU2003269239A1 (fr)
CA (1) CA2501565C (fr)
DE (1) DE60313993T2 (fr)
WO (1) WO2004035599A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036122A1 (es) * 2001-07-03 2004-08-11 Avecia Biotechnology Inc Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita
GB0229443D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
EP4089099A1 (fr) * 2020-01-08 2022-11-16 Nitto Denko Corporation Procédé de synthèse d'acide nucléique utilisant un amidite de type segment
WO2023140040A1 (fr) * 2022-01-21 2023-07-27 国立大学法人東海国立大学機構 Monomère amidite

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034534A (en) * 1988-07-15 1991-07-23 E. I. Du Pont De Nemours And Company Process for producing saccharin, saccharin analogues or their salts
US5662111A (en) * 1991-01-28 1997-09-02 Cosman; Eric R. Process of stereotactic optical navigation
US6034534A (en) * 1995-05-25 2000-03-07 Kiyota; Shigeo Laminated contact probe for inspection of ultra-microscopic pitch
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
AR036122A1 (es) * 2001-07-03 2004-08-11 Avecia Biotechnology Inc Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita

Also Published As

Publication number Publication date
CA2501565C (fr) 2011-03-15
DE60313993D1 (de) 2007-07-05
KR101065715B1 (ko) 2011-09-19
JP2006508081A (ja) 2006-03-09
CN1705675A (zh) 2005-12-07
JP4756863B2 (ja) 2011-08-24
CN1329408C (zh) 2007-08-01
ATE362937T1 (de) 2007-06-15
AU2003269239A1 (en) 2004-05-04
US7247720B2 (en) 2007-07-24
EP1554300A1 (fr) 2005-07-20
US20060069247A1 (en) 2006-03-30
KR20050055004A (ko) 2005-06-10
DE60313993T2 (de) 2008-01-24
WO2004035599A1 (fr) 2004-04-29
EP1554300B1 (fr) 2007-05-23

Similar Documents

Publication Publication Date Title
JP4923216B2 (ja) 化合物
KR940021543A (ko) 2-데벤조일-2-아실 탁솔 유도체 및 그의 제조방법
CA2192950A1 (fr) Nouveau procede de production de nucleosides connus et nouveaux, modifies en position 2' par deplacement nucleophile intramoleculaire
JP2003519176A5 (fr)
UA86013C2 (ru) Производные арилалкилкарбаматов, их получение и применение в лечении
IL37984A (en) 2,4-diamino-5-benzylpyrimidine derivatives,their preparation and pharmaceutical compositions containing them
UA96411C2 (en) Synthesis of oligonucleotides
CA2501565A1 (fr) Procede de phosphitylation
JP4473445B2 (ja) リボヌクレオシド−誘導体およびその製造方法
WO2003051897B1 (fr) Composes et bibliotheques d'analogues de nucleosides
KR830007512A (ko) 단시간 작용 β-차단제의 제조방법
CA2253912A1 (fr) Derives de taxane, leur preparation et formulations les contenant
CA2540158A1 (fr) Procede de preparation de composes de 2-halo-2'-deoxyadenosine a partir de 2'-deoxyguanosine
CA1185614A (fr) Agent anti-tumoral contenant un organosilicone
TW200420574A (en) Avermectin-and avermectin monosaccharide derivatives substituted in the 4"-or 4'-position having pesticidal properties
RU2009106034A (ru) Производное 3'-этинилцитидина
CA2337280A1 (fr) Methode de synthese d'amidinohydrazones substituees de cyanure de benzoyle
CA2887025C (fr) Derives de 2,3'-anhydro-2'-desoxy-5-fluorouridine a activite cytotoxique, procede de fabrication et application
RU2008107976A (ru) Противоопухолевые соединения
KR930023031A (ko) 아졸 유도체를 함유하는 항아로마타제제
CA2006734A1 (fr) Derives de carboximidamide
CA2429720A1 (fr) Composes tricycliques servant a inhiber la farnesyl proteine transferase
KR101167297B1 (ko) 포스피틸화제의 제조방법
CA2148613A1 (fr) Derives de substitution 2-perhalogenoalkyliques de benzimidazoles; preparation et utilisation comme pesticides
Korshun et al. Uridine 2′‐Carbamates: Facile Tools for Oligonucleotide 2′‐Functionalization

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20231010